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Week of September 12, 2010

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"Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis," by Marta Paez-Ribes and 9 others, Cancer Cell, 15(3): 220-31, 3 March 2009..

[Authors' affiliations: Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain; University of California, San Francisco; Osaka Medical Center, Japan; University of Barcelona, Spain]

Abstract: "Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis. Increased invasiveness is also seen by genetic ablation of the Vegf-A gene in both models, substantiating the results of the pharmacological inhibitors. The realization that potent angiogenesis inhibition can alter the natural history of tumors by increasing invasion and metastasis warrants clinical investigation, as the prospect has important implications for the development of enduring antiangiogenic therapies."

This 2009 report from Cancer Cell was cited 46 times in current journal articles indexed by Clarivate Analytics during May-June 2010. No other biology paper published in the last two years, aside from reviews, collected a higher number of citations during that two-month period. Prior to the most recent bimonthly count, citations to the paper have accrued as follows:

March-April 2010: 15 citations
January-February 2010: 26
November-December 2009: 25
September-October 2009: 20
July-August 2009: 11
May-June 2009: 5
March-April 2009: 5

Total citations to date: 153

SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed. An updated CD containing the most recent bimonthly data is mailed with every new issue of Science Watch, six times a year. The CD also includes an electronic version of the Science Watch issue in HTML format, for personal desktop access.


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