| The Hottest Research of 2003-04 |
|
|
 n its latest annual roundup of recent research, Science Watch
presents the list of authors who, as of late 2004, had published the
greatest number of Hot Papers over the preceding two years. The table
below
lists the (non-review) papers published in 2004 that achieved the highest
citation totals by year’s end (those papers cited more than 35 times).
Atop the list of scientists is the University of Hong Kong’s Malik Peiris,
interviewed last fall in these pages (15[5]: 3-4, September/October
2004), with
nine highly cited reports on severe acute respiratory syndrome, or SARS. As a
measure of SARS’s continuing influence on the medical literature in 2004, half
of the current Medicine Top Ten is devoted to the topic, and five
of the featured researchers above had a hand in four of those papers. Peiris is
lead author on paper #9 (from The Lancet), with Kwok-Yung Yuen among the
coauthors. Wilina Lim contributed to that paper as well as to the report
currently ranked at #1 in medicine (T.G. Ksiazek, et al., NEJM),
while Erasmus University virologists Albert Osterhaus and Ron Fouchier added
their expertise to the papers at #2 and #8 (C. Drosten, et al., NEJM;
P.A. Rota, et al., Science).
On the second rung with eight Hot Papers, and returning to the list after a
four-year absence, is Claire M. Fraser of The Institute for Genomic Research (TIGR).
One of her recent hot reports, on the genome sequence of the Brown Norway rat,
proved to be among 2004’s hottest, ranking at #3 in the table
below
(R.A.
Gibbs, et al., Nature). Fraser’s TIGR colleague Ian T. Paulsen
joined her on six hot reports. (The order of names within each tier of the
table, incidentally, is determined by average citations per Hot Paper.)
Henry R. Black of the Rush University Medical Center makes his first
appearance in an annual roundup, thanks to seven Hot Papers in medicine. One of
these, on estrogen treatments in postmenopausal women (G.L. Anderson, et al.,
JAMA), emerged as 2004’s most-cited paper, and a late-2002 report is
still going strong, appearing at #3 in the current Medicine Top Ten
(C.D.
Furberg, et al., JAMA).
Theoretical physicist Arkady A. Tseytlin, who spoke to Science Watch
in the previous issue (16[1]: 3-4, January/February
2005), has fielded seven Hot
Papers, joined on six of those by coauthor Sergey A. Frolov. Another familiar
name, Rory Collins of the Clinical Trial Service Unit, University of Oxford,
appears for the second year in a row; Science Watch interviewed him last
year (15[4]: 3-4, July/August
2004).
Shizuo Akira’s six Hot Papers on toll-like receptors include two of 2004’s
hottest (#11, F. Heil, et al., and #12, S.S. Diebold et al., both
from Science). Astronomers Jeffrey A. Munn, Robert H. Lupton, and Donald
G. York contributed to one of 2004’s most cited (#10, M. Tegmark, et al.,
Phys. Rev. D), while Daniel J. Jacob’s six Hot Papers report on ozone,
pollution, and other atmospheric phenomena.
The
Red Hot Research Papers of 2004 |
|
| Rank |
Paper |
Cites |
|
Rank |
Paper |
Cites |
| 1 |
G.L.
Anderson, et al., "Effects of
conjugated, equine estrogen in postmenopausal women with hysterectomy – The
Women’s Health Initiative randomized controlled trial," JAMA-J.
Amer. Med. Assn., 291(14): 1701-12, 14 April 2004. |
93 |
 |
24 |
V. Kubarovsky, et al., "Observation
of an exotic baryon with S = +1 in photoproduction from the proton," Phys.
Rev. Lett., 92(3): No. 032001, 23 January 2004.
|
48 |
| 2 |
T.J. Lynch, et al., "Activating
mutations in the epidermal growth factor receptor underlying responsiveness of
non-small-cell lung cancer to gefitinib," New Engl. J. Med.,
350(21): 2129-39, 20 May 2004. |
91 |
25 |
R.M. Goldberg, et al., "A
randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and
oxaliplatin combinations in patients with previously untreated metastatic
colorectal cancer," J. Clin. Oncol., 22(1): 23-30, 1 January
2004.
|
48 |
| 3 |
R.A. Gibbs, et al., "Genome
sequence of the Brown Norway rat yields insights into mammalian evolution,"
Nature, 428(6982): 493-521, 1 April 2004.
|
76 |
26 |
C.L. Kuo, et al., "High-resolution
observations of the cosmic microwave background power spectrum with ACBAR,"
Astrophys. J., 600(1): 32-51, 1 January 2004.
|
48 |
| 4 |
G.W. Stone, et al., "A
polymer-based, paclitaxel-eluting stent in patients with coronary artery
disease," New Engl. J. