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 Yale’s
Josephine Hoh: An Eye for Disease Genes
At
the center of the retina is a circular area of yellow
photoreceptor cells that play the critical role in our
central vision. This area, known as the macula, will also
commonly decay as we get older, causing a vision-impairment
disorder known as age-related macular degeneration, or AMD,
which afflicts some 10 million Americans. If you were a
young researcher wanting to make a name for yourself, one
way to do it might be to find the gene or genes that
predispose us to AMD. Another way might be to pioneer a new
method for identifying the genes involved in such common
chronic diseases.
When Josephine Hoh, a statistician turned genetic epidemiologist, managed to do both, just three years out of her post-doc, the results were nothing short of spectacular. In April 2005, Hoh and her colleagues published "Complement factor H polymorphism in age-related macular degeneration" in
Science, simultaneously demonstrating that a technique
known as a genome-wide association study could be remarkably
effective in pinpointing genes related to common...read |
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![Centre National de la Recherche Scientific [CNRS]](cnrs.gif) Research
From the Ground Up
Six
years ago, when Science Watch last surveyed geosciences research, the listings were dominated by atmospheric science and climatology (12[6]: 1-2,
November/December 2001).
On that occasion, Science Watch examined publications and
citations within the broad selection of journals defining the
"Geosciences" category in Thomson Scientific’s
Essential Science Indicators . This time, for a slightly different view, Science Watch attempted to narrow the focus more towards geology, with a population of journals drawn from Thomson’s Science Citation Index
categories denoting "Geology," "Geochemistry & Geophysics,"
"Geosciences-Multidisciplinary," and "Mineralogy."
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Questions Continue
for
Type-2 Diabetes Agents |
Fathoming a Tragedy:
2004 Quake/Tsunami
Analyzed |
Organocatalysis Perks Up
With Proline Compounds |
After Hep-C Culture War,
Rival Teams Share
Victory |
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The Research Services
Group
of Thomson Scientific.
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