Archive ScienceWatch

 ScienceWatch

TOP TOPICS

Top Topics Research Front Map - April 2010

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Thomson Reuters. The size of a research front is determined by the number of core papers it contains. This Research Front on INTERLEUKIN PRODUCING HELPER T CELLS AND INFLAMMATION from the field of Clinical Medicine was selected for mapping from the list of Top Topics for April 2010 (data from the sixth bimonthly period of 2009). The map is a diagrammatic representation of the 47 core papers comprising the front in Clinical Medicine.

This front was also selected as a Fast Moving Front (May 2010) in Clinical Medicine for the same time period.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps. Murphy-2003 Kolls-2004 Langrish-2005 Rogers-2005 Underhill-2005 Harrington-2005 Park-2005 Brown-2006 Veldhoen-2006 Bettelli-2006 Mangan-2006 Wolk-2006 Sutton-2006 Gross-2006 Batten-2006 Stumhofer-2006 Ivanov-2006 Liang-2006 Taylor-2007 Saijo-2007 Zheng-2007 Laurence-2007 Yang-2007 Mathur-2007 Acosta-Rodriguez-2007 LeibundGut-Landmann-2007 Korn-2007 Nurieva-2007 Annunziato-2007 Acosta-Rodriguez-2007 Wilson-2007 Zhou-2007 Chen-2007 Wei-2007 Yang-2008 Ma-2008 Ouyang-2008 Zhou-2008 Manel-2008 Volpe-2008 Ichiyama-2008 Lochner-2008 Yang-2008 Pene-2008 Yang-2008 Cosmi-2008 Santarlasci-2009

 

INTERLEUKIN PRODUCING HELPER T CELLS AND INFLAMMATION

 


 Core Papers 


Label: Bettelli-2006
Title: Reciprocal developmental pathways for the generation of pathogenic effector T(H)17 and regulatory T cells
Journal: NATURE, 441 (7090): 235-238 MAY 11 2006
Citations: 897
Authors: Bettelli, E;Carrier, YJ;Gao, WD;Korn, T;Strom, TB;Oukka, M;Weiner, HL;Kuchroo, VK
Addresses:
Brigham & Womens Hosp, Ctr Neurol Dis, 77 Ave Louis Pasteur, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Harvard Univ, Sch Med, Beth Israel Hosp, Transplant Res Ctr, Boston, MA 02115 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA


[Back to Map]     

Label: Langrish-2005
Title: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Journal: J EXP MED, 201 (2): 233-240 JAN 17 2005
Citations: 859
Authors: Langrish, CL;Chen, Y;Blumenschein, WM;Mattson, J;Basham, B;Sedgwick, JD;McClanahan, T;Kastelein, RA;Cua, DJ
Addresses:
DNAX Res Inst Mol & Cellular Biol Inc, Discovery Res, 901 Calif Ave, Palo Alto, CA 94304 USA
DNAX Res Inst Mol & Cellular Biol Inc, Discovery Res, Palo Alto, CA 94304 USA
DNAX Res Inst Mol & Cellular Biol Inc, Expt Pathol & Pharmacol, Palo Alto, CA 94304 USA
DNAX Res Inst Mol & Cellular Biol Inc, Bioinformat, Palo Alto, CA 94304 USA


[Back to Map]     

Label: Harrington-2005
Title: Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Journal: NAT IMMUNOL, 6 (11): 1123-1132 NOV 2005
Citations: 826
Authors: Harrington, LE;Hatton, RD;Mangan, PR;Turner, H;Murphy, TL;Murphy, KM;Weaver, CT
Addresses:
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol & Immunol, St Louis, MO 63110 USA


[Back to Map]     

Label: Veldhoen-2006
Title: TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
Journal: IMMUNITY, 24 (2): 179-189 FEB 2006
Citations: 816
Authors: Veldhoen, M;Hocking, RJ;Atkins, CJ;Locksley, RM;Stockinger, B
Addresses:
Natl Inst Med Res, MRC, Div Mol Immunol, Mill Hill, London NW7 1AA, England
Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England
Univ Calif San Francisco, Natl Inst Med Res, Div Immunoregulat, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Microbiol Immunol, San Francisco, CA 94143 USA


[Back to Map]     

Label: Park-2005
Title: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Journal: NAT IMMUNOL, 6 (11): 1133-1141 NOV 2005
Citations: 759
Authors: Park, H;Li, ZX;Yang, XO;Chang, SH;Nurieva, R;Wang, YH;Wang, Y;Hood, L;Zhu, Z;Tian, Q;Dong, C
Addresses:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
Univ Washington, Dept Immunol, Seattle, WA 98195 USA
Inst Syst Biol, Seattle, WA 98103 USA
Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA


[Back to Map]     

Label: Mangan-2006
Title: Transforming growth factor-beta induces development of the T(H)17 lineage
Journal: NATURE, 441 (7090): 231-234 MAY 11 2006
Citations: 694
Authors: Mangan, PR;Harrington, LE;O'Quinn, DB;Helms, WS;Bullard, DC;Elson, CO;Hatton, RD;Wahl, SM;Schoeb, TR;Weaver, CT
Addresses:
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA
Univ Alabama, Dept Genom, Birmingham, AL 35294 USA
Univ Alabama, Dept Med, Birmingham, AL 35294 USA
Natl Inst Dent & Craniofacial Dis, Cellular Immunol Sect, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA


[Back to Map]     

Label: Ivanov-2006
Title: The orphan nuclear receptor ROR gamma t directs the differentiation program of proinflammatory IL-17(+) T helper cells
Journal: CELL, 126 (6): 1121-1133 SEP 22 2006
Citations: 577
Authors: Ivanov, II;McKenzie, BS;Zhou, L;Tadokoro, CE;Lepelley, A;Lafaille, JJ;Cua, DJ;Littman, DR
Addresses:
NYU, Sch Med, Skirball Inst Biomol Med, Mol Pathogenesis Program, 550 1St Ave, New York, NY 10016 USA
NYU, Sch Med, Skirball Inst Biomol Med, Mol Pathogenesis Program, New York, NY 10016 USA
NYU, Sch Med, Howard Hughes Med Inst, Skirball Inst Biomol Med, New York, NY 10016 USA
Schering Plough BioPharm, DNAX Discovery Res, Palo Alto, CA 94304 USA


[Back to Map]     

Label: Murphy-2003
Title: Divergent pro- and Antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
Journal: J EXP MED, 198 (12): 1951-1957 DEC 15 2003
Citations: 476
Authors: Murphy, CA;Langrish, CL;Chen, Y;Blumenschein, C;McClanahan, T;Kastelein, RA;Sedgwick, JD;Cua, DJ
Addresses:
901 Calif Ave, Palo Alto, CA 94304 USA
DNA Res Inc, Discovery Res, Palo Alto, CA 94304 USA


[Back to Map]     

Label: Kolls-2004
Title: Interleukin-17 family members and inflammation
Journal: IMMUNITY, 21 (4): 467-476 OCT 2004
Citations: 394
Authors: Kolls, JK;Linden, A
Addresses:
Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm, Pittsburgh, PA 15213 USA
Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Pittsburgh, PA 15260 USA
Sahlgrenska Acad, Inst Internal Med, Dept Allergol & Resp Med, S-41345 Gothenburg, Sweden
Univ Gothenburg, S-41345 Gothenburg, Sweden


[Back to Map]     

Label: Korn-2007
Title: IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
Journal: NATURE, 448 (7152): 484-U9 JUL 26 2007
Citations: 331
Authors: Korn, T;Bettelli, E;Gao, W;Awasthi, A;Jager, A;Strom, TB;Oukka, M;Kuchroo, VK
Addresses:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, 65 Landsdowne St, Cambridge, MA 02139 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Cambridge, MA 02139 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Transplant Res Ctr, Boston, MA 02115 USA


[Back to Map]     

Label: Liang-2006
Title: Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Journal: J EXP MED, 203 (10): 2271-2279 OCT 2 2006
Citations: 299
Authors: Liang, SC;Tan, XY;Luxenberg, DP;Karim, R;Dunussi-Joannopoulos, K;Collins, M;Fouser, LA
Addresses:
Wyeth Res, Inflammat, Cambridge, MA 02140 USA
Wyeth Res, Inflammat, Cambridge, MA 02140 USA
Wyeth Res, Antibody Technol Grp, Cambridge, MA 02140 USA


