"Induced pluripotent stem cell lines derived from human somatic
cells," by Junying Yu and 11 others, Science, 318(5858):
1917-20, 21 December 2007.
[Authors' affiliations: University of Wisconsin, Madison; WiCell Research
Institute, Madison, WI]
Abstract: "Somatic cell nuclear transfer allows
trans-acting factors present in the mammalian oocyte to reprogram somatic
cell nuclei to an undifferentiated state. We show that four factors (OCT4,
SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to
pluripotent stem cells that exhibit the essential characteristics of
embryonic stem (ES) cells. These induced pluripotent human stem cells have
normal karyotypes, express telomerase activity, express cell surface
markers and genes that characterize human ES cells, and maintain the
developmental potential to differentiate into advanced derivatives of all
three primary germ layers. Such induced pluripotent human cell lines should
be useful in the production of new disease models and in drug development,
as well as for applications in transplantation medicine, once technical
limitations (for example, mutation through viral integration) are
eliminated."
This 2007 report from Science was cited 93
times in current journal articles indexed by Clarivate
during November-December 2009. With that latest two-month total, the report
has now scored for three successive bimonthly counts as the most-cited
paper indexed under the heading of clinical medicine in the last two years,
aside from reviews. Prior to the most recent two-month tally, citations to
the paper have accrued as follows:
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