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 ScienceWatch

SPECIAL TOPICS

Autophagy - July 2009

Research Front Maps

Research front maps are diagrammatic representations of the core papers comprising each front. They are selected from the current Research Front set that are relevant to the featured special topic. The title for this Research Front Map is "AUTOPHAGY," containing 48 core papers. Source dates: 1999-February 28, 2009 (first bimonthly period 2009).

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The solid lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together); weaker links are indicated by dashed lines. Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps.

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Webb-2003 Melendez-2003 Qu-2003 Cuervo-2004 Mizushima-2004 Gozuacik-2004 Yu-2004 Ravikumar-2004 Levine-2004 Cuervo-2004 Shintani-2004 Kuma-2004 Shimizu-2004 Boya-2005 Lum-2005 Klionsky-2005 Komatsu-2005 Pyo-2005 Pattingre-2005 Levine-2005 Rubinszfein-2005 Tanida-2005 Yu-2006 Hara-2006 Komatsu-2006 Degenhardt-2006 Rubinsztein-2006 Yousefi-2006 Jin-2007 Amaravadi-2007 Hoyer-Hansen-2007 Qu-2007 Matsui-2007 Scherz-Shouval-2007 Oberstein-2007 Nakai-2007 Maiuri-2007 Zhu-2007 Pankiv-2007 Maiuri-2007 Klionsky-2007 Mizushima-2007 Mathew-2007 Chen-2008 Komatsu-2007 Maclean-2008 Mizushima-2008 Levine-2008
AUTOPHAGY


 Core Papers 


Label: Levine-2004
Title: Development by self-digestion: Molecular mechanisms and biological functions of autophagy
Journal: DEV CELL, 6 (4): 463-477 APR 2004
Citations: 552
Authors: Levine, B;Klionsky, DJ
Addresses:
Columbia Univ, Dept Med, New York, NY 10032 USA
Columbia Univ, Dept Med, New York, NY 10032 USA
Univ Michigan, Inst Life Sci, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Dept Biol Chem, Ann Arbor, MI 48109 USA


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Label: Shintani-2004
Title: Autophagy in health and disease: A double-edged sword
Journal: SCIENCE, 306 (5698): 990-995 NOV 5 2004
Citations: 374
Authors: Shintani, T;Klionsky, DJ
Addresses:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA


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Label: Pattingre-2005
Title: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Journal: CELL, 122 (6): 927-939 SEP 23 2005
Citations: 338
Authors: Pattingre, S;Tassa, A;Qu, XP;Garuti, R;Liang, XH;Mizushima, N;Packer, M;Schneider, MD;Levine, B
Addresses:
Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Ctr Biostat & Clin Sci, Dallas, TX 75390 USA
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Japan Sci & Technol Agcy, Precursory Res Embryol Sci & Technol, Kawaguchi 3320012, Japan
Baylor Coll Med, Dept Med, Houston, TX 77030 USA


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Label: Ravikumar-2004
Title: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Journal: NAT GENET, 36 (6): 585-595 JUN 2004
Citations: 335
Authors: Ravikumar, B;Vacher, C;Berger, Z;Davies, JE;Luo, SQ;Oroz, LG;Scaravilli, F;Easton, DF;Duden, R;O'Kane, CJ;Rubinsztein, DC
Addresses:
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Wellcome MRC Bldg,Hills Rd, Cambridge CB2 2XY, England
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 2XY, England
Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
Univ Coll London, Inst Neurol, Div Neuropathol, London, England
Univ Cambridge, Dept Publ Hlth, Genet Epidemiol Unit, Canc Res UK, Cambridge, England
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Cambridge CB2 2XY, England


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Label: Yu-2004
Title: Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
Journal: SCIENCE, 304 (5676): 1500-1502 JUN 4 2004
Citations: 335
Authors: Yu, L;Alva, A;Su, H;Dutt, P;Freundt, E;Welsh, S;Baehrecke, EH;Lenardo, MJ
Addresses:
NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA
Univ Oxford, Weatherall Inst Mol Med, Oxford OX39D, England


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Label: Komatsu-2006
Title: Loss of autophagy in the central nervous system causes neurodegeneration in mice
Journal: NATURE, 441 (7095): 880-884 JUN 15 2006
Citations: 326
Authors: Komatsu, M;Waguri, S;Chiba, T;Murata, S;Iwata, J;Tanida, I;Ueno, T;Koike, M;Uchiyama, Y;Kominami, E;Tanaka, K
Addresses:
Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
Juntendo Univ, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo 1138421, Japan
Osaka Univ, Grad Sch Med, Dept Cell Biol & Neurosci, Suita, Osaka 5650871, Japan


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Label: Hara-2006
Title: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Journal: NATURE, 441 (7095): 885-889 JUN 15 2006
Citations: 325
Authors: Hara, T;Nakamura, K;Matsui, M;Yamamoto, A;Nakahara, Y;Suzuki-Migishima, R;Yokoyama, M;Mishima, K;Saito, I;Okano, H;Mizushima, N
Addresses:
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Mitsubishi Kagaku Inst Life Sci, Mouse Genome Technol Lab, Tokyo, Japan
Grad Univ Adv Studies, Sch Life Sci, Dept Basic Biol, Okazaki, Aichi 4448585, Japan
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan
Nagahama Inst Biosci & Technol, Dept Biosci, Nagahama 5260829, Japan
Niigata Univ, Brain Res Inst, Niigata 9518510, Japan
Tsurumi Univ, Sch Dent Med, Dept Pathol, Yokohama, Kanagawa 2308501, Japan
Keio Univ, Sch Med, Dept Physiol, Tokyo 1608582, Japan
Japan Sci & Technol Agcy, PRESTO, Kawaguchi 3320012, Japan
Japan Sci & Technol Agcy, SORST, Kawaguchi 3320012, Japan


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Label: Kuma-2004
Title: The role of autophagy during the early neonatal starvation period
Journal: NATURE, 432 (7020): 1032-1036 DEC 23 2004
Citations: 302
Authors: Kuma, A;Hatano, M;Matsui, M;Yamamoto, A;Nakaya, H;Yoshimori, T;Ohsumi, Y;Tokuhisa, T;Mizushima, N
Addresses:
Japan Sci & Technol Agcy, PRESTO, Times Arrow & Biosignaling, Kawaguchi 3320012, Japan
Japan Sci & Technol Agcy, PRESTO, Times Arrow & Biosignaling, Kawaguchi 3320012, Japan
Chiba Univ, Dept Dev Genet H2, Chiba 2608670, Japan
Chiba Univ, Grad Sch Med, Dept Pharmacol F2, Chiba 2608670, Japan
Chiba Univ, Biomed Res Ctr, Chiba 2608670, Japan
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 444, Japan
Grad Univ Adv Studies, Sch Life Sci, Dept Mol Biomech, Okazaki, Aichi 4448585, Japan
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Nagahama Inst Biosci & Technol, Dept Biosci, Nagahama 5260829, Japan
Natl Inst Genet, Dept Cell Genet, Mishima, Shizuoka 4118540, Japan


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Label: Shimizu-2004
Title: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
Journal: NAT CELL BIOL, 6 (12): 1221-1228 DEC 2004
Citations: 302
Authors: Shimizu, S;Kanaseki, T;Mizushima, N;Mizuta, T;Arakawa-Kobayashi, S;Thompson, CB;Tsujimoto, Y
Addresses:
Osaka Univ, Sch Med, Dept Post Genom & Dis, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
Osaka Univ, Sch Med, Dept Post Genom & Dis, Suita, Osaka 5650871, Japan
JST, CREST, Suita, Osaka 5650871, Japan
JST, SORST, Suita, Osaka 5650871, Japan
JST, Natl Inst Bas Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan
JST, PRESTO, Okazaki, Aichi 4448585, Japan
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Univ Penn, Abramson Family Canc Res Inst, Dept Med, Philadelphia, PA 19104 USA
Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA


