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 ScienceWatch

CORPORATE RESEARCH FRONTS - Research Front MAP

April 2010

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Thomson Reuters. The size of a research front is determined by the number of core papers it contains. This Research Front on GENE SILENCING USING SMALL INTERFERING RNAS from the field of Physics was selected for mapping from the list of Corporate Research Fronts for April 2010 (data from the fourth bimonthly period of 2009). The map is a diagrammatic representation of the 40 core papers comprising the front in Biology & Biochemistry.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps.

 Kim-2004Layzer-2004Takei-2004Ge-2004Tompkins-2004Soutschek-2004Schiffelers-2004Bitko-2005Zhang-2005Elmen-2005Urban-Klein-2005Hornung-2005Judge-2005Thomas-2005Song-2005Landen-2005Morrissey-2005Takeshita-2005Li-2005Hu-Lieskovan-2005Palliser-2006Judge-2006Zimmermann-2006Marques-2006McNamara-2006Howard-2006Liu-2007Tan-2007Kim-2007Heidel-2007deFougerolles-2007Kumar-2007Rozema-2007Bartlett-2007Wolfrum-2007Wolff-2008Li-2008Peer-2008Li-2008Sato-2008

GENE SILENCING USING SMALL INTERFERING RNAS

 

 


 Core Papers 


Label: Soutschek-2004
Title: Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Journal: NATURE, 432 (7014): 173-178 NOV 11 2004
Citations: 588
Authors: Soutschek, J;Akinc, A;Bramlage, B;Charisse, K;Constien, R;Donoghue, M;Elbashir, S;Geick, A;Hadwiger, P;Harborth, J;John, M;Kesavan, V;Lavine, G;Pandey, RK;Racie, T;Rajeev, KG;Rohl, I;Toudjarska, I;Wang, G;Wuschko, S;Bumcrot, D;Koteliansky, V;Limmer, S;Manoharan, M;Vornlocher, HP
Addresses:
Alnylam Europe AG, Fritz Hornschuch Str 9, D-95326 Kulmbach, Germany
Alnylam Europe AG, D-95326 Kulmbach, Germany
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA


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Label: Hornung-2005
Title: Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
Journal: NATURE MED, 11 (3): 263-270 MAR 2005
Citations: 332
Authors: Hornung, V;Guenthner-Biller, M;Bourquin, C;Ablasser, A;Schlee, M;Uematsu, S;Noronha, A;Manoharan, M;Akira, S;de Fougerolles, A;Endres, S;Hartmann, G
Addresses:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, Ziemssenstr 1, D-80336 Munich, Germany
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany
GSF, Natl Res Ctr & Environm & Hlth, Inst Clin Mol Biol & Tumor Genet, D-81377 Munich, Germany
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, Japan


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Label: Judge-2005
Title: Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
Journal: NAT BIOTECHNOL, 23 (4): 457-462 APR 2005
Citations: 280
Authors: Judge, AD;Sood, V;Shaw, JR;Fang, D;McClintock, K;MacLachlan, I
Addresses:
Protiva Biotherapeut, 100-3480 Gilmore Way, Burnaby, BC V5G 4Y1, Canada
Protiva Biotherapeut, Burnaby, BC V5G 4Y1, Canada


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Label: Song-2005
Title: Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
Journal: NAT BIOTECHNOL, 23 (6): 709-717 JUN 2005
Citations: 269
Authors: Song, EW;Zhu, PC;Lee, SK;Chowdhury, D;Kussman, S;Dykxhoorn, DM;Feng, Y;Palliser, D;Weiner, DB;Shankar, P;Marasco, WA;Lieberman, J
Addresses:
Harvard Univ, Sch Med, CBR Inst Biomed Res, 200 Longwood Ave, Boston, MA 02115 USA
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA


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Label: Zimmermann-2006
Title: RNAi-mediated gene silencing in non-human primates
Journal: NATURE, 441 (7089): 111-114 MAY 4 2006
Citations: 247
Authors: Zimmermann, TS;Lee, ACH;Akinc, A;Bramlage, B;Bumcrot, D;Fedoruk, MN;Harborth, J;Heyes, JA;Jeffs, LB;John, M;Judge, AD;Lam, K;McClintock, K;Nechev, LV;Palmer, LR;Racie, T;Rohl, I;Seiffert, S;Shanmugam, S;Sood, V;Soutschek, J;Toudjarska, I;Wheat, AJ;Yaworski, E;Zedalis, W;Koteliansky, V;Manoharan, M;Vornlocher, HP;MacLachlan, I
Addresses:
Alnylam Pharmaceut Inc, 300 3rd St, Cambridge, MA 02142 USA
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA
Protiva Biotherapeut Inc, Burnaby, BC V5G 4Y1, Canada
Alnylam Europe AG, D-95326 Kulmbach, Germany


