Sci-Bytes> Hot Paper in Biology
Week of July 17, 2011
"A human gut microbial gene catalogue established by metagenomic sequencing," by Junjie Qin and 53 others, Nature, 464(7285): 59-65, 4 March 2010.
[Authors' affiliations: 14 institutions worldwide]
Abstract: "To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, similar to 150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively."
This 2010 report from Nature was cited 59 times
in current journal articles indexed by Clarivate during March-April
2011. During that two-month period, no other biology paper published in the
last two years (aside from reviews) attracted a higher number of citations.
The paper had previously achieved this distinction after the count for
November-December 2010, and, following a slight dip in the January-February
2011 tally, now reclaims the top spot. Prior to the most recent bimonthly
count, citations have accrued as follows:
January-February 2011: 19 citations
November-December 2010: 32
September-October 2010: 28
July-August 2010: 14
May-June 2010: 4
March-April 2010: 4
Total citations to date: 160
SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed.
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