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The Hottest Research of 2002-03 |
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|
 t’s
time once again for Science Watch’s yearly look back at the hottest of
recent research. Presented in the table below are the authors who, as of late
2003, had published the greatest number of Hot Papers over the preceding two
years. The table below lists the (non-review) papers published in 2003 that
achieved the highest citation totals by the end of the year (those cited 40 or
more times as of late December).
Topping the list of researchers, and making his fourth
consecutive appearance among the year’s "hottest" authors (also
having made the honor roll back in 1997), is Eric
S. Lander of the Whitehead Institute’s Center for Genome Research. Lander’s
eight Hot Papers on genomics and gene-expression profiling include a 2002 Nature
report on the initial sequencing of the mouse genome; this paper is currently #2
in the Biology Top Ten. Another
Lander report, from Science, examining haplotype blocks in the human
genome, also appears in the current Top
Ten (paper #10). More recently, in addition to his eight Hot Papers over the
last two years, Lander co-authored two of 2003’s most-cited papers (#33 and
#35).
|
Scientists
with Multiple
Hot Papers |
|
|
|
|
Field
|
Number
of
Hot Papers
|
|
Eric
S. Lander |
Whitehead Institute, MIT |
Genomics |
8 |
|
Rory Collins |
CTSU, University of Oxford |
Epidemiology |
8 |
|
Brian J. Druker |
HHMI, Oregon Health & Sci. U. |
Clinical Medicine |
7 |
|
Michael J. Thun |
American Cancer Society |
Epidemiology |
6 |
|
Richard Peto |
CTSU, University of Oxford |
Epidemiology |
6 |
|
Roderick MacKinnon |
HHMI, Rockefeller U. |
Biochemistry |
6 |
|
Steven M. Haffner |
U.
Texas, San Antonio |
Clinical Medicine |
6 |
|
SOURCE:
Thomson
ISI
Hot Papers Database |
Sharing the top spot with Lander is a name long familiar
in biomedical circles, although new to the Science Watch annual
roundup: Rory Collins, of the Clinical Trial Service Unit (CTSU),
University of Oxford. Collins’s eight Hot Papers include six
co-authored with his equally eminent colleague, CTSU founder Sir Richard
Peto, who is also featured on the list. Among their highly cited
clinical studies and meta-analyses published over the last two years are
two of the hottest papers in medicine: a study of the
cholesterol-lowering drug simvastatin (see Medicine,
paper #3) and a meta-analysis of antiplatelet therapy in cardiovascular
disease (paper #10). One of Collins’s current Hot Papers published in
2003 also registered among the year’s most cited (#30).
Howard Hughes Medical Institute investigator Brian J. Druker
returns to the list for the second year in a row, thanks to seven Hot
Papers on the anti-leukemia drug imatinib (including one of 2003’s
hottest, paper #15).
Among authors with six Hot Papers (the names in each
tier of the table are ranked according to citations per Hot Paper), the
first is Michael J. Thun of the American Cancer Society. The
compilations of cancer statistics by Thun and colleagues, although not
included among the "discovery accounts" typically featured in
this publication’s regular Top Ten coverage, are very highly cited. In
fact, the latest such report, "Cancer Statistics, 2003" (A.
Jemal, et al., CA-Canc. J. Clin., 53[1]: 5-26, Jan-Feb
2003), was cited over 200 times in 2003—more than any other paper
published last year (although it’s excluded, along with reviews, from
the accompanying list of the year’s most cited). Thun’s other Hot
Papers over the last two years include studies of lung cancer and
nonsteroidal anti-inflammatory drugs.
In a timely appearance, HHMI’s Roderick MacKinnon,
co-winner of the 2003 Nobel Prize in chemistry, makes the list with six
Hot Papers on the structure and function of cellular potassium channels.
Two such reports from 2003 rank with the year’s most cited (#12 and
#40).
Rounding out the list is Steven M. Haffner, University
of Texas Health Science Center, San Antonio, with six Hot Papers on
aspects of diabetes and
heart disease.
As to the list of 2003’s most-cited reports (presented
with the usual caveat that papers published early in the year have an
obvious advantage in accruing citations), perhaps the most striking
feature is its correspondence to current events, with 11 of the 45
papers devoted to SARS
[see also].
[Note: Readers can track Fast-Breaking Papers,
New Hot Papers, and read comments from authors at the
ISI Essential Science Indicators
editorial website component: ESI-Special
Topics.
The
Red Hot Research Papers of 2003 |
|
| Rank |
Paper |
Cites |
|
Rank |
Paper |
Cites |
| 1 |
A.L. Spek, "Single-crystal structure
validation with the program PLATON," J. Appl. Cryst., 36: 7-13,
February 2003. |
204 |
 |
24 |
E.W. Song, et al., "RNA interference
targeting Fas protects mice from fulminant hepatitis " Nature
Medicine, 9(3): 347-51, March 2003.
|
52 |
| 2 |
K. Eguchi, et al., "First results
from KamLAND: Evidence for reactor antineutrino disappearance," Phys.
