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Top Topics Research Front Map - February 2010

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Thomson Reuters. The size of a research front is determined by the number of core papers it contains. This Research Front on AGING OF HEMATOPOIETIC STEM CELLS from the field of Multidisciplinary was selected for mapping from the list of Top Topics for February 2010 (data from the fifth bimonthly period of 2009). The map is a diagrammatic representation of the 14 core papers comprising the front in Multidisciplinary.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Annotations may have been added to this map which represent the main research themes. These appear as labels attached to specific regions on the maps. Hosaka-2004 Hu-2004 Accili-2004 Ito-2004 Huang-2005 Rossi-2005 Greer-2005 Ito-2006 Paik-2007 Tothova-2007 Nijnik-2007 Rossi-2007 Chambers-2007 Miyamoto-2007

 

AGING OF HEMATOPOIETIC STEM CELLS

 


 Core Papers 


Label: Accili-2004
Title: FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
Journal: CELL, 117 (4): 421-426 MAY 14 2004
Citations: 292
Authors: Accili, D;Arden, KC
Addresses:
Columbia Univ Coll Phys & Surg, 630 W 168th St, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
Univ Calif San Diego, Ludwig Inst Canc Res, San Diego, CA USA


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Label: Hu-2004
Title: I kappa B kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
Journal: CELL, 117 (2): 225-237 APR 16 2004
Citations: 222
Authors: Hu, MCT;Lee, DF;Xia, WY;Golfman, LS;Fu, OY;Yang, JY;Zou, YY;Bao, SL;Hanada, N;Saso, H;Kobayashi, R;Hung, MC
Addresses:
Univ Texas, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
Univ Texas, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA
Univ Texas, Grad Sch Biomed Sci, Houston, TX 77030 USA


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Label: Greer-2005
Title: FOXO transcription factors at the interface between longevity and tumor suppression
Journal: ONCOGENE, 24 (50): 7410-7425 NOV 14 2005
Citations: 212
Authors: Greer, EL;Brunet, A
Addresses:
Stanford Univ, Dept Genet, 300 Pasteur Dr,Alway M336, Stanford, CA 94305 USA
Stanford Univ, Dept Genet, Stanford, CA 94305 USA
Stanford Univ, Canc Biol Program, Stanford, CA 94305 USA


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Label: Ito-2004
Title: Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Journal: NATURE, 431 (7011): 997-1002 OCT 21 2004
Citations: 175
Authors: Ito, K;Hirao, A;Arai, F;Matsuoka, S;Takubo, K;Hamaguchi, I;Nomiyama, K;Hosokawa, K;Sakurada, K;Nakagata, N;Ikeda, Y;Mak, TW;Suda, T
Addresses:
Keio Univ, Sch Med, Dept Cell Differentiat, Sakaguchi Lab Dev Biol,Shinjuku Ku, 35 Shinano Machi, Tokyo 1608582, Japan
Keio Univ, Sch Med, Dept Cell Differentiat, Sakaguchi Lab Dev Biol,Shinjuku Ku, Tokyo 1608582, Japan
Keio Univ, Sch Med, Dept Internal Med, Div Hematol,Shinjuku Ku, Tokyo 1608582, Japan
Kyowa Hakko Kogyo Co Ltd, Biofrontier Labs, Machida, Tokyo 1948533, Japan
Kumamoto Univ, Ctr Anim Resources & Dev, Div Reprod Engn, Kumamoto 8600811, Japan
Univ Toronto, Adv Med Discovery Inst, Ontario Canc Inst, Dept Med Biophys, Toronto, ON M5G 2C1, Canada
Univ Toronto, Adv Med Discovery Inst, Ontario Canc Inst, Dept Immunol, Toronto, ON M5G 2C1, Canada


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Label: Hosaka-2004
Title: Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
Journal: PROC NAT ACAD SCI USA, 101 (9): 2975-2980 MAR 2 2004
Citations: 167
Authors: Hosaka, T;Biggs, WH;Tieu, D;Boyer, AD;Varki, NM;Cavenee, WK;Arden, KC
Addresses:
Univ Calif San Diego, Ludwig Inst Canc Res, 9500 Gilman Dr, La Jolla, CA 92093 USA
Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA


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Label: Tothova-2007
Title: FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Journal: CELL, 128 (2): 325-339 JAN 26 2007
Citations: 162
Authors: Tothova, Z;Kollipara, R;Huntly, BJ;Lee, BH;Castrillon, DH;Cullen, DE;McDowell, EP;Lazo-Kallanian, S;Williams, IR;Sears, C;Armstrong, SA;Passegue, E;DePinho, RA;Gilliland, DG
Addresses:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Hematol, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Hematol, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Genet, Boston, MA 02115 USA
Howard Hughes Med Inst, Boston, MA 02115 USA
Harvard Mit Div Hlth Sci & Technol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Appl Canc Sci, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Robert A & Renee E Belfer Fdn Inst Innovat Canc S, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Univ Cambridge, Med Res Inst, Dept Haematol, Cambridge CB2 2XY, England
Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
Harvard Univ, Sch Med, Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
Univ Calif San Francisco, Dev & Stem Cell Biol Program, San Francisco, CA 94143 USA


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Label: Ito-2006
Title: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Journal: NATURE MED, 12 (4): 446-451 APR 2006
Citations: 134
Authors: Ito, K;Hirao, A;Arai, F;Takubo, K;Matsuoka, S;Miyamoto, K;Ohmura, M;Naka, K;Hosokawa, K;Ikeda, Y;Suda, T
Addresses:
Keio Univ, Sch Med, Dept Cell Differentiat, Sakaguchi Lab Dev Biol,Shinjuku Ku, 35 Shinano Machi, Tokyo 1608582, Japan
Keio Univ, Sch Med, Dept Cell Differentiat, Sakaguchi Lab Dev Biol,Shinjuku Ku, Tokyo 1608582, Japan
Keio Univ, Sch Med, Div Hematol, Dept Internal Med,Shinjuku Ku, Tokyo 1608582, Japan
Kanazawa Univ, Div Mol Genet, Dept Mol Oncol, Inst Canc Res, Kanazawa, Ishikawa 9200934, Japan
Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan


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Label: Rossi-2005
Title: Cell intrinsic alterations underlie hematopoietic stem cell aging
Journal: PROC NAT ACAD SCI USA, 102 (26): 9194-9199 JUN 28 2005
Citations: 134
Authors: Rossi, DJ;Bryder, D;Zahn, JM;Ahlenius, H;Sonu, R;Wagers, AJ;Weissman, IL
Addresses:
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA


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Label: Rossi-2007
Title: Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Journal: NATURE, 447 (7145): 725-U15 JUN 7 2007
Citations: 117
Authors: Rossi, DJ;Bryder, D;Seita, J;Nussenzweig, A;Hoeijmakers, J;Weissman, IL
Addresses:
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
NCI, Lab Receptor Biol, NIH, Bethesda, MD 20892 USA
Erasmus MC, MGC CBG Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands


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Label: Paik-2007
Title: FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Journal: CELL, 128 (2): 309-323 JAN 26 2007
Citations: 116
Authors: Paik, JH;Kollipara, R;Chu, G;Ji, HK;Xiao, YH;Ding, ZH;Miao, LL;Tothova, Z;Horner, JW;Carrasco, DR;Jiang, S;Gilliland, DG;Chin, L;Wong, WH;Castrillon, DH;DePinho, RA
Addresses:
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dana Farber Canc Inst, Belfer Fdn,Inst Innovat Canc Sci,Ctr Appl Canc Sc, Boston, MA 02115 USA
Harvard Univ, Dept Stat, Cambridge, MA 02138 USA
Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA
Stanford Univ, Dept Stat, Stanford, CA 94305 USA
Univ Texas, SW Med Sch, Dept Pathol, Dallas, TX 75390 USA
Univ Texas, SW Med Sch, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA