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Label: Mizushima-2004
Title: In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
Journal: MOL BIOL CELL, 15 (3): 1101-1111 MAR 2004
Citations: 299
Authors: Mizushima, N;Yamamoto, A;Matsui, M;Yoshimori, T;Ohsumi, Y
Addresses:
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan
PRESTO, Times Arrow & Biosignaling, Kawaguchi 3320012, Japan
PRESTO, Unit Proc & Combined Circuit, Kawaguchi 3320012, Japan
Japan Sci & Technol Agcy, CREST, Kawaguchi 3320012, Japan
Nagaham Inst Biosci & Technol, Dept Biosci, Shiga 5260829, Japan
Grad Univ Adv Studies, Sch Life Sci, Dept Mol Biomech, Okazaki, Aichi 4448585, Japan
Natl Inst Genet, Dept Cell Genet, Mishima, Shizuoka 411, Japan


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Label: Gozuacik-2004
Title: Autophagy as a cell death and tumor suppressor mechanism
Journal: ONCOGENE, 23 (16): 2891-2906 APR 12 2004
Citations: 282
Authors: Gozuacik, D;Kimchi, A
Addresses:
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel


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Label: Levine-2005
Title: Autophagy in cell death: an innocent convict?
Journal: J CLIN INVEST, 115 (10): 2679-2688 OCT 2005
Citations: 280
Authors: Levine, B;Yuan, JY
Addresses:
Univ Texas, SW Med Ctr, Div Infect Dis, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA
Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX USA
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA USA


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Label: Lum-2005
Title: Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Journal: CELL, 120 (2): 237-248 JAN 28 2005
Citations: 278
Authors: Lum, JJ;Bauer, DE;Kong, M;Harris, MH;Li, C;Lindsten, T;Thompson, CB
Addresses:
Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA


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Label: Boya-2005
Title: Inhibition of macroautophagy triggers apoptosis
Journal: MOL CELL BIOL, 25 (3): 1025-1040 FEB 2005
Citations: 270
Authors: Boya, P;Gonzalez-Polo, RA;Casares, N;Perfettini, JL;Dessen, P;Larochette, N;Metivier, D;Meley, D;Souquere, S;Yoshimori, T;Pierron, G;Codogno, P;Kroemer, G
Addresses:
Inst Gustave Roussy, CNRS, UMR 8125, 39 Rue Camille Desmoulins,Pavillon Rech 1, F-94805 Villejuif, France
Inst Gustave Roussy, CNRS, UMR 8125, F-94805 Villejuif, France
Natl Inst Genet, Mishima, Shizuoka 411, Japan
Inst Andre Lwoff, INSERM, U504, Villejuif, France
Lab Replicat ADN & Ultrastruct Noyau, UPR 1983, Villejuif, France


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Label: Melendez-2003
Title: Autophagy genes are essential for dauer development and life-span extension in C-elegans
Journal: SCIENCE, 301 (5638): 1387-1391 SEP 5 2003
Citations: 267
Authors: Melendez, A;Talloczy, Z;Seaman, M;Eskelinen, EL;Hall, DH;Levine, B
Addresses:
Columbia Univ Coll Phys & Surg, Dept Med, 630 W 168th St, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Cambridge CB2 2XY, England
Univ Kiel, Inst Biochem, D-24098 Kiel, Germany
Albert Einstein Coll Med, Ctr C Elegans Anat, Bronx, NY 10461 USA


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Label: Qu-2003
Title: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Journal: J CLIN INVEST, 112 (12): 1809-1820 DEC 2003
Citations: 233
Authors: Qu, XP;Yu, J;Bhagat, G;Furuya, N;Hibshoosh, H;Troxel, A;Rosen, J;Eskelinen, EL;Mizushima, N;Ohsumi, Y;Cattoretti, G;Levine, B
Addresses:
Columbia Univ Coll Phys & Surg, Dept Med, 630 W 168th St,P&S 8-463, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
Columbia Univ, Mailman Sch Publ Hlth, Dept Med, New York, NY USA
Columbia Univ, Mailman Sch Publ Hlth, Dept Pathol, New York, NY USA
Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX USA
Baylor Coll Med, Dept Med, Houston, TX USA
Univ Kiel, Inst Biochem, Kiel, Germany
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi, Japan
Japan Sci & Technol Corp, PRESTO, Kawaguchi, Japan
Columbia Univ, Inst Canc Genet, New York, NY USA


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Label: Cuervo-2004
Title: Autophagy: in sickness and in health
Journal: TR CELL BIOL, 14 (2): 70-77 FEB 2004
Citations: 208
Authors: Cuervo, AM
Addresses:
Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, 1300 Morris Pk Ave,Ullman B 614, Bronx, NY 10461 USA
Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, Bronx, NY 10461 USA