Rev. Lett., 90(2): 1802, 17 January 2003. |
157 |
25 |
M. Holzenberger, et al., "IGF-1
receptor regulates lifespan and resistance to oxidative stress in mice,"
Nature, 421(6919): 182-7, 9 January 2003.
|
52 |
| 3 |
J.S.M. Peiris, et al., "Coronavirus
as a possible cause of severe acute respiratory syndrome," Lancet,
361(9366): 1319-25, 19 April 2003.
|
135 |
26 |
C.J. Bakkenist, M.B. Kastan, "DNA damage
activates ATM through intermolecular autophosphorylation and dimer
association," Nature, 421(6922): 499-506, 30 January 2003.
|
51 |
| 4 |
T.G. Ksiazek, et al., "A novel
coronavirus associated with severe
acute respiratory syndrome," New Engl. J. Med., 348(20):
1953- 66, 15 May 2003.
|
117 |
27 |
B. Boeckmann, et al., "The SWISS-PROT
protein knowledgebase and its supplement TrEMBL in 2003," Nucl.
Acids Res., 31(1): 365-70, 1 January 2003.
|
51 |
| 5 |
N. Lee, et al., "A major outbreak of
severe acute respiratory syndrome in Hong Kong," New Engl. J. Med.,
348(20): 1986-1994, 15 May 2003.
|
112 |
28 |
G. Vassilopoulos, et al., "Transplanted
bone marrow regenerates liver by cell fusion," Nature,
422(6934): 901-4, 24 April 2003.
|
48 |
| 6 |
C. Drosten, et al., "Identification
of a novel coronavirus in patients with severe acute respiratory syndrome,"
New Engl. J. Med., 348(20): 1967-76, 15 May 2003.
|
104 |
29 |
R. Kamiya, J.R. Shen, "Crystal structure of
oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7
angstrom resolution," Proc. Natl. Acad. Sci. USA, 100(1):
98-103, 7 January 2003.
|
48 |
| 7 |
D.N.
Spergel, et al., "First-year Wilkinson Microwave Anisotropy
Probe (WMAP) observation: Determination of cosmological parameters," Astrophys.
J. Suppl. Ser., 148(1): 175-94, September 2003.
|
94 |
30 |
P.S. Sever, et al., "Prevention of
coronary and stroke events with atorvastatin in hypertensive patients who have
average or lower-than-average cholesterol concentrations, in the
Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A
multicentre randomised controlled trial," Lancet, 361(9364):
1149-58, 5 April 2003.
|
47 |
| 8 |
S.M.
Poutanen, et al., "Identification
of severe acute respiratory syndrome in Canada," New Engl. J.
Med., 348(20): 1995-2005, 15 May 2003.
|
88 |
31 |
P. Gaede, et al., "Multifactorial
intervention and cardiovascular disease in patients with type 2 diabetes,"
New Engl. J. Med., 348(5): 383-93, 20 January 2003. |
47 |
| 9 |
R.S.
Kamath, et al., "Systematic functional
analysis of the Caenorhabditis elegans genome using
RNAi," Nature, 421(6920): 231-7, 16
January 2003.
|
82 |
32 |
J.P. Richard, et al., "Cell-penetrating
peptides: A reevaluation of the mechanism of cellular uptake," J.
Biol. Chem., 278(1): 585-90, 3 January 2003. |
46 |
| 10 |
K.W.
Tsang, et al., "A cluster of cases of
severe acute respiratory syndrome in Hong Kong," New
Engl. J. Med., 348(20): 1977-85, 15 May 2003.
|
81 |
33 |
S. Ramaswamy, et al., "A molecular
signature of metastasis in primary solid tumors," Nature Genetics,
33(1): 49-54, January 2003. |
45 |
| 11 |
L.M.H.
Wing, et al., "A comparison of outcomes
with angiotensin-converting-enzyme inhibitors and
diuretics for hypertension in the elderly," New
Engl. J. Med., 348(7): 583-92, 13 February 2003.
|
74 |
34 |
G.L. Tang, et al., "A biochemical
framework for RNA silencing in plants" Genes & Devel.,
17(1): 49-63, 1 January 2003.
|
45 |
| 12 |
Y.X.
Jiang, et al., "X-ray structure of a
voltage-dependent K+ channel," Nature,
423(6935): 33-41, 1 May 2003.
|
72 |
35 |
K.E. Lohmueller, et al., "Meta-analysis
of genetic association studies supports a contribution of common variants to
susceptibility to common disease," Nature Genetics, 33(2):
177-82, February 2003.
|
44 |
| 13 |
P.A.
Rota, et al., "Characterization of a novel
coronavirus associated with severe acute respiratory
syndrome," Science, 300(5624): 1394-9, 30
May 2003.
|
68 |
|
36 |
N. Nakao, et al., "Combination
treatment of angiotensin-H receptor blocker and angiotensin-enzyme inhibitor in
non-diabetic renal disease (COOPERATE): a randomized controlled trial,"
Lancet, 361(9352): 117-24, 11 January 2003.
|
43 |
| 14 |
M.A.
Marra, et al., "The genome sequence of the
SARS-associated coronavirus," Science,
300(5624): 1399-1404, 30 May 2003.
|
68 |
|
37 |
E.C. Keeley, J.A. Boura, C.L. Grines, "Primary
angioplasty versus intravenous thrombolytic therapy for acute myocardial
infarction: a quantitative review of 23 randomised trials," Lancet,
361(9351): 13-20, 4 January 2003.
|
43 |
| 15 |
S.G.
O’Brien, et al., "Imatinib compared with
interferon and low-dose cytarabine for newly diagnosed
chronic-phase chronic myeloid leukemia," New
Engl. J. Med., 348(11): 994-1004, 13 March 2003.
|
68 |
|
38 |
K. Ashrafi, et al., "Genome-wide RNAi
analysis of Caenorhabditis elegans fat regulatory genes," Nature,
421(6920): 268-72, 16 January 2003.
|
42 |
| 16 |
V.
Bonifati, et al., "Mutations
in the DJ-1 gene associated with autosomal recessive
early-onset parkinsonism," Science,
299(5604): 256-9, 10 January 2003.
|
61 |
|
39 |
A.H. Mokdad, et al., "Prevalence of
obesity, diabetes, and obesity-related health risk factors," JAMA-J.
Am. Med. Assoc., 289(1): 76-9, 1 January 2003.
|
42 |
| 17 |
B.
Pitt, et al., "Eplerenone, a selective
aldosterone blocker, in patients with left ventricular
dysfunction after myocardial infarction," New
Engl. J. Med., 348(14): 1309-21, 3 April 2003.
|
60 |
|
40 |
Y.X. Jiang, et al., "The principle of
gating charge movement in a voltage-dependent K+ channel," Nature,
423(6935): 42-8, 1 May 2003.
|
41 |
| 18 |
J.S.M.
Peiris, et al., "Clinical progression and
viral load in a community outbreak of
coronavirus-associated SARS pneumonia: A prospective
study," Lancet, 361(9371): 1767-72, 24 May
2003.
|
59 |
|
41 |
C. M. Booth, et al., "Clinical
features and short-term outcomes of 144 patients with SARS in the greater
Toronto area," JAMA-J. Am. Med. Assoc., 289(21): 2801-9, 4 June
2003.
|
40 |
| 19 |
C.L.
Bennett, et al., "First-year Wilkinson
Microwave Anisotropy Probe (WMAP) observations:
Preliminary maps and basic results," Astrophys.
J. Suppl. Ser., 148(1): 1-27, September 2003.
|
55 |
|
42 |
C.A. Donnelly, et al., "Epidemiological
determinants of spread of causal agent of severe acute respiratory syndrome in
Hong Kong," Lancet, 361(9371): 1761-6, 24 May 2003.
|
40 |
| 20 |
S.A.
Shumaker, et al., "Estrogen plus progestin
and the incidence of dementia and mild cognitive
impairment in postmenopausal women-The Women’s Health
Initiative Memory Study: a randomized controlled
trial," JAMA-J. Am. Med. Assoc., 289(20):
2651-62, 28 May 2003.
|
55 |
|
43 |
D.A. Rubinson, et al., "A lentivirus-based
system to functionally silence genes in primary mammalian cells, stem cells and
transgenic mice by RNA interference," Nature Genetics, 33(3):
401-6, March 2003.
|
40 |
| 21 |
X.
Wang, et al., "Cell fusion is the principal
source of bone-marrow-derived hepatocytes," Nature,
422(6934): 897-901, 24 April 2003.
|
55 |
|
44 |
P.M.
Ridker, et al., "C-reactive protein, the metabolic syndrome,
and risk of incident cardiovascular events," Circulation,
107(3): 391-7, 28 January 2003.
|
40 |
| 22 |
S.
Hori, T. Nomura, S. Sakaguchi, "Control of
regulatory T cell development by the transcription factor
Foxp3," Science, 299(5609): 1057-61, 14
February 2003.
|
55 |
|
45 |
X.F. Qin, et al., "Inhibiting HIV-1
infection in human T cells by lentiviral-mediated delivery of small interfering
RNA against CCR5," Proc. Natl. Acad. Sci. USA, 100(1): 183-8, 7
January 2003.
|
40 |
| 23 |
H.
Oshiumi, et al., "TICAM-1, an adaptor
molecule that participates in Toll-like receptor
3-mediated interferon-beta induction," Nature
Immunol., 4(2): 161-7, February 2003.
|
53 |
|
Source:
Thomson
ISI
Web of Science
(Citations recorded as of late December 2003.) |
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Science
Watch®, March/April 2004, Vol. 15, No. 2
Citing URL: http://www.sciencewatch.com/march-april2004/sw_march-april2004_page1.htm |
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