TUBEROUS SCLEROSIS COMPLEX

Research Front Map

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Clarivate Analytics. The size of a research front is determined by the number of core papers it contains. This Research Front titled "TUBEROUS SCLEROSIS COMPLEX" from the field of Neuroscience & Behavior, was selected for mapping from the list of Top Topics for April 2011 (the sixth bimonthly period of 2010; January 2005-December 31, 2010 [sliding 6-year period]). The map is a diagrammatic representation of the 18 core papers comprising the front in Neuroscience & Behavior.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The solid lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together); weaker links are indicated by dashed lines. Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink.


TUBEROUS SCLEROSIS COMPLEX

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex The tuberous sclerosis complex Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors Dendritic mRNA: transport, translation and function Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis Correction of fragile X syndrome in mice Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex The fragile X continuum: new advances and perspectives Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD Reversal of learning deficits in a Tsc2(+/-) mouse model of tuberous sclerosis Tuberous sclerosis Autism Profiles of Males With Fragile X Syndrome Advances in the Treatment of Fragile X Syndrome Unusual Repertoire of Vocalizations in the BTBR T plus tf/J Mouse Model of Autism A pilot open label, single dose trial of fenobam in adults with fragile X syndrome From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population

Core Papers


Label: Crino-2006
Title: The tuberous sclerosis complex
Journal: N ENGL J MED, 355 (13): 1345-1356 SEP 28 2006
Citations: 211
Authors: Crino, PB;Nathanson, KL;Henske, EP
Addresses:
Univ Penn, Med Ctr, Dept Neurol, 3 W Gates Bldg,3400 Spruce St, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA
Univ Penn, Med Ctr, Div Med Genet, Philadelphia, PA 19104 USA
Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA 19111 USA
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Label: Bissler-2008
Title: Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
Journal: N ENGL J MED, 358 (2): 140-151 JAN 10 2008
Citations: 161
Authors: Bissler, JJ;McCormack, FX;Young, LR;Elwing, JM;Chuck, G;Leonard, JM;Schmithorst, VJ;Laor, T;Brody, AS;Bean, J;Salisbury, S;Franz, DN
Addresses:
Childrens Hosp, Med Ctr, Div Nephrol & Hypertens, MLC 7022,3333 Burnet Ave, Cincinnati, OH 45229 USA
Childrens Hosp, Med Ctr, Div Nephrol & Hypertens, Cincinnati, OH 45229 USA
Childrens Hosp, Med Ctr, Div Pulm Med, Cincinnati, OH 45229 USA
Childrens Hosp, Med Ctr, Div Neurol, Cincinnati, OH 45229 USA
Childrens Hosp, Med Ctr, Div Radiol, Cincinnati, OH 45229 USA
Childrens Hosp, Med Ctr, Div Biostat, Cincinnati, OH 45229 USA
Univ Cincinnati, Coll Med, Div Pulm & Crit Care, Cincinnati, OH USA
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Label: Dolen-2007
Title: Correction of fragile X syndrome in mice
Journal: NEURON, 56 (6): 955-962 DEC 20 2007
Citations: 128
Authors: Dolen, G;Osterweil, E;Rao, BSS;Smith, GB;Auerbach, BD;Chattarji, S;Bear, MF
Addresses:
MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Howard Hughes Med Inst, E25-618, Cambridge, MA 02139 USA
MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Howard Hughes Med Inst, Cambridge, MA 02139 USA
Brown Univ, Sch Med, Dept Neurosci, Providence, RI 02912 USA
Div Biol & Med, Providence, RI 02912 USA
Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore 560002, Karnataka, India
Tata Inst Fundamental Res, Natl Ctr Biol Sci, Bangalore 560002, Karnataka, India
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Label: Shepherd-2006
Title: Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
Journal: NEURON, 52 (3): 475-484 NOV 9 2006
Citations: 123
Authors: Shepherd, JD;Rumbaugh, G;Wu, J;Chowdhury, S;Plath, N;Kuhl, D;Huganir, RL;Worley, PF
Addresses:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Cellular & Mol Med Grad Program, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Free Univ Berlin, Dept Biol Chem Pharm, D-14195 Berlin, Germany
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Label: Franz-2006
Title: Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
Journal: ANN NEUROL, 59 (3): 490-498 MAR 2006
Citations: 121
