It's time again for Science Watch from
Clarivate to
take its annual look back at the hottest of recent research. The
first table below
lists the researchers who, during 2008, accounted for the the highest
numbers of Hot Papers published over the preceding two years. The
second table
features the papers published during 2008 (aside from reviews) that
were most cited by year's end.
Among the scientists, none fielded more Hot Papers during 2008 than
Kuo-Chen Chou of the Gordon Life Sciences Institute and
Shanghai Jiao Tong University. His 17 Hot Papers published since
2007 cover a variety of sequencing tools for predicting protein
location (e.g., "Euk-mPloc: a fusion classifier for large-scale
eukaryotic protein subcellular location prediction by incorporating
multiple sites," J. Proteome Res., 6[5]: 1728-34, 2007).
Thirteen of these reports were coauthored with another of the
featured scientists, Hong-Bin Shen.
Rudolf
Jaenisch of the Whitehead Institute at MIT, who's interviewed
in this issue, contributed to 13 Hot Papers, primarily on
reprogramming fibroblast cells to a pluripotent state comparable to
embryonic stem cells.
The list is also notable for the number of researchers previously
interviewed in these pages or featured at the
ScienceWatch.com
site: Georgia Tech's
Zhong Lin Wang (November/December 2008), whose Hot Papers
report on nanogenerators and other materials;
Andre K. Geim (July/August 2008), who, with Manchester
colleague
Konstantin Novoselov, has published recent Hot Papers on
graphene;
Virginia M.-Y. Lee (January/February 2007), who has contributed
to nine Hot Papers on neurodegenerative disease, joined by coauthor
and Penn colleague John Q. Trojanowski; and
Salim Yusuf (September/October 1993)
(see also), whose Hot Papers report on
therapy in cardiovascular medicine.
Ji-Huan He (see also:
1 ¦
2) has written on the variational iteration method and
other mathematical concepts. Chemist Benjamin List's Hot Papers
focus chiefly on asymmetric catalysis. Donald P. Schneider has made
the most of his contribution to highly cited reports from the Sloan
Digital Sky Survey, with investigations of quasars and other
phenomena. And Hiroaki Ohnishi, this year's sole high-energy
physicist, is a member of the PHENIX Collaboration, studying
quark-gluon plasma and other states of matter.
The list of 2008's most-cited papers is striking for the prominence
of physical-sciences reports in the top spots—especially
those on iron-based
superconductors,
a topic that accounts for the #1 paper and three others in the top
ten (#5, #6, #7). Theoretical physics, and specifically string
theory, also registers strongly, with several papers examining
recent refinements to M-theory (#9, #12, #29, #34, #35, #40; see
also Physics correspondent Simon Mitton's Top Ten column in this
issue).
Overall, the New England Journal of Medicine makes the
same strong showing as in recent years, accounting for 12 of the 42
papers.
And one 2008 paper, although technically a review and therefore
excluded from the list, certainly merits an honorable mention. "A
short history of SHELX," from Acta Crystallographica A
(G.M. Sheldrick, 64: 112-22, January 2008) was cited a whopping
3,000 times by December 2008, demonstrating that this system of
programs for small-molecule determination is still finding wide
application after more than 30 years in existence.
Christopher King is the Editor of the Science
Watch® Newsletter, Clarivate.
Y. Kamihara, et
al., "Iron-based
superconductor with
La[O1-xFx]FeAs (x =
0.05-0.12) with Tc = 26 K,"J. Am. Chem. Soc., 130(11): 3296-7, 19
March 2008.
249
2
I.H. Park, et al., "Reprogramming
of human somatic cells to pluripotency with defined
factors,"Nature, 451(7175):
141-6, 10 January 2008.
116
3
F.M. Brunkhorst, et al.,
"Intensive insulin therapy and pentastarch
resuscitation in severe sepsis,"New
Engl. J. Med., 358(2): 125-39, 10 January
2008.
112
4
M. Nakagawa, et al., "Generation
of induced pluripotent stem cells without Myc from
mouse and human fibroblasts,"Nature
Biotech., 26(1): 101-6, January 2008.
102
5
X.H. Chen, et al.,
"Superconductivity at 43 K in
SmFeAsO1-xFx,"Nature, 453(7196): 761-2, 5 June 2008.
97
6
C. de la Cruz, et al., "Magnetic
order close to superconductivity in the iron-based
layered LaO1-xFxFeAs
systems,"Nature, 453(7197):
899-902, 12 June 2008.
91
7
Z.A. Ren, et al.,
"Superconductivity at 55K in iron-based
F-doped layered quaternary compound
Sm[O1-xFx]FeAs,"Chinese Phys. Lett., 25(6): 2215-6, June
2008.
85
8
S. Yusuf, et al., "Telmisartan,
ramipril, or both in patients at high risk for
vascular events,"New Engl. J.
Med., 358(15): 1547-59, 10 April 2008.
84
9
J. Bagger, N. Lambert, "Gauge symmetry and
supersymmetry of multiple M2-branes,"Phys. Rev. D, 77(6): no. 065008, 7 March
2008.
79
10
E.H. Turner, et al., "Selective
publication of antidepressant trials and its
influence on apparent efficacy,"New
Engl. J. Med., 358(3): 252-60, 17 January
2008.
77
11
H. Takahashi, et al.,
"Superconductivity at 43K in an iron-based
layered compound
LaO1-xFxFeAs,"Nature, 453(7193): 376-8, 15 April 2008.
76
12
J. Bagger, N. Lambert, "Comments on
multiple M2 branes,"J. High Energy
Phys., 2: no. 105, February 2008.
72
13
J.K. Adelman-McCarthy, et al.,
"The Sixth Data Release of the Sloan
Digital Sky Survey,"Astrophys. J.
Suppl. Ser., 175(2): 297-313, April 2008.
71
14
J.J.P. Kastelein, et al.,
"Simvastatin with or without ezetimibe in
familial hypercholesterolemia,"New
Engl. J. Med., 358(14): 1431-3, 3 April 2008.
69
15
H.C. Gerstein, et al., "Effects of
intensive glucose lowering in type 2
diabetes,"New Engl. J. Med.,
358(24): 2545-59, 12 June 2008.
65
16
P. Gaede, et al., "Effect of a
multifactorial intervention on mortality in type 2
diabetes,"New Engl. J. Med.,
358(6): 580-91, 7 February 2008.
64
17
C.L. Sprung, et al.,
"Hydrocortisone therapy for patients with
septic shock,"New Engl. J. Med.,
358(2): 111-24, 10 January 2008.
64
18
A. Lievre, et al., "KRAS mutations
as an independent prognostic factor in patients
with advanced colorectal cancer treated with
cetuximab,"J. Clin. Oncol.,
26(3): 374-9, 20 January 2008.
55
19
A. Patel, et al., "Intensive blood
glucose control and vascular outcomes in patients
with type 2 diabetes,"New Engl. J.
Med., 358(24): 2560-72, 12 June 2008.
52
20
J. Dong, et al., "Competing orders
and spin-density-wave instability in
La(O1-xFx)FeAs,"EPL-Europhys. Lett., 83(2): no. 27006,
July 2008.
51
21
X.L. Li, et al., "Chemically
derived, ultrasmooth graphene nanoribbon
semiconductors,"Science,
319(5867): 1229-32, 29 February 2008.
51
22
S.L. Hauser, et al., "B-cell
depletion with rituximab in relapsing-remitting
multiple sclerosis,"New Engl. J.
Med., 358(7): 676-88, 14 February 2008.
51
23
A.I. Hochbaum, et al., "Enhanced
thermoelectric performance of rough silicon
nanowires,"Nature, 451(7175):
163-7, 10 January 2008.
51
24
E. Zeggini, et al., "Meta-analysis
of genome-wide association data and large-scale
replication identifies additional susceptibility
loci for type 2 diabetes,"Nature
Genetics, 40(5): 638-45, May 2008.
