Abstract: "Inherited genetic variation has a critical but
as yet largely uncharacterized role in human disease. Here we report a
public database of common variation in the human genome: more than one
million single nucleotide polymorphisms (SNPs) for which accurate and
complete genotypes have been obtained in 269 DNA samples from four
populations, including ten 500-kilobase regions in which essentially all
information about common DNA variation has been extracted. These data
document the generality of recombination hotspots, a block-like structure
of linkage disequilibrium and low haplotype diversity, leading to
substantial correlations of SNPs with many of their neighbours. We show how
the HapMap resource can guide the design and analysis of genetic
association studies, shed light on structural variation and recombination,
and identify loci that may have been subject to natural selection during
human evolution."
This 2005 report from Nature was cited 154
times in current journal articles indexed by Thomson
Scientific during September-October 2007. For its tenth consecutive
bimonthly period--a streak that now goes back two years--this report stands
atop the list of the most-cited biology papers (excluding reviews) indexed
since late 2005. Prior to the most recent two-month count, citations to the
paper have accrued as follows:
SOURCE:
Hot Papers Database (Included with a subscription to the print
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Database contains data on hundreds of highly cited papers published during
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Sci-Bytes : 2008 : 02.03.2008 - Hot Paper in Biology