Archive ScienceWatch

 ScienceWatch

SPECIAL TOPICS

Diabetes - May 2009

Research Front Maps

Research front maps are diagrammatic representations of the core papers comprising each front. They are selected from the current Research Front set that are relevant to the featured special topic. The title for this Research Front Map is "TYPE 2 DIABETES SUSCEPTIBILITY GENE," containing 40 core papers. Source dates: 1999-February 28, 2009 (first bimonthly period 2009).

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The solid lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together); weaker links are indicated by dashed lines. Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps.

Note: For best results use the "landscape orientation" option when printing this page.

 Yi-2005Grant-2006Florez-2006Groves-2006Zhang-2006Scott-2006Damcott-2006Saxena-2006Cauchi-2006Liese-2006Lehman-2007Sladek-2007Helgason-2007Horikoshi-2007Winckler-2007Frayling-2007Scott-2007Zeggini-2007Steinthorsdottir-2007Dabelea-2007Dina-2007Gudmundsson-2007Scuteri-2007Lyssenko-2007Florez-2007Gerken-2007Pascoe-2007Grarup-2007Maiese-2007Andreasen-2008Li-2008Cauchi-2008Wahlen-2008Shu-2008Kirchhoff-2008Liu-2008Stratigopoulos-2008Do-2008Fredriksson-2008Freathy-2008
TYPE 2 DIABETES SUSCEPTIBILITY GENE


 Core Papers 


Label: Sladek-2007
Title: A genome-wide association study identifies novel risk loci for type 2 diabetes
Journal: NATURE, 445 (7130): 881-885 FEB 22 2007
Citations: 371
Authors: Sladek, R;Rocheleau, G;Rung, J;Dina, C;Shen, L;Serre, D;Boutin, P;Vincent, D;Belisle, A;Hadjadj, S;Balkau, B;Heude, B;Charpentier, G;Hudson, TJ;Montpetit, A;Pshezhetsky, AV;Prentki, M;Posner, BI;Balding, DJ;Meyre, D;Polychronakos, C;Froguel, P
Addresses:
McGill Univ, Dept Human Genet, Fac Med, Montreal, PQ H3H 1P3, Canada
McGill Univ, Dept Human Genet, Fac Med, Montreal, PQ H3H 1P3, Canada
McGill Univ, Dept Med, Fac Med, Montreal, PQ H3H 1P3, Canada
McGill Univ, Dept Pediat, Fac Med, Montreal, PQ H3H 1P3, Canada
McGill Univ, Montreal, PQ H3A 1A4, Canada
Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada
Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
Univ Hosp, F-86021 Poitiers, France
INSERM, U780, IFR69, F-94807 Villejuif, France
Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, F-91100 Corbeil Essonnes, France
Ontario Inst Canc Res, Toronto, ON M5G 1L7, Canada
Montreal Diabet Res Ctr, Montreal, PQ H2L 4M1, Canada
Univ Montreal, Mol Nutr Unit, Montreal, PQ H3C 3J7, Canada
Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada
Univ Montreal, Ctr Hosp, Montreal, PQ H3C 3J7, Canada
Polypeptide Hormone Lab, Montreal, PQ H3A 2B2, Canada
Dept Anat & Cell Biol, Montreal, PQ H3A 2B2, Canada
Univ London Imperial Coll Sci & Technol, Dept Epidemiol & Publ Hlth, London W2 1PG, England
Univ London Imperial Coll Sci & Technol, Sect Genom Med, London W12 0NN, England
Hammersmith Hosp, London W12 0HS, England


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Label: Grant-2006
Title: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Journal: NAT GENET, 38 (3): 320-323 MAR 2006
Citations: 355
Authors: Grant, SFA;Thorleifsson, G;Reynisdottir, I;Benediktsson, R;Manolescu, A;Sainz, J;Helgason, A;Stefansson, H;Emilsson, V;Helgadottir, A;Styrkarsdottir, U;Magnusson, KP;Walters, GB;Palsdottir, E;Jonsdottir, T;Gudmundsdottir, T;Gylfason, A;Saemundsdottir, J;Wilensky, RL;Reilly, MP;Rader, DJ;Bagger, Y;Christiansen, C;Gudnason, V;Sigurdsson, G;Thorsteinsdottir, U;Gulcher, JR;Kong, A;Stefansson, K
Addresses:
deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
deCODE Genet, IS-101 Reykjavik, Iceland
Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Natl Univ Hosp Reykjavik, IS-108 Reykjavik, Iceland
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Ctr Clin & Basic Res AS, DK-2750 Ballerup, Denmark


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Label: Scott-2007
Title: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Journal: SCIENCE, 316 (5829): 1341-1345 JUN 1 2007
Citations: 330
Authors: Scott, LJ;Mohlke, KL;Bonnycastle, LL;Willer, CJ;Li, Y;Duren, WL;Erdos, MR;Stringham, HM;Chines, PS;Jackson, AU;Prokunina-Olsson, L;Ding, CJ;Swift, AJ;Narisu, N;Hu, T;Pruim, R;Xiao, R;Li, XY;Conneely, KN;Riebow, NL;Sprau, AG;Tong, M;White, PP;Hetrick, KN;Barnhart, MW;Bark, CW;Goldstein, JL;Watkins, L;Xiang, F;Saramies, J;Buchanan, TA;Watanabe, RM;Valle, TT;Kinnunen, L;Abecasis, GR;Pugh, EW;Doheny, KF;Bergman, RN;Tuomilehto, J;Collins, FS;Boehnke, M
Addresses:
Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr State Genet, Ann Arbor, MI 48109 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Calvin Coll, Dept Math & Stat, Grand Rapids, MI 49546 USA
Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA
Savitaipale Hlth Ctr, Savitaipate 54800, Finland
Univ So Calif, Keck Sch Med, Div Endocrinol, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA
Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet Unit, SF-00300 Helsinki, Finland
Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland
S Ostrobothnia Cent Hosp, Seinajoki 60220, Finland


