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SCI-BYTES - WHAT'S NEW IN RESEARCH: 2009

Week of December 6, 2009 < Back ¦ 2009 ¦ Home

 
Hot Paper in Biology
 

"A second generation human haplotype map of over 3.1 million SNPs," by the International HapMap Consortium (K.A. Frazer, et al.), Nature, 449(7164): 854-61, 18 October 2007.

[Authors' affiliations: 72 institutions worldwide]

Abstract: "We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r(2) of between 0.9 and 0.96 depending on population. We demonstrate that the current generation of commercial genome-wide genotyping products captures common Phase II SNPs with an average maximum r(2) of up to 0.8 in African and up to 0.95 in non-African populations, and that potential gains in power in association studies can be obtained through imputation. These data also reveal novel aspects of the structure of linkage disequilibrium. We show that 10-30% of pairs of individuals within a population share at least one region of extended genetic identity arising from recent ancestry and that up to 1% of all common variants are untaggable, primarily because they lie within recombination hotspots. We show that recombination rates vary systematically around genes and between genes of different function. Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations."

This 2007 report from Nature was cited 73 times in current journal articles indexed by Clarivate Analytics during July-August 2009. As was the case after the previous two-month tally for May-June 2009, this is currently the second-most-cited biology paper published in the last two years, aside from reviews. Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

May-June 2009: 72 citations
March-April 2009: 62
January-February 2009: 83
November-December 2008: 61
September-October 2008: 38
July-August 2008: 32
May-June 2008: 29
March-April 2008: 31
January-February 2008: 7
November-December 2007: 1

Total citations to date: 489


Related information: What's Hot in Biology: "HapMap, The Next Generation: More SNPs, More Insights," by Jeremy Cherfas


SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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