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Week of March 22, 2009 < Back ¦ 2009 ¦ Home

Hot Paper in Medicine

"Induced pluripotent stem cell lines derived from human somatic cells," by Junying Yu and 11 others, Science, 318(5858): 1917-20, 21 December 2007.

[Authors' affiliations: University of Wisconsin, Madison; WiCell Research Institute, Madison, WI]

Abstract: "Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful in the production of new disease models and in drug development, as well as for applications in transplantation medicine, once technical limitations (for example, mutation through viral integration) are eliminated."

This 2007 report from Science was cited 87 times in current journal articles indexed by Clarivate Analytics during November-December 2008. During that two-month period, no other paper indexed in the last two years under the heading of clinical medicine (excluding reviews) received a higher number of citations. Prior to the most recently bimonthly count, citations to the paper have accrued as follows:

September-October 2008: 43 citations
July-August 2008: 89
May-June 2008: 53
March-April 2008: 33
January-February 2008: 5
November-December 2007: 1

Total citations to date: 311

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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