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Label: Zeggini-2007
Title: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Journal: SCIENCE, 316 (5829): 1336-1341 JUN 1 2007
Citations: 309
Authors: Zeggini, E;Weedon, MN;Lindgren, CM;Frayling, TM;Elliott, KS;Lango, H;Timpson, NJ;Perry, JRB;Rayner, NW;Freathy, RM;Barrett, JC;Shields, B;Morris, AP;Ellard, S;Groves, CJ;Harries, LW;Marchini, JL;Owen, KR;Knight, B;Cardon, LR;Walker, M;Hitman, GA;Morris, AD;Doney, ASF;McCarthy, MI;Hattersley, AT;WTCCC
Addresses:
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, S Parks Rd, Oxford OX3 7LJ, England
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
PEninsula Med Sch, Inst Biomed & Clin Sci, Exeter EX1 2LU, Devon, England
Peninsula Med Sch, Inst Biomed & Clin Sci, Diabet Genet Grp, Exeter EX2 5DW, Devon, England
Univ Bristol, MRC, Ctr Casual Anal Translat Epidemiol, Bristol BS2 8PR, Avon, England
Royal Devon & Exeter NHS FDn Trust, Genet Mol Lab, Exeter EX2 5DW, Devon, England
Univ Oxford, Dept Stat, Oxford OX1 3TG, England
Univ Newcastle, Sch Clin Med Sci, Diabet Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Barts & London Royal London Hosp, Ctr Diabet & Metab Med, London E1 1BB, England
Univ Dundee, Ninewells Hosp & Med Sch, Div Med & Therapeut, Diabet Res Grp, Dundee DD1 9SY, Scotland


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Label: Frayling-2007
Title: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Journal: SCIENCE, 316 (5826): 889-894 MAY 11 2007
Citations: 268
Authors: Frayling, TM;Timpson, NJ;Weedon, MN;Zeggini, E;Freathy, RM;Lindgren, CM;Perry, JRB;Elliott, KS;Lango, H;Rayner, NW;Shields, B;Harries, LW;Barrett, JC;Ellard, S;Groves, CJ;Knight, B;Patch, AM;Ness, AR;Ebrahim, S;Lawlor, DA;Ring, SM;Ben-Shlomo, Y;Jarvelin, MR;Sovio, U;Bennett, AJ;Melzer, D;Ferrucci, L;Loos, RJF;Barroso, I;Wareham, NJ;Karpe, F;Owen, KR;Cardon, LR;Walker, M;Hitman, GA;Palmer, CNA;Doney, ASF;Morris, AD;Smith, GD;Hattersley, AT;McCarthy, MI;Wellcome Trust Case Control
Addresses:
Peninsula Med Sch, Inst Biomed & Clin Sci, Magdalen Rd, Exeter, Devon, England
Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England
Univ Oxford, Wellcome Trust, Ctr Human Genet, Oxford, England
Univ Bristol, MRC, Ctr Casual Anal Translat Epidemiol, Bristol, Avon, England
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
Royal Devon & Exeter Natl Hlth Serv Fdn Trust, Mol Genet Lab, Exeter, Devon, England
Univ Bristol, Dept Oral & Dent Sci, Sch Dent, Bristol, Avon, England
London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England
Univ Bristol, Dept Social Med, Bristol, Avon, England
Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England
Univ Oulu, Dept Publ Hlth Sci & Gen Practice, FIN-90014 Oulu, Finland
Peninsula Med Sch, Epidemiol & Publ Hlth Grp, Exeter, Devon, England
NIA, Lonitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA
Strangeways Res Labs, MRC, Epidemiol Unit, Cambridge, England
Sanger Inst, Metab Dis Grp, Wellcome Trust, Cambridge, England
Univ Newcastle, Diabet Res Grp, Sch Clin Med Sci, Newcastle Upon Tyne, Tyne & Wear, England
Barts & London Royal London Hosp, Dept Diabet & Metab Med, London, England
Univ Dundee, Populat Pharmacogenet Grp, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland
Univ Dundee, Ninewells Hosp & Med Sch, Diabet Res Grp, Div Med & Therapeut,Sch Med, Dundee DD1 9SY, Scotland


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Label: Steinthorsdottir-2007
Title: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Journal: NAT GENET, 39 (6): 770-775 JUN 2007
Citations: 144
Authors: Steinthorsdottir, V;Thorleifsson, G;Reynisdottir, I;Benediktsson, R;Jonsdottir, T;Walters, GB;Styrkarsdottir, U;Gretarsdottir, S;Emilsson, V;Ghosh, S;Baker, A;Snorradottir, S;Bjarnason, H;Ng, MCY;Hansen, T;Bagger, Y;Wilensky, RL;Reilly, MP;Adeyemo, A;Chen, YX;Zhou, J;Gudnason, V;Chen, GJ;Huang, HX;Lashley, K;Doumatey, A;So, WY;Ma, RCY;Andersen, G;Borch-Johnsen, K;Jorgensen, T;van Vliet-Ostaptchouk, JV;Hofker, MH;Wijmenga, C;Christiansen, C;Rader, DJ;Rotimi, C;Gurney, M;Chan, JCN;Pedersen, O;Sigurdsson, G;Gulcher, JR;Thorsteinsdottir, U;Kong, A;Stefansson, K
Addresses:
deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
deCODE Genet, IS-101 Reykjavik, Iceland
Landspitali Univ Hosp, IS-101 Reykjavik, Iceland
Icelandic Heart Assoc, IS-201 Kopavogur, Iceland
Chinese Univ Hong Kong, Dept Med & Therapeut, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Ctr Clin & Basic Res AS, DK-2750 Ballerup, Denmark
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Howard Univ, Natl Human Genome Ctr, Dept Community & Family Med, Washington, DC 20060 USA
Aarhus Univ, Fac Hlth Sci, DK-8000 Aarhus, Denmark
Glostrup Univ Hosp, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark
Maastricht Univ, Dept Mol Genet, NL-6200 MD Maastricht, Netherlands
Rijksuniv Groningen, Med Ctr, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands
Rijksuniv Groningen, Med Ctr, Dept Genet, NL-9700 RB Groningen, Netherlands
Univ Utrecht, Med Ctr, Dept Biomed Genet, Complex Genet Sect, NL-3508 AB Utrecht, Netherlands


