"Identification and analysis of functional elements in 1% of
the human genome by the ENCODE pilot
project," by the ENCODE Project Consortium (E. Birney, et
al.), Nature, 447(7146): 799-815, 14 June 2007.
Abstract: "We report the generation and analysis of
functional data from multiple, diverse experiments performed on a
targeted 1% of the human genome as part of the pilot phase of the
ENCODE Project. These data have been further integrated and augmented
by a number of evolutionary and computational analyses. Together, our
results advance the collective knowledge about human genome function in
several major areas. First, our studies provide convincing evidence
that the genome is pervasively transcribed, such that the majority of
its bases can be found in primary transcripts, including
non-protein-coding transcripts, and those that extensively overlap one
another. Second, systematic examination of transcriptional
regulation has yielded new understanding about transcription start
sites, including their relationship to specific regulatory sequences
and features of chromatin accessibility and histone modification.
Third, a more sophisticated view of chromatin structure has emerged,
including its inter-relationship with DNA replication and
transcriptional regulation. Finally, integration of these new sources
of information, in particular with respect to mammalian evolution based
on inter-and intra-species sequence comparisons, has yielded new
mechanistic and evolutionary insights concerning the functional
landscape of the human genome. Together, these studies are defining a
path for pursuit of a more comprehensive characterization of human
genome function."
This 2007 report from Nature was cited 49
times in current journal articles indexed by Thomson
Reuters during January-February 2008. Only one other biology paper
published in the last two years, aside from reviews, garnered a higher
number of citations during that two-month period. Prior to the most
recent bimonthly count, citations to the paper have accrued as follows:
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