Research front maps are diagrammatic representations of the core papers
comprising each front. They are selected from the current Research Front set
that are relevant to the featured special topic. The title for this Research
Front Map is "DRUG TREATMENT FOR TYPE 2 DIABETES," containing
32 core papers. Source dates: 1999-February 28, 2009 (first bimonthly
period 2009).
Each circle represents a highly cited paper whose bibliographic information
is displayed when the user clicks on the circle. The solid lines between circles
represent the strongest co-citation links for each paper (that is, indicating
that the papers are frequently cited together); weaker links are indicated by
dashed lines. Papers close to each other on the map are generally more highly
co-cited. The most recent paper(s) are indicated in pink. Annotations may have
been added to this map which represent the main research themes. These appear as
labels attached to specific regions on the maps.
Note: For best results use the
"landscape orientation" option when printing this page.
Core Papers
Label: Dormandy-2005 Title: Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial Journal: LANCET, 366 (9493): 1279-1289 OCT 8 2005 Citations: 683 Authors: Dormandy, JA;Charbonnel, B;Eckland, DJA;Erdmann, E;Massi-Benedetti, M;Kmoules, IK;Skene, AM;Tan, MH;Lefebvre, PJ;Murray, GD;Standl, E;Wilcox, RG;Wlhelmsen, L;Betteridge, J;Birkeland, K;Golay, A;Heine, RJ;Koranyi, L;Laakso, M;Mokan, M;Norkus, A;Pirags, V;Podar, T;Scheen, A;Scherbaum, W;Schernthaner, G;Schmitz, O;Skrha, J;Smith, U;Taton, J;PROactive Investigators Addresses:
Univ London St Georges Hosp, Dept Clin Vasc Res, Ingelby House,Blackshaw Rd, London SW17 0QT, England
Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0QT, England
Hop Hotel Dieu, Clin Endocrinol, Nantes 1, France
Univ Cologne, Innere Med Klin 3, Cologne, Germany
Univ Perugia, I-06100 Perugia, Italy
Takeda Europe R&D Ctr, London, England
Nottingham Clin Res Ltd, Isaac Newton Ctr, Nottingham, England
Eli Lilly & Co, Lilly Corp Ctr, Diabet & Endocrine Platform, Indianapolis, IN 46285 USA
CHU Sart Tilman, Int Diabet Federat, Div Diabet, Dept Med, B-4000 Liege, Belgium
Univ Edinburgh, Sch Med, Dept Publ Hlth Sci, Edinburgh, Midlothian, Scotland
Munich Diabet Res Inst, Munich, Germany
Univ Hosp, Dept Cardiovasc Med, Nottingham, England
Univ Gothenburg, Inst Cardiovasc Med, Gothenburg, Sweden
Univ Coll London, Middlesex Hosp, Dept Med, London, England
Univ Oslo, Aker Univ Hosp, Res Ctr, Oslo, Norway
Univ Hosp Geneva, Serv Therapeut Educ Chron Dis, Geneva, Switzerland
VU Univ Med Ctr, Ctr Diabet, Amsterdam, Netherlands
Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland
Comenius Univ, Martin Fac Hosp, Jessenius Med Fac, Internal Clin 1, Martin, Slovakia
Kaunas Univ Med, Inst Endocrinol, Kaunas, Lithuania
Univ Slimnica, Paula Strandina Klin, Riga, Latvia
Endocrinol Ctr, Tartu, Estonia
Univ Liege, CHU Sart Tilman, Div Diabet Nutr & Metab Disorders, Liege, Belgium
Univ Dusseldorf, German Diabet Ctr, Dusseldorf, Germany
Rudolfstiftung Hosp, Dept Med 1, Vienna, Austria
Univ Aarhus, Inst Clin Pharmacol, Aarhus, Denmark
Czech Diabet Soc, Clin Dept Endocrinol & Metab, Dept Med 3, Prague, Czech Republic
Gothenburg Univ, Lundberg Lab Diabet Res, S-41124 Gothenburg, Sweden
Warsaw Med Univ, Dept Internal Med & Diabetol, Warsaw, Poland
Label: Nissen-2007 Title: Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes Journal: N ENGL J MED, 356 (24): 2457-2471 JUN 14 2007 Citations: 483 Authors: Nissen, SE;Wolski, K Addresses:
Cleveland Clin Fdn, Dept Cardiovasc Med, 9500 Euclid Ave, Cleveland, OH 44195 USA
Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA
Label: Kahn-2006 Title: Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy Journal: N ENGL J MED, 355 (23): 2427-2443 DEC 7 2006 Citations: 293 Authors: Kahn, SE;Haffner, SM;Heise, MA;Herman, WH;Holman, RR;Jones, NP;Kravitz, BG;Lachin, JM;O'Neill, MC;Zinman, B;Viberti, G;ADOPT Study Grp Addresses:
Vet Affairs Puget Sound Hlth Care Syst, 1660 S Columbian Way, Seattle, WA 98108 USA
Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA 98108 USA
Univ Washington, Seattle, WA 98195 USA
Univ Texas, Hlth Sci Ctr, San Antonio, TX USA
GlaxoSmithKline Inc, King Of Prussia, PA USA
GlaxoSmithKline Inc, Harlow, Essex, England
Univ Michigan, Ann Arbor, MI 48109 USA
Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
George Washington Univ, Ctr Biostat, Rockville, MD USA
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Toronto, ON, Canada
Univ London, Kings Coll London Sch Med, London WC1E 7HU, England
Label: Goldberg-2005 Title: A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia Journal: DIABETES CARE, 28 (7): 1547-1554 JUL 2005 Citations: 191 Authors: Goldberg, RB;Kendall, DM;Deeg, MA;Buse, JB;Zagar, AJ;Pinaire, JA;Tan, MH;Khan, MA;Perez, AT;Jacober, SJ;GLAI Study Investigators Addresses:
Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, DC 5116, Indianapolis, IN 46285 USA
Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA
Takeda Pharmaceut N Amer, Lincolnshire, IL USA
Takeda Global Res & Dev Ctr, Lincolnshire, IL USA
Univ N Carolina, Sch Med, Div Endocrinol, Chapel Hill, NC USA
Univ N Carolina, Sch Med, Div Gen Med, Chapel Hill, NC USA
Indiana Univ, Sch Med, Indianapolis, IN 46204 USA
Dept Vet Affairs, Div Endocrinol & Metab, Indianapolis, IN 46204 USA
Pk Nicollet Inst, Int Diabet Ctr, Minneapolis, MN USA
Univ Miami, Sch Med, Div Endocrinol Diabet & Metab, Miami, FL 33152 USA
Label: Satoh-2003 Title: Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect Journal: DIABETES CARE, 26 (9): 2493-2499 SEP 2003 Citations: 146 Authors: Satoh, N;Ogawa, Y;Usui, T;Tagami, T;Kono, S;Uesugi, H;Sugiyama, H;Sugawara, A;Yamada, K;Shimatsu, A;Kuzuya, H;Nakao, K Addresses:
Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Med & Metab, Chiyoda Ku, 2-3-10 Kandasurugadai, Tokyo 1010062, Japan
Kyoto Natl Hosp, Ctr Diabet, Kyoto, Japan
Kyoto Natl Hosp, Clin Res Inst, Kyoto, Japan
Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan
Saiseikai Noe Hosp, Dept Internal Med, Osaka, Japan
Label: Nissen-2005 Title: Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus Journal: JAMA-J AM MED ASSN, 294 (20): 2581-2586 NOV 23 2005 Citations: 136 Authors: Nissen, SE;Wolski, K;Topol, EJ Addresses:
Cleveland Clin Fdn, Dept Cardiovasc Med, 9500 Euclid Ave, Cleveland, OH 44195 USA
Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA
Label: Sidhu-2004 Title: Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus Journal: ARTERIOSCLER THROMB VASC BIOL, 24 (5): 930-934 MAY 2004 Citations: 103 Authors: Sidhu, JS;Kaposzta, Z;Markus, HS;Kaski, JC Addresses:
Univ London St Georges Hosp, Sch Med, Coronary Artery Dis Res Unit, Cranmer Terrace, London SW17 0RE, England
Univ London St Georges Hosp, Sch Med, Coronary Artery Dis Res Unit, London SW17 0RE, England
Univ London St Georges Hosp, Sch Med, Dept Clin Neurosci, London SW17 0RE, England
Label: Choi-2004 Title: Preventative effects of rosiglitazone on restenosis after coronary stent implantation in patients with type 2 diabetes Journal: DIABETES CARE, 27 (11): 2654-2660 NOV 2004 Citations: 102 Authors: Choi, D;Kim, SK;Choi, SH;Ko, YG;Ahn, CW;Jang, YS;Lim, SK;Lee, HC;Cha, BS Addresses:
