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Week of October 10, 2010

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"Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis," by John M.L. Ebos and 5 others, Cancer Cell, 15(3); 232-9, 3 March 2009.

[Authors' affiliations: Sunnybrook Health Sciences Center, Toronto, Canada; University of Toronto; Sunnybrook Odette Cancer Center, Toronto; Pfizer, La Jolla, CA]

Abstract: "Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in various metastasis assays, including after intravenous injection of tumor cells or after removal of primary orthotopically grown tumors. Acceleration of metastasis was also observed in mice receiving sunitinib prior to intravenous implantation of tumor cells, suggesting possible "metastatic conditioning" in multiple organs. Similar findings with additional VEGF receptor tyrosine kinase inhibitors implicate a class-specific effect for such agents. Importantly, these observations of metastatic acceleration were in contrast to the demonstrable antitumor benefits obtained when the same human breast cancer cells, as well as mouse or human melanoma cells, were grown orthotopically as primary tumors and subjected to identical sunitinib treatments."

This 2009 report from Cancer Cell was cited 43 times in current journal articles indexed by Clarivate Analytics during May-June 2010. With that latest two-month tally, the paper currently ranks as the second-most-cited biology paper published in the last two years, aside from reviews (second only to another paper from the same journal issue, also on metastasis subsequent to anti-angiogenic therapy). Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

March-April 2010: 14 citations
January-February 2010: 21
November-December 2009: 21
September-October 2009: 15
July-August 2009: 10
May-June 2009: 5
March-April 2009: 5

Total citations to date: 134

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years.

User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.


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