"A second generation human haplotype map of over 3.1 million
SNPs," by the International HapMap Consortium (K.A. Frazer, et
al.), Nature, 449(7164): 854-61, 18 October 2007.
Abstract: "We describe the Phase II HapMap, which
characterizes over 3.1 million human single nucleotide polymorphisms (SNPs)
genotyped in 270 individuals from four geographically diverse populations
and includes 25-35% of common SNP variation in the populations surveyed.
The map is estimated to capture untyped common variation with an average
maximum r(2) of between 0.9 and 0.96 depending on population. We
demonstrate that the current generation of commercial genome-wide
genotyping products captures common Phase II SNPs with an average maximum
r(2) of up to 0.8 in African and up to 0.95 in non-African populations, and
that potential gains in power in association studies can be obtained
through imputation. These data also reveal novel aspects of the structure
of linkage disequilibrium. We show that 10-30% of pairs of individuals
within a population share at least one region of extended genetic identity
arising from recent ancestry and that up to 1% of all common variants are
untaggable, primarily because they lie within recombination hotspots. We
show that recombination rates vary systematically around genes and between
genes of different function. Finally, we demonstrate increased
differentiation at non-synonymous, compared to synonymous, SNPs, resulting
from systematic differences in the strength or efficacy of natural
selection between populations."
This 2007 report from Nature was cited 72
times in current journal articles indexed by Clarivate
during May-June 2009. Only one other biology paper published in the last
two years, aside from reviews, attracted a greater number of citations
during that two-month period. Prior to the most recent bimonthly count,
citations to the paper have accrued as follows:
SOURCE:
Hot Papers Database (Included with a subscription to the print
newsletter
Science Watch®, available from the
Research Services
Group of
Thomson
Reuters. Packaged on a CD that is mailed
with each Science Watch issue, the Hot Papers
Database contains data on hundreds of highly cited papers published during
the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as
citations accrued during successive bimonthly periods, can be assessed and
graphed. An updated CD containing the most recent bimonthly data is mailed
with every new issue of Science Watch, six times a
year. The CD also includes an electronic version of the Science
Watch issue in HTML format, for personal desktop
access.