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Label: Florez-2006
Title: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
Journal: N ENGL J MED, 355 (3): 241-250 JUL 20 2006
Citations: 137
Authors: Florez, JC;Jablonski, KA;Bayley, N;Pollin, TI;de Bakker, PIW;Shuldiner, AR;Knowler, WC;Nathan, DM;Altshuler, D;Diabet Prevention Program Res Grp
Addresses:
George Washington Univ, Ctr Biostat, Diabet Prevent Program Coordinating Ctr, 6110 Execut Blvd,Suite 750, Rockville, MD 20852 USA
George Washington Univ, Diabet Prevent Program Outcomes Study Coordinatin, Rockville, MD USA


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Label: Dina-2007
Title: Variation in FTO contributes to childhood obesity and severe adult obesity
Journal: NAT GENET, 39 (6): 724-726 JUN 2007
Citations: 96
Authors: Dina, C;Meyre, D;Gallina, S;Durand, E;Korner, A;Jacobson, P;Carlsson, LMS;Kiess, W;Vatin, V;Lecoeur, C;Delplanque, J;Vaillant, E;Pattou, F;Ruiz, J;Weill, J;Levy-Marchal, C;Horber, F;Potoczna, N;Hercberg, S;Le Stunff, C;Bougneres, P;Kovacs, P;Marre, M;Balkau, B;Cauchi, S;Chevre, JC;Froguel, P
Addresses:
Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
Univ Leipzig, Univ Hosp Children & Adolescents, D-7010 Leipzig, Germany
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, S-40020 Gothenburg, Sweden
Univ Lille 2, INSERM, U859, F-59045 Lille, France
CHU Vaudois, Lausanne, Switzerland
Jeanne Flandre Hosp, Paediat Endocrine Unit, Lille, France
Hop Robert Debre, INSERM, U690, F-75019 Paris, France
Klin Lindberg, Winterthur, Switzerland
INRA, U1125, Bobigny, France
INSERM, U557, Bobigny, France
CNAM, EA3200, Paris, France
Univ Paris 13, Paris, France
CRNH, Paris, France
Univ Paris 05, St Vincent Paul Hosp, Dept Pediat Endocrinol, F-75005 Paris, France
Univ Paris 05, St Vincent Paul Hosp, INSERM U561, F-75005 Paris, France
Univ Leipzig, Dept Internal Med 2, D-7010 Leipzig, Germany
Univ Leipzig, Interdisciplinary Ctr Clin Res, D-7010 Leipzig, Germany
Hop Bichat Claude Bernard, AP HP, Dept Diabetol, F-75877 Paris 18, France
INSERM, U780, IFR69, Villejuif, France
Univ Paris Sud, Villejuif, France
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London SW7 2AY, England


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Label: Saxena-2006
Title: Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
Journal: DIABETES, 55 (10): 2890-2895 OCT 2006
Citations: 92
Authors: Saxena, R;Gianniny, L;Burtt, NP;Lyssenko, V;Giuducci, C;Sjogren, M;Florez, JC;Almgren, P;Isomaa, B;Orho-Melander, M;Lindblad, U;Daly, MJ;Tuomi, T;Hirschhorn, JN;Ardlie, KG;Groop, LC;Altshuler, D
Addresses:
Dept Mol Biol Endocrinol, Simches Res Bldg,175 Cambridge St,CPZN-6818, Boston, MA 02114 USA
MIT, Cambridge, MA 02139 USA
Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02138 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Lund Univ, Malmo Univ Hosp, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
Univ Helsinki, Cent Hosp, Dept Med, Folkhalsan Inst Genet,Folkhalsan Res Ctr, Helsinki, Finland
Univ Helsinki, Res Program Mol Med, Helsinki, Finland
Skaraborg Inst, Skovde, Sweden
Childrens Hosp, Div Genet, Boston, MA 02115 USA
Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Gen Collaborat, Cambridge, MA USA


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Label: Scuteri-2007
Title: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
Journal: PLOS GENET, 3 (7): art. no.-e115 JUL 2007
Citations: 91
Authors: Scuteri, A;Sanna, S;Chen, WM;Uda, M;Albai, G;Strait, J;Najjar, S;Nagaraja, R;Orru, M;Usala, G;Dei, M;Lai, S;Maschio, A;Busonero, F;Mulas, A;Ehret, GB;Fink, AA;Weder, AB;Cooper, RS;Galan, P;Chakravarti, A;Schlessinger, D;Cao, A;Lakatta, E;Abecasis, GR
Addresses:
Ist patol Endocrina & Metabol, Unita Operat Geriat, Rome, Italy
Ist patol Endocrina & Metabol, Unita Operat Geriat, Rome, Italy
NIA, Ctr Gerontol Res, Baltimore, MD 21224 USA
Univ Michigan, Ctr Stat Genet, Dept Biostat, Ann Arbor, MI 48109 USA
Cittadella Univ Monserrato, Ist Neurogenet & Neurofarmacol, Consiglio Nazl Ric, Cagliari, Italy
Presidio Osped Santa Barbara, Div Med, UNita Operat Semplice Cardiol, Iglesias, Italy
Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD USA
Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA
Loyola Stritch Sch Med, Dept Prevent Med & Epidemiol, Chicago, IL USA
Inst Sci & Tech Nutr & Alimentat, Paris, France
INSERM, INRA, CNAM, U557, Paris, France


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Label: Damcott-2006
Title: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish - Replication and evidence for a role in both insulin secretion and insulin resistance
Journal: DIABETES, 55 (9): 2654-2659 SEP 2006
Citations: 86
Authors: Damcott, CM;Pollin, TI;Reinhart, LJ;Ott, SH;Shen, HQ;Silver, KD;Mitchell, BD;Shuldiner, AR
Addresses:
Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, 660 W Redwood St,Rm 592, Baltimore, MD 21201 USA
Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA
Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, MD 21218 USA


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Label: Helgason-2007
Title: Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
Journal: NAT GENET, 39 (2): 218-225 FEB 2007
Citations: 84
Authors: Helgason, A;Palsson, S;Thorleifsson, G;Grant, SFA;Emilsson, V;Gunnarsdottir, S;Adeyemo, A;Chen, YX;Chen, GJ;Reynisdottir, I;Benediktsson, R;Hinney, A;Hansen, T;Andersen, G;Borch-Johnsen, K;Jorgensen, T;Schafer, H;Faruque, M;Doumatey, A;Zhou, J;Wilensky, RL;Reilly, MP;Rader, DJ;Bagger, Y;Christiansen, C;Sigurdsson, G;Hebebrand, J;Pedersen, O;Thorsteinsdottir, U;Gulcher, JR;Kong, A;Rotimi, C;Stefansson, K
Addresses:
DeCODE Genet, IS-101 Reykjavik, Iceland
DeCODE Genet, IS-101 Reykjavik, Iceland
Univ Iceland, IS-101 Reykjavik, Iceland
Howard Univ, Natl Human Gen Ctr, Dept Community & Family Med, Washington, DC 20060 USA
Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Natl Univ Hosp Reykjavik, IS-101 Reykjavik, Iceland
Univ Duisburg Essen, Rhein Klin Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Univ Aarhus, DK-8000 Aarhus, Denmark
Univ Hosp Glostrup, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark
Univ Marburg, Inst Med Biometry & Epidemiol, D-35037 Marburg, Germany
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Ctr Clin & Basic Res AS, DK-2750 Ballerup, Denmark


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Label: Cauchi-2006
Title: Transcription factor TCF7L2 genetic study in the French population - Expression in human beta-cells and adipose tissue and strong association with type 2 diabetes
Journal: DIABETES, 55 (10): 2903-2908 OCT 2006
Citations: 81
Authors: Cauchi, S;Meyre, D;Dina, C;Choquet, H;Samson, C;Gallina, S;Balkau, B;Charpentier, G;Pattou, F;Stetsyuk, V;Scharfmann, R;Staels, B;Fruhbeck, G;Froguel, P
Addresses:
Univ London Imperial Coll Sci Technol & Med, Sect Gen Med, Hammersmith Hosp, Du Cane Rd, London W12 0NN, England
Univ London Imperial Coll Sci Technol & Med, Sect Gen Med, Hammersmith Hosp, London W12 0NN, England
Inst Pasteur, CNRS, Inst Biol, Lille, France
INSERM, U780, IFR69, Villejuif, France
INSERM, ERITM 0106, Lille, France
Corbeil Hosp, Corbeil Essonnes, France
Hop Necker Enfants Malad, INSERM, E363, Paris, France
Inst Pasteur, Atherosclerosis Dept, F-59019 Lille, France
INSERM, U545, Lille, France
Univ Lille 2, Lille, France
Univ Navarra Clin, Dept Metabol Res, Pamplona, Spain


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Label: Groves-2006
Title: Association analysis of 6,736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk
Journal: DIABETES, 55 (9): 2640-2644 SEP 2006
Citations: 80
Authors: Groves, CJ;Zeggini, E;Minton, J;Frayling, TM;Weedon, MN;Rayner, NW;Hitman, GA;Walker, M;Wiltshire, S;Hattersley, AT;McCarthy, MI
Addresses:
Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Diabet Res Labs, Old Rd, Oxford OX3 7LJ, England
Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Diabet Res Labs, Oxford OX3 7LJ, England
Wellcome Trust Ctr Human Genet, Oxford, England
Peninsula Med Sch, Dept Diabet Res & Vasc Med, Exeter, Devon, England
Univ London, Dept Diabet & Metab Med, Barts & London Queen Mary Sch Med & Dent, London, England
Univ Newcastle Upon Tyne, Sch Med, Dept Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England


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Label: Scott-2006
Title: Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample
Journal: DIABETES, 55 (9): 2649-2653 SEP 2006
Citations: 79
Authors: Scott, LJ;Bonnycastle, LL;Willer, CJ;Sprau, AG;Jackson, AU;Narisu, N;Duren, WL;Chines, PS;Stringham, HM;Erdos, MR;Valle, TT;Tuomilehto, J;Bergman, RN;Mohlke, KL;Collins, FS;Boehnke, M
Addresses:
Univ Michigan, Sch Publ Hlth, Dept Biostat, 1420 Washington Heights, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet & Genet Epidemiol Unit, Helsinki, Finland
Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
S Ostrobothnia Cent Hosp, Seinajoki, Finland
Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA USA
Univ N Carolina, Dept Genet, Chapel Hill, NC USA


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Label: Yi-2005
Title: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3 beta
Journal: J BIOL CHEM, 280 (2): 1457-1464 JAN 14 2005
Citations: 79
Authors: Yi, FH;Brubaker, PL;Jin, TR
Addresses:
Univ Hlth Network, Toronto Gen Res Inst, Div Cell & Mol Biol, Rm 421,67 Coll St, Toronto, ON M5G 2M1, Canada
Univ Hlth Network, Toronto Gen Res Inst, Div Cell & Mol Biol, Toronto, ON M5G 2M1, Canada
Univ Toronto, Dept Physiol, Toronto, ON M5G 2M1, Canada
Univ Toronto, Dept Med, Toronto, ON M5G 2M1, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 2M1, Canada
Univ Toronto, Inst Med Sci, Toronto, ON M5G 2M1, Canada