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Label: Komatsu-2005
Title: Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
Journal: J CELL BIOL, 169 (3): 425-434 MAY 9 2005
Citations: 208
Authors: Komatsu, M;Waguri, S;Ueno, T;Iwata, J;Murata, S;Tanida, I;Ezaki, J;Mizushima, N;Ohsumi, Y;Uchiyama, Y;Kominami, E;Tanaka, K;Chiba, T
Addresses:
Tokyo Metropolitan Inst Med Sci, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138613, Japan
Tokyo Metropolitan Inst Med Sci, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138613, Japan
Osaka Univ, Grad Sch Med, Dept Cell Biol & Neurosci, Suita, Osaka 5650871, Japan
Juntendo Univ, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo 1138421, Japan
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Bunkyo Ku, Tokyo 1138613, Japan
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan


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Label: Klionsky-2005
Title: The molecular machinery of autophagy: unanswered questions
Journal: J CELL SCI, 118 (1): 7-18 JAN 1 2005
Citations: 199
Authors: Klionsky, DJ
Addresses:
Univ Michigan, Inst Life Sci, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA


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Label: Cuervo-2004
Title: Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
Journal: SCIENCE, 305 (5688): 1292-1295 AUG 27 2004
Citations: 186
Authors: Cuervo, AM;Stefanis, L;Fredenburg, R;Lansbury, PT;Sulzer, D
Addresses:
Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, Bronx, NY 10461 USA
Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, Bronx, NY 10461 USA
Acad Athens, Fdn Biomed Res, Neurobiol Lab, Athens 11527, Greece
Columbia Univ, Dept Neurol & Pathol, New York, NY 10032 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis,Dept Neurol, Cambridge, MA 02139 USA
Columbia Univ, Dept Neurosci, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA
Columbia Univ, Dept Neurosci, New York State Psychiat Inst, Dept Neurol, New York, NY 10032 USA


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Label: Webb-2003
Title: alpha-synuclein is degraded by both autophagy and the proteasome
Journal: J BIOL CHEM, 278 (27): 25009-25013 JUL 4 2003
Citations: 172
Authors: Webb, JL;Ravikumar, B;Atkins, J;Skepper, JN;Rubinsztein, DC
Addresses:
Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Wellcome MRC Bldg,Hills Rd, Cambridge CB2 2XY, England
Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 2XY, England
Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England


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Label: Rubinsztein-2006
Title: The roles of intracellular protein-degradation pathways in neurodegeneration
Journal: NATURE, 443 (7113): 780-786 OCT 19 2006
Citations: 149
Authors: Rubinsztein, DC
Addresses:
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Hills Rd, Cambridge CB2 2XY, England
Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 2XY, England


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Label: Degenhardt-2006
Title: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Journal: CANCER CELL, 10 (1): 51-64 JUL 2006
Citations: 137
Authors: Degenhardt, K;Mathew, R;Beaudoin, B;Bray, K;Anderson, D;Chen, GH;Mukherjee, C;Shi, YF;Gelinas, C;Fan, YJ;Nelson, DA;Jin, SK;White, E
Addresses:
Ctr Adv Biotechnol & Med, 679 Hoes Lane, Piscataway, NJ 08854 USA
Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
Rutgers State Univ, Piscataway, NJ 08854 USA
Canc Inst New Jersey, New Brunswick, NJ 08903 USA
Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet Microbiol & Immunol, Piscataway, NJ 08854 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA


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Label: Maiuri-2007
Title: Self-eating and self-killing: crosstalk between autophagy and apoptosis
Journal: NAT REV MOL CELL BIOL, 8 (9): 741-752 SEP 2007
Citations: 114
Authors: Maiuri, MC;Zalckvar, E;Kimchi, A;Kroemer, G
Addresses:
INSERM, U 848, F-94805 Villejuif, France
INSERM, U 848, F-94805 Villejuif, France
Inst Gustave Roussy, F-94805 Villejuif, France
Univ Naples Federico 2, Fac Sci Biotechnol, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
Univ Paris Sud, F-94805 Villejuif, France


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Label: Yousefi-2006
Title: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Journal: NAT CELL BIOL, 8 (10): 1124-U146 OCT 2006
Citations: 111
Authors: Yousefi, S;Perozzo, R;Schmid, I;Ziemiecki, A;Schaffner, T;Scapozza, L;Brunner, T;Simon, HU
Addresses:
Univ Bern, Dept Pharmacol, CH-3010 Bern, Switzerland
Univ Bern, Dept Pharmacol, CH-3010 Bern, Switzerland
Univ Geneva, Sch Pharmaceut Sci, EPGL, Pharmaceut Biochem Grp, CH-1211 Geneva 4, Switzerland
Univ Bern, Dept Clin Res, CH-3010 Bern, Switzerland
Univ Bern, Dept Pathol, CH-3010 Bern, Switzerland


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Label: Levine-2008
Title: Autophagy in the pathogenesis of disease
Journal: CELL, 132 (1): 27-42 JAN 11 2008
Citations: 107
Authors: Levine, B;Kroemer, G
Addresses:
Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
Univ Paris 11, Paris, France
INSERM, U848, F-94805 Villejuif, France


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Label: Pyo-2005
Title: Essential roles of Atg5 and FADD in autophagic cell death - Dissection of autophagic cell death into vacuole formation and cell death
Journal: J BIOL CHEM, 280 (21): 20722-20729 MAY 27 2005
Citations: 106
Authors: Pyo, JO;Jang, MH;Kwon, YK;Lee, HJ;Jun, JIL;Woo, HN;Cho, DH;Choi, B;Lee, H;Kim, JH;Mizushima, N;Oshumi, Y;Jung, YK
Addresses:
Gwangju Inst Sci & Technol, Dept Life Sci, 1 Oryong Dong, Kwangju 500712, South Korea
Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
Ulsan Med Sch, Seoul 138736, South Korea
Yonsei Med Sch, Seoul 120749, South Korea
Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan


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Label: Tanida-2005
Title: Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Journal: AUTOPHAGY, 1 (2): 84-91 JUL-SEP 2005
Citations: 102
Authors: Tanida, I;Minematsu-Ikeguchi, N;Ueno, T;Kominami, E
Addresses:
Juntendo Univ, Dept Biochem, Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan
Juntendo Univ, Dept Biochem, Sch Med, Bunkyo Ku, Tokyo 1138421, Japan


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Label: Mizushima-2008
Title: Autophagy fights disease through cellular self-digestion
Journal: NATURE, 451 (7182): 1069-1075 FEB 28 2008
Citations: 98
Authors: Mizushima, N;Levine, B;Cuervo, AM;Klionsky, DJ
Addresses:
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan
Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat, Bronx, NY 10461 USA
Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Biol Struct, Bronx, NY 10461 USA
Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Dev & Mol Biol, Bronx, NY 10461 USA


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Label: Yu-2006
Title: Autophagic programmed cell death by selective catalase degradation
Journal: PROC NAT ACAD SCI USA, 103 (13): 4952-4957 MAR 28 2006
Citations: 94
Authors: Yu, L;Wan, FY;Dutta, S;Welsh, S;Liu, ZH;Freundt, E;Baehrecke, EH;Lenardo, M
Addresses:
NIAID, Immunol Lab, NIH, Rockville, MD 20852 USA
NIAID, Immunol Lab, NIH, Rockville, MD 20852 USA
Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA
Harvard Univ, Sch Med, Harvard Ctr Neurodegenerat & Repair, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England


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Label: Klionsky-2007
Title: Autophagy: from phenomenology to molecular understanding in less than a decade
Journal: NAT REV MOL CELL BIOL, 8 (11): 931-937 NOV 2007
Citations: 92
Authors: Klionsky, DJ
Addresses:
Univ Michigan, Inst Life Sci, 210 Washtenaw Ave, Ann Arbor, MI 48109 USA
Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA


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Label: Maiuri-2007
Title: Functional and physical interaction between Bcl-X-L and a BH3-like domain in Beclin-1
Journal: EMBO J, 26 (10): 2527-2539 MAY 16 2007
Citations: 80
Authors: Maiuri, MC;Le Toumelin, G;Criollo, A;Rain, JC;Gautier, F;Juin, P;Tasdemir, E;Pierron, G;Troulinaki, K;Tavernarakis, N;Hickman, JA;Geneste, O;Kroemer, G
Addresses:
Inst Gustave Roussy, PRI, INSERM, U878, 39 Rue Camille Desmoulins, F-94805 Villejuif, France
Inst Gustave Roussy, PRI, INSERM, U878, F-94805 Villejuif, France
Inst Gustave Roussy, Villejuif, France
Univ Paris 11, Villejuif, France
Univ Naples Federico II, Fac Sci Biotecnol, Naples, Italy
Inst Rech Servier, Croissy Sur Seine, France
Hybrigen, Paris, France
Univ Nantes, Fac Med, INSERM, U604, Nantes, France
CNRS, Inst Andre Lwoff, FRE 2937, Villejuif, France
Fdn Res & Technol, Inst Mol Biol & Biotechnol, Iraklion, Greece


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Label: Scherz-Shouval-2007
Title: Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Journal: EMBO J, 26 (7): 1749-1760 APR 4 2007
Citations: 77
Authors: Scherz-Shouval, R;Shvets, E;Fass, E;Shorer, H;Gil, L;Elazar, Z
Addresses:
Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel


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Label: Amaravadi-2007
Title: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Journal: J CLIN INVEST, 117 (2): 326-336 FEB 2007
Citations: 76
Authors: Amaravadi, RK;Yu, DN;Lum, JJ;Bui, T;Christophorou, MA;Evan, GI;Thomas-Tikhonenko, A;Thompson, CB
Addresses:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, 421 Curie Blvd,450 BRB 2-3, Philadelphia, PA 19104 USA
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
Univ Penn, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA
Univ Penn, Dept Pathobiol, Philadelphia, PA 19104 USA
Univ Calif San Francisco, Ctr Comprehens Canc, Canc Res Inst, San Francisco, CA 94143 USA


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Label: Rubinszfein-2005
Title: Autophagy and its possible roles in nervous system diseases, damage and repair
Journal: AUTOPHAGY, 1 (1): 11-22 APR-JUN 2005
Citations: 74
Authors: Rubinszfein, DC;DiFiglia, M;Heintz, N;Nixon, RA;Qin, ZH;Ravikumar, B;Stefanis, L;Tolkovsy, A
Addresses:
Univ Cambridge, Dept Med Genet, Cambridge Inst Med Res, Addenbrookes Hosp, Wellcome Trust-MRC Bldg,Hills Rd, Cambridge CB2 2XY, England
Univ Cambridge, Dept Med Genet, Cambridge Inst Med Res, Addenbrookes Hosp, Cambridge CB2 2XY, England
Massachusetts Gen Hosp, Lab Cell Neurobiol, Charlestown, MA USA
Harvard Univ, Sch Med, Charlestown, MA USA
Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA
Nathan S Kline Inst, Ctr Dement Res, Orangeburg, NY USA
NYU, Dept Psychiat, New York, NY 10016 USA
NYU, Dept Cell Biol, New York, NY 10016 USA
Acad Athens, Fdn Biomed Res, Neurobiol Lab, Athens, Greece
Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England


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Label: Mizushima-2007
Title: Autophagy: process and function
Journal: GENE DEVELOP, 21 (22): 2861-2873 NOV 15 2007
Citations: 71
Authors: Mizushima, N
Addresses:
Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan
Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan
Japan sci & Technol Agcy, Solut Oriented Res Sci & Technol, Tokyo 1020075, Japan


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Label: Qu-2007
Title: Autophagy gene-dependent clearance of apoptotic cells during embryonic development
Journal: CELL, 128 (5): 931-946 MAR 9 2007
Citations: 71
Authors: Qu, XP;Zou, ZJ;Sun, QH;Luby-Phelps, K;Cheng, PF;Hogan, RN;Gilpin, C;Levine, B
Addresses:
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Ophthalmol, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA
Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA


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Label: Hoyer-Hansen-2007
Title: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
Journal: MOL CELL, 25 (2): 193-205 JAN 26 2007
Citations: 67
Authors: Hoyer-Hansen, M;Bastholm, L;Szyniarowski, P;Campanella, M;Szabadkai, G;Farkas, T;Bianchi, K;Fehrenbacher, N;Elling, F;Rizzuto, R;Mathiasen, IS;Jaattela, M
Addresses:
Danish Canc Soc, Inst Canc Biol, Apoptosis Dept, DK-2100 Copenhagen, Denmark
Danish Canc Soc, Inst Canc Biol, Apoptosis Dept, DK-2100 Copenhagen, Denmark
Danish Canc Soc, Inst Canc Biol, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark
Univ Copenhagen, Fac Hlth Sci, Inst Mol Pathol, DK-2100 Copenhagen, Denmark
Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy
Univ Paris 05, Necker Fac, INSERM, U 807, F-75015 Paris, France


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Label: Pankiv-2007
Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Journal: J BIOL CHEM, 282 (33): 24131-24145 AUG 17 2007
Citations: 67
Authors: Pankiv, S;Clausen, TH;Lamark, T;Brech, A;Bruun, JA;Outzen, H;Overvatn, A;Bjorkoy, G;Johansen, T
Addresses:
Univ Tromso, Inst Med Biol, Dept Biochem, N-9037 Tromso, Norway
Univ Tromso, Inst Med Biol, Dept Biochem, N-9037 Tromso, Norway
Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, N-0310 Oslo, Norway


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Label: Nakai-2007
Title: The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Journal: NATURE MED, 13 (5): 619-624 MAY 2007
Citations: 60
Authors: Nakai, A;Yamaguchi, O;Takeda, T;Higuchi, Y;Hikoso, S;Taniike, M;Omiya, S;Mizote, I;Matsumura, Y;Asahi, M;Nishida, K;Hori, M;Mizushima, N;Otsu, K
Addresses:
Osaka Univ, Dept Cardiovasc Med, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
Osaka Univ, Dept Cardiovasc Med, Grad Sch Med, Suita, Osaka 5650871, Japan
Osaka Univ, Dept Med Informat Sci, Grad Sch Med, Suita, Osaka 5650871, Japan
Osaka Univ, Dept Biochem, Grad Sch Med, Suita, Osaka 5650871, Japan
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Bunkyo Ku, Tokyo 1138613, Japan
Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
Japan Sci & Technol Agcy, Solut Oriented Res Sci & Technol, Kawaguchi, Saitama 3320012, Japan


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Label: Oberstein-2007
Title: Crystal structure of the Bcl-X-L-beclin 1 peptide complex - Beclin 1 is a novel BH3-only protein
Journal: J BIOL CHEM, 282 (17): 13123-13132 APR 27 2007
Citations: 59
Authors: Oberstein, A;Jeffrey, PD;Shi, YG
Addresses:
Princeton Univ, Dept Mol Biol, Lewis Thomas Lab, Princeton, NJ 08544 USA
Princeton Univ, Dept Mol Biol, Lewis Thomas Lab, Princeton, NJ 08544 USA


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Label: Komatsu-2007
Title: Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
Journal: CELL, 131 (6): 1149-1163 DEC 14 2007
Citations: 55
Authors: Komatsu, M;Waguri, S;Koike, M;Sou, Y;Ueno, T;Hara, T;Mizushima, N;Iwata, J;Ezaki, J;Murata, S;Hamazaki, J;Nishito, Y;Iemura, S;Natsume, T;Yanagawa, T;Uwayama, J;Warabi, E;Yoshida, H;Ishii, T;Kobayashi, A;Yamamoto, M;Yue, Z;Uchiyama, Y;Kominami, E;Tanaka, K
Addresses:
Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan
Juntendo Univ, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo 1138421, Japan
Japan Sci & Technol Corp, PRESTO, Kawaguchi, Saitama 3320012, Japan
Fukushima Med Univ, Sch Med, Dept Anat & Histol, Fukushima 9601295, Japan
Osaka Univ, Grad Sch Med, Dept Cell Biol & Neurosci, Suita, Osaka 5650871, Japan
Tokyo Med & Dent Univ, Grad Sch, Dept Physiol & Cell Biol, Bunkyo Ku, Tokyo 1138519, Japan
Tokyo Med & Dent Univ, Fac Med, Bunkyo Ku, Tokyo 1138519, Japan
Japan Sci & Technol Corp, SORST, Kawaguchi, Saitama 3320012, Japan
Biol Informat Res Ctr JBIRC, Natl Inst Adv Ind Sci & Technol, Kohtoh Ku, Tokyo 1350064, Japan
Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan
Tohoku Univ, Grad Sch Med, Dept Med Biochem, Aoba Ku, Sendai, Miyagi 9808575, Japan
Tohoku Univ, Grad Sch Med, ERATO JST, Aoba Ku, Sendai, Miyagi 9808575, Japan
Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA


