As part of this bimonthly processing,
ScienceWatch.com selects the Research Fronts with the largest absolute
increase in size in each of the 22 major
fields covered by
Essential Science IndicatorsSM
from Thomson
Reuters. The size of a research front is determined by the number of
core papers it contains. This Research Front on KISSPEPTIN AND THE
REGULATION OF REPRODUCTION from the field of
Neuroscience & Behavior was
elected for mapping from the list of Top Topics for
June 2009 (data from the first bimonthly period of
2009). The map is a diagrammatic
representation of the 32 core papers comprising the front
in
Neuroscience & Behavior.
Each circle
represents a highly cited paper whose bibliographic information is displayed
when the user clicks on the circle. The lines between circles represent the
strongest co-citation links for each paper (that is, indicating that the papers
are frequently cited together). Papers close to each other on the map are
generally more highly co-cited. The most recent paper(s) are indicated in pink.
Annotations may have been added to this map which represent the main research
themes. These appear as labels attached to specific regions on the maps.
Core Papers
Label: Seminara-2003 Title: The GPR54 gene as a regulator of puberty Journal: N ENGL J MED, 349 (17): 1614-U8 OCT 23 2003 Citations: 297 Authors: Seminara, SB;Messager, S;Chatzidaki, EE;Thresher, RR;Acierno, JS;Shagoury, JK;Bo-Abbas, Y;Kuohung, W;Schwinof, KM;Hendrick, AG;Zahn, D;Dixon, J;Kaiser, UB;Slaugenhaupt, SA;Gusella, JF;O'Rahilly, S;Carlton, MBL;Crowley, WF;Aparicio, SAJR;Colledge, WH Addresses:
Paradigm Therapeut, 214 Cambridge Sci Pk,Milton Rd, Cambridge CB4 0WA, England
Paradigm Therapeut, Cambridge CB4 0WA, England
Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Mol Neurogenet Unit, Boston, MA 02114 USA
Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA
Harvard Univ, Sch Med, Harvard Inst Human Genet, Boston, MA USA
Univ Cambridge, Dept Physiol, Cambridge, England
Univ Cambridge, Dept Oncol, Cambridge, England
Univ Cambridge, Dept Clin Biochem, Cambridge, England
Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 2QQ, England
Kuwait Univ, Fac Med, Al Jabriyah, Kuwait
Label: deRoux-2003 Title: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 Journal: PROC NAT ACAD SCI USA, 100 (19): 10972-10976 SEP 16 2003 Citations: 267 Authors: de Roux, N;Genin, E;Carel, JC;Matsuda, F;Chaussain, JL;Milgrom, E Addresses:
Hop Bicetre, Inst Natl Sante & Rech Med Unite 135, Unite Rech Hormones Genes & Reprod, F-94275 Le Kremlin Bicetre, France
Hop Bicetre, Inst Natl Sante & Rech Med Unite 135, Unite Rech Hormones Genes & Reprod, F-94275 Le Kremlin Bicetre, France
Fac Med Necker Enfants Malad, Inst Natl Sante & Rech Med Unite 584, F-75015 Paris, France
Hop Bicetre, Inst Natl Sante & Rech Med Unite 535, F-94275 Le Kremlin Bicetre, France
Hop St Vincent De Paul, Serv Endocrinol Pediat, F-75014 Paris, France
Ctr Natl Genotypage, F-91057 Evry, France
Label: Gottsch-2004 Title: A role for kisspeptins in the regulation of gonadotropin secretion in the mouse Journal: ENDOCRINOLOGY, 145 (9): 4073-4077 SEP 2004 Citations: 164 Authors: Gottsch, ML;Cunningham, MJ;Smith, JT;Popa, SM;Acohido, BV;Crowley, WF;Seminara, S;Clifton, DK;Steiner, RA Addresses:
Univ Washington, Sch Med G424, Dept Physiol & Biophys, Hlth Sci Bldg,Box 357290,1959 NE Pacific St, Seattle, WA 98195 USA
Univ Washington, Sch Med G424, Dept Physiol & Biophys, Seattle, WA 98195 USA
Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Univ Washington, Dept Biol, Seattle, WA 98195 USA
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02114 USA