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Label: Gudmundsson-2007
Title: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
Journal: NAT GENET, 39 (8): 977-983 AUG 2007
Citations: 66
Authors: Gudmundsson, J;Sulem, P;Steinthorsdottir, V;Bergthorsson, JT;Thorleifsson, G;Manolescu, A;Rafnar, T;Gudbjartsson, D;Agnarsson, BA;Baker, A;Sigurdsson, A;Benediktsdottir, KR;Jakobsdottir, M;Blondal, T;Stacey, SN;Helgason, A;Gunnarsdottir, S;Olafsdottir, A;Kristinsson, KT;Birgisdottir, B;Ghosh, S;Thorlacius, S;Magnusdottir, D;Stefansdottir, G;Kristjansson, K;Bagger, Y;Wilensky, RL;Reilly, MP;Morris, AD;Kimber, CH;Adeyemo, A;Chen, Y;Zhou, J;So, WY;Tong, PCY;Ng, MCY;Hansen, T;Andersen, G;Borch-Johnsen, K;Jorgensen, T;Tres, A;Fuertes, F;Ruiz-Echarri, M;Asin, L;Saez, B;van Boven, E;Klaver, S;Swinkels, DW;Aben, KK;Graif, T;Cashy, J;Suarez, BK;van Vierssen, O;Frigge, ML;Ober, C;Hofker, MH;Wijmenga, C;Christiansen, C;Rader, DJ;Palmer, CNA;Rotimi, C;Chan, JCN;Pedersen, O;Sigurdsson, G;Benediktsson, R;Jonsson, E;Einarsson, GV;Mayordomo, JI;Catalona, WJ;Kiemeney, LA;Barkardottir, RB;Gulcher, JR;Thorsteinsdottir, U;Kong, A;Stefansson, K
Addresses:
deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
deCODE Genet, IS-101 Reykjavik, Iceland
Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland
Ctr Clin & Basic Res AS, DK-2750 Ballerup, Denmark
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Univ Dundee, Ninewells Hosp & Med Sch, Div Med & Therapeut, Dundee DD1 9SY, Scotland
Univ Dundee, Ninewells Hosp & Med Sch, Populat Pharmacogenet Grp, Biomed Res Ctr, Dundee DD1 9SY, Scotland
Howard Univ, Natl Human Genome Ctr, Dept Community & Family Med, Washington, DC 20060 USA
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
Steno Diabet Ctr, DK-2820 Copenhagen, Denmark
Univ Aarhus, Fac Hlth Sci, DK-8000 Aarhus, Denmark
Glostrup Univ Hosp, Ctr Res Prevent & Hlth, DK-2600 Glostrup, Denmark
Univ Zaragoza, Lozano Blesa Univ Hosp, Div Med Oncol, E-50009 Zaragoza, Spain
Nanotechnol Inst Aragon, Inst Hlth Sci, Zaragoza 50009, Spain
Univ Zaragoza, Lozano Blesa Univ Hosp, Div Radiat Oncol, E-50009 Zaragoza, Spain
Maas Ziekenhuis, Dept Urol, NL-5830 AB Boxmeer, Netherlands
Radboud Univ Nijmegen Med Ctr, Dept Clin Chem, NL-6500 HB Nijmegen, Netherlands
Radboud Univ Nijmegen Med Ctr, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands
Comprehens Canc Ctr E, NL-6501 BG Nijmegen, Netherlands
Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Gelderse Vallei Hosp, Dept Urol, NL-6716 RP Ede, Netherlands
Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
Univ Med Ctr Groningen, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands
Maastricht Univ, Dept Mol Genet, NL-6200 MD Maastricht, Netherlands
Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands
Univ Med Ctr Utrecht, Dept Biomed Genet, Complex Genet Sect, NL-3508 AB Utrecht, Netherlands
Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Landspitali Univ Hosp, Dept Urol, IS-101 Reykjavik, Iceland
Radboud Univ Nijmegen Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands


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Label: Zhang-2006
Title: Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of US women and men
Journal: DIABETES, 55 (9): 2645-2648 SEP 2006
Citations: 59
Authors: Zhang, CL;Qi, L;Hunter, DJ;Meigs, JB;Manson, JE;van Dam, RM;Hu, FB
Addresses:
Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
Massachusetts Gen Hosp, Gen Internal Med Unit, Boston, MA 02114 USA
Massachusetts Gen Hosp, Clin Epidemiol Unit, Div Gen Med, Dept Med, Boston, MA 02114 USA
Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA


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Label: Gerken-2007
Title: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
Journal: SCIENCE, 318 (5855): 1469-1472 NOV 30 2007
Citations: 57
Authors: Gerken, T;Girard, CA;Tung, YCL;Webby, CJ;Saudek, V;Hewitson, KS;Yeo, GSH;McDonough, MA;Cunliffe, S;McNeill, LA;Galvanovskis, J;Rorsman, P;Robins, P;Prieur, X;Coll, AP;Ma, M;Jovanovic, Z;Farooqi, IS;Sedgwick, B;Barroso, I;Lindahl, T;Ponting, CP;Ashcroft, FM;O'Rahilly, S;Schofield, CJ
Addresses:
Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, S Pks Rd, Oxford OX1 3QX, England
Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
Univ Oxford, Chem Res Lab, Oxford OX1 3TA, Oxon, England
Univ Oxford, Oxford Ctr Integrat Syst, Oxford OX1 3TA, Oxon, England
Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Cambridge CB2 0QQ, England
ReOx Ltd, Magdalen Ctr, Oxford OX4 4GA, Oxon, England
Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England
Canc Res UK, London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England
Wellcome Trust Sanger Inst, Metab Dis Grp, Cambridge, England


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Label: Lyssenko-2007
Title: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
Journal: J CLIN INVEST, 117 (8): 2155-2163 AUG 2007
Citations: 56
Authors: Lyssenko, V;Lupi, R;Marchetti, P;Del Guerra, S;Orho-Melander, M;Almgren, P;Sjogren, M;Ling, C;Eriksson, KF;Lethagen, AL;Mancarella, R;Berglund, G;Tuomi, T;Nilsson, P;Del Prato, S;Groop, L
Addresses:
Lund Univ, Dept Clin Sci Diabet Endocrinol, Malmo, Sweden
Lund Univ, Dept Clin Sci Diabet Endocrinol, Malmo, Sweden
Lund Univ, Diabet Ctr, Malmo, Sweden
Univ Pisa, Metab Unit, Dept Endocrinol & Metab, I-56100 Pisa, Italy
Lund Univ, Fac Med, Dept Clin Sci, Malmo, Sweden
Univ Helsinki, Res Program Mol Med, FIN-00014 Helsinki, Finland
Folkhalsan Res Ctr, Genet Inst, Helsinki, Finland
Univ Helsinki, Cent Hosp, Dept Med, FIN-00014 Helsinki, Finland


