Science Watch® - Tracking Trends and Performance in Basic Research
March/April 2004


Americans Are Getting Fatter—and They Are Not Alone by David W. Sharp, M.A.
WHAT'S HOT IN MEDICINE
Rank      Paper Citations This Period (Sep -
Oct 03)
Rank Last Period (Jul - Aug 03)
1 J.E. Rossouw, et al. (Women’s Health Initiat. Invest.), "Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women’s Health Initiative randomized controlled trial," JAMA-J. Amer. Med. Assoc., 288(3): 321-3, 17 July 2002. [8 U.S. institutions] *573AK 183 1
2 W.C. Knowler, et al. (Diabetes Prevention Prog. Res. Group), "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin," New Engl. J. Med., 346(6): 393-403, 7 February 2002. [35 U.S. institutions] *518UN 130 4
3 R. Collins, et al. (Heart Protection Study Collaborative Group), "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial," Lancet, 360(9326): 7-22, 6 July 2002. [Authors’ affilations: multiple U.K. institutions, based at Radcliffe Infirmary, Oxford] *569JR 98 2
4 B. Dahlof, et al., "Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol," Lancet, 359(9311): 995-1003, 23 March 2002. [15 institutions worldwide] *534KP 58
5 L.J. van ‘t Veer, et al., "Gene expression profiling predicts clinical outcome of breast cancer," Nature, 415(6871): 530-6, 31 January 2002. [Netherlands Cancer Inst., Amsterdam; Rosetta Inpharmatics, Kirkland, WA] *516PQ 58
6 C.D. Furberg, et al. (ALLHAT officers and coordinators), "Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)," JAMA-J. Amer. Med. Assoc., 288(23): 2981-97, 18 December 2002. [Corresponding authors: Case Western Reserve U., Cleveland, OH; U. Texas Houston Health Center] *626CG 57 8
7 K.M. Flegal, et al., "Prevalence and trends in obesity among US adults, 1999-2000," JAMA-J. Amer. Med. Assoc., 288(14): 1723-7, 9 October 2002. [CDC, Hyattsville, MD] *602BJ 49
8 G. Van den Berghe, et al., "Intensive insulin therapy in critically ill patients," New Engl. J. Med., 345(19): 1359-67, 8 November 2001. [Catholic U. Leuven, Belgium] *489VY 48
9 T. Yamauchi, et al., "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity," Nature Medicine, 7(8): 941-6, August 2001. [9 institutions worldwide] *485EK 46
10 C. Baigent, et al. (Antithrombotic Trialists’ Collaboration), "Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients," Brit. Med. J., 324(7329): 71-86, 12 January 2002. [Radcliffe Infirmary, Oxford, U.K.] *512LG 45
 SOURCE: ISI's Hot Papers DatabaseRead  the full legend.

   For 1960-62 the U.S. National Health Examination Survey recorded the prevalence of obesity in adults as 13.4%. The latest figure we have is from the successor to that inquiry, the now continuous National Health and Nutrition Examination Survey (NHANES, see paper #7). For 1999-2002 the prevalence in the age group 20-74 was 30.9%, and this huge increase over four decades can largely be ascribed to the 1980s and 1990s. (NHANES has included the over-75s in its last two publications but obesity is much less of an issue at that age.) In January, 2004, a British television program charged a U.S. city with being the fattest city in the west, appealing to smug European prejudice that dietary overindulgence is a problem for the United States alone. It is not. For example, the British government is alarmed at obesity in children, while a recent paper reports a rising prevalence of obesity, from 4.6% to 11.4% in men and from 6.1% to 9.8% in women between 1986 and 1994 in Malmo, Sweden (M. Lindstrom, S.O. Isacsson, J. Merlo, Eur. J. Publ. Health, 13: 306-12, 2003).

There are various ways of judging how fat someone is. You can, for instance, measure skinfold thickness with callipers or look at waist-to-hip ratios. The body mass index was used in NHANES and is the most popular. Using kilograms and meters, divide weight by height squared. For adults, 25 or more is overweight, 30-plus is obese, and 40 and over is extremely obese (1 in every 21 U.S. adults today). That BMI may not mean the same all over the world is nicely illustrated by a recent World Health Organization meeting (Lancet, 363: 157-63, 2004), but the WHO experts decided against any radical adjustment. As paper #7 suggests, BMI is more reliable than indices based on self-reported weight and height. For example, the Behavioral Risk Factor Surveillance System (A.H. Mokdad, et al., JAMA, 286:1519-22, 1999) yielded obesity rates one-third lower than the NHANES figure for a similar time frame.

Medical concern over obesity relates to its association with cardiovascular disease and diabetes. Dr. Katherine M. Flegal and her colleagues from the National Center for Health Statistics, Hyattsville, Maryland, note that over the years when obesity has increased, cardiovascular mortality has fallen. This may not be as paradoxical as it sounds. Relationships between risk factors are complex (e.g., recent guidelines on blood pressure suggest that systolic blood pressure falls by between 5 and 20 mm Hg for every 10 kg of weight loss). Furthermore, the falls in mortality might have been even more impressive if obesity had not been increasing. The management of heart disease has improved too. The public health importance of the NHANES series lies in the accuracy of the data, as Dr. Flegal emphasizes to Science Watch. Having data based on measured weights and heights "enable us to document clearly the marked and continuing increases in obesity in the U.S. since 1980, which are a matter of considerable concern," she says. They serve as a "starting point" for discussions about the causes of the rise and policies to reverse it. Unfortunately, reversing this trend has become a political hot potato in 2004 with U.S. officials not seeing eye to eye with the World Health Organization’s Global Strategy on Diet, Physical Activity and Health, notably on diet.

One might argue that the starting point of obesity lies largely in children’s eating and exercise habits, and much preventive activity in the U.K. at present is focused on that notion. An accompanying NHANES paper to #7 has fewer total citations (111 versus 227, as of late January 2004) but seems just as important. Dr. Cynthia L. Ogden and her colleagues (JAMA, 288: 1728-32, 2002) found that 15% of U.S. children aged 6-19 years were overweight, this being defined as being at or above the 95th percentile for the appropriate BMI.

Mr. David W. Sharp, M.A. (Cambridge),
is a contributing editor to The Lancet, London, U.K.

Science Watch®, March/April 2004, Vol. 15, No. 2
Citing URL: http://www.sciencewatch.com/march-april2004/sw_march-april2004_page5.htm

Search | Mar/Apr 2004 Index | Archives | Contact | Home

What's New in Research - (Updated weekly) - What's NEW in Research
The Most-Cited Researchers in...
  |  Analysis Of...  |  Site Map by Field | ! QUICK SCIENCE !
Alphabetized List of All Essential Science Indicators Editorial Features/Interviews


Science Watch® is an editorial component of Essential Science Indicators. RSS Feeds for Essential Science Indicator's editorial Web sites
Visit other editorial components of ESI: "in-cites" and "Special Topics."
Write to the Webmaster with questions or comments about this site. Terms of Usage.
View all the products of the Research Services Group from Thomson Scientific.


(c) 2008 The Thomson Corporation.
Thomson Scientific