[Back to Map]     

Label: Wilson-2007
Title: Development, cytokine profile and function of human interleukin 17-producing helper T cells
Journal: NAT IMMUNOL, 8 (9): 950-957 SEP 2007
Citations: 298
Authors: Wilson, NJ;Boniface, K;Chan, JR;McKenzie, BS;Blumenschein, WM;Mattson, JD;Basham, B;Smith, K;Chen, T;Morel, F;Lecron, JC;Kastelein, RA;Cua, DJ;McClanahan, TK;Bowman, EP;Malefyt, RD
Addresses:
Schering Plough Biopharma, Dept Discovery Res, Palo Alto, CA 94304 USA
Schering Plough Biopharma, Dept Discovery Res, Palo Alto, CA 94304 USA
Schering Plough Biopharma, Dept Expt Pathol & Pharmacol, Palo Alto, CA 94304 USA
Univ Poitiers, Ctr Hosp, EA 3806, Lab Cytokines & Inflammat, F-86022 Poitiers, France


[Back to Map]     

Label: Zheng-2007
Title: Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Journal: NATURE, 445 (7128): 648-651 FEB 8 2007
Citations: 292
Authors: Zheng, Y;Danilenko, DM;Valdez, P;Kasman, I;Eastham-Anderson, J;Wu, JF;Ouyang, WJ
Addresses:
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA


[Back to Map]     

Label: Nurieva-2007
Title: Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Journal: NATURE, 448 (7152): 480-U8 JUL 26 2007
Citations: 291
Authors: Nurieva, R;Yang, XXO;Martinez, G;Zhang, YL;Panopoulos, AD;Ma, L;Schluns, K;Tian, Q;Watowich, SS;Jetten, AM;Dong, C
Addresses:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, 1515 Holcombe Blvd, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
Inst Syst Engn, Seattle, WA 98103 USA
NIEHS, Cell Biol Sect, LRB, NIH, Res Triangle Pk, NC 27709 USA


[Back to Map]     

Label: Zhou-2007
Title: IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Journal: NAT IMMUNOL, 8 (9): 967-974 SEP 2007
Citations: 287
Authors: Zhou, LA;Ivanov, II;Spolski, R;Min, R;Shenderov, K;Egawa, T;Levy, DE;Leonard, WJ;Littman, DR
Addresses:
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA
NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA


[Back to Map]     

Label: Acosta-Rodriguez-2007
Title: Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
Journal: NAT IMMUNOL, 8 (9): 942-949 SEP 2007
Citations: 274
Authors: Acosta-Rodriguez, EV;Napolitani, G;Lanzavecchia, A;Sallusto, F
Addresses:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Inst Res Biomed, CH-6500 Bellinzona, Switzerland


[Back to Map]     

Label: Acosta-Rodriguez-2007
Title: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
Journal: NAT IMMUNOL, 8 (6): 639-646 JUN 2007
Citations: 264
Authors: Acosta-Rodriguez, EV;Rivino, L;Geginat, J;Jarrossay, D;Gattorno, M;Lanzavecchia, A;Sallusto, F;Napolitani, G
Addresses:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Ist Giannina Gaslini, I-16148 Genoa, Italy


[Back to Map]     

Label: Annunziato-2007
Title: Phenotypic and functional features of human Th17 cells
Journal: J EXP MED, 204 (8): 1849-1861 AUG 6 2007
Citations: 252
Authors: Annunziato, F;Cosmi, L;Santarlasci, V;Maggi, L;Liotta, F;Mazzinghi, B;Parente, E;Fili, L;Ferri, S;Frosali, F;Giudici, F;Romagnani, P;Parronchi, P;Tonelli, F;Maggi, E;Romagnani, S
Addresses:
Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy
Univ Florence, Ctr Res Transfer & High Educ Chron Imflammatory D, I-50134 Florence, Italy
Univ Florence, Dept Pathophysiol, I-50134 Florence, Italy