Authors: Franz, DN;Leonard, J;Tudor, C;Chuck, G;Care, M;Sethuraman, G;Dinopoulos, A;Thomas, G;Crone, KR
Addresses:
Univ Cincinnati, Med Ctr, Dept Neurol, Cincinnati Childrens Hosp,Coll Med, 3333 Burnet Ave,ML 2015, Cincinnati, OH 45229 USA
Univ Cincinnati, Med Ctr, Dept Neurol, Cincinnati Childrens Hosp,Coll Med, Cincinnati, OH 45229 USA
Univ Cincinnati, Med Ctr, Dept Pediat, Cincinnati Childrens Hosp,Coll Med, Cincinnati, OH 45229 USA
Univ Cincinnati, Med Ctr, Dept Radiol, Cincinnati Childrens Hosp,Coll Med, Cincinnati, OH 45229 USA
Eli Lilly & Co, Neurosi Platform, Indianapolis, IN 46285 USA
Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp, Dept Genome Sci & Neurosurg, Cincinnati, OH 45221 USA
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Label: Chowdhury-2006
Title: Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Journal: NEURON, 52 (3): 445-459 NOV 9 2006
Citations: 116
Authors: Chowdhury, S;Shepherd, JD;Okuno, H;Lyford, G;Petralia, RS;Plath, N;Kuhl, D;Huganir, RL;Worley, PF
Addresses:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Cellular & Mol Med Grad Program, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Natl Inst Deafness & Other Commun Disorders, Neurochem Lab, NIH, Bethesda, MD 20892 USA
Free Univ Berlin, Dept Biol Chem Pharm, D-14195 Berlin, Germany
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Label: Bramham-2007
Title: Dendritic mRNA: transport, translation and function
Journal: NAT REV NEUROSCI, 8 (10): 776-789 OCT 2007
Citations: 112
Authors: Bramham, CR;Wells, DG
Addresses:
Univ Bergen, Dept Biomed, Jonas Lies Vei 91, N-5009 Bergen, Norway
Univ Bergen, Dept Biomed, N-5009 Bergen, Norway
Univ Bergen, Bergen Mental Hlth Res Ctr, N-5009 Bergen, Norway
Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
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Label: Ehninger-2008
Title: Reversal of learning deficits in a Tsc2(+/-) mouse model of tuberous sclerosis
Journal: NATURE MED, 14 (8): 843-848 AUG 2008
Citations: 71
Authors: Ehninger, D;Han, S;Shilyansky, C;Zhou, Y;Li, WD;Kwiatkowski, DJ;Ramesh, V;Silva, AJ
Addresses:
Univ Calif Los Angeles, Dept Neurobiol, 695 Charles E Young Dr S, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Human Genet Res,Richard B Simches Res Ctr, Boston, MA 02114 USA
Harvard Univ, Brigham & Womens Hosp, Sch Med, Genet Lab,Div Translat Med, Boston, MA 02115 USA
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Label: Zeng-2008
Title: Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
Journal: ANN NEUROL, 63 (4): 444-453 APR 2008
Citations: 62
Authors: Zeng, LH;Xu, L;Gutmann, DH;Wong, M
Addresses:
Washington Univ, Sch Med, Dept Neurol, Box 8111,660 S Euclid Ave, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA
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Label: Park-2008
Title: Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
Journal: NEURON, 59 (1): 70-83 JUL 10 2008
Citations: 54
Authors: Park, S;Park, JM;Kim, S;Kim, JA;Shepherd, JD;Smith-Hicks, CL;Chowdhury, S;Kaufmann, W;Kuhl, D;Ryazanov, AG;Huganir, RL;Linden, DJ;Worley, PF
Addresses:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Bethesda, MD 20205 USA
Johns Hopkins Univ, Sch Med, Dept Neurosci, Bethesda, MD 20205 USA
Johns Hopkins Univ, Sch Med, Dept Neurol, Bethesda, MD 20205 USA
Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Bethesda, MD 20205 USA
MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA
Free Univ Berlin, Dept Biol Chem Pharm, D-14195 Berlin, Germany
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
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Label: Curatolo-2008
Title: Tuberous sclerosis
Journal: LANCET, 372 (9639): 657-668 AUG 23 2008
Citations: 48
Authors: Curatolo, P;Bombardieri, R;Jozwiak, S
Addresses:
Univ Roma Tor Vergata, Pediat Neurol Unit, Dept Neurosci, Via Montpellier 1, I-00133 Rome, Italy
Univ Roma Tor Vergata, Pediat Neurol Unit, Dept Neurosci, I-00133 Rome, Italy
Childrens Mem Hlth Inst, Dept Neurol & Epileptol, Warsaw, Poland
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Label: Hagerman-2009
Title: Advances in the Treatment of Fragile X Syndrome
Journal: PEDIATRICS, 123 (1): 378-390 JAN 2009
Citations: 43
Authors: Hagerman, RJ;Berry-Kravis, E;Kaufmann, WE;Ono, MY;Tartaglia, N;Lachiewicz, A;Kronk, R;Delahunty, C;Hessl, D;Visootsak, J;Picker, J;Gane, L;Tranfaglia, M
Addresses:
Univ Calif Davis, Sch Med, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA
Univ Calif Davis, Sch Med, MIND Inst, Sacramento, CA 95817 USA
Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA
Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA
Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA
Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Ctr Genet Disorders Cognit & Behav, Baltimore, MD 21205 USA
Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA
Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA
Univ Pittsburgh, Dept Educ Psychol, Pittsburgh, PA USA
Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA
Akron Childrens Hosp, Neurodev Ctr, Akron, OH USA
Emory Univ, Dept Human Genet, Atlanta, GA 30322 USA
Emory Univ, Dept Pediat, Atlanta, GA 30322 USA
Childrens Hosp, Dept Genet, Boston, MA 02115 USA
Childrens Hosp, Dept Child & Adolescent Psychiat, Boston, MA 02115 USA
FRAXA Res Fdn, Newburyport, MA USA
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Label: Berry-Kravis-2009
Title: A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
Journal: J MED GENET, 46 (4): 266-271 APR 2009
Citations: 39
Authors: Berry-Kravis, E;Hessl, D;Coffey, S;Hervey, C;Schneider, A;Yuhas, J;Hutchison, J;Snape, M;Tranfaglia, M;Nguyen, DV;Hagerman, R
Addresses:
Rush Univ, Med Ctr, Dept Pediat, 1725 W Harrison St,Suite 718, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA
Univ Calif Davis, MIND Inst, Med Ctr, Davis, CA 95616 USA
Neuropharm Ltd, Leatherhead, Surrey, England
FRAXA Res Fdn, Newburyport, MA USA
Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA
Univ Calif Davis, Med Ctr, Dept Pediat, Davis, CA 95616 USA
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Label: Cornish-2008
Title: The fragile X continuum: new advances and perspectives
Journal: J INTELLECT DISABIL RES, 52: 469-482 Part 6 JUN 2008
Citations: 23
Authors: Cornish, K;Turk, J;Hagerman, R
Addresses:
McGill Univ, McGill Child Lab Res & Educ Dev Disorders, 3700 McTavish St, Montreal, PQ H3A 1Y2, Canada
McGill Univ, McGill Child Lab Res & Educ Dev Disorders, Montreal, PQ H3A 1Y2, Canada
St Georges Univ London, Div Clin Dev Sci, London, England
Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA
Univ Calif Davis, Sch Med, MIND Inst, Sacramento, CA 95817 USA
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Label: Harris-2008
Title: Autism Profiles of Males With Fragile X Syndrome
Journal: AMER J MENT RETARD, 113 (6): 427-438 NOV 2008
Citations: 17
Authors: Harris, SW;Hessl, D;Goodlin-Jones, B;Ferranti, J;Bacalman, S;Barbato, I;Tassone, F;Hagerman, PJ;Herman, K;Hagerman, RJ
Addresses:
Univ Calif Davis, Med Ctr, UC Davis Hlth Syst, MIND Inst, Sacramento, CA 95817 USA
Univ Calif Davis, Med Ctr, UC Davis Hlth Syst, MIND Inst, Sacramento, CA 95817 USA
Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA
Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA
Neurogene Clin Lab, Florianopolis, SC, Brazil
Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
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Label: Ehninger-2009
Title: From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis
Journal: J INTELLECT DISABIL RES, 53: 838-851 Part 10 OCT 2009
Citations: 9
Authors: Ehninger, D;de Vries, PJ;Silva, AJ
Addresses:
695 Charles Young Dr S, Rm2554, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA
Cambridgeshire & Peterborough NHS Fdn Trust, NDS, Cambridge, England
Univ Cambridge, Dev Psychiat Sect, Cambridge, England
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Label: Scattoni-2008
Title: Unusual Repertoire of Vocalizations in the BTBR T plus tf/J Mouse Model of Autism
Journal: PLOS ONE, 3 (8): art. no.-e3067 AUG 27 2008
Citations: 9
Authors: Scattoni, ML;Gandhy, SU;Ricceri, L;Crawley, JN
Addresses:
NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA
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Label: Moss-2009
Title: Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population
Journal: J INTELLECT DISABIL RES, 53: 852-873 Part 10 OCT 2009
Citations: 8
Authors: Moss, J;Howlin, P
Addresses:
Kings Coll London, Dept Psychol, Inst Psychiat, Henry Wellcome Bldg,PO 77,Crespigny Pk, London SE5 8AF, England
Kings Coll London, Dept Psychol, Inst Psychiat, London SE5 8AF, England
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KEYWORDS: TUBEROUS SCLEROSIS COMPLEX; FRAGILE X SYNDROME; FRAGILE X MENTAL RETARDATION PROTEIN CONTROL; FRAGILE X CONTINUUM; BTBR T PLUS TF/J MOUSE MODEL.
[7703 (2000-2010_5) (neu/soc: Top Topics) (April 2011)]

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