ALZHEIMER'S BETA-AMYLOID FIBRILS

Research Front Map for the Special Topic of Alzheimer's Disease, March 2011

Research front maps are diagrammatic representations of the core papers comprising each front. They are selected from the current Research Front set that are relevant to the featured special topic, in this case, Alzheimer's Disease. The title for this Research Front Map is "ALZHEIMER'S BETA-AMYLOID FIBRILS," containing 23 core papers. Source dates: November 2004-October 31, 2010, the fifth bimonthly period of 2010 (sliding 6-year period).

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The solid lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together); weaker links are indicated by dashed lines. Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps. Note: For best results use the "landscape orientation" option when printing this page.

ALZHEIMER'S BETA-AMYLOID FIBRILS

Self-propagating, molecular-level polymorphism in Alzheimer Molecular basis for amyloid fibril formation and stability Structural insights into a yeast prion illuminate nucleation and strain diversity Structure of the cross-beta spine of amyloid-like fibrils Correlation of structural elements and infectivity of the HET-s prion Protein structure determination by high-resolution solid-state NMR spectroscopy: Application to microcrystalline ubiquitin Magic-angle spinning solid-state NMR spectroscopy of the beta 1 immunoglobulin binding domain of protein G (GB1): N-15 and C-13 chemical shift assignments and conformational analysis Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR 3D structure of Alzheimer Experimental constraints on quaternary structure in Alzheimer Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR The physical basis of how prion conformations determine strain phenotypes Protein misfolding, functional amyloid, and human disease Molecular structure of amyloid fibrils: insights from solid-state NMR Curli biogenesis and function Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure Polymorphism in the intermediates and products of amyloid assembly Atomic structures of amyloid cross-beta spines reveal varied steric zippers Functional amyloid - from bacteria to humans The structural basis of yeast prion strain variants Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core Molecular structural basis for polymorphism in Alzheimer Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Core Papers


Label: Chiti-2006
Title: Protein misfolding, functional amyloid, and human disease
Journal: ANNU REV BIOCHEM, 75: 333-366 2006
Citations: 749
Authors: Chiti, F;Dobson, CM
Addresses:
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Univ Florence, Dipartimento Sci Biochim, I-50134 Florence, Italy
Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
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Label: Nelson-2005
Title: Structure of the cross-beta spine of amyloid-like fibrils
Journal: NATURE, 435 (7043): 773-778 JUN 9 2005
Citations: 538
Authors: Nelson, R;Sawaya, MR;Balbirnie, M;Madsen, AO;Riekel, C;Grothe, R;Eisenberg, D
Addresses:
Univ Calif Los Angeles, Howard Hughes Med Inst, UCLA DOE Inst Genom & Proteom, Box 951570, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Howard Hughes Med Inst, UCLA DOE Inst Genom & Proteom, Los Angeles, CA 90095 USA
European Synchrotron Radiat Facil, F-38043 Grenoble, France
Univ Copenhagen, Ctr Crystallog Studies, Dept Chem, DK-2100 KBH, Denmark
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Label: Petkova-2005
Title: Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
Journal: SCIENCE, 307 (5707): 262-265 JAN 14 2005
Citations: 426
Authors: Petkova, AT;Leapman, RD;Guo, ZH;Yau, WM;Mattson, MP;Tycko, R
Addresses:
NIDDKD, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
NIDDKD, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
NIH, Div Bioengn & Phys Sci, Off Res Serv, Bethesda, MD 20892 USA
NIA, Neurosci Lab, NIH, Baltimore, MD 21224 USA
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Label: Luhrs-2005
Title: 3D structure of Alzheimer's amyloid-beta(1-42) fibrils
Journal: PROC NAT ACAD SCI USA, 102 (48): 17342-17347 NOV 29 2005
Citations: 367
Authors: Luhrs, T;Ritter, C;Adrian, M;Riek-Loher, D;Bohrmann, B;Doeli, H;Schubert, D;Riek, R
Addresses:
Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
Salk Inst Biol Studies, La Jolla, CA 92037 USA
F Hoffmann La Roche, CH-4070 Basel, Switzerland
Univ Lausanne, Lab Analyse Ultrastruct, CH-1015 Lausanne, Switzerland
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Label: Sawaya-2007
Title: Atomic structures of amyloid cross-beta spines reveal varied steric zippers
Journal: NATURE, 447 (7143): 453-457 MAY 24 2007
Citations: 318
Authors: Sawaya, MR;Sambashivan, S;Nelson, R;Ivanova, MI;Sievers, SA;Apostol, MI;Thompson, MJ;Balbirnie, M;Wiltzius, JJW;McFarlane, HT;Madsen, AO;Riekel, C;Eisenberg, D
Addresses:
Univ Calif Los Angeles, DOE Inst Genom & Proteom, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, DOE Inst Genom & Proteom, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
Univ Copenhagen, Ctr Crystallog Studies, Dept Chem, DK-2100 Copenhagen, Denmark
European Synchrotron Radiat Facil, BP 220, F-38043 Grenoble, France
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Label: Petkova-2006
Title: Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils
Journal: BIOCHEMISTRY-USA, 45 (2): 498-512 JAN 17 2006
Citations: 249
Authors: Petkova, AT;Yau, WM;Tycko, R
Addresses:
NIDDK, Chem Phys Lab, NIH, Bldg 5,Room 112, Bethesda, MD 20892 USA
NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
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Label: Ritter-2005
Title: Correlation of structural elements and infectivity of the HET-s prion
Journal: NATURE, 435 (7043): 844-848 JUN 9 2005
Citations: 208
Authors: Ritter, C;Maddelein, ML;Siemer, AB;Luhrs, T;Ernst, M;Meier, BH;Saupe, SJ;Riek, R
Addresses:
Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
Salk Inst Biol Studies, La Jolla, CA 92037 USA
Univ Bordeaux 2, CNRS,Unite Mixte Rech 5095, Inst Biochim & Genet Cellulaires, Lab Genet Mol Champignons, F-33077 Bordeaux, France
ETH Honggerberg, ETH Zurich, Phys Chem, CH-8093 Zurich, Switzerland
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Label: Makin-2005
Title: Molecular basis for amyloid fibril formation and stability
Journal: PROC NAT ACAD SCI USA, 102 (2): 315-320 JAN 11 2005
Citations: 204
Authors: Makin, OS;Atkins, E;Sikorski, P;Johansson, J;Serpell, LC
Addresses:
Univ Sussex, Dept Biochem, Sch Life Sci, John Maynard Smith Bldg, Falmer BN1 9QG, England
Univ Sussex, Dept Biochem, Sch Life Sci, Falmer BN1 9QG, England
Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 2XY, England
Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
Norwegian Univ Sci & Technol, Dept Phys, NO-7491 Trondheim, Norway
Swedish Univ Agr Sci, Ctr Biomed, Dept Mol Biosci, S-75123 Uppsala, Sweden
Univ Sussex, Sch Life Sci, Dept Biochem, Brighton BN1 9QG, E Sussex, England
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Label: Krishnan-2005
Title: Structural insights into a yeast prion illuminate nucleation and strain diversity
Journal: NATURE, 435 (7043): 765-772 JUN 9 2005
Citations: 192
Authors: Krishnan, R;Lindquist, SL
Addresses:
Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
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Label: Heise-2005
Title: Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR
Journal: PROC NAT ACAD SCI USA, 102 (44): 15871-15876 NOV 1 2005
Citations: 164
Authors: Heise, H;Hoyer, W;Becker, S;Andronesi, OC;Riedel, D;Baldus, M
Addresses:
Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Mol Biol, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Electron Microscopy, D-37077 Gottingen, Germany
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Label: Wasmer-2008
Title: Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core
Journal: SCIENCE, 319 (5869): 1523-1526 MAR 14 2008
Citations: 136
Authors: Wasmer, C;Lange, A;Van Melckebeke, H;Siemer, AB;Riek, R;Meier, BH
Addresses:
ETH, CH-8093 Zurich, Switzerland
ETH, CH-8093 Zurich, Switzerland
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Label: Lange-2006
Title: Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR
Journal: NATURE, 440 (7086): 959-962 APR 13 2006
Citations: 130
Authors: Lange, A;Giller, K;Hornig, S;Martin-Eauclaire, MF;Pongs, O;Becker, S;Baldus, M
Addresses:
Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
Univ Hamburg, Zentrum Mol Neurobiol, Inst Neurale Signalverarbeitung, D-20251 Hamburg, Germany
Univ Mediterranee, CNRS, Inst Jean Roche, F-13916 Marseille, France
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Label: Tanaka-2006
Title: The physical basis of how prion conformations determine strain phenotypes
Journal: NATURE, 442 (7102): 585-589 AUG 3 2006
Citations: 123
Authors: Tanaka, M;Collins, SR;Toyama, BH;Weissman, JS
Addresses:
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
Calif Inst Quantitat Biomed Res, San Francisco, CA 94143 USA
Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan
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Label: Franks-2005
Title: Magic-angle spinning solid-state NMR spectroscopy of the beta 1 immunoglobulin binding domain of protein G (GB1): N-15 and C-13 chemical shift assignments and conformational analysis
Journal: J AM CHEM SOC, 127 (35): 12291-12305 SEP 7 2005
Citations: 109
Authors: Franks, WT;Zhou, DH;Wylie, BJ;Money, BG;Graesser, DT;Frericks, HL;Sahota, G;Rienstra, CM
Addresses:
Univ Illinois, Dept Chem, 600 S Mathews Ave, Urbana, IL 61801 USA
Univ Illinois, Dept Chem, Urbana, IL 61801 USA
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Label: Zech-2005
Title: Protein structure determination by high-resolution solid-state NMR spectroscopy: Application to microcrystalline ubiquitin
Journal: J AM CHEM SOC, 127 (24): 8618-8626 JUN 22 2005
Citations: 109
Authors: Zech, SG;Wand, AJ;McDermott, AE
Addresses:
Columbia Univ, Dept Chem, 3000 Broadway Mail Code 3113, New York, NY 10027 USA
Columbia Univ, Dept Chem, New York, NY 10027 USA
Univ Penn, Johnson Res Fdn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
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Label: Fowler-2007
Title: Functional amyloid - from bacteria to humans
Journal: TRENDS BIOCHEM SCI, 32 (5): 217-224 MAY 2007
Citations: 107
Authors: Fowler, DM;Koulov, AV;Balch, WE;Kelly, JW
Addresses:
Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA
Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA
Skaggs Inst Chem Biol, Scripps Res Inst, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA
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Label: Tycko-2006
Title: Molecular structure of amyloid fibrils: insights from solid-state NMR
Journal: QUART REV BIOPHYS, 39 (1): 1-55 FEB 2006
Citations: 104
Authors: Tycko, R
Addresses:
NIDDK, Chem Phys Lab, NIH, Bldg 5,Room 112, Bethesda, MD 20892 USA
NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
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Label: Barnhart-2006
Title: Curli biogenesis and function
Journal: ANNU REV MICROBIOL, 60: 131-147 2006
Citations: 93
Authors: Barnhart, MM;Chapman, MR
Addresses:
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
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Label: Shewmaker-2006
Title: Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure
Journal: PROC NAT ACAD SCI USA, 103 (52): 19754-19759 DEC 26 2006
Citations: 79
Authors: Shewmaker, F;Wickner, RB;Tycko, R
Addresses:
Natl Inst Diab & Digest & Kidney DIs, Lab Chem Phys, NIH, Bldg 5,Room 112, Bethesda, MD 20892 USA
Natl Inst Diab & Digest & Kidney DIs, Lab Chem Phys, NIH, Bethesda, MD 20892 USA
Natl Inst Diab & Digest & Kidney DIs, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA
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Label: Kodali-2007
Title: Polymorphism in the intermediates and products of amyloid assembly
Journal: CURR OPIN STRUCT BIOL, 17 (1): 48-57 FEB 2007
Citations: 75
Authors: Kodali, R;Wetzel, R
Addresses:
Univ Pittsburgh, Sch Med, Dept Struct Biol, 2046 Biomed Sci Tower 3,3501 5th Ave, Pittsburgh, PA 15260 USA
Univ Pittsburgh, Sch Med, Dept Struct Biol, Pittsburgh, PA 15260 USA
Univ Pittsburgh, Sch Med, Pittsburgh Inst Nuerodegenerat Dis, Pittsburgh, PA 15260 USA
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Label: Toyama-2007
Title: The structural basis of yeast prion strain variants
Journal: NATURE, 449 (7159): 233-U8 SEP 13 2007
Citations: 72
Authors: Toyama, BH;Kelly, MJS;Gross, JD;Weissman, JS
Addresses:
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Calif Inst Quantitat biomed Res, San Francisco, CA 94158 USA
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Label: Paravastua-2008
Title: Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils
Journal: PROC NAT ACAD SCI USA, 105 (47): 18349-18354 NOV 25 2008
Citations: 70
Authors: Paravastua, AK;Leapman, RD;Yau, WM;Tycko, R
Addresses:
NIDDKD, Chem Phys Lab, NIH, Bldg 2, Bethesda, MD 20892 USA
NIDDKD, Chem Phys Lab, NIH, Bethesda, MD 20892 USA
Natl Inst Biomed Imaging & Bioengn, Lab Bioengn & Phys Sci, NIH, Bethesda, MD 20892 USA
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Label: Maji-2009
Title: Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Journal: SCIENCE, 325 (5938): 328-332 JUL 17 2009
Citations: 35
Authors: Maji, SK;Perrin, MH;Sawaya, MR;Jessberger, S;Vadodaria, K;Rissman, RA;Singru, PS;Nilsson, KPR;Simon, R;Schubert, D;Eisenberg, D;Rivier, J;Sawchenko, P;Vale, W;Riek, R
Addresses:
ETH, Phys Chem Lab, Wolfgang Paulistr 10, CH-8093 Zurich, Switzerland
ETH, Phys Chem Lab, CH-8093 Zurich, Switzerland
Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA
Univ Calif Los Angeles, Howard Hughes Med Inst, DOE Inst Genom & Prote, Los Angeles, CA 90095 USA
ETH, Inst Cell Biol, Dept Biol, CH-8093 Zurich, Switzerland
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02111 USA
Linkoping Univ, IFM, Dept Chem, SE-58183 Linkoping, Sweden
Salk Inst Biol Studies, Cellular Neurobiol Lab, La Jolla, CA 92037 USA
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KEYWORDS: AMYLOID FIBRILS; ALZHEIMER'S BETA-AMYLOID FIBRILS; MAGIC-ANGLE SPINNING SOLID-STATE NMR SPECTROSCOPY; HIGH-RESOLUTION SOLID-STATE NMR SPECTROSCOPY; ALZHEIMER'S AMYLOID-BETA(1-42) FIBRILS.
[9611 (2000-2010_5) (BIO/CHE: ST ALZHEIMER'S DISEASE) (MARCH 2011)]

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