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Label: Liese-2006
Title: The burden of diabetes mellitus among US youth: Prevalence estimates from the SEARCH for Diabetes in Youth Study
Journal: PEDIATRICS, 118 (4): 1510-1518 OCT 2006
Citations: 48
Authors: Liese, AD;D'Agostino, RB;Hamman, RF;Kilgo, PD;Lawrence, JM;Liu, LL;Loots, B;Linder, B;Marcovina, S;Rodriguez, B;Williams, DE;Petitti, DB;Kershnar, AK;Holmquist, KJ;Pettitt, DJ;Dabelea, D;Hamman, RF;Martinez, E;Rojas, SP;Klingensmith, GJ;Rewers, MJ;Bloch, CA;Krakoff, J;Bennett, PH;DeGroat, JA;Rodriguez, BL;Waitzfelder, B;Fujimoto, W;Curb, JD;Kennedy, F;Uramoto, G;Waxman, S;Hillier, T;Chung, R;Dolan, LM;Standiford, D;Daniels, SR;Johansen, JM;Mayer-Davies, EJ;Liese, AD;McKeown, R;Moran, RR;Oeltmann, J;Thomas, J;Truell, D;Gaillard-McBride, G;Lawler, D;Irby, A;Schwartz, ID;Heinze, H;Hartel, L;Appiagyei-Dankah, Y;Key, L;Willi, S;Amrhein, J;Clark, P;Muir, A;Parker, M;Pihoker, C;Gilliam, L;Hirsch, I;Liu, LL;Paris, C;Loots, B;Tseng, J;Vacanti, S;Greenbaum, C;Imperatore, G;Williams, DE;Engelgau, MM;Kahn, H;Narayan, KMV;Linder, B;Marcovina, S;Strylewicz, G;Bell, R;D'Agostino, R;Snively, B;Morgan, T;Vestal, S;Zvara, B;SEARCH Diabet Youth Study Grp
Addresses:
Univ S Carolina, Dept Epidemiol & Biostat, 800 Sumter St, Columbia, SC 29208 USA
Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA


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Label: Dabelea-2007
Title: Incidence of diabetes in youth in the United States
Journal: JAMA-J AM MED ASSN, 297 (24): 2716-2724 JUN 27 2007
Citations: 33
Authors: Dabelea, D;Bell, RA;D'Agostino, RB;Imperatore, G;Johansen, JM;Linder, B;Liu, LL;Loots, B;Marcovina, S;Mayer-Davis, EJ;Pettitt, DJ;Waitzfelder, B;Writing Grp SEARCH Diabet Youth St
Addresses:
Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, 4200 E 9th Ave,Box C245, Denver, CO 80262 USA
Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, Denver, CO 80262 USA
Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA
Ctr Dis Control & Prevent, Atlanta, GA USA
Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA
NIDDK, Bethesda, MD USA
Univ Washington, Inst Child Hlth, Seattle, WA 98195 USA
Childrens Hosp & Reg Med Ctr, Seattle, WA USA
Univ S Carolina, Columbia, SC 29208 USA
Sansum Diabet Res Inst, Santa Barbara, CA USA
Pacific Hlth Res Inst, Honolulu, HI USA


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Label: Lehman-2007
Title: Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
Journal: DIABETES, 56 (2): 389-393 FEB 2007
Citations: 30
Authors: Lehman, DM;Hunt, KJ;Leach, RJ;Hamlington, J;Arya, R;Abboud, HE;Duggirala, R;Blangero, J;Goring, HHH;Stern, MP
Addresses:
Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA
Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, San Antonio, TX 78229 USA
Med Univ S Carolina, Dept Biostat Bioinformat & Epidemiol, Charleston, SC 29425 USA
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA
Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX 78284 USA
Univ Texas, Hlth Sci Ctr, Dept Med, Div Nephrol, San Antonio, TX 78284 USA
SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78284 USA


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Label: Winckler-2007
Title: Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
Journal: DIABETES, 56 (3): 685-693 MAR 2007
Citations: 30
Authors: Winckler, W;Weedon, MN;Graham, RR;McCarrolll, SA;Purcell, S;Almgren, P;Tuomi, T;Gaudet, D;Bostrom, KB;Walker, M;Hitman, G;Hattersley, AT;McCarthy, MI;Ardlie, KG;Hirschhorn, JN;Daly, MJ;Frayling, TM;Groop, L;Altshuler, D
Addresses:
Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA
Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Cambridge, MA 02142 USA
MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England
Lund Univ, Univ Hosp MAS, Dept Endocrinol, Malmo, Sweden
Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland
Univ Helsinki, Folkhalsan Inst Genet, Folkhalsan Res Ctr, Helsinki, Finland
Univ Helsinki, Res Program Mol Med, Helsinki, Finland
Univ Montreal, Community Genom Ctr, Chicoutimi Hosp, Chicoutimi, PQ, Canada
Lund Univ, Univ Hosp MAS, Dept Clin Sci, Malmo, Sweden
Univ Newcastle Upon Tyne, Dept Med, Sch Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Univ London, Dept Diabet & Metab Med, Barts & London Queen Mary Sch Med & Dent, London, England
Churchill Hosp, Dept Endocrinol & Metab, Diabet Res Labs, Oxford Ctr Diabet, Oxford OX3 7LJ, England
Genom Collaborat, Cambridge, MA USA
Childrens Hosp, Div Genet, Boston, MA 02115 USA
Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA


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Label: Horikoshi-2007
Title: A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
Journal: DIABETOLOGIA, 50 (4): 747-751 APR 2007
Citations: 28
Authors: Horikoshi, M;Hara, K;Ito, C;Nagai, R;Froguel, P;Kadowaki, T
Addresses:
Univ Tokyo, Grad Sch Med, Dept Metab Dis, Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan
Univ Tokyo, Grad Sch Med, Dept Metab Dis, Bunkyo Ku, Tokyo 1138655, Japan
CREST, JST, Tokyo, Japan
Med Court Life Care Clin, Hiroshima, Japan
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan
CNRS, UMR 8090, Lille, France