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Label: Huang-2005
Title: Skp2 inhibits FOX01 in tumor suppression through ubiquitin-mediated degradation
Journal: PROC NAT ACAD SCI USA, 102 (5): 1649-1654 FEB 1 2005
Citations: 94
Authors: Huang, H;Regan, KM;Wang, F;Wang, DP;Smith, DI;van Deursen, JMA;Tindall, DJ
Addresses:
Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Urol, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA


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Label: Nijnik-2007
Title: DNA repair is limiting for haematopoietic stem cells during ageing
Journal: NATURE, 447 (7145): 686-U9 JUN 7 2007
Citations: 88
Authors: Nijnik, A;Woodbine, L;Marchetti, C;Dawson, S;Lambe, T;Liu, C;Rodrigues, NP;Crockford, TL;Cabuy, E;Vindigni, A;Enver, T;Bell, JI;Slijepcevic, P;Goodnow, CC;Jeggo, PA;Cornall, RJ
Addresses:
Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
Univ Oxford, Oxford OX3 9DU, England
Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy
Australian Natl Univ, Australia & Australian Phenom Facil, Australian Canc Res Fdn Genet Lab, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Brunel Univ, Brunel Inst Canc Genet & Pharmacogenom, Uxbridge UB8 3PH, Middx, England


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Label: Chambers-2007
Title: Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
Journal: PLOS BIOL, 5 (8): art. no.-e201 AUG 2007
Citations: 55
Authors: Chambers, SM;Shaw, CA;Gatza, C;Fisk, CJ;Donehower, LA;Goodell, MA
Addresses:
Baylor Coll Med, Program Cell & Mol Biol, Houston, TX 77030 USA
Baylor Coll Med, Program Cell & Mol Biol, Houston, TX 77030 USA
Baylor Coll Med, Stem Cells & Regenerat Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
Baylor Coll Med, Dept Virol & Microbiol, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA


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Label: Miyamoto-2007
Title: Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Journal: CELL STEM CELL, 1 (1): 101-112 JUL 2007
Citations: 53
Authors: Miyamoto, K;Araki, KY;Naka, K;Arai, F;Takubo, K;Yamazaki, S;Matsuoka, S;Miyamoto, T;Ito, K;Ohmura, M;Chen, C;Hosokawa, K;Nakauchi, H;Nakayama, K;Nakayama, KI;Harada, M;Motoyama, N;Suda, T;Hirao, A
Addresses:
Kanazawa Univ, Ctr Canc & Stem Cell Res, Canc Res Inst, Div Mol Genet, Kanazawa, Ishikawa 9200934, Japan
Kanazawa Univ, Ctr Canc & Stem Cell Res, Canc Res Inst, Div Mol Genet, Kanazawa, Ishikawa 9200934, Japan
Keio Univ, Sch Med, Dept Cell Differentiat, Sakaguchi Lab Dev Biol, Tokyo 1608582, Japan
Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, Fukuoka 8128582, Japan
Natl Ctr Geriatr & Gerontol, Natl Inst Longet Sci, Dept Geriatr Med, Aichi, Japan
Univ Tokyo, Ctr Med Expt, Inst Med Sci, Lab Stem Cell Therapy,Minato Ku, Tokyo 1088639, Japan
Tohoku Univ, Ctr Translat And Adv Anim Res Human Dis, Grad Sch Med, Dept Dev Genet, Sendai, Miyagi 9808575, Japan
Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cell Biol, Fukuoka 8128582, Japan
Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan


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KEYWORDS: CELL INTRINSIC ALTERATIONS UNDERLIE HEMATOPOIETIC STEM CELL AGING; AGING HEMATOPOIETIC STEM CELLS DECLINE; HEMATOPOIETIC STEM CELL RESISTANCE; HEMATOPOIETIC STEM CELL POOL; HAEMATOPOIETIC STEM CELLS.
[8214 (2003-2009_5) (mol/multi: TT, Feb 2010)]

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