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Label: Morrissey-2005
Title: Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
Journal: NAT BIOTECHNOL, 23 (8): 1002-1007 AUG 2005
Citations: 239
Authors: Morrissey, DV;Lockridge, JA;Shaw, L;Blanchard, K;Jensen, K;Breen, W;Hartsough, K;Machemer, L;Radka, S;Jadhav, V;Vaish, N;Zinnen, S;Vargeese, C;Bowman, K;Shaffer, CS;Jeffs, LB;Judge, A;MacLachlan, I;Polisky, B
Addresses:
Sirna Therapeut Inc, 2950 Wilderness Pl, Boulder, CO 80301 USA
Sirna Therapeut Inc, Boulder, CO 80301 USA
Protiva Biotherapeut Inc, Burnaby, BC V5G 4Y1, Canada


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Label: Bitko-2005
Title: Inhibition of respiratory viruses by nasally administered siRNA
Journal: NATURE MED, 11 (1): 50-55 JAN 2005
Citations: 223
Authors: Bitko, V;Musiyenko, A;Shulyayeva, O;Barik, S
Addresses:
Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, MSB 2370,307 Univ Blvd, Mobile, AL 36688 USA
Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA


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Label: Schiffelers-2004
Title: Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
Journal: NUCL ACID RES, 32 (19): art. no.-e149 2004
Citations: 216
Authors: Schiffelers, RM;Ansari, A;Xu, J;Zhou, Q;Tang, QQ;Storm, G;Molema, G;Lu, PY;Scaria, PV;Woodle, MC
Addresses:
Intradigm Corp, 12115K Parklawn Dr, Rockville, MD 20852 USA
Intradigm Corp, Rockville, MD 20852 USA
Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3508 TB Utrecht, Netherlands
Univ Groningen, Dept Pathol & Lab Med, Med Biol Sect, Inst Drug Explorat, NL-9713 GZ Groningen, Netherlands


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Label: Urban-Klein-2005
Title: RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
Journal: GENE THERAPY, 12 (5): 461-466 MAR 2005
Citations: 179
Authors: Urban-Klein, B;Werth, S;Abuharbeid, S;Czubayko, F;Aigner, A
Addresses:
Univ Marburg, Sch Med, Dept Pharmacol & Toxicol, Karl von Frisch Str 1, D-35033 Marburg, Germany
Univ Marburg, Sch Med, Dept Pharmacol & Toxicol, D-35033 Marburg, Germany


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Label: Kim-2007
Title: Strategies for silencing human disease using RNA interference
Journal: NAT REV GENET, 8 (3): 173-184 MAR 2007
Citations: 171
Authors: Kim, DH;Rossi, JJ
Addresses:
City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, Duarte, CA 91010 USA


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Label: Ge-2004
Title: Inhibition of influenza virus production in virus-infected mice by RNA interference
Journal: PROC NAT ACAD SCI USA, 101 (23): 8676-8681 JUN 8 2004
Citations: 170
Authors: Ge, Q;Filip, L;Bai, AL;Nguyen, T;Eisen, HN;Chen, J
Addresses:
MIT, Ctr Canc Res & Dev Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
MIT, Ctr Canc Res & Dev Biol, Cambridge, MA 02139 USA


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Label: Kim-2004
Title: Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
Journal: NAT BIOTECHNOL, 22 (3): 321-325 MAR 2004
Citations: 165
Authors: Kim, DH;Longo, M;Han, Y;Lundberg, P;Cantin, E;Rossi, JJ
Addresses:
City Hope Natl Med Ctr, Div Mol Biol, 1450 E Duarte Rd, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Div Mol Biol, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Div Virol, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Grad Sch Biol Sci, Duarte, CA 91010 USA
City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA


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Label: deFougerolles-2007
Title: Interfering with disease: a progress report on siRNA-based therapeutics
Journal: NAT REV DRUG DISCOV, 6 (6): 443-453 JUN 2007
Citations: 151
Authors: de Fougerolles, A;Vornlocher, HP;Maraganore, J;Lieberman, J
Addresses:
Alnylam Pharmaceut Inc, 300 3rd St, Cambridge, MA 02142 USA
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA
Alnylam Europe AG, D-95326 Kulmbach, Germany
CBR Inst Biomed Res, Boston, MA 02115 USA


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Label: Takei-2004
Title: A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
Journal: CANCER RES, 64 (10): 3365-3370 MAY 15 2004
Citations: 148
Authors: Takei, Y;Kadomatsu, K;Yuzawa, Y;Matsuo, S;Muramatsu, T
Addresses:
Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan
Nagoya Univ, Grad Sch Med, Dept Biochem, Showa Ku, Nagoya, Aichi 4668550, Japan
Nagoya Univ, Grad Sch Med, Dept Clin Immunol Internal Med, Showa Ku, Nagoya, Aichi 4668550, Japan


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Label: Layzer-2004
Title: In vivo activity of nuclease-resistant siRNAs
Journal: RNA, 10 (5): 766-771 MAY 2004
Citations: 140
Authors: Layzer, JM;McCaffrey, AP;Tanner, AK;Huang, Z;Kay, MA;Sullenger, BA
Addresses:
Duke Univ, Med Ctr, Dept Surg, Ctr Genet & Cellular Therapies, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Surg, Ctr Genet & Cellular Therapies, Durham, NC 27710 USA
Stanford Univ, Sch Med, Dept Pediat, Program Human Gene Therapy, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Genet, Program Human Gene Therapy, Stanford, CA 94305 USA


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Label: Hu-Lieskovan-2005
Title: Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
Journal: CANCER RES, 65 (19): 8984-8992 OCT 1 2005
Citations: 134
Authors: Hu-Lieskovan, S;Heidel, JD;Bartlett, DW;Davis, ME;Triche, TJ
Addresses:
Childrens Hosp Los Angeles, Dept Pathol & Lab Med, Box 43,4650 Sunset Blvd, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Dept Pathol, Los Angeles, CA 90027 USA
CALTECH, Pasadena, CA 91125 USA


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Label: Kumar-2007
Title: Transvascular delivery of small interfering RNA to the central nervous system
Journal: NATURE, 448 (7149): 39-U2 JUL 5 2007
Citations: 129
Authors: Kumar, P;Wu, HQ;McBride, JL;Jung, KE;Kim, MH;Davidson, BL;Lee, SK;Shankar, P;Manjunath, N
Addresses:
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
Univ Iowa, Dept Internal Med, Roy J & Lucille J Carver Coll Med, Iowa City, IA 52242 USA
Samchully Pharm Co Ltd, Res Ctr, Seoul 135735, South Korea
Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea
Hanyang Univ, Hanyang Fus Mat Program, Seoul 133791, South Korea


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Label: Li-2005
Title: Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque
Journal: NATURE MED, 11 (9): 944-951 SEP 2005
Citations: 129
Authors: Li, BJ;Tang, QQ;Cheng, D;Qin, C;Xie, FY;Wei, Q;Xu, J;Liu, YJ;Zheng, BJ;Woodle, MC;Zhong, NS;Lu, PY
Addresses:
Intradigm Corp, 12115 K Parklawn Dr, Rockville, MD 20852 USA
Intradigm Corp, Rockville, MD 20852 USA
Sun Yatsen Univ, Biotechnol Res Ctr, Guangzhou, Peoples R China
Minist Educ State, Key Lab Gene Engn, Guangzhou, Peoples R China
Guangzhou Top Genom Ltd, Guangzhou, Peoples R China
Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China
Peking Union Med Coll, Beijing, Peoples R China
Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
Guangzhou Inst Resp Dis, Guangzhou, Peoples R China


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Label: McNamara-2006
Title: Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
Journal: NAT BIOTECHNOL, 24 (8): 1005-1015 AUG 2006
Citations: 129
Authors: McNamara, JO;Andrechek, ER;Wang, Y;D Viles, K;Rempel, RE;Gilboa, E;Sullenger, BA;Giangrande, PH
Addresses:
Duke Univ, Med Ctr, Duke Ctr Translat Res, Dept Surg, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Ctr Translat Res, Dept Surg, Durham, NC 27710 USA
Duke Univ, Med Ctr, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA