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Label: Pascoe-2007
Title: Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
Journal: DIABETES, 56 (12): 3101-3104 DEC 2007
Citations: 26
Authors: Pascoe, L;Tura, A;Patel, SK;Ibrahim, IM;Ferrannini, E;Zeggini, E;Weedon, MN;Mari, A;Hattersley, AT;McCarthy, MI;Frayling, TM;Walker, M;RISC Consortium;UK Type 2 Diabet Genet Consortium
Addresses:
Univ Newcastle Upon Tyne, Sch Med, Sch Clin Med Sci, Diabet Res Grp, 4th Floor William Leech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Univ Newcastle Upon Tyne, Sch Med, Sch Clin Med Sci, Diabet Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
CNR, Inst Biomed Engn, Padua, Italy
Univ Melbourne, Dept Med, Cardiovasc Res Grp, Melbourne, Vic, Australia
Univ Pisa, Sch Med, I-56100 Pisa, Italy
Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
Peninsula Med Sch, Diabet Genet Grp, Exeter, Devon, England
Peninsula Med Sch, Genet Complex Traits, Exeter, Devon, England


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Label: Grarup-2007
Title: Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects - Validation and extension of genome-wide association studies
Journal: DIABETES, 56 (12): 3105-3111 DEC 2007
Citations: 22
Authors: Grarup, N;Rose, CS;Andersson, EA;Andersen, G;Nielsen, AL;Albrechtsen, A;Clausen, JO;Rasmussen, SS;Jorgensen, T;Sandbaek, A;Lauritzen, T;Schmitz, O;Hansen, T;Pedersen, O
Addresses:
Steno Diabet Ctr, Niels Steensens Vej 1,NLC2 14, DK-2820 Gentofte, Denmark
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Univ Copenhagen, Dept Biostat, Copenhagen, Denmark
Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Univ Aarhus, Dept Gen Practice, Aarhus, Denmark
Aarhus Univ Hosp, Dept Endocrinol & Diabet, DK-8000 Aarhus, Denmark
Univ Aarhus, Dept Clin Pharmacol, Aarhus, Denmark
Univ Aarhus, Fac Hlth Sci, Aarhus, Denmark


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Label: Li-2008
Title: Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
Journal: DIABETES, 57 (1): 264-268 JAN 2008
Citations: 20
Authors: Li, HX;Wu, Y;Loos, RJF;Hu, FB;Liu, Y;Wang, J;Yu, Z;Lin, X
Addresses:
Chinese Acad Sci, Key Lab Syst Biol, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
Chinese Acad Sci, Key Lab Syst Biol, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
Addenbrookes Hosp, Inst Metab Sci, MRC Epidemol Unit, Cambridge, England
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA


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Label: Andreasen-2008
Title: Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
Journal: DIABETES, 57 (1): 95-101 JAN 2008
Citations: 17
Authors: Andreasen, CH;Stender-Petersen, KL;Mogensen, MS;Torekov, SS;Wegner, L;Andersen, G;Nielsen, AL;Albrechtsen, A;Borch-Johnsen, K;Rasmussen, SS;Clausen, JO;Sandbaek, A;Lauritzen, T;Hansen, L;Jorgensen, T;Pedersen, O;Hansen, T
Addresses:
Steno Diabet Ctr, NIels Steensens Vej 1,NLC2 13, DK-2820 Gentofte, Denmark
Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Univ Copenhagen, Dept Biostat, Copenhagen, Denmark
Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Univ Aarhus, Fac Hlth Sci, Aarhus, Denmark
Univ Aarhus, Dept Gen Practice, Aarhus, Denmark


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Label: Freathy-2008
Title: Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
Journal: DIABETES, 57 (5): 1419-1426 MAY 2008
Citations: 12
Authors: Freathy, RM;Timpson, NJ;Lawlor, DA;Pouta, A;Ben-Shlomo, Y;Ruokonen, A;Ebrahim, S;Shields, B;Zeggini, E;Weedon, MN;Lindgren, CM;Lango, H;Melzer, D;Ferrucci, L;Paolisso, G;Neville, MJ;Karpe, F;Palmer, CNA;Morris, AD;Elliott, P;Jarvelin, MR;Smith, GD;McCarthy, MI;Hattersley, AT;Frayling, TM
Addresses:
Peninsula Med Sch, Inst Biomed & Clin Sci, Magdalen Rd, Exeter EX1 2LU, Devon, England
Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter EX1 2LU, Devon, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
Univ Bristol, MRC, Ctr Causal Anal Translat Epidemiol, Bristol, Avon, England
Univ Bristol, Dept Social Med, Bristol, Avon, England
Natl Publ Hlth Inst, Oulu, Finland
Oulu Univ, Oulu, Finland
London Sch Hyg & Trop Med, London WC1, England
Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
NIA, NIH, Bethesda, MD 20892 USA
Univ Naples 2, Naples, Italy
Univ Dundee, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland
Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England


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Label: Shu-2008
Title: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
Journal: DIABETES, 57 (3): 645-653 MAR 2008
Citations: 12
Authors: Shu, L;Sauter, NS;Schulthess, FT;Matveyenko, AV;Oberholzer, J;Maedler, K
Addresses:
Univ Bremen, Ctr Biomol Interact Bremen, NW2,Box 33 04 40, D-28334 Bremen, Germany
Univ Calif Los Angeles, Larry L Hillblom Islet Res Ctr, Dept Med, Los Angeles, CA USA
Univ Calif Los Angeles, Div Transplantat, Los Angeles, CA USA


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Label: Stratigopoulos-2008
Title: Regulation of Fto/Ftm gene expression in mice and humans
Journal: AMER J PHYSIOL-REGUL INTEGR C, 294 (4): R1185-R1196 APR 2008
Citations: 11
Authors: Stratigopoulos, G;Padilla, SL;Leduc, CA;Watson, E;Hattersley, AT;McCarthy, MI;Zeltser, LM;Chung, WK;Leibel, RL
Addresses:
Naomi Berrie Diabet Ctr, Div Mol Genet, 1150 St Nicholas Ave,Russs Berrie Med Sci Pavil,R, New York, NY 10032 USA
Naomi Berrie Diabet Ctr, Div Mol Genet, New York, NY 10032 USA
Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX1 2JD, England
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England
Penn Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England


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Label: Florez-2007
Title: The new type 2 diabetes gene TCF7L2
Journal: CURR OPIN CLIN NUTR METAB CA, 10 (4): 391-396 JUL 2007
Citations: 10
Authors: Florez, JC
Addresses:
Massachusetts Gen Hosp, Ctr Human Genet Res, Diabet Unit, Simches Res Bldg,CPZN 6820, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Diabet Unit, Boston, MA 02114 USA
MIT, Cambridge, MA 02139 USA
Harvard Univ, Sch Med, Dept Med, Cambridge, MA 02138 USA


