Science Watch® - Tracking Trends and Performance in Basic Research
March/April 2001


The Hottest Research of 1999-2000

The Red Hot Research Papers of 2000

Rank

Paper

Cites   Rank

Paper

Cites
1 M.D. Adams, et al., "The genome sequence of Drosophila melanogaster," Science, 287(5461):2185-95, 24 March 2000 129 13 A. Rossi, et al., "Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I-k-B kinase," Nature, 403(6):103-8, 6 January 2000. 31
2 H.M. Berman, et al., "The Protein Data Bank," Nucl. Acids Res., 28(1):235-42, 1 January 2000. 76 14 A. Hirao, et al., "DNA damage-induced activation of p53 by the checkpoint kinase Chk2," Science, 287(54598):1824-7, 10 March 2000. 30
3 A.A. Alizadeh, et al., "Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling," Nature, 403(6769):503-11, 3 February 2000. 57 15 H.L. Lai, et al., "Global QCD analysis of parton structure of the nucleon: CTEQ5 parton distributions," Eur. Phys. J. C, 12(3):375-92, February 2000. 30
4 B.D. Strahl, C.D. Allis, "The language of covalent histone modifications," Nature, 403(6765):41-5, 6 January 2000. 55 16 B. Sauter, et al., "Consequences of cell death: Exposure to necrotic tumor cells, but not primary tumor cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells," J. Exp. Med., 191(3):423-3, 7 February 2000. 30
5 P. Uetz, et al., "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae," Nature, 403(6770):623-7, 10 February 2000. 52 17 P. Binétruy, C. Deffayet, D. Langlois, "Non-conventional cosmology from a brane universe," Nucl. Phys. B, 565(1-2):269-87, 17 January 2000. 30
6 A. Bairoch, R. Apweiler, "The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000," Nucl. Acids Res., 28(1):45-8, 1 January 2000. 51 18 P. de Bernardis, et al., "A flat Universe from high-resolution maps of the cosmic microwave background radiation," Nature, 404(6781):955-9, 27 April 2000. 28
7 A. Bateman, et al., "The Pfam protein families database," Nucl. Acids Res., 28(1):263-6, 1 January 2000. 49 19 R.L. Tatusov, et al., "The COG database: a tool for genome-scale analysis of protein functions and evolution," Nucl. Acids Res., 28(1):33-6, 1 January 2000. 27
8 C. Schairer, et al., "Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk," JAMA-J. Amer. Med. Assoc., 283(4):485-91, 26 January 2000. 43 20 S. Imai, et al., "Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase," Nature, 403(6771):795-800, 17 February 2000. 26
9 S. Yusuf, et al., "Effects of angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients," New Engl. J. Med., 342(3):145-53, 20 January 2000. 41 21 J. Schultz, et al., "SMART: a web-based tool for the study of genetically mobile domains," Nucl. Acids Res., 28(1):231-4, 1 January 2000. 26
10 Y. Nakagawa,et al., "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid -b," Nature, 403(6765):98-103, 6 January 2000. 35 22 S. Black, et al., "Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children," Pediat. Infect. Dis. J., 19(3):1987-95, March 2000. 25
11 M. Hattori, et al., "The DNA sequence of human chromosome 21," Nature, 405(6784):311-9, 18 May 2000 32 23 S.-Y. Shieh, et al., "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites," Genes & Devel., 14(3):289-300, 1 February 2000. 25
12 M.P. Rout, et al., "The yeast nuclear pore complex: Composition, architecture, and transport mechanism," J. Cell Biol., 148(4):635-51, 21 February 2000. 31 24 P. Ducy, et al., "Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass," Cell, 100(2):197-207, 21 January 2000. 25

SOURCE: ISI's Hot Papers Database

Science Watch®, March/April 2001, Vol. 12, No. 2
Citing URL: http://www.sciencewatch.com/march-april2001/sw_march-april2001_page2.htm

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