Yonsei Univ, Coll Med, Dept Internal Med, 134 Shinchon Dong, Seoul 120749, South Korea
Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120749, South Korea
Yonsei Univ, Coll Med, Brain Korea 21 Project Med Sci, Seoul, South Korea
Pochon CHA Univ, Coll Med, Dept Internal Med, Sungnam, Kyonggi Do, South Korea
Label: Mazzone-2006 Title: Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes - A randomized trial Journal: JAMA-J AM MED ASSN, 296 (21): 2572-2581 DEC 6 2006 Citations: 90 Authors: Mazzone, T;Meyer, PM;Feinstein, SB;Davidson, MH;Kondos, GT;D'Agostino, RB;Perez, A;Provost, JC;Haffner, SM Addresses:
Univ Illinois, Coll Med, Dept Med, Sect Endocrinol Diabet & Metab, 1819 W Polk St,612 CMW MC 797, Chicago, IL 60612 USA
Univ Illinois, Coll Med, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL 60612 USA
Univ Illinois, Coll Med, Cardiol Sect, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Med, Cardiol Sect, Chicago, IL 60612 USA
Boston Univ, Dept Math, Stat & Consulting Unit, Boston, MA 02215 USA
Takeda Global Res & Dev Inc, Lincolnshire, IL USA
Synarc, Paris, France
Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78284 USA
Label: Masoudi-2005 Title: Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure - An observational study Journal: CIRCULATION, 111 (5): 583-590 FEB 8 2005 Citations: 79 Authors: Masoudi, FA;Inzucchi, SE;Wang, YF;Havranek, EP;Foody, JM;Krumholz, HM Addresses:
Denver Hlth Med Ctr, Div Cardiol, Dept Med, MC 0960,777 Bannock St, Denver, CO 80204 USA
Denver Hlth Med Ctr, Div Cardiol, Dept Med, Denver, CO 80204 USA
Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA
Colorado Fdn Med Care, Aurora, CO USA
Colorado Hlth Outcomes Program, Aurora, CO USA
Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA
Yale New Haven Med Ctr, Ctr Outcomes Res & Evaluat, New Haven, CT 06504 USA
Label: Schwartz-2006 Title: Thiazolidinedione use and bone loss in older diabetic adults Journal: J CLIN ENDOCRINOL METAB, 91 (9): 3349-3354 SEP 2006 Citations: 64 Authors: Schwartz, AV;Sellmeyer, DE;Vittinghoff, E;Palermo, L;Lecka-Czernik, B;Feingold, KR;Strotmeyer, ES;Resnick, HE;Carbone, L;Beamer, BA;Park, SW;Lane, NE;Harris, TB;Cummings, SR;Hlth Aging Body Composition Hlth A Addresses:
Univ Calif San Francisco, Dept Epidemiol & Biostat, 185 Berry St,Lobby 4,Suite 5700, San Francisco, CA 94107 USA
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA
Univ Calif San Francisco, Div Endocrinol, San Francisco, CA 94107 USA
Univ Calif San Francisco, Dept Med, San Francisco, CA 94107 USA
Univ Arkansas Med Sci, Dept Geriatr, Reynolds Inst Aging, Little Rock, AR 72202 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
MedStar Res Inst, Dept Epidemiol, Landover, MD 20785 USA
Univ Tennessee, Div Rheumatol, Dept Med, Memphis, TN 38163 USA
Johns Hopkins Univ, Dept Med, Baltimore, MD 21205 USA
Pochon CHA Univ, Dept Med, Seoul 135081, South Korea
Univ Calif Davis, Dept Med, Davis, CA 95616 USA
NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94120 USA
Label: Szapary-2006 Title: Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome Journal: ARTERIOSCLER THROMB VASC BIOL, 26 (1): 182-188 JAN 2006 Citations: 55 Authors: Szapary, PO;Bloedon, LT;Samaha, FF;Duffy, D;Wolfe, ML;Soffer, D;Reilly, MP;Chittams, J;Rader, DJ Addresses:
Univ Penn, Med Ctr, Inst Translat Med & Therapeut, 654 BRB2-3 Labs,421 Curie Blvd, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Div Gen Internal Med, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Div Cardiovasc Med, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Label: Lago-2007 Title: Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials Journal: LANCET, 370 (9593): 1129-1136 SEP 29 2007 Citations: 51 Authors: Lago, RM;Singh, PP;Nesto, RW Addresses:
Lahey Clin Fdn, Med Ctr, 41 Mall Rd, Burlington, MA 01805 USA
Lahey Clin Fdn, Med Ctr, Burlington, MA 01805 USA
Label: Erdmann-2007 Title: The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction - Results from the PROactive (PROactive 05) study Journal: J AMER COLL CARDIOL, 49 (17): 1772-1780 MAY 1 2007 Citations: 47 Authors: Erdmann, E;Dormandy, JA;Charbonnel, B;Massi-Benedetti, M;Moules, IK;Skene, AM;PROactive Investigators Addresses:
Univ Cologne, Med Klin 3, Kerpener Str 62, D-50937 Cologne, Germany
Univ Cologne, Med Klin 3, D-50937 Cologne, Germany
St George Hosp, London, England
Hop Hotel Dieu, Clin Endocrinol, Nantes, France
Univ Perugia, I-06100 Perugia, Italy
Takeda Global Res & Dev Ctr Europe Ltd, London, England
Nottingham Clin Res Ltd, Nottingham, England
Label: Wilcox-2007 Title: Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke - Results from PROactive (PROspective pioglitAzone Clinical Trial in macroVascular Events 04) Journal: STROKE, 38 (3): 865-873 MAR 2007 Citations: 46 Authors: Wilcox, R;Bousser, MG;Betteridge, DJ;Schernthaner, G;Pirags, V;Kupfer, S;Dormandy, J;PROactive Investigators Addresses:
Univ Nottingham Hosp, Queens Med Ctr, Dept Cardiovasc Med, Nottingham NG7 2UH, England
Univ Nottingham Hosp, Queens Med Ctr, Dept Cardiovasc Med, Nottingham NG7 2UH, England
Univ Coll London Hosp, Dept Med, London, England
Rudolfstiftung Hosp, Dept Med 1, Vienna, Austria
Riga Tech Univ, Paula Stradina Klin Slimnica, Riga, Latvia
Univ London St Georges Hosp, Dept Clin Vasc Res, London SW17 0RE, England
Takeda Global Res & Dev, Deerfield, IL USA
Label: Diamond-2007 Title: Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death Journal: ANN INTERN MED, 147 (8): 578-581 OCT 16 2007 Citations: 32 Authors: Diamond, GA;Bax, L;Kaul, S Addresses:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, 8700 Beverly Blvd, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90048 USA
Label: Dargie-2007 Title: A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association functional class I or II heart failure Journal: J AMER COLL CARDIOL, 49 (16): 1696-1704 APR 24 2007 Citations: 29 Authors: Dargie, HJ;Hildebrandt, PR;Riegger, GAJ;McMurray, JJV;McMorn, SO;Roberts, JN;Zambanini, A;Wilding, JPH Addresses:
Univ Glasgow, Western Infirm, CRI Dept, Level 4, Glasgow G11 6NT, Lanark, Scotland
Univ Glasgow, Western Infirm, CRI Dept, Glasgow G11 6NT, Lanark, Scotland
Frederiksberg Univ Hosp, Dept Cardiol, Frederiksberg, Denmark
Univ Regensburg, Dept Cardiol, D-8400 Regensburg, Germany
GlaxoSmithKline Inc, Cardiovasc & Metab Med Dev Ctr, Harlow, Essex, England
GlaxoSmithKline Inc, Biomed Data Sci, Oakville, ON, Canada
Univ Hosp Aintree, Ctr Clin Sci, Liverpool, Merseyside, England
Label: Heckbert-2008 Title: Use of alendronate and risk of incident atrial fibrillation in women Journal: ARCH INTERN MED, 168 (8): 826-831 APR 28 2008 Citations: 7 Authors: Heckbert, SR;Li, G;Cummings, SR;Smith, NL;Psaty, BM Addresses:
Univ Washington, Cardiovasc Hlth Res Unit, 1730 Minor Ave,Ste 1360, Seattle, WA 98101 USA
Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
Univ Washington, Dept Med, Seattle, WA USA
Ctr Hlth Studies, Grp Hlth, Seattle, WA USA
San Francisco Coordinating Ctr, Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA
Univ Calif San Francisco, San Francisco, CA 94143 USA
Seattle Epidemiol Res & Informat Ctr, Vet Adm Puget Soung Hlth Care Syst, Seattle, WA USA