[Back to Map]     

Label: Rogers-2005
Title: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
Journal: IMMUNITY, 22 (4): 507-517 APR 2005
Citations: 235
Authors: Rogers, NC;Slack, EC;Edwards, AD;Nolte, MA;Schulz, O;Schweighoffer, E;Williams, DL;Gordon, S;Tybulewicz, VL;Brown, GD;Sousa, CRE
Addresses:
Canc Res UK, London Res Inst, Immunobiol Lab, 44 Lincolns Inn Fields, London WC2A 3PX, England
Canc Res UK, London Res Inst, Immunobiol Lab, London WC2A 3PX, England
Natl Inst Med Res, London NW7 1AA, England
E Tennessee State Univ, James H Quillen Coll Med, Dept Surg, Johnson City, TN 37614 USA
Univ Oxford, Sir William Dunn Sch Psychol, Oxford OX1 3RE, England


[Back to Map]     

Label: Laurence-2007
Title: Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
Journal: IMMUNITY, 26 (3): 371-381 MAR 2007
Citations: 222
Authors: Laurence, A;Tato, CM;Davidson, TS;Kanno, Y;Chen, Z;Yao, Z;Blank, RB;Meylan, F;Siegel, R;Hennighausen, L;Shevach, EM;O'Shea, JJ
Addresses:
NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA
NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA
NIAID, Immunol Lab, Bethesda, MD 20892 USA
NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
NIAMSD, Autoimmun Branch, NIH, Bethesda, MD 20892 USA
NIDDKD, NIH, Bethesda, MD 20892 USA


[Back to Map]     

Label: Brown-2006
Title: Dectin-1: a signalling non-TLR pattern-recognition receptor
Journal: NAT REV IMMUNOL, 6 (1): 33-43 JAN 2006
Citations: 208
Authors: Brown, GD
Addresses:
Univ Cape Town, Fac Hlth Sci, CLS, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
Univ Cape Town, Fac Hlth Sci, CLS, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa


[Back to Map]     

Label: Batten-2006
Title: Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
Journal: NAT IMMUNOL, 7 (9): 929-936 SEP 2006
Citations: 206
Authors: Batten, M;Li, J;Yi, S;Kljavin, NM;Danilenko, DM;Lucas, S;Lee, J;de Sauvage, FJ;Ghilardi, N
Addresses:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
Catholic Univ Louvain, Christian Duve Inst Cellular Pathol, B-3000 Louvain, Belgium


[Back to Map]     

Label: Stumhofer-2006
Title: Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Journal: NAT IMMUNOL, 7 (9): 937-945 SEP 2006
Citations: 202
Authors: Stumhofer, JS;Laurence, A;Wilson, EH;Huang, E;Tato, CM;Johnson, LM;Villarino, AV;Huang, QL;Yoshimura, A;Sehy, D;Saris, CJM;O'Shea, JJ;Hennighausen, L;Ernst, M;Hunter, CA
Addresses:
Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA
eBiosci, New Technol Dept, San Diego, CA 92121 USA
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Fukuoka 8128582, Japan
Amgen Corp, Dept Inflammat Res, Newbury Pk, CA 91320 USA
NIDDKD, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA
Ludwig Inst Canc Res, Melbourne, Vic 3050, Australia


[Back to Map]     

Label: Sutton-2006
Title: A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
Journal: J EXP MED, 203 (7): 1685-1691 JUL 10 2006
Citations: 191
Authors: Sutton, C;Brereton, C;Keogh, B;Mills, KHG;Lavelle, EC
Addresses:
Trinity Coll Dublin, Sch Biochem & Immunol, Adjuvant Res Grp, Dublin, Ireland
Trinity Coll Dublin, Sch Biochem & Immunol, Adjuvant Res Grp, Dublin, Ireland
Trinity Coll Dublin, Immune Regulat Res Grp, Dublin, Ireland


[Back to Map]     

