EARLY ALZHEIMER DISEASE

Research Front Map for the Special Topic of Alzheimer's Disease, March 2011

Research front maps are diagrammatic representations of the core papers comprising each front. They are selected from the current Research Front set that are relevant to the featured special topic, in this case, Alzheimer's Disease. The title for this Research Front Map is "EARLY ALZHEIMER DISEASE," containing 13 core papers. Source dates: November 2004-October 31, 2010, the fifth bimonthly period of 2010 (sliding 6-year period).

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The solid lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together); weaker links are indicated by dashed lines. Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps. Note: For best results use the "landscape orientation" option when printing this page.

EARLY ALZHEIMER DISEASE

Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice A beta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer Modeling Spinal Muscular Atrophy in Drosophila A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice Development of a Single Vector System that Enhances Trans-Splicing of SMN2 Transcripts Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

Core Papers


Label: Nixon-2005
Title: Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
Journal: J NEUROPATHOL EXP NEUROL, 64 (2): 113-122 FEB 2005
Citations: 169
Authors: Nixon, RA;Wegiel, J;Kumar, A;Yu, WH;Peterhoff, C;Cataldo, A;Cuervo, AM
Addresses:
NYU, Sch Med, Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA
NYU, Sch Med, Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
NYU, Sch Med, Dept Psychiat, New York, NY USA
NYU, Sch Med, Dept Cell Biol, New York, NY USA
New York State Inst Basic Res Dev Disabil, Dept Pathol Neurobiol, Staten Isl, NY USA
McLean Hosp, Mailman Res Ctr, Lab Mol Neuropathol, Belmont, MA 02178 USA
Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, Bronx, NY 10461 USA


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Label: Pickford-2008
Title: The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
Journal: J CLIN INVEST, 118 (6): 2190-2199 JUN 2008
Citations: 67
Authors: Pickford, F;Masliah, E;Britschgi, M;Lucin, K;Narasimhan, R;Jaeger, PA;Small, S;Spencer, B;Rockenstein, E;Levine, B;Wyss-Coray, T
Addresses:
Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, SUMC Room A343, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
UCSD, Dept Neurosci & Pathol, La Jolla, CA USA
Free Univ Berlin, Inst Chem & Biochem, D-1000 Berlin, Germany
Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
Univ Texas SW Med Ctr Dallas, Div Infect Dis, Dallas, TX 75390 USA
VA Palo Alto Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Palo Alto, CA USA


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Label: Boland-2008
Title: Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Journal: J NEUROSCI, 28 (27): 6926-6937 JUL 2 2008
Citations: 66
Authors: Boland, B;Kumar, A;Lee, S;Platt, FM;Wegiel, J;Yu, WH;Nixon, RA
Addresses:
Univ Coll Dublin, Conway Inst, Lab Neurodegenerat Res, Sch Biomol & Biomed Sci, Dublin 4, Ireland
Univ Coll Dublin, Conway Inst, Lab Neurodegenerat Res, Sch Biomol & Biomed Sci, Dublin 4, Ireland
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
NYU, Dept Psychiat, New York, NY 10016 USA
NYU, Dept Cell Biol, New York, NY 10016 USA
NYU, Dept Neurosci, New York, NY 10016 USA
Columbia Univ, Taub Inst, New York, NY 10032 USA
Columbia Univ, Dept Pathol, New York, NY 10032 USA
New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA


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Label: Foust-2009
Title: Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
Journal: NAT BIOTECHNOL, 27 (1): 59-65 JAN 2009
Citations: 42
Authors: Foust, KD;Nurre, E;Montgomery, CL;Hernandez, A;Chan, CM;Kaspar, BK
Addresses:
Nationwide Childrens Hosp, Res Inst, Ctr Gene Therapy, 700 Childrens Dr, Columbus, OH 43205 USA
Nationwide Childrens Hosp, Res Inst, Ctr Gene Therapy, Columbus, OH 43205 USA
Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43205 USA
Preclin Serv Nevada, Special Pathol Serv, Reno, NV 89511 USA


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Label: Burghes-2009
Title: Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?
Journal: NAT REV NEUROSCI, 10 (8): 597-609 AUG 2009
Citations: 31
Authors: Burghes, AHM;Beattie, CE
Addresses:
Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA
Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA
Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA
Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
Ohio State Univ, Ctr Mol Neurobiol, Columbus, OH 43210 USA


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Label: Kong-2009
Title: Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice
Journal: J NEUROSCI, 29 (3): 842-851 JAN 21 2009
Citations: 31
Authors: Kong, LL;Wang, XY;Choe, DW;Polley, M;Burnett, BG;Bosch-Marce, M;Griffin, JW;Rich, MM;Sumner, CJ
Addresses:
Johns Hopkins Univ, Dept Neurol, 600 N Wolfe St,Meyer 5-119B, Baltimore, MD 21287 USA
Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21287 USA
Wright State Univ, Dept Neurol Neurosci Cell Biol & Physiol, Dayton, OH 45435 USA
NINDS, Neurogenet Branch, NIH, Bethesda, MD 20892 USA


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Label: Iijima-2008
Title: A beta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
Journal: PLOS ONE, 3 (2): art. no.-e1703 FEB 27 2008
Citations: 15
Authors: Iijima, K;Chiang, HC;Hearn, SA;Hakker, I;Gatt, A;Shenton, C;Granger, L;Leung, A;Iijima-Ando, K;Zhong, Y
Addresses:
Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA


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Label: Ling-2009
Title: Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila
Journal: PLOS ONE, 4 (1): art. no.-e4201 JAN 15 2009
Citations: 14
Authors: Ling, DJ;Song, HJ;Garza, D;Neufeld, TP;Salvaterra, PM
Addresses:
Beckman Res Inst City Hope, Div Neurosci, Duarte, CA USA


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Label: Foust-2010
Title: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN
Journal: NAT BIOTECHNOL, 28 (3): 271-U126 MAR 2010
Citations: 12
Authors: Foust, KD;Wang, XY;McGovern, VL;Braun, L;Bevan, AK;Haidet, AM;Le, TT;Morales, PR;Rich, MM;Burghes, AHM;Kaspar, BK
Addresses:
Nationwide Childrens Hosp, Res Inst, Ctr Gene Therapy, Columbus, OH USA
Nationwide Childrens Hosp, Res Inst, Ctr Gene Therapy, Columbus, OH USA
Wright State Univ, Dayton, OH 45435 USA
Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA
Ohio State Univ, Integrated Biomed Grad Program, Columbus, OH 43210 USA
Mannheimer Fdn Inc, Homestead, FL USA


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Label: Ratnaparkhi-2008
Title: A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism
Journal: PLOS ONE, 3 (6): art. no.-e2334 JUN 4 2008
Citations: 11
Authors: Ratnaparkhi, A;Lawless, GM;Schweizer, FE;Golshani, P;Jackson, GR
Addresses:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA


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Label: Singh-2009
Title: A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy
Journal: RNA BIOL, 6 (3): 341-350 JUL-AUG 2009
Citations: 11
Authors: Singh, NN;Shishimorova, M;Cao, LC;Gangwani, L;Singh, RN
Addresses:
Iowa State Univ, Coll Vet Med, Dept Biomed Sci, 2034 Vet Med Bldg, Ames, IA USA
Iowa State Univ, Coll Vet Med, Dept Biomed Sci, Ames, IA USA
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA
Med Coll Georgia, Sch Med, Dept Cellular Biol & Anat, Augusta, GA 30912 USA


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Label: Chang-2008
Title: Modeling Spinal Muscular Atrophy in Drosophila
Journal: PLOS ONE, 3 (9): art. no.-e3209 SEP 15 2008
Citations: 10
Authors: Chang, HCH;Dimlich, DN;Yokokura, T;Mukherjee, A;Kankel, MW;Sen, A;Sridhar, V;Fulga, TA;Hart, AC;Van Vactor, D;Artavanis-Tsakonas, S
Addresses:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02163 USA


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Label: Coady-2008
Title: Development of a Single Vector System that Enhances Trans-Splicing of SMN2 Transcripts
Journal: PLOS ONE, 3 (10): art. no.-e3468 OCT 22 2008
Citations: 9
Authors: Coady, TH;Baughan, TD;Shababi, M;Passini, MA;Lorson, CL
Addresses:
Univ Missouri, Bond Life Sci Ctr, Dept Vet Pathobiol, Columbia, MO 65211 USA


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KEYWORDS: SPINAL MUSCULAR ATROPHY MICE; SPINAL MUSCULAR ATROPHY PHENOTYPE; MODELING SPINAL MUSCULAR ATROPHY; EARLY ALZHEIMER DISEASE; DROSOPHILA MODEL.
[7054 (2000-2010_5) (CLI/NEU: ST ALZHEIMER'S DISEASE) (MARCH 2011)]

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