Label: Funes-2003 Title: The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system Journal: BIOCHEM BIOPHYS RES COMMUN, 312 (4): 1357-1363 DEC 26 2003 Citations: 131 Authors: Funes, S;Hedrick, JA;Vassileva, G;Markowitz, L;Abbondanzo, S;Golovko, A;Yang, SJ;Monsma, FJ;Gustafson, EL Addresses:
Schering Plough Corp, Res Inst, Discovery Technol Dept, Func Genomics Res, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA
Schering Plough Corp, Res Inst, Discovery Technol Dept, Func Genomics Res, Kenilworth, NJ 07033 USA
Label: Irwig-2004 Title: Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat Journal: NEUROENDOCRINOLOGY, 80 (4): 264-272 2004 Citations: 130 Authors: Irwig, MS;Fraleyb, GS;Smith, JT;Acohido, BV;Popa, SM;Cunningham, MJ;Gottsch, ML;Clifton, DK;Steiner, RA Addresses:
Univ Washington, Sch Med, Dept Physiol & Biophys, Hlth Sci Bldg,G-424,Box 357290, Seattle, WA 98195 USA
Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA
Univ Washington, Dept Med, Seattle, WA 98195 USA
Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Univ Washington, Dept Biol, Seattle, WA 98195 USA
Univ Washington, Undergrad Program Neurobiol, Seattle, WA 98195 USA
Label: Matsui-2004 Title: Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat Journal: BIOCHEM BIOPHYS RES COMMUN, 320 (2): 383-388 JUL 23 2004 Citations: 118 Authors: Matsui, H;Takatsu, Y;Kumano, S;Matsumoto, H;Ohtaki, T Addresses:
Takeda Chem Ind Ltd, Div Pharmaceut Res, Discovery Res Labs, Wadai 10, Tsukuba, Ibaraki 3004293, Japan
Takeda Chem Ind Ltd, Div Pharmaceut Res, Discovery Res Labs, Tsukuba, Ibaraki 3004293, Japan
Label: Smith-2005 Title: Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse Journal: ENDOCRINOLOGY, 146 (7): 2976-2984 JUL 2005 Citations: 101 Authors: Smith, JT;Dungan, HM;Stoll, EA;Gottsch, ML;Braun, RE;Eacker, SM;Clifton, DK;Steiner, RA Addresses:
Univ Washington, Sch Med, Dept Physiol & Biophys, Hlth Sci Bldg,G-424,Box 357290, Seattle, WA 98195 USA
Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Univ Washington, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA
Label: Smith-2007 Title: KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season Journal: ENDOCRINOLOGY, 148 (3): 1150-1157 MAR 2007 Citations: 39 Authors: Smith, JT;Clay, CM;Caraty, A;Clarke, IJ Addresses:
Monash Univ, Dept Physiol, POB 13F, Clayton, Vic 3168, Australia
Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia
Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA
Univ Tours, Inst Federat Rech 135, Haras Nat,UMR 6175, CNRS,INRA, Nouzilly, France
Label: Roa-2008 Title: New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function Journal: FRONT NEUROENDOCRINOL, 29 (1): 48-69 JAN 2008 Citations: 19 Authors: Roa, J;Aguilar, E;Dieguez, C;Pinilla, L;Tena-Sempere, M Addresses:
Univ Cordoba, Fac Med, Dept Cell Biol Physiol & Immunol, Physiol Sect, Avda Menendez Pidal S-N, Cordoba 14004, Spain
Univ Cordoba, Fac Med, Dept Cell Biol Physiol & Immunol, Physiol Sect, Cordoba 14004, Spain
Univ Santiago de Compostela, Dept Physiol, Santiago De Compostela 15705, Spain
Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06103, Madrid 28029, Spain
Label: Teles-2008 Title: A GPR54-activating mutation in a patient with central precocious puberty Journal: N ENGL J MED, 358 (7): 709-715 FEB 14 2008 Citations: 16 Authors: Teles, MG;Bianco, SDC;Brito, VN;Trarbach, EB;Kuohung, W;Xu, SY;Seminara, SB;Mendonca, BB;Kaiser, UB;Latronico, AC Addresses:
Univ Sao Paulo, Hosp Clin, Disciplina Endocrinol & Metabol, Fac Med,Med Sch,Med Invest Lab, Av Dr Eneas Carvalho Aguiar 155-2 Andar Bloco 6, BR-05403900 Sao Paulo, Brazil
Univ Sao Paulo, Hosp Clin, Disciplina Endocrinol & Metabol, Fac Med,Med Sch,Med Invest Lab, BR-05403900 Sao Paulo, Brazil
Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA
Harvard Reprod Endocrine Sci Ctr, Boston, MA USA
Boston Univ, Sch Med, Boston, MA 02118 USA
Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA
Label: Nakao-2008 Title: Thyrotrophin in the pars tuberalis triggers photoperiodic response Journal: NATURE, 452 (7185): 317-U1 MAR 20 2008 Citations: 14 Authors: Nakao, N;Ono, H;Yamamura, T;Anraku, T;Takagi, T;Higashi, K;Yasuo, S;Katou, Y;Kageyama, S;Uno, Y;Kasukawa, T;Iigo, M;Sharp, PJ;Iwasawa, A;Suzuki, Y;Sugano, S;Niimi, T;Mizutani, M;Namikawa, T;Ebihara, S;Ueda, HR;Yoshimura, T Addresses:
Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Div Biomodelling, Furo Cho, Nagoya, Aichi 4648601, Japan
Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Div Biomodelling, Nagoya, Aichi 4648601, Japan
RIKEN, Funct Genom Subunit, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan
Utsunomiya Univ, Fac Agr, Dept Appl Biochem, Utsunomiya, Tochigi 3218505, Japan
Univ Edinburgh, Div Genet & Genom, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland
Univ Edinburgh, Div Genet & Genom, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland
Gifu Univ, Lab Comparat Biochem, Grad Sch Appl Biol Sci, Gifu 5011193, Japan
Univ Tokyo, Dept Med Genome Sci, Grad Sch Frontier Sci, Minato Ku, Tokyo 1088639, Japan
Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Div Biofunct Dev, Nagoya, Aichi 4648601, Japan
Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Avian Biosci Res Ctr, Nagoya, Aichi 4648601, Japan
RIKEN, Lab Syst Biol, Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan
Nagoya Univ, Chikusa Ku, Inst Adv Res, Nagoya, Aichi 4648601, Japan
Label: Popa-2008 Title: The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction Journal: ANNU REV PHYSIOL, 70: 213-238 2008 Citations: 14 Authors: Popa, SM;Clifton, DK;Steiner, RA Addresses:
Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA
Univ Washington, Grad Program Mol & Cellular Biol, Seattle, WA 98195 USA
Label: Smith-2008 Title: Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: Evidence that gonadotropes are not direct targets of kisspeptin in vivo Journal: ENDOCRINOLOGY, 149 (4): 1951-1959 APR 2008 Citations: 12 Authors: Smith, JT;Rao, A;Pereira, A;Caraty, A;Millar, RP;Clarke, IJ Addresses:
Monash Univ, Dept Physiol, PO Box 13F, Clayton, Vic 3880, Australia
Monash Univ, Dept Physiol, Clayton, Vic 3880, Australia
Univ Tours, Inst Natl Rech Agronom, Ctr Natl Rech Sci, Unite Mixte Rech 6175,Inst Fed Rech 135, F-37380 Nouzilly, France
Queens Med Res Inst, Med Res Council Human Reprod Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
Label: Kanda-2008 Title: Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (Oryzias latipes) Journal: ENDOCRINOLOGY, 149 (5): 2467-2476 MAY 2008 Citations: 11 Authors: Kanda, S;Akazome, Y;Matsunaga, T;Yamamoto, N;Yamada, S;Tsukamura, H;Maeda, KI;Oka, Y Addresses:
Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan
Univ Tokyo, Dept Biol Sci, Grad Sch Sci, Tokyo 1130033, Japan
Nagoya Univ, Grad Sch Bioagr Sci, Lab Fish Biol, Nagoya, Aichi 4648601, Japan
Nagoya Univ, Grad Sch Bioagr Sci, Lab Reproduct Sci, Nagoya, Aichi 4648601, Japan
Label: Suzuki-2008 Title: Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells Journal: ANIM REPROD SCI, 103 (3-4): 360-365 JAN 30 2008 Citations: 10 Authors: Suzuki, S;Kadokawa, H;Hashizume, T Addresses:
Yamaguchi Univ, Fac Agr, Yamaguchi 16771, Japan
Yamaguchi Univ, Fac Agr, Yamaguchi 16771, Japan
Iwate Univ, Fac Agr, Morioka, Iwate 0208550, Japan