As
part of this bimonthly processing,
ScienceWatch.com selects the Research Fronts with the largest absolute
increase in size in each of the 22 major
fields covered by
Essential Science IndicatorsSM
from Thomson
Reuters. The size of a research front is determined by the number of
core papers it contains. This Research Front on GENE SILENCING USING
SMALL INTERFERING RNAS from the field of
Physics was
selected for mapping from the list of Corporate Research Fronts for
April 2010 (data
from the fourth bimonthly period of
2009). The map is a diagrammatic
representation of the 40 core papers comprising the front
in Biology & Biochemistry.
Each circle
represents a highly cited paper whose bibliographic information is displayed
when the user clicks on the circle. The lines between circles represent the
strongest co-citation links for each paper (that is, indicating that the papers
are frequently cited together). Papers close to each other on the map are
generally more highly co-cited. The most recent paper(s) are indicated in pink.
Annotations may have been added to this map which represent the main research
themes. These appear as labels attached to specific regions on the maps.
Core Papers
Label: Soutschek-2004 Title: Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Journal: NATURE, 432 (7014): 173-178 NOV 11 2004 Citations: 588 Authors: Soutschek, J;Akinc, A;Bramlage, B;Charisse, K;Constien, R;Donoghue, M;Elbashir, S;Geick, A;Hadwiger, P;Harborth, J;John, M;Kesavan, V;Lavine, G;Pandey, RK;Racie, T;Rajeev, KG;Rohl, I;Toudjarska, I;Wang, G;Wuschko, S;Bumcrot, D;Koteliansky, V;Limmer, S;Manoharan, M;Vornlocher, HP Addresses:
Alnylam Europe AG, Fritz Hornschuch Str 9, D-95326 Kulmbach, Germany
Alnylam Europe AG, D-95326 Kulmbach, Germany
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA
Label: Kim-2007 Title: Strategies for silencing human disease using RNA interference Journal: NAT REV GENET, 8 (3): 173-184 MAR 2007 Citations: 171 Authors: Kim, DH;Rossi, JJ Addresses:
City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, Duarte, CA 91010 USA
Label: Ge-2004 Title: Inhibition of influenza virus production in virus-infected mice by RNA interference Journal: PROC NAT ACAD SCI USA, 101 (23): 8676-8681 JUN 8 2004 Citations: 170 Authors: Ge, Q;Filip, L;Bai, AL;Nguyen, T;Eisen, HN;Chen, J Addresses:
MIT, Ctr Canc Res & Dev Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
MIT, Ctr Canc Res & Dev Biol, Cambridge, MA 02139 USA
Label: Kim-2004 Title: Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase Journal: NAT BIOTECHNOL, 22 (3): 321-325 MAR 2004 Citations: 165 Authors: Kim, DH;Longo, M;Han, Y;Lundberg, P;Cantin, E;Rossi, JJ Addresses:
City Hope Natl Med Ctr, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Div Mol Biol, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Div Virol, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Grad Sch Biol Sci, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA
Label: deFougerolles-2007 Title: Interfering with disease: a progress report on siRNA-based therapeutics Journal: NAT REV DRUG DISCOV, 6 (6): 443-453 JUN 2007 Citations: 151 Authors: de Fougerolles, A;Vornlocher, HP;Maraganore, J;Lieberman, J Addresses:
Alnylam Pharmaceut Inc, 300 3rd St, Cambridge, MA 02142 USA
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA
Alnylam Europe AG, D-95326 Kulmbach, Germany
CBR Inst Biomed Res, Boston, MA 02115 USA
Label: Takei-2004 Title: A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics Journal: CANCER RES, 64 (10): 3365-3370 MAY 15 2004 Citations: 148 Authors: Takei, Y;Kadomatsu, K;Yuzawa, Y;Matsuo, S;Muramatsu, T Addresses:
Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan
Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, Nagoya, Aichi 4668550, Japan
Nagoya Univ, Grad Sch Med, Dept Clin Immunol Internal Med, Showa Ku, Nagoya, Aichi 4668550, Japan
Label: Layzer-2004 Title: In vivo activity of nuclease-resistant siRNAs Journal: RNA, 10 (5): 766-771 MAY 2004 Citations: 140 Authors: Layzer, JM;McCaffrey, AP;Tanner, AK;Huang, Z;Kay, MA;Sullenger, BA Addresses:
Duke Univ, Med Ctr, Dept Surg, Ctr Genet & Cellular Therapies, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Surg, Ctr Genet & Cellular Therapies, Durham, NC 27710 USA
Stanford Univ, Sch Med, Dept Pediat, Program Human Gene Therapy, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Genet, Program Human Gene Therapy, Stanford, CA 94305 USA
Label: Hu-Lieskovan-2005 Title: Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma Journal: CANCER RES, 65 (19): 8984-8992 OCT 1 2005 Citations: 134 Authors: Hu-Lieskovan, S;Heidel, JD;Bartlett, DW;Davis, ME;Triche, TJ Addresses:
Childrens Hosp Los Angeles, Dept Pathol & Lab Med, Box 43,4650 Sunset Blvd, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Dept Pathol, Los Angeles, CA 90027 USA
CALTECH, Pasadena, CA 91125 USA
Label: Kumar-2007 Title: Transvascular delivery of small interfering RNA to the central nervous system Journal: NATURE, 448 (7149): 39-U2 JUL 5 2007 Citations: 129 Authors: Kumar, P;Wu, HQ;McBride, JL;Jung, KE;Kim, MH;Davidson, BL;Lee, SK;Shankar, P;Manjunath, N Addresses:
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
Univ Iowa, Dept Internal Med, Roy J & Lucille J Carver Coll Med, Iowa City, IA 52242 USA
Samchully Pharm Co Ltd, Res Ctr, Seoul 135735, South Korea
Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea
Hanyang Univ, Hanyang Fus Mat Program, Seoul 133791, South Korea
Label: Li-2005 Title: Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque Journal: NATURE MED, 11 (9): 944-951 SEP 2005 Citations: 129 Authors: Li, BJ;Tang, QQ;Cheng, D;Qin, C;Xie, FY;Wei, Q;Xu, J;Liu, YJ;Zheng, BJ;Woodle, MC;Zhong, NS;Lu, PY Addresses:
Intradigm Corp, 12115 K Parklawn Dr, Rockville, MD 20852 USA
Intradigm Corp, Rockville, MD 20852 USA
Sun Yatsen Univ, Biotechnol Res Ctr, Guangzhou, Peoples R China
Minist Educ State, Key Lab Gene Engn, Guangzhou, Peoples R China
Guangzhou Top Genom Ltd, Guangzhou, Peoples R China
Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China
Peking Union Med Coll, Beijing, Peoples R China
Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
Guangzhou Inst Resp Dis, Guangzhou, Peoples R China
Label: McNamara-2006 Title: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras Journal: NAT BIOTECHNOL, 24 (8): 1005-1015 AUG 2006 Citations: 129 Authors: McNamara, JO;Andrechek, ER;Wang, Y;D Viles, K;Rempel, RE;Gilboa, E;Sullenger, BA;Giangrande, PH Addresses:
Duke Univ, Med Ctr, Duke Ctr Translat Res, Dept Surg, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Ctr Translat Res, Dept Surg, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA
Label: Zhang-2005 Title: Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene Journal: NATURE MED, 11 (1): 56-62 JAN 2005 Citations: 115 Authors: Zhang, WD;Yang, H;Kong, XY;Mohapatra, S;San Juan-Vergara, H;Hellermann, G;Behera, S;Singam, R;Lockey, RF;Mohapatra, SS Addresses:
Univ S Florida, Dept Internal Med, Joy McCann Culverhouse Airway Dis Res Ctr, Div Allergy Immunol, MDC-19,Rm 2536,12901 Bruce B Downs Blvd, Tampa, FL 33612 USA
Univ S Florida, Dept Internal Med, Joy McCann Culverhouse Airway Dis Res Ctr, Div Allergy Immunol, Tampa, FL 33612 USA
James A Haley Vet Hosp, Tampa, FL 33612 USA
H Lee Moffitt Canc Ctr, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA
Transgenex Nanobiotech Inc, Tampa, FL 33612 USA
Label: Takeshita-2005 Title: Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo Journal: PROC NAT ACAD SCI USA, 102 (34): 12177-12182 AUG 23 2005 Citations: 104 Authors: Takeshita, F;Minakuchi, Y;Nagahara, S;Honma, K;Sasaki, H;Hirai, K;Teratani, T;Namatame, N;Yamamoto, Y;Hanai, K;Kato, T;Sano, A;Ochiya, T Addresses:
Natl Canc Ctr, Inst Res, Sect Studies Metastasis, Chuo Ku, 1-1 Tsukiji S Chome, Tokyo 1040045, Japan
Natl Canc Ctr, Inst Res, Sect Studies Metastasis, Chuo Ku, Tokyo 1040045, Japan
Sumitomo Pharmaceut Co Ltd, Formulat Res Labs, Osaka 5670878, Japan
Keken Biosci Inst, Tokyo 1150051, Japan
Waseda Univ, Sch Educ, Dept Biol, Tokyo 1690051, Japan
Label: Thomas-2005 Title: Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung Journal: PROC NAT ACAD SCI USA, 102 (16): 5679-5684 APR 19 2005 Citations: 93 Authors: Thomas, M;Lu, JJ;Ge, Q;Zhang, CC;Chen, JZ;Klibanov, AM Addresses:
MIT, Dept Chem, Cambridge, MA 02139 USA
MIT, Dept Chem, Cambridge, MA 02139 USA
MIT, Div Biol Engn, Cambridge, MA 02139 USA
MIT, Ctr Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA
Label: Bartlett-2007 Title: Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Journal: PROC NAT ACAD SCI USA, 104 (39): 15549-15554 SEP 25 2007 Citations: 65 Authors: Bartlett, DW;Su, H;Hildebrandt, IJ;Weber, WA;Davis, ME Addresses:
CALTECH, 1200 E Calif Blvd,MC 210-41, Pasadena, CA 91125 USA
CALTECH, Pasadena, CA 91125 USA
Univ Calif Los Angeles, David Geffem Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Univ Freiburg, Div Nucl Med, D-79106 Freiburg, Germany
Label: Rozema-2007 Title: Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes Journal: PROC NAT ACAD SCI USA, 104 (32): 12982-12987 AUG 7 2007 Citations: 60 Authors: Rozema, DB;Lewis, DL;Wakefield, DH;Wong, SC;Klein, JJ;Roesch, PL;Bertin, SL;Reppen, TW;Chu, Q;Blokhin, AV;Hagstrom, JE;Wolff, JA Addresses:
Mirus Bio Corp, 505 S Rosa Rd, Madison, WI 53719 USA
Mirus Bio Corp, Madison, WI 53719 USA
Univ Wisconsin, Waisman Ctr, Dept Pediat, Madison, WI 53719 USA
Univ Wisconsin, Waisman Ctr, Dept Med Genet, Madison, WI 53719 USA
Label: Sato-2008 Title: Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone Journal: NAT BIOTECHNOL, 26 (4): 431-442 APR 2008 Citations: 29 Authors: Sato, Y;Murase, K;Kato, J;Kobune, M;Sato, T;Kawano, Y;Takimoto, R;Takada, K;Miyanishi, K;Matsunaga, T;Takayama, T;Niitsu, Y Addresses:
Sapporo Med Univ, Sch Med, Dept Internal Med 4, Sapporo, Hokkaido 0608543, Japan
Sapporo Med Univ, Sch Med, Dept Internal Med 4, Sapporo, Hokkaido 0608543, Japan
Label: Li-2008 Title: Tumor-targeted delivery of siRNA by self-assembled nanoparticles Journal: MOL THER, 16 (1): 163-169 JAN 2008 Citations: 27 Authors: Li, SD;Chen, YC;Hackett, MJ;Huang, L Addresses:
2316 Kerr Hall,311 Pharm Lane, Chapel Hill, NC 27599 USA
Univ N Carolina, Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC USA
Label: Wolff-2008 Title: Breaking the bonds: Non-viral vectors become chemically dynamic Journal: MOL THER, 16 (1): 8-15 JAN 2008 Citations: 22 Authors: Wolff, JA;Rozema, DB Addresses:
Univ Wisconsin, Waisman Ctr, Dept Pediat & Med Genet, 1500 Highland Ave, Madison, WI 53705 USA
Univ Wisconsin, Waisman Ctr, Dept Pediat & Med Genet, Madison, WI 53705 USA
Mirus Bio Corp, Madison, WI USA
Label: Li-2008 Title: Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles Journal: J CONTROL RELEASE, 126 (1): 77-84 FEB 18 2008 Citations: 19 Authors: Li, SD;Chono, S;Huang, L Addresses:
2316 Kerr Hall,311 Pharm Lane, Chapel Hill, NC 27599 USA
Univ N Carolina, Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA