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Week of August 16, 2009 < Back ¦ 2009 ¦ Home

Hot Paper in Biology

"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project," by the ENCODE Project Consortium (E. Birney, et al.), Nature, 447(7146): 799-815, 14 June 2007.

[Authors' affiliations: 80 institutions worldwide]

Abstract: "We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function."

This 2007 report from Nature was cited 55 times in current journal articles indexed by Clarivate Analytics during March-April 2009. During that two-month period, only two other biology papers published in the last two years, aside from reviews, collected higher citation totals. Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

January-February 2009: 36 citations
November-December 2008: 68
September-October 2008: 35
July-August 2008: 61
May-June 2008: 44
March-April 2008: 39
January-February 2008: 49
November-December 2007: 37
September-October 2007: 15
July-August 2007: 3

Total citations to date: 442

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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