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Top Topics Research Front Map - August 2009

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Thomson Reuters. The size of a research front is determined by the number of core papers it contains. This Research Front on GENE DELIVERY SYSTEMS from the field of Pharmacology & Toxicology was selected for mapping from the list of Top Topics for August 2009 (data from the second bimonthly period of 2009). The map is a diagrammatic representation of the 13 core papers comprising the front in Pharmacology & Toxicology. This front was also selected as a Fast Moving Front in Chemistry for the same time-period.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps. Kunath-2003 Akinc-2003 Anderson-2003 Forrest-2003 Sonawane-2003 Pack-2005 Putnam-2006 Park-2006 Arote-2007 Lee-2007 Luten-2008 Ou-2008 Takae-2008

GENE DELIVERY SYSTEMS


 Core Papers 


Label: Pack-2005
Title: Design and development of polymers for gene delivery
Journal: NAT REV DRUG DISCOV, 4 (7): 581-593 JUL 2005
Citations: 181
Authors: Pack, DW;Hoffman, AS;Pun, S;Stayton, PS
Addresses:
Univ Illinois, Dept Chem & Biomol Engn, Box C-3,600 S Mathews Ave, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Washington, Dept Bioengn, Seattle, WA 98195 USA


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Label: Sonawane-2003
Title: Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
Journal: J BIOL CHEM, 278 (45): 44826-44831 NOV 7 2003
Citations: 165
Authors: Sonawane, ND;Szoka, FC;Verkman, AS
Addresses:
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, 1246 Hlth Sci E Tower,Box 0521, San Francisco, CA 94143 USA
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, San Francisco, CA 94143 USA
Univ Calif San Francisco, Cardiovasc Res Inst, Dept Physiol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Sch Pharm, Dept Biopharmaceut Sci & Pharmaceut Chem, San Francisco, CA 94143 USA


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Label: Kunath-2003
Title: Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
Journal: J CONTROL RELEASE, 89 (1): 113-125 APR 14 2003
Citations: 139
Authors: Kunath, K;von Harpe, A;Fischer, D;Peterson, H;Bickel, U;Voigt, K;Kissel, T
Addresses:
Univ Marburg, Dept Pharmaceut & Biopharm, Ketzerbach 63, D-35032 Marburg, Germany
Univ Marburg, Dept Pharmaceut & Biopharm, D-35032 Marburg, Germany
Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Amarillo, TX 79106 USA
Univ Marburg, Dept Normal & Pathol Physiol, D-35032 Marburg, Germany


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Label: Park-2006
Title: Current status of polymeric gene delivery systems
Journal: ADVAN DRUG DELIVERY REV, 58 (4): 467-486 JUL 7 2006
Citations: 103
Authors: Park, TG;Jeong, JH;Kim, SW
Addresses:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, CCCD, Salt Lake City, UT 84112 USA
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, CCCD, Salt Lake City, UT 84112 USA
Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea


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Label: Forrest-2003
Title: A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery
Journal: BIOCONJUGATE CHEMISTRY, 14 (5): 934-940 SEP-OCT 2003
Citations: 100
Authors: Forrest, ML;Koerber, JT;Pack, DW
Addresses:
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA


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Label: Akinc-2003
Title: Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery
Journal: J AM CHEM SOC, 125 (18): 5316-5323 MAY 7 2003
Citations: 98
Authors: Akinc, A;Lynn, DM;Anderson, DG;Langer, R
Addresses:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Univ Wisconsin, Dept Chem Engn, Madison, WI 53706 USA


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Label: Anderson-2003
Title: Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery
Journal: ANGEW CHEM INT ED, 42 (27): 3153-3158 2003
Citations: 97
Authors: Anderson, DG;Lynn, DM;Langer, R
Addresses:
MIT, Dept Chem Engn, Room E25-342, Cambridge, MA 02139 USA
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Univ Wisconsin, Dept Biol & Chem Engn, Madison, WI 53706 USA


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Label: Putnam-2006
Title: Polymers for gene delivery across length scales
Journal: NAT MATER, 5 (6): 439-451 JUN 2006
Citations: 77
Authors: Putnam, D
Addresses:
Cornell Univ, Dept Biomed Engn, 270 Olin Hall, Ithaca, NY 14853 USA
Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA
Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14853 USA


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Label: Lee-2007
Title: Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery
Journal: BIOCONJUGATE CHEMISTRY, 18 (1): 13-18 JAN-FEB 2007
Citations: 31
Authors: Lee, Y;Mo, H;Koo, H;Park, JY;Cho, MY;Jin, GW;Park, JS
Addresses:
Seoul Natl Univ, Sch Chem & Mol Engn, San 56-1, Seoul 151742, South Korea
Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea


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Label: Arote-2007
Title: A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier
Journal: BIOMATERIALS, 28 (4): 735-744 FEB 2007
Citations: 19
Authors: Arote, R;Kim, TH;Kim, YK;Hwang, SK;Jiang, HL;Song, HH;Nah, JW;Cho, MH;Cho, CS
Addresses:
Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea
Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea
Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea
Sunchon Natl Univ, Dept Polymer Sci & Engn, Sunchon 540742, South Korea


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Label: Luten-2008
Title: Biodegradable polymers as non-viral carriers for plasmid DNA delivery
Journal: J CONTROL RELEASE, 126 (2): 97-110 MAR 3 2008
Citations: 14
Authors: Luten, J;van Nostruin, CF;De Smedt, SC;Hennink, WE
Addresses:
Univ Utrecht, Fac Sci, Dept Pharmaceut, UIPS, POB 80 082, NL-3508 TB Utrecht, Netherlands
Univ Utrecht, Fac Sci, Dept Pharmaceut, UIPS, NL-3508 TB Utrecht, Netherlands
Univ Ghent, Dept Pharmaceut, Lab Gen Biochem & Phys Pharm, B-9000 Ghent, Belgium


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Label: Takae-2008
Title: PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors
Journal: J AM CHEM SOC, 130 (18): 6001-6009 MAY 7 2008
Citations: 13
Authors: Takae, S;Miyata, K;Oba, M;Ishii, T;Nishiyama, N;Itaka, K;Yamasaki, Y;Koyama, H;Kataoka, K
Addresses:
Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Dept Bioengn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Dept Clin Vasc Regenerat, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan
Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan


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Label: Ou-2008
Title: Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity
Journal: BIOCONJUGATE CHEMISTRY, 19 (3): 626-633 MAR 2008
Citations: 11
Authors: Ou, M;Wang, XL;Xu, RZ;Chang, CW;Bull, DA;Kim, SW
Addresses:
Univ Utah, CCCD, Dept Pharmaceut & Pharmaceut Chem, 421 Wakara Way,Suite 318, Salt Lake City, UT 84112 USA
Univ Utah, CCCD, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Univ Utah, Sch Med, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA


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KEYWORDS: HIGHLY EFFICIENT GENE DELIVERY; POLYMERIC GENE DELIVERY SYSTEMS; PLASMID DNA DELIVERY; BIORESPONSIVE NONVIRAL GENE VECTORS; GENE CARRIER.
[10014: (2003-2009_2) (PHA/CHE TT, AUG 2009) (CHE FMF, Sep 2009)]

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Top Topics : 2009 : Aug. 2009 - GENE DELIVERY SYSTEMS - Research Front Map