According to our Special Topics analysis of bisphenol A
research over the past decade, the work of Dr. Ana Soto ranks
at #2 by total cites, based on 27 papers cited a total of 930
times. In
Essential Science IndicatorsSMfrom
Thomson
Reuters, Dr. Soto's record includes 74 papers cited a total
of 1,820 times between January 1, 1999 and April 30, 2009.
Fetal and perinatal exposure to
environmentally relevant doses of BPA
induce a precancerous lesion,
intraductal hyperplasias, during adult
life. A. Mammary gland whole-mounts
from a 3-month old mouse exposed
perinatally to 250 ng BPA/kg/day. Most
ducts in the field look like a string
of beads (Beaded ducts). B. Confocal
image of a beaded duct in BPA-exposed
females demonstrate the presence of
cells inside the ductal lumen. C.
Beaded ducts in a whole-mounted mammary
gland from BPA-exposed offspring.
Glands from 9-month-old females exposed
to BPA during perinatal development;
beads are marked by arrowheads D.
Quantification of the proliferative
index in normal ducts (non-beads) and
beaded ducts , indicate an almost
5-fold increase in proliferation in
beaded ducts (p = 0.001).
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Figure
2:
Figure 2:
This photo was taken in the lab. I am
at center of the first row, between my
partners, professors Beverly Rubin and
Carlos Sonnenschein.
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