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Week of April 26, 2009 < Back ¦ 2009 ¦ Home

Hot Paper in Biology

"Induction of pluripotent stem cells from adult human fibroblasts by defined factors," by Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ischisaka, Kiichiro Tomoda, and Shinya Yamanaka, Cell, 131(5): 861-72, 30 November 2007.

[Authors' affiliations: Kyoto University, Japan; CREST, Kawaguchi, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA]

Abstract: "Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts."

This 2007 report from Cell was cited 93 times in current journal articles indexed by Clarivate Analytics during November-December 2008. Thanks to this latest two-month total, the report's run as the most-cited biology paper published in the last two years (excluding reviews) continues for a fourth consecutive bimonthly period. Prior to the most recent two-month count, citations to the paper have accrued as follows:

September-October 2008: 51 citations
July-August 2008: 96
May-June 2008:
March-April 2008: 41
January-February 2008: 23
November-December 2007: 3
Total citations to date: 366

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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