"High-resolution profiling of histone methylations in the human
genome," by Artem Barski and 8 others, Cell, 364(54):
823-37, 18 May 2007.
[Authors' affiliations: NHLBI, NIH, Bethesda, MD; University of California,
Los Angeles]
Abstract: "Histone modifications are implicated in
influencing gene expression. We have generated high-resolution maps for the
genome-wide distribution of 20 histone lysine and arginine methylations as
well as histone variant H2A.Z, RNA polymerase II, and the insulator binding
protein CTCF across the human genome using the Solexa 1G sequencing
technology. Typical patterns of histone methylations exhibited at
promoters, insulators, enhancers, and transcribed regions are identified.
The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked
to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are
linked to repression. H2A.Z associates with functional regulatory elements,
and CTCF marks boundaries of histone methylation domains. Chromosome
banding patterns are correlated with unique patterns of histone
modifications. Chromosome breakpoints detected in T cell cancers frequently
reside in chromatin regions associated with H3K4 methylations. Our data
provide new insights into the function of histone methylation and chromatin
organization in genome function."
This 2007 report from Cell was cited 54
times in current journal articles indexed by Clarivate
during January-February 2009. During that two-month period, only two other
biology papers published in the last two years, excluding reviews,
attracted higher citation totals. Prior to the most recent bimonthly count,
citations to the paper have accrued as follows:
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