Label: LeibundGut-Landmann-2007
Title: Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
Journal: NAT IMMUNOL, 8 (6): 630-638 JUN 2007
Citations: 190
Authors: LeibundGut-Landmann, S;Gross, O;Robinson, MJ;Osorio, F;Slack, EC;Tsoni, SV;Schweighoffer, E;Tybulewicz, V;Brown, GD;Ruland, J;Sousa, CRE
Addresses:
London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany
Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
Natl Inst Med Res, London NW7 1AA, England


[Back to Map]     

Label: Ouyang-2008
Title: The biological functions of T helper 17 cell effector cytokines in inflammation
Journal: IMMUNITY, 28 (4): 454-467 APR 2008
Citations: 177
Authors: Ouyang, WJ;Kolls, JK;Zheng, Y
Addresses:
Genentech Inc, Dept Immunol, 1 DNA Way, San Francisco, CA 94080 USA
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm Med Allergy & Immunol, Pittsburgh, PA 15213 USA
Pfizer Global Res & Dev, St Louis Labs, Inflammat Pathways Grp, Chesterfield, MO 63017 USA


[Back to Map]     

Label: Zhou-2008
Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing ROR gamma t function
Journal: NATURE, 453 (7192): 236-U14 MAY 8 2008
Citations: 163
Authors: Zhou, L;Lopes, JE;Chong, MMW;Ivanov, II;Min, R;Victora, GD;Shen, YL;Du, JG;Rubtsov, YP;Rudensky, AY;Ziegler, SF;Littman, DR
Addresses:
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, Howard Hughes Med Inst, New York, NY 10016 USA
Benaroya Res Inst, Program Immunol, Seattle, WA 98101 USA
Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA
Univ Washington, Dept Immunol, Howard Hughes Med Inst, Seattle, WA 98195 USA


[Back to Map]     

Label: Yang-2007
Title: STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
Journal: J BIOL CHEM, 282 (13): 9358-9363 MAR 30 2007
Citations: 160
Authors: Yang, XXO;Panopoulos, AD;Nurieva, R;Chang, SH;Wang, DM;Watowich, SS;Dong, C
Addresses:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, 1515 Holcombe Blvd, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
Blood Ctr Wisconsin, Blood Res Inst, Milwaukee, WI 53226 USA


[Back to Map]     

Label: Manel-2008
Title: The differentiation of human T-H-17 cells requires transforming growth factor-beta and induction of the nuclear receptor ROR gamma t
Journal: NAT IMMUNOL, 9 (6): 641-649 JUN 2008
Citations: 145
Authors: Manel, N;Unutmaz, D;Littman, DR
Addresses:
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA


[Back to Map]     

Label: Taylor-2007
Title: Dectin-1 is required for beta-glucan recognition and control of fungal infection
Journal: NAT IMMUNOL, 8 (1): 31-38 JAN 2007
Citations: 136
Authors: Taylor, PR;Tsoni, SV;Willment, JA;Dennehy, KM;Rosas, M;Findon, H;Haynes, K;Steele, C;Botto, M;Gordon, S;Brown, GD
Addresses:
Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
Univ London Imperial Coll Sci Technol & Med, London W12 0NN, England
Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Dept Pediat,Div Pulmonol, Pittsburgh, PA 15213 USA


[Back to Map]     

Label: Saijo-2007
Title: Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
Journal: NAT IMMUNOL, 8 (1): 39-46 JAN 2007
Citations: 132
Authors: Saijo, S;Fujikado, N;Furuta, T;Chung, SH;Kotaki, H;Seki, K;Sudo, K;Akira, S;Adachi, Y;Ohno, N;Kinjo, T;Nakamura, K;Kawakami, K;Iwakura, Y
Addresses:
Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Dept Immunol & Microbiol, Minato Ku, Tokyo 1088639, Japan
Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan
Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Immunopharmacol Microbial Prod, Hachioji, Tokyo 1920392, Japan
Univ Ryukyus, Fac Med, Dept Med & Therapeut Control & Prevent Infect Dis, Okinawa 9030215, Japan
Tohoku Univ, Sch Hlth Sci, Dept Med Technol, Aoba Ku, Sendai, Miyagi 98088575, Japan


[Back to Map]     

