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Week of July 18, 2010

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"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease," by Jeffrey C. Barrett and 60 others, Nature Genetics, 40(8): 955-62, August 2008.

[Authors' affiliations: 38 institutions worldwide]

Abstract: "Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development."

This report from Nature Genetics was cited 46 times in current journal articles indexed by Clarivate Analytics during March-April 2010. During that two-month period, no other biology paper published in the last two years, aside from reviews, collected a higher number of citations. Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

January-February 2010: 26 citations
November-December 2009: 49
September-October 2009: 35
July-August 2009: 26
May-June 2009: 26
March-April 2009: 31
January-February 2009: 21
November-December 2008: 8
September-October 2008: 1

Total citations to date: 269

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.

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