50
25
S. Kathiresan, et al., "Six new
loci associated with blood low-density lipoprotein
cholesterol, high-density lipoprotein cholesterol
or triglycerides in humans,"Nature
Genetics, 40(2): 189-97, February 2008.
49
26
C.J. Willer, et al., "Newly
identified loci that influence lipid concentrations
and risk of coronary artery disease,"Nature Genetics, 40(2): 161-9, February
2008.
49
27
S. Mallal, et al., "HLA-B*5701
screening for hypersensitivity to
abacavir,"New Engl. J. Med.,
358(6): 568-79, 7 February 2008.
49
28
N.S. Beckett, et al., "Treatment
of hypertension in patients 80 years of age or
older,"New Engl. J. Med.,
358(18): 1887-98, 1 May 2008.
48
29
J. Distler, et al., "M2-branes on
M-folds,"J. High Energy Phys.,
5: no. 38, May 2008.
47
30
T.E. Thorgeirsson, et al., "A
variant associated with nicotine dependence, lung
cancer and peripheral arterial disease,"Nature, 452(7187): 638-42, 3 April 2008.
47
31
S.F. Tavazoie, et al., "Endogenous
human microRNAs that suppress breast cancer
metastasis,"Nature, 451(7175):
147-52, 10 January 2008.
47
32
Z.A. Ren, et al.,
"Superconductivity and phase diagram in
iron-based arsenic-oxides ReFeAsO1-d (Re
= rare-earth metal) without fluorine
doping,"EPL- Europhys. Lett.,
83(1): no 17002, July 2008.
46
33
I. Kirsch, et al., "Initial
severity and antidepressant benefits: A
meta-analysis of data submitted to the Food and
Drug Administration,"PloS Med.,
5(2): 260-8, February 2008.
46
34
M. Van Raamsdonk, "Comments on the
Bagger-Lambert theory and multiple
M2-branes,"J. High Energy Phys.,
5: no. 105, May 2008.
45
35
A. Gustavsson, "Selfdual strings and loop
space Nahm equations,"J. High Energy
Phys., 4: no. 083, April 2008.
45
36
R.J. Hung, et al., "A
susceptibility locus for lung cancer maps to
nicotinic acetylcholine receptor subunit genes on
15q25,"Nature, 452(7187): 633-7,
3 April 2008.
45
37
J. Angle, et al., "First results
from the XENON10 dark matter experiment at the Gran
Sasso National Laboratory,"Phys. Rev.
Lett., 100(2): no. 021303, 18 January 2008.
45
38
T. Walsh, et al., "Rare structural
variants disrupt multiple genes in
neurodevelopmental pathways in
schizophrenia,"Science,
320(5875): 539-43, 25 April 2008.
43
39
S.V. Morozov, et al., "Giant
intrinsic carrier mobilities in graphene and its
bilayer,"Phys. Rev. Lett.,
100(1): no. 016602, 11 January 2008.
43
40
P.M. Ho, "M2 to D2 revisited,"J. High Energy Phys., 7: no. 003, July
2008.
42
41
L.A. Weiss, et al., "Association
between microdeletion and microduplication at
16p11.2 and autism,"New Engl. J.
Med., 358(7): 667-75, 14 February 2008.
42
42
X.X.O. Yang, et al., "T helper 17
lineage differentiation is programmed by orphan
nuclear receptors RORa and ROR?,"Immunity, 28(1): 29-39, January 2008.
42
SOURCE:
ISI
Web of Knowledge® from
Clarivate (Citations recorded as of late
December 2008).
KEYWORDS: HOTTEST RESEARCH OF 2007-08, HOTTEST PAPERS OF 2008,
MOST-CITED PAPERS OF 2008, MULTIPLE HOT PAPERS, KUO-CHEN CHOU,
IRON-BASED SUPERCONDUCTORS, M-THEORY, NEW ENGLAND JOURNAL OF
MEDICINE.