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Label: Matsui-2007
Title: Distinct roles of autophagy in the heart during ischemia and reperfusion - Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
Journal: CIRC RES, 100 (6): 914-922 MAR 30 2007
Citations: 54
Authors: Matsui, Y;Takagi, H;Qu, XP;Abdellatif, M;Sakoda, H;Asano, T;Levine, B;Sadoshima, J
Addresses:
Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, 185 S Orange Ave,MSB G-609, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Cell Biol & Mol Med, Newark, NJ 07103 USA
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA
Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX USA
Univ Tokyo, Grad Sch Med, Dept Internal Med, Tokyo, Japan
Hiroshima Univ, Program Biomed Res, Div Mol Med Sci, Hiroshima 730, Japan


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Label: Jin-2007
Title: Role of autophagy in cancer - Management of metabolic stress
Journal: AUTOPHAGY, 3 (1): 28-31 JAN-FEB 2007
Citations: 44
Authors: Jin, SK;White, E
Addresses:
Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, 675 Hoes Lane, Piscataway, NJ 08854 USA
Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA
Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ USA
Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ USA
Canc Inst New Jersey, Piscataway, NJ USA


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Label: Mathew-2007
Title: Role of autophagy in cancer
Journal: NAT REV CANCER, 7 (12): 961-967 DEC 2007
Citations: 39
Authors: Mathew, R;Karantza-Wadsworth, V;White, E
Addresses:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Div Med Oncol, Piscataway, NJ 08854 USA
Inst Canc New Jersey, New Brunswick, NJ 08901 USA
Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA


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Label: Zhu-2007
Title: Cardiac autophagy is a maladaptive response to hemodynamic stress
Journal: J CLIN INVEST, 117 (7): 1782-1793 JUL 2007
Citations: 33
Authors: Zhu, HX;Tannous, P;Johnstone, JL;Kong, YL;Shelton, JM;Richardson, JA;Lei, V;Levine, B;Rothermel, BA;Hill, JA
Addresses:
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75235 USA
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75235 USA
Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA
Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX USA
Univ Texas, SW Med Ctr, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX USA


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Label: Chen-2008
Title: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
Journal: CELL DEATH DIFFERENTIATION, 15 (1): 171-182 JAN 2008
Citations: 20
Authors: Chen, Y;McMillan-Ward, E;Kong, J;Israels, SJ;Gibson, SB
Addresses:
Manitoba Inst Cell Biol, 675 McDermot Ave, Winnipeg, MB R3E 0V9, Canada
Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada
Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada
CancerCare Manitoba, Winnipeg, MB, Canada


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Label: Maclean-2008
Title: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
Journal: J CLIN INVEST, 118 (1): 79-88 JAN 2008
Citations: 18
Authors: Maclean, KH;Dorsey, FC;Cleveland, JL;Kastan, MB
Addresses:
St Jude Childrens Hosp, Dept Oncol, Div Mol Therapeut, 332 N Lauderdale St, Memphis, TN 38105 USA
Scripps Res Inst, Dept Canc Biol, Jupiter, FL 33458 USA
St Jude Childrens Hosp, Dept Oncol, Div Mol Therapeut, Memphis, TN 38105 USA


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KEYWORDS: AUTOPHAGY PROMOTES TUMOR CELL SURVIVAL; BCL-2 ANTIAPOPTOTIC PROTEINS INHIBIT BECLIN 1-DEPENDENT AUTOPHAGY; AUTOPHAGY INHIBITION ENHANCES THERAPY-INDUCED APOPTOSIS; BECLIN 1 AUTOPHAGY GENE; AUTOPHAGY FIGHTS
[5816 (2003-2009_1) (BIO/MOL; ST Autophagy, Jul 2009)]



Special Topics : Autophagy : AUTOPHAGY - Autophagy