Label: Gross-2006
Title: Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Journal: NATURE, 442 (7103): 651-656 AUG 10 2006
Citations: 129
Authors: Gross, O;Gewies, A;Finger, K;Schafer, M;Sparwasser, T;Peschel, C;Forster, I;Ruland, J
Addresses:
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, Ismaninger Str 22, D-81675 Munich, Germany
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany
Tech Univ Munich, Inst Med Mikrobiol Immunol & Hyg, D-81675 Munich, Germany


[Back to Map]     

Label: Yang-2008
Title: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
Journal: NATURE, 454 (7202): 350-U55 JUL 17 2008
Citations: 128
Authors: Yang, L;Anderson, DE;Baecher-Allan, C;Hastings, WD;Bettelli, E;Oukka, M;Kuchroo, VK;Hafler, DA
Addresses:
Harvard Univ, Sch Med, Div Mol Immunol, Ctr Neurol Dis,Brigham & Womens Hosp, Boston, MA 02115 USA
Harvard Univ, Sch Med, Div Mol Immunol, Ctr Neurol Dis,Brigham & Womens Hosp, Boston, MA 02115 USA


[Back to Map]     

Label: Yang-2008
Title: T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
Journal: IMMUNITY, 28 (1): 29-39 JAN 2008
Citations: 126
Authors: Yang, XXO;Pappu, BP;Nurieva, R;Akimzhanov, A;Kang, HS;Chung, Y;Ma, L;Shah, B;Panopoulos, AD;Schluns, KS;Watowich, SS;Tian, Q;Jetten, AM;Dong, C
Addresses:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, 1515 Holcombe Blvd, Houston, TX 77030 USA
Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
NIEHS, Cell Biol Sect, LRB, NIH, Res Triangle Pk, NC 27709 USA
Inst Syst Biol, Seattle, WA 98103 USA


[Back to Map]     

Label: Wolk-2006
Title: IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
Journal: EUR J IMMUNOL, 36 (5): 1309-1323 MAY 2006
Citations: 118
Authors: Wolk, K;Witte, E;Wallace, E;Docke, WD;Kunz, S;Asadullah, K;Volk, HD;Sterry, W;Sabat, R
Addresses:
Univ Hosp Charite, Interdisciplinary Grp Mol Immunopathol Dermatol M, Campus Charite Mitte,Schumannstr 20-21, D-10117 Berlin, Germany
Univ Hosp Charite, Interdisciplinary Grp Mol Immunopathol Dermatol M, D-10117 Berlin, Germany
Scheing AG, CRBA Dermatol, Berlin, Germany
Univ Hosp Charite, Inst Med Immunol, D-10117 Berlin, Germany
Univ Hosp Charite, Dept Dermatol, D-10117 Berlin, Germany


[Back to Map]     

Label: Volpe-2008
Title: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T-H-17 responses
Journal: NAT IMMUNOL, 9 (6): 650-657 JUN 2008
Citations: 109
Authors: Volpe, E;Servant, N;Zollinger, R;Bogiatzi, SI;Hupe, P;Barillot, E;Soumelis, V
Addresses:
INSERM, U653, F-75248 Paris, France
INSERM, U653, F-75248 Paris, France
Inst Curie, Clin Immunol Lab, F-75248 Paris, France
INSERM, U900, F-75248 Paris, France
ParisTech, Ecole Mines Paris, F-77300 Fontainebleau, France
CNRS, UMR144, F-75248 Paris, France


[Back to Map]     

Label: Underhill-2005
Title: Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
Journal: BLOOD, 106 (7): 2543-2550 OCT 1 2005
Citations: 102
Authors: Underhill, DM;Rossnagle, E;Lowell, CA;Simmons, RM
Addresses:
Inst Syst Biol, 1441 N 34th St, Seattle, WA 98103 USA
Inst Syst Biol, Seattle, WA 98103 USA
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA


[Back to Map]     

Label: Chen-2007
Title: Distinct regulation of interleukin-17 in human T helper lymphocytes
Journal: ARTHRITIS RHEUM, 56 (9): 2936-2946 SEP 2007
Citations: 89
Authors: Chen, Z;Tato, CM;Muul, L;Laurence, A;O'Shea, JJ
Addresses:
NIAMSD, NIH, Bldg 10,Room 9N262,10 Ctr Dr,MSC-1820, Bethesda, MD 20892 USA
NIAMSD, NIH, Bethesda, MD 20892 USA
NHGRI, NIH, Bethesda, MD 20892 USA


