Science Watch® - Tracking Trends and Performance in Basic Research
March/April 2000


The Hottest Research of 1998-99

The Red Hot Research Papers of 1999

Rank

Paper

Cites   Rank

Paper

Cites
1 S.A. Susin, et al., "Molecular characterization of mitochondrial apoptosis-inducing factor," Nature, 397(6718):441-6, 4 February 1999. 55 13 L.C. Hartmann, et al., "Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer," New Engl. J. Med., 340(2):77-84, 14 January 1999. 30
2 V.R. Iyer, et al., "The transcriptional program in the response of human fibroblasts to serum," Science, 283(5398):83-7, 1 January 1999.  50 14 Y.-Y. Kong, et al., "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis," Nature, 397(6717):315-23, 28 Jannuary 1999. 29
3 N. Arkani-Hamed, S. Dimopoulos, G. Dvali, "Phenomenology, astrophysics, and cosmology of theories with submillimeter dimensions and TeV scale quantum gravity," Phys. Rev. D, 59(8):6004, 15 April 1999. 37 37 15 R. Kuner, et al., "Role of heteromer formation in GABAB receptor function," Science, 283(5398):74-7, 1 January 1999. 29
4 A. Brunet, et al., "Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor," Cell, 96(6):857-68, 19 March 1999. 37 16 S.K. Bhattacharya, et al., "A mammalian protein with specific demethylase activity for mCpG DNA," Nature, 397(6720):579-83, 18 February 1999. 28 28
5 J.T. Winston, et al., "The SCFb-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ika and b-catenin and stimulates IkBa ubiquitination in vitro," Genes Devel., 13(3):270-83, 1 February 1999. 36 17 R.E. Johnson, S. Prakash, L. Prakash, "Efficient bypass of a thymine-thymine dimer by yeast DNA polh, PolETA," Science, 283(5404):1001-4, 12 February 1999. 28
6 M.-C. Rissoan, et al., "Reciprocal control of T helper cell and dendritic cell differentiation," Science, 283(5405):1183-6, 19 February 1999. 35 18 D. Skowyra, et al., "Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1, " Science, 284(5414):662-5, 23 April 1999. 27
7 C.B. Johansson, et al., "Identification of a neural stem cell in the adult mammalian central nervous system," Cell, 96(1):25-34, 8 January 1999. 35 19 F. Gao, et al., "Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes," Nature, 397(6718):436-41, 4 February 1999. 27 27
8 B. De Strooper, et al., "A presenlin-1-dependent g-secretase-like protease mediates release of Notch intracelluar domain," Nature, 398(6727):518-22, 8 April 1999. 32 20 T. Kamura, et al., "Rbx1, a component of the VHL tumor suppressor comlex and SCF ubiquitin ligase," Science, 284(5414):657-61, 23 April 1999. 26
9 M.S. Wolfe, et al., "Two transmembrane aspartates in presenlin-1 required for presenlin endoproteolysis and g-secretase activity," Nature, 398(6727):513-7, 8 April 1999. 32 21

R. Rohatgi, et al., "The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly," Cell, 97(2):221-31, 16 April 1999. 26

 

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10 A. Gross, et al., "Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death," J. Biol. Chem., 274(2):1156-63, 8 January 1999. 32 22

E.A. Slee, et al., "Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7,-8, and -10 in a caspase-9-dependent manner," J. Cell Biol., 144(2):281-92, 25 January 1999.

 

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11 A. Lopez-Girona, et al., "Nuclear localization of Cdc25 is regulated by DNA damage and 14-3-3 protein," Nature, 397(6715):172-5, 14 January 1999. 31 23 B.L. Maidak, et al., "A new version of the RDP (Ribosomal Database Project)," Nucl. Acids Res., 27(1):171-3, 1 January 1999. 25
12 A. Viola, et al. "T lymphocyte costimulation mediated by reorganization of membrane microdomains," Science, 283(5402):680-2, 29 January 1999. 30 SOURCE: ISI's Hot Papers Database
Science Watch®, March/April 2000, Vol. 11, No. 2
Citing URL: http://www.sciencewatch.com/march-april2000/sw_march-april2000_page2.htm

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