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SCI-BYTES - WHAT'S NEW IN RESEARCH : 2009

Week of January 4, 2009 < Back ¦ 2009 ¦ Home

 
Hot Paper in Biology

"High-resolution crystal structure of an engineered human bet (2)-adrenergic G protein-coupled receptor," by Vadim Cherezov and 10 others, Science, 318(5854): 1258-65, 23 November 2007.

[Authors' affiliations: Scripps Research Institute, La Jolla, CA; Stanford University, CA]

Abstract: "Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane. We report the crystal structure of a human beta(2)-adrenergic receptor-T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution. The structure provides a high-resolution view of a human G protein-coupled receptor bound to a diffusible ligand. Ligand-binding site accessibility is enabled by the second extracellular loop, which is held out of the binding cavity by a pair of closely spaced disulfide bridges and a short helical segment within the loop. Cholesterol, a necessary component for crystallization, mediates an intriguing parallel association of receptor molecules in the crystal lattice. Although the location of carazolol in the beta(2)-adrenergic receptor is very similar to that of retinal in rhodopsin, structural differences in the ligand-binding site and other regions highlight the challenges in using rhodopsin as a template model for this large receptor family."

This 2007 report from Science was cited 43 times in current journal articles indexed by Clarivate Analytics during September-October 2008. Only one other biology paper published in the last two years, aside from reviews, garnered a higher number of citations during that two-month period. Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

July-August 2008: 37 citations
May-June 2008: 23
March-April 2008: 25
January-February 2008: 10
November-December 2007: 2

Total citations to date: 140


SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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