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Label: Tompkins-2004
Title: Protection against lethal influenza virus challenge by RNA interference in vivo
Journal: PROC NAT ACAD SCI USA, 101 (23): 8682-8686 JUN 8 2004
Citations: 124
Authors: Tompkins, SM;Lo, CY;Tumpey, TM;Epstein, SL
Addresses:
US FDA, Lab Immunol & Dev Biol, Div Cellular & Gene Therapies, Off Cell Tissue & Gene Therapies,Ctr Biol & Evalu, 1401 Rockville Pike,HFM-730, Rockville, MD 20852 USA
US FDA, Ctr Biol Evaluat & Res, Lab Immunol & Dev Biol, Div Cell & Gene Therapies, Bethesda, MD 20892 USA
Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Influenza Branch, Atlanta, GA 30333 USA


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Label: Elmen-2005
Title: Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
Journal: NUCL ACID RES, 33 (1): 439-447 2005
Citations: 119
Authors: Elmen, J;Thonberg, H;Ljungberg, K;Frieden, M;Westergaard, M;Xu, YH;Wahren, B;Liang, ZC;Urum, H;Koch, T;Wahlestedt, C
Addresses:
Karolinska Inst, Ctr Genom & Bioinformat, S-17177 Stockholm, Sweden
Karolinska Inst, Ctr Genom & Bioinformat, S-17177 Stockholm, Sweden
Swedish Inst Infect Dis Control, Dept Virol, S-17182 Solna, Sweden
Santaris Pharma AS, DK-2970 Horsholm, Denmark


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Label: Zhang-2005
Title: Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene
Journal: NATURE MED, 11 (1): 56-62 JAN 2005
Citations: 115
Authors: Zhang, WD;Yang, H;Kong, XY;Mohapatra, S;San Juan-Vergara, H;Hellermann, G;Behera, S;Singam, R;Lockey, RF;Mohapatra, SS
Addresses:
Univ S Florida, Dept Internal Med, Joy McCann Culverhouse Airway Dis Res Ctr, Div Allergy Immunol, MDC-19,Rm 2536,12901 Bruce B Downs Blvd, Tampa, FL 33612 USA
Univ S Florida, Dept Internal Med, Joy McCann Culverhouse Airway Dis Res Ctr, Div Allergy Immunol, Tampa, FL 33612 USA
James A Haley Vet Hosp, Tampa, FL 33612 USA
H Lee Moffitt Canc Ctr, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA
Transgenex Nanobiotech Inc, Tampa, FL 33612 USA


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Label: Palliser-2006
Title: An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Journal: NATURE, 439 (7072): 89-94 JAN 5 2006
Citations: 112
Authors: Palliser, D;Chowdhury, D;Wang, QY;Lee, SJ;Bronson, RT;Knipe, DM;Lieberman, J
Addresses:
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA


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Label: Marques-2006
Title: A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
Journal: NAT BIOTECHNOL, 24 (5): 559-565 MAY 2006
Citations: 109
Authors: Marques, JT;Devosse, T;Wang, D;Zamanian-Daryoush, M;Serbinowski, P;Hartmann, R;Fujita, T;Behlke, MA;Williams, BRG
Addresses:
Cleveland Clin Fdn, Dept Canc Biol, Lerner Res Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA
Cleveland Clin Fdn, Dept Canc Biol, Lerner Res Inst, Cleveland, OH 44195 USA
Univ Aarhus, Dept Mol Biol, DK-8000 Aarhus, Denmark
Kyoto Univ, Inst Virus Res, Genet Mol Lab, Kyoto 6068507, Japan
Integrated DNA Technol Inc, Coralville, Iwate 52241, Japan
Monash Univ, Monash Inst Med Res, Clayton, Vic 3168, Australia


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Label: Landen-2005
Title: Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
Journal: CANCER RES, 65 (15): 6910-6918 AUG 1 2005
Citations: 108
Authors: Landen, CN;Chavez-Reyes, A;Bucana, C;Schmandt, R;Deavers, MT;Lopez-Berestein, G;Sood, AK
Addresses:
Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, 1155 Herman Pressler,CPB6-3244,Unit 1362, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA


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Label: Takeshita-2005
Title: Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
Journal: PROC NAT ACAD SCI USA, 102 (34): 12177-12182 AUG 23 2005
Citations: 104
Authors: Takeshita, F;Minakuchi, Y;Nagahara, S;Honma, K;Sasaki, H;Hirai, K;Teratani, T;Namatame, N;Yamamoto, Y;Hanai, K;Kato, T;Sano, A;Ochiya, T
Addresses:
Natl Canc Ctr, Inst Res, Sect Studies Metastasis, Chuo Ku, 1-1 Tsukiji S Chome, Tokyo 1040045, Japan
Natl Canc Ctr, Inst Res, Sect Studies Metastasis, Chuo Ku, Tokyo 1040045, Japan
Sumitomo Pharmaceut Co Ltd, Formulat Res Labs, Osaka 5670878, Japan
Keken Biosci Inst, Tokyo 1150051, Japan
Waseda Univ, Sch Educ, Dept Biol, Tokyo 1690051, Japan


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Label: Judge-2006
Title: Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
Journal: MOL THER, 13 (3): 494-505 MAR 2006
Citations: 94
Authors: Judge, AD;Bola, G;Lee, ACH;MacLachlan, I
Addresses:
Protiva Biotherapeut, 100-3480 Gilmore Way, Burnaby, BC V5G 4Y1, Canada
Protiva Biotherapeut, Burnaby, BC V5G 4Y1, Canada


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Label: Thomas-2005
Title: Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
Journal: PROC NAT ACAD SCI USA, 102 (16): 5679-5684 APR 19 2005
Citations: 93
Authors: Thomas, M;Lu, JJ;Ge, Q;Zhang, CC;Chen, JZ;Klibanov, AM
Addresses:
MIT, Dept Chem, Cambridge, MA 02139 USA
MIT, Dept Chem, Cambridge, MA 02139 USA
MIT, Div Biol Engn, Cambridge, MA 02139 USA
MIT, Ctr Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA


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Label: Howard-2006
Title: RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system
Journal: MOL THER, 14 (4): 476-484 OCT 2006
Citations: 79
Authors: Howard, KA;Rahbek, UL;Liu, XD;Damgaard, CK;Glud, SZ;Andersen, MO;Hovgaard, MB;Schmitz, A;Nyengaard, JR;Besenbacher, F;Kjems, J
Addresses:
Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus C, Denmark
Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus C, Denmark
Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus, Denmark
Aarhus Univ, Stereol & Electron Microscopy Res Lab, DK-8000 Aarhus C, Denmark


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Label: Heidel-2007
Title: Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
Journal: PROC NAT ACAD SCI USA, 104 (14): 5715-5721 APR 3 2007
Citations: 72
Authors: Heidel, JD;Yu, ZP;Liu, JYC;Rele, SM;Liang, YC;Zeidan, RK;Kornbrust, DJ;Davis, ME
Addresses:
CALTECH, Div Chem & Chem Engn, 1200 E Calif Blvd,MC 210-41, Pasadena, CA 91125 USA
CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Preclinsight, Reno, NV 89502 USA
Calando Pharmaceut Inc, Pasadena, CA 91107 USA


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Label: Wolfrum-2007
Title: Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Journal: NAT BIOTECHNOL, 25 (10): 1149-1157 OCT 2007
Citations: 66
Authors: Wolfrum, C;Shi, S;Jayaprakash, KN;Jayaraman, M;Wang, G;Pandey, RK;Rajeev, KG;Nakayama, T;Charrise, K;Ndungo, EM;Zimmermann, T;Koteliansky, V;Manoharan, M;Stoffel, M
Addresses:
ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
ETH, Competence Ctr Syst Biol & Metab Dis, CH-8093 Zurich, Switzerland
Rockefeller Univ, New York, NY 10021 USA
Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA


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Label: Bartlett-2007
Title: Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
Journal: PROC NAT ACAD SCI USA, 104 (39): 15549-15554 SEP 25 2007
Citations: 65
Authors: Bartlett, DW;Su, H;Hildebrandt, IJ;Weber, WA;Davis, ME
Addresses:
CALTECH, 1200 E Calif Blvd,MC 210-41, Pasadena, CA 91125 USA
CALTECH, Pasadena, CA 91125 USA
Univ Calif Los Angeles, David Geffem Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Univ Freiburg, Div Nucl Med, D-79106 Freiburg, Germany