[Back to Map]     

Label: Mathur-2007
Title: Stat3 and Stat4 direct development of IL-17-secreting Th cells
Journal: J IMMUNOL, 178 (8): 4901-4907 APR 15 2007
Citations: 89
Authors: Mathur, AN;Chang, HC;Zisoulis, DG;Stritesky, GL;Yu, Q;O'Malley, JT;Kapur, R;Levy, DE;Kansas, GS;Kaplan, MH
Addresses:
Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, 702 Barnhill Dr R12600, Indianapolis, IN 46202 USA
Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
Indiana Univ, Sch Med, Walther Canc Inst, Indianapolis, IN 46202 USA
Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
NYU, Sch Med, Dept Pathol & Microbiol, New York, NY 10016 USA


[Back to Map]     

Label: Yang-2008
Title: Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
Journal: IMMUNITY, 29 (1): 44-56 JUL 18 2008
Citations: 83
Authors: Yang, XO;Nurieva, R;Martinez, GJ;Kang, HS;Chung, Y;Pappu, BP;Shah, B;Chang, SH;Schluns, KS;Watowich, SS;Feng, XH;Jetten, AM;Dong, C
Addresses:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
NIEHS, Cell Biol Sect, LRB, NIH, Res Triangle Pk, NC 27709 USA
Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA


[Back to Map]     

Label: Ma-2008
Title: IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
Journal: J CLIN INVEST, 118 (2): 597-607 FEB 2008
Citations: 68
Authors: Ma, HL;Liang, S;Li, J;Napierata, L;Brown, T;Benoit, S;Senices, M;Gill, D;Dunussi-Joannopoulos, K;Collins, M;Nickerson-Nutter, C;Fouser, LA;Young, DA
Addresses:
Wyeth Ayerst Res, 87 Cambridge Pk Dr, Cambridge, MA 02140 USA
Wyeth Ayerst Res, Cambridge, MA 02140 USA


[Back to Map]     

Label: Wei-2007
Title: IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
Journal: J BIOL CHEM, 282 (48): 34605-34610 NOV 30 2007
Citations: 68
Authors: Wei, L;Laurence, A;Elias, KM;O'Shea, JJ
Addresses:
NIH, NIAMSD, Mol Immunol & Inflammat Branch, Bethesda, MD 20892 USA
NIH, NIAMSD, Mol Immunol & Inflammat Branch, Bethesda, MD 20892 USA
NIH, Howard Hughes Med Inst, Bethesda, MD 20892 USA


[Back to Map]     

Label: Lochner-2008
Title: In vivo equilibrium of proinflammatory IL-17(+) and regulatory IL-10(+) Foxp3(+) ROR gamma t(+) T cells
Journal: J EXP MED, 205 (6): 1381-1393 JUN 9 2008
Citations: 51
Authors: Lochner, M;Peduto, L;Cherrier, M;Sawa, S;Langa, F;Varona, R;Riethmacher, D;Si-Tahar, M;Di Santo, JP;Eberl, G
Addresses:
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France
Inst Pasteur, Lab Lymphoid Tissue Dev, CNRS, URA 1961, F-75724 Paris, France
Inst Pasteur, Ctr Ingn Genet Murine, F-75724 Paris, France
Inst Pasteur, Unite Def Innee & Inflammat, INSERM, U874, F-75724 Paris, France
Inst Pasteur, Unite Cytokines & Dev Lymphoide, INSERM, U668, F-75724 Paris, France
CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, E-28049 Madrid, Spain
Univ Southampton, Southampton Gen Hosp, Div Human Genet, Southampton SO16 6YD, Hants, England


[Back to Map]     