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Label: Liu-2008
Title: Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
Journal: J BIOL CHEM, 283 (13): 8723-8735 MAR 28 2008
Citations: 9
Authors: Liu, ZY;Habener, JF
Addresses:
Massachusetts Gen Hosp, Mol Endocrinol Lab, 55 Fruit St,Thier 306, Boston, MA 02114 USA
Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USA


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Label: Wahlen-2008
Title: The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
Journal: J LIPID RES, 49 (3): 607-611 MAR 2008
Citations: 9
Authors: Wahlen, K;Sjolin, E;Hoffstedt, J
Addresses:
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden


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Label: Cauchi-2008
Title: Effects of TCF7L2 polymorphisms on obesity in European populations
Journal: OBESITY, 16 (2): 476-482 FEB 2008
Citations: 8
Authors: Cauchi, S;Choquet, H;Gutierrez-Aguilar, R;Capel, F;Grau, K;Proenca, C;Dina, C;Duval, A;Balkau, B;Marre, M;Potoczna, N;Langin, D;Horber, F;Sorensen, TIA;Charpentier, G;Meyre, D;Froguel, P
Addresses:
Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France
Obes Res Lab, Rangueil Inst Mol Med, Inst Natl Sante & Rech Med, U858, Toulouse, France
Univ Toulouse 3, Louis Bugnard Inst, F-31062 Toulouse, France
Univ Copenhagen Hosp, Inst Prevent Med, Ctr Hlth & Soc, DK-2100 Copenhagen, Denmark
Jean Dausset CEPH Fdn, Inst Natl Sante & Rech Med, U762, Paris, France
Univ Paris 06, Paris, France
Hop Paul Brousse, Inst Natl Sante & Rech Med, U780 IFR69, Villejuif, France
Hop Xavier Bichat, Inst Natl Sante & Rech Med, U695, Paris, France
Klin Lindberg, Obes Ctr, Winterthur, Switzerland
Toulouse Hosp, Lab Clin Biochem, Biol Inst Purpan, Toulouse, France
Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England
Corbeil Hosp, Corbeil Essonnes, France


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Label: Do-2008
Title: Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
Journal: DIABETES, 57 (4): 1147-1150 APR 2008
Citations: 8
Authors: Do, R;Bailey, SD;Desbiens, K;Belisle, A;Montpetit, A;Bouchard, C;Perusse, L;Vohl, MC;Engert, JC
Addresses:
McGill Univ, Royal Victoria Hosp, Div Cardiol, H7-30,687 Pine Ave W, Montreal, PQ, Canada
McGill Univ, Dept Human Genet, Montreal, PQ H3A 1A1, Canada
McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H3A 1A1, Canada
Genome Quebec Innovat Ctr, Montreal, PQ, Canada
Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
Univ Laval, Div Kinesiol, Dept Social & Prevent Med, Ste Foy, PQ, Canada
Laval Univ Hosp, Res Ctr, Lipid Res Ctr, Ste Foy, PQ, Canada
Univ Laval, Dept Food Sci & Nutr, Ste Foy, PQ, Canada
McGill Univ, Dept Med, Montreal, PQ H3A 1A1, Canada


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Label: Kirchhoff-2008
Title: Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
Journal: DIABETOLOGIA, 51 (4): 597-601 APR 2008
Citations: 8
Authors: Kirchhoff, K;Machicao, F;Haupt, A;Schafer, SA;Tschritter, O;Staiger, H;Stefan, N;Haring, HU;Fritsche, A
Addresses:
Univ Tubingen, Dept Internal Med, Div Endocrinol Diabetol Vasc Med Nephrol & Clin C, Otfried Muller Str 10, D-72076 Tubingen, Germany
Univ Tubingen, Dept Internal Med, Div Endocrinol Diabetol Vasc Med Nephrol & Clin C, D-72076 Tubingen, Germany


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Label: Maiese-2007
Title: "Sly as a FOXO": New paths with forkhead signaling in the brain
Journal: CURR NEUROVASC RES, 4 (4): 295-302 NOV 2007
Citations: 8
Authors: Maiese, K;Chong, ZZ;Shang, YC
Addresses:
Wayne State Univ, Sch Med, Dept Neurol, Div Cell & Mol Cerebral Ischemia, 4201 St Antoine, Detroit, MI 48201 USA
Wayne State Univ, Sch Med, Dept Neurol, Div Cell & Mol Cerebral Ischemia, Detroit, MI 48201 USA
Wayne State Univ, Ctr Mol Med & Genet & Inst Environm Hlth Sci, Inst Environm Hlth Sci, Dept Neurol & Anat, Detroit, MI 48201 USA
Wayne State Univ, Ctr Mol Med & Genet, Inst Environm Hlth Sci, Dept Cell Biol, Detroit, MI 48201 USA


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Label: Fredriksson-2008
Title: The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
Journal: ENDOCRINOLOGY, 149 (5): 2062-2071 MAY 2008
Citations: 7
Authors: Fredriksson, R;Hagglund, M;Olszewski, PK;Stephansson, O;Jacobsson, JA;Olszewska, AM;Levine, AS;Lindblom, J;Schioth, HB
Addresses:
Uppsala Univ, Dept Neurosci, Biomed Ctr, Box 593, SE-75124 Uppsala, Sweden
Uppsala Univ, Dept Neurosci, Biomed Ctr, SE-75124 Uppsala, Sweden
Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA


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KEYWORDS: NEW TYPE 2 DIABETES GENE TCF7L2; TYPE 2 DIABETES SUSCEPTIBILITY GENE; TRANSCRIPTION FACTOR 7-LIKE 2 (TCF7L2) GENE CONFERS RISK; NOVEL TYPE 2 DIABETES GENES CDKAL1; TRANSCRIPTION FACTOR 7-LIKE 2 GENE.
[6071: (2002-2008_6) (CLI-MOL: ST Diabetes)]



Special Topics : Diabetes : TYPE 2 DIABETES SUSCEPTIBILITY GENE - Diabetes