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Label: Rozema-2007
Title: Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
Journal: PROC NAT ACAD SCI USA, 104 (32): 12982-12987 AUG 7 2007
Citations: 60
Authors: Rozema, DB;Lewis, DL;Wakefield, DH;Wong, SC;Klein, JJ;Roesch, PL;Bertin, SL;Reppen, TW;Chu, Q;Blokhin, AV;Hagstrom, JE;Wolff, JA
Addresses:
Mirus Bio Corp, 505 S Rosa Rd, Madison, WI 53719 USA
Mirus Bio Corp, Madison, WI 53719 USA
Univ Wisconsin, Waisman Ctr, Dept Pediat, Madison, WI 53719 USA
Univ Wisconsin, Waisman Ctr, Dept Med Genet, Madison, WI 53719 USA


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Label: Peer-2008
Title: Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
Journal: SCIENCE, 319 (5863): 627-630 FEB 1 2008
Citations: 46
Authors: Peer, D;Park, EJ;Morishita, Y;Carman, CV;Shimaoka, M
Addresses:
Harvard Univ, Sch Med, Immune Dis Inst, 200 Longwood Ave, Boston, MA 02115 USA
Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Anesthesia, Boston, MA 02115 USA
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA 02215 USA


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Label: Tan-2007
Title: Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference
Journal: BIOMATERIALS, 28 (8): 1565-1571 MAR 2007
Citations: 34
Authors: Tan, WB;Jiang, S;Zhang, Y
Addresses:
Natl Univ Singapore, NUS Nanosci & Nanotechnol Inst, Singapore 117576, Singapore
Natl Univ Singapore, NUS Nanosci & Nanotechnol Inst, Singapore 117576, Singapore
Natl Univ Singapore, Fac Engn, Div Bioengn, Singapore 117576, Singapore


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Label: Liu-2007
Title: The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing
Journal: BIOMATERIALS, 28 (6): 1280-1288 FEB 2007
Citations: 33
Authors: Liu, XD;Howard, KA;Dong, MD;Andersen, MO;Rahbek, UL;Johnsen, MG;Hansen, OC;Besenbacher, F;Kjems, J
Addresses:
Univ Aarhus, Dept Mol Biol, iNANO, Bldg 1130, DK-8200 Aarhus, Denmark
Univ Aarhus, Dept Mol Biol, iNANO, DK-8200 Aarhus, Denmark
Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus, Denmark


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Label: Sato-2008
Title: Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
Journal: NAT BIOTECHNOL, 26 (4): 431-442 APR 2008
Citations: 29
Authors: Sato, Y;Murase, K;Kato, J;Kobune, M;Sato, T;Kawano, Y;Takimoto, R;Takada, K;Miyanishi, K;Matsunaga, T;Takayama, T;Niitsu, Y
Addresses:
Sapporo Med Univ, Sch Med, Dept Internal Med 4, Sapporo, Hokkaido 0608543, Japan
Sapporo Med Univ, Sch Med, Dept Internal Med 4, Sapporo, Hokkaido 0608543, Japan


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Label: Li-2008
Title: Tumor-targeted delivery of siRNA by self-assembled nanoparticles
Journal: MOL THER, 16 (1): 163-169 JAN 2008
Citations: 27
Authors: Li, SD;Chen, YC;Hackett, MJ;Huang, L
Addresses:
2316 Kerr Hall,311 Pharm Lane, Chapel Hill, NC 27599 USA
Univ N Carolina, Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC USA


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Label: Wolff-2008
Title: Breaking the bonds: Non-viral vectors become chemically dynamic
Journal: MOL THER, 16 (1): 8-15 JAN 2008
Citations: 22
Authors: Wolff, JA;Rozema, DB
Addresses:
Univ Wisconsin, Waisman Ctr, Dept Pediat & Med Genet, 1500 Highland Ave, Madison, WI 53705 USA
Univ Wisconsin, Waisman Ctr, Dept Pediat & Med Genet, Madison, WI 53705 USA
Mirus Bio Corp, Madison, WI USA


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Label: Li-2008
Title: Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles
Journal: J CONTROL RELEASE, 126 (1): 77-84 FEB 18 2008
Citations: 19
Authors: Li, SD;Chono, S;Huang, L
Addresses:
2316 Kerr Hall,311 Pharm Lane, Chapel Hill, NC 27599 USA
Univ N Carolina, Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA


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KEYWORDS: VIVO USING NEUTRAL LIPOSOMAL SMALL INTERFERING RNA DELIVERY; NONINFLAMMATORY SYNTHETIC SIRNA MEDIATING POTENT GENE SILENCING; SMALL INTERFERING RNA TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR; SILENCING HUMAN DISEASE USING RNA INTERFERENCE. Front# 5797.

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