Label: Pene-2008
Title: Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
Journal: J IMMUNOL, 180 (11): 7423-7430 JUN 1 2008
Citations: 48
Authors: Pene, J;Chevalier, S;Preisser, L;Venereau, E;Guilleux, MH;Ghannam, S;Moles, JP;Danger, Y;Ravon, E;Lesaux, S;Yssel, H;Gascan, H
Addresses:
Univ Angers, Inst Natl Sante Rech Med, Unite Mixte 564, F-49033 Angers, France
Univ Angers, Inst Natl Sante Rech Med, Unite Mixte 564, F-49033 Angers, France
Inst Natl Sante & Rech Med, Unite 844, Montpellier, France
Inst Univ Rech Clin, Montpellier, France


[Back to Map]     

Label: Ichiyama-2008
Title: Foxp3 inhibits ROR gamma t-mediated IL-17A mRNA transcription through direct interaction with ROR gamma t
Journal: J BIOL CHEM, 283 (25): 17003-17008 JUN 20 2008
Citations: 39
Authors: Ichiyama, K;Yoshida, H;Wakabayashi, Y;Chinen, T;Saeki, K;Nakaya, M;Takaesu, G;Hori, S;Yoshimura, A;Kobayashi, T
Addresses:
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, Fukuoka 8128582, Japan
Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan
RIKEN Res Ctr Allergy & Immunol, Res Unit Immune Homeostasis, Tsurumi Ku, Kanagawa 2300045, Japan


[Back to Map]     

Label: Cosmi-2008
Title: Human interleukin 17-producing cells originate from a CD161(+)CD4(+) T cell precursor
Journal: J EXP MED, 205 (8): 1903-1916 AUG 4 2008
Citations: 38
Authors: Cosmi, L;De Palma, R;Santarlasci, V;Maggi, L;Capone, M;Frosali, F;Rodolico, G;Querci, V;Abbate, G;Angeli, R;Berrino, L;Fambrini, M;Caproni, M;Tonelli, F;Lazzeri, E;Parronchi, P;Liotta, F;Maggi, E;Romagnani, S;Annunziato, F
Addresses:
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, Dept Internal Med, I-50134 Florence, Italy
Univ Florence, DENOTHE Ctr, I-50134 Florence, Italy
Univ Florence, Dept Gynecol Perinatol & Human Reprod, I-50134 Florence, Italy
Univ Florence, Dept Pathophysiol, I-50134 Florence, Italy
Univ Naples 2, Dept Clin & Expt Med, I-80131 Naples, Italy
Ctr Reg Competenza Genom, I-80131 Naples, Italy
Univ Naples 2, Sect Pharmacol Sci, I-80131 Naples, Italy
Univ Florence, Dept Dermatol Sci, I-50121 Florence, Italy


[Back to Map]     

Label: Santarlasci-2009
Title: TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells
Journal: EUR J IMMUNOL, 39 (1): 207-215 JAN 2009
Citations: 13
Authors: Santarlasci, V;Maggi, L;Capone, M;Frosali, F;Querci, V;De Palma, R;Liotta, F;Cosmi, L;Maggi, E;Romagnani, S;Annunziato, F
Addresses:
Univ Florence, Dipartimento Med Interna, Ctr Excellence DENOthe, Viale Morgagni 85, I-50134 Florence, Italy
Univ Florence, Dipartimento Med Interna, Ctr Excellence DENOthe, I-50134 Florence, Italy
Univ Naples 2, Dept Clin & Expt Med, Naples, Italy


[Back to Map]

KEYWORDS: HUMAN INTERLEUKIN 17-PRODUCING T HELPER MEMORY CELLS; HUMAN INTERLEUKIN 17-PRODUCING HELPER T CELLS; INTERLEUKIN 17-PRODUCING HUMAN T HELPER CELLS; INTERLEUKIN 17-PRODUCING T HELPER CELLS; INTERLEUKIN 17-PRODUCING CD4(+) EFFECTOR T CELLS DEVELOP.
[FRONT NUMBER: 6190 (2003-2009_6) (cli/imm: TT, APR 2010) (cli: fmf may 2010)]

<Return to previous page  ¦  Research Front Maps



Top Topics : 2010 : Apr. 2010 - INTERLEUKIN PRODUCING HELPER T CELLS AND INFLAMMATION - Research Front Map