

Americans
Are Getting Fatter—and They Are Not Alone |
by David W.
Sharp, M.A. |
|
| WHAT'S
HOT IN MEDICINE |
| Rank |
Paper |
Citations
This Period (Sep -
Oct 03) |
Rank
Last Period (Jul - Aug 03) |
| 1 |
J.E. Rossouw, et
al. (Women’s Health Initiat. Invest.), "Risks
and benefits of estrogen plus progestin in healthy postmenopausal women.
Principal results from the Women’s Health Initiative randomized
controlled trial," JAMA-J. Amer. Med. Assoc., 288(3):
321-3, 17 July 2002. [8 U.S. institutions] *573AK |
183 |
1 |
| 2 |
W.C. Knowler, et
al. (Diabetes Prevention Prog. Res. Group), "Reduction
in the incidence of type 2 diabetes with lifestyle intervention or
metformin," New Engl. J. Med., 346(6): 393-403, 7
February 2002. [35 U.S. institutions] *518UN |
130 |
4 |
| 3 |
R. Collins, et
al. (Heart Protection Study Collaborative Group), "MRC/BHF
Heart Protection Study of cholesterol lowering with simvastatin in 20 536
high-risk individuals: a randomised placebo-controlled trial,"
Lancet, 360(9326): 7-22, 6 July 2002. [Authors’ affilations:
multiple U.K. institutions, based at Radcliffe Infirmary, Oxford] *569JR |
98 |
2 |
| 4 |
B. Dahlof, et
al., "Cardiovascular morbidity and mortality in the Losartan
Intervention For Endpoint reduction in hypertension study (LIFE): a
randomised trial against atenolol," Lancet, 359(9311):
995-1003, 23 March 2002. [15 institutions worldwide] *534KP |
58 |
† |
| 5 |
L.J. van ‘t
Veer, et al., "Gene expression profiling predicts clinical
outcome of breast cancer," Nature, 415(6871): 530-6, 31
January 2002. [Netherlands Cancer Inst., Amsterdam; Rosetta Inpharmatics,
Kirkland, WA] *516PQ |
58 |
† |
| 6 |
C.D. Furberg, et
al. (ALLHAT officers and coordinators), "Major outcomes in
high-risk hypertensive patients randomized to angiotensin-converting
enzyme inhibitor or calcium channel blocker vs diuretic. The
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack
Trial (ALLHAT)," JAMA-J. Amer. Med. Assoc., 288(23):
2981-97, 18 December 2002. [Corresponding authors: Case Western Reserve
U., Cleveland, OH; U. Texas Houston Health Center] *626CG |
57 |
8 |
| 7 |
K.M. Flegal, et
al., "Prevalence and trends in obesity among US adults,
1999-2000," JAMA-J. Amer. Med. Assoc., 288(14): 1723-7, 9
October 2002. [CDC, Hyattsville, MD] *602BJ |
49 |
† |
| 8 |
G. Van den
Berghe, et al., "Intensive insulin therapy in critically
ill patients," New Engl. J. Med., 345(19): 1359-67, 8
November 2001. [Catholic U. Leuven, Belgium] *489VY |
48 |
† |
| 9 |
T. Yamauchi, et
al., "The fat-derived hormone adiponectin reverses insulin
resistance associated with both lipoatrophy and obesity," Nature
Medicine, 7(8): 941-6, August 2001. [9 institutions worldwide] *485EK |
46 |
† |
| 10 |
C. Baigent, et
al. (Antithrombotic Trialists’ Collaboration), "Collaborative
meta-analysis of randomised trials of antiplatelet therapy for prevention
of death, myocardial infarction, and stroke in high risk patients,"
Brit. Med. J., 324(7329): 71-86, 12 January 2002. [Radcliffe
Infirmary, Oxford, U.K.] *512LG |
45 |
† |
SOURCE:
ISI's
Hot Papers Database.
the full legend. |
or
1960-62 the U.S. National Health Examination Survey recorded the
prevalence of obesity
in adults as 13.4%. The latest figure we have is from the successor to
that inquiry, the now continuous National Health and Nutrition
Examination Survey (NHANES, see paper #7). For 1999-2002 the prevalence
in the age group 20-74 was 30.9%, and this huge increase over four
decades can largely be ascribed to the 1980s and 1990s. (NHANES has
included the over-75s in its last two publications but obesity is much
less of an issue at that age.) In January, 2004, a British television
program charged a U.S. city with being the fattest city in the west,
appealing to smug European prejudice that dietary overindulgence is a
problem for the United States alone. It is not. For example, the British
government is alarmed at obesity in children, while a recent paper
reports a rising prevalence of obesity, from 4.6% to 11.4% in men and
from 6.1% to 9.8% in women between 1986 and 1994 in Malmo, Sweden (M.
Lindstrom, S.O. Isacsson, J. Merlo, Eur. J. Publ. Health, 13:
306-12, 2003).
There are various ways of judging how fat someone is. You can, for
instance, measure skinfold thickness with callipers or look at
waist-to-hip ratios. The body mass index was used in NHANES and is the
most popular. Using kilograms and meters, divide weight by height
squared. For adults, 25 or more is overweight, 30-plus is obese, and 40
and over is extremely obese (1 in every 21 U.S. adults today). That BMI
may not mean the same all over the world is nicely illustrated by a
recent World Health Organization meeting (Lancet, 363: 157-63,
2004), but the WHO experts decided against any radical adjustment. As
paper #7 suggests, BMI is more reliable than indices based on
self-reported weight and height. For example, the Behavioral Risk Factor
Surveillance System (A.H. Mokdad, et al., JAMA,
286:1519-22, 1999) yielded obesity rates one-third lower than the
NHANES figure for a similar time frame.
Medical concern over obesity relates to its association with
cardiovascular disease and diabetes.
Dr. Katherine M. Flegal and her colleagues from the National Center for
Health Statistics, Hyattsville, Maryland, note that over the years when
obesity has increased, cardiovascular mortality has fallen. This may not
be as paradoxical as it sounds. Relationships between risk factors are
complex (e.g., recent guidelines on blood pressure suggest that systolic
blood pressure falls by between 5 and 20 mm Hg for every 10 kg of weight
loss). Furthermore, the falls in mortality might have been even more
impressive if obesity had not been increasing. The management of heart
disease has improved too. The public health importance of the NHANES
series lies in the accuracy of the data, as Dr. Flegal emphasizes to Science
Watch. Having data based on measured weights and heights
"enable us to document clearly the marked and continuing increases
in obesity in the U.S. since 1980, which are a matter of considerable
concern," she says. They serve as a "starting point" for
discussions about the causes of the rise and policies to reverse it.
Unfortunately, reversing this trend has become a political hot potato in
2004 with U.S. officials not seeing eye to eye with the World Health
Organization’s Global Strategy on Diet, Physical Activity and Health,
notably on diet.
One might argue that the starting point of obesity lies largely in
children’s eating and exercise habits, and much preventive activity in
the U.K. at present is focused on that notion. An accompanying NHANES
paper to #7 has fewer total citations (111 versus 227, as of late
January 2004) but seems just as important. Dr. Cynthia L. Ogden and her
colleagues (JAMA, 288: 1728-32, 2002) found that 15% of U.S.
children aged 6-19 years were overweight, this being defined as being at
or above the 95th percentile for the appropriate BMI.
Mr. David
W. Sharp, M.A. (Cambridge),
is a contributing editor to The Lancet, London, U.K.
Science
Watch®, March/April 2004, Vol. 15, No. 2
Citing URL:
http://www.sciencewatch.com/march-april2004/sw_march-april2004_page5.htm |
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