As part of this bimonthly processing,
ScienceWatch.com selects the Research Fronts with the largest absolute
increase in size in each of the 22 major
fields covered by
Essential Science IndicatorsSM
from Thomson
Reuters. The size of a research front is determined by the number of
core papers it contains. This Research Front on GENE DELIVERY SYSTEMS from the field of
Pharmacology & Toxicology was
selected for mapping from the list of Top Topics for
August 2009 (data
from the second bimonthly period of
2009). The map is a diagrammatic
representation of the 13 core papers comprising the front
in
Pharmacology & Toxicology. This front was also
selected as a Fast Moving Front in Chemistry for the same
time-period.
Each circle
represents a highly cited paper whose bibliographic information is displayed
when the user clicks on the circle. The lines between circles represent the
strongest co-citation links for each paper (that is, indicating that the papers
are frequently cited together). Papers close to each other on the map are
generally more highly co-cited. The most recent paper(s) are indicated in pink.
Annotations may have been added to this map which represent the main research
themes. These appear as labels attached to specific regions on the maps.
Core Papers
Label: Pack-2005 Title: Design and development of polymers for gene delivery Journal: NAT REV DRUG DISCOV, 4 (7): 581-593 JUL 2005 Citations: 181 Authors: Pack, DW;Hoffman, AS;Pun, S;Stayton, PS Addresses:
Univ Illinois, Dept Chem & Biomol Engn, Box C-3,600 S Mathews Ave, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
Label: Sonawane-2003 Title: Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes Journal: J BIOL CHEM, 278 (45): 44826-44831 NOV 7 2003 Citations: 165 Authors: Sonawane, ND;Szoka, FC;Verkman, AS Addresses:
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, 1246 Hlth Sci E Tower,Box 0521, San Francisco, CA 94143 USA
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, San Francisco, CA 94143 USA
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Physiol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Sch Pharm, Dept Biopharmaceut Sci & Pharmaceut Chem, San Francisco, CA 94143 USA
Label: Park-2006 Title: Current status of polymeric gene delivery systems Journal: ADVAN DRUG DELIVERY REV, 58 (4): 467-486 JUL 7 2006 Citations: 103 Authors: Park, TG;Jeong, JH;Kim, SW Addresses:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, CCCD, Salt Lake City, UT 84112 USA
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, CCCD, Salt Lake City, UT 84112 USA
Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Label: Akinc-2003 Title: Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery Journal: J AM CHEM SOC, 125 (18): 5316-5323 MAY 7 2003 Citations: 98 Authors: Akinc, A;Lynn, DM;Anderson, DG;Langer, R Addresses:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Univ Wisconsin, Dept Chem Engn, Madison, WI 53706 USA
Label: Anderson-2003 Title: Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery Journal: ANGEW CHEM INT ED, 42 (27): 3153-3158 2003 Citations: 97 Authors: Anderson, DG;Lynn, DM;Langer, R Addresses:
MIT, Dept Chem Engn, Room E25-342, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Univ Wisconsin, Dept Biol & Chem Engn, Madison, WI 53706 USA
Label: Lee-2007 Title: Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery Journal: BIOCONJUGATE CHEMISTRY, 18 (1): 13-18 JAN-FEB 2007 Citations: 31 Authors: Lee, Y;Mo, H;Koo, H;Park, JY;Cho, MY;Jin, GW;Park, JS Addresses:
Seoul Natl Univ, Sch Chem & Mol Engn, San 56-1, Seoul 151742, South Korea
Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea
Label: Arote-2007 Title: A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier Journal: BIOMATERIALS, 28 (4): 735-744 FEB 2007 Citations: 19 Authors: Arote, R;Kim, TH;Kim, YK;Hwang, SK;Jiang, HL;Song, HH;Nah, JW;Cho, MH;Cho, CS Addresses:
Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea
Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea
Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea
Sunchon Natl Univ, Dept Polymer Sci & Engn, Sunchon 540742, South Korea
Label: Takae-2008 Title: PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors Journal: J AM CHEM SOC, 130 (18): 6001-6009 MAY 7 2008 Citations: 13 Authors: Takae, S;Miyata, K;Oba, M;Ishii, T;Nishiyama, N;Itaka, K;Yamasaki, Y;Koyama, H;Kataoka, K Addresses:
Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Dept Bioengn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Dept Clin Vasc Regenerat, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan
Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan
Label: Ou-2008 Title: Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity Journal: BIOCONJUGATE CHEMISTRY, 19 (3): 626-633 MAR 2008 Citations: 11 Authors: Ou, M;Wang, XL;Xu, RZ;Chang, CW;Bull, DA;Kim, SW Addresses:
Univ Utah, CCCD, Dept Pharmaceut & Pharmaceut Chem, 421 Wakara Way,Suite 318, Salt Lake City, UT 84112 USA
Univ Utah, CCCD, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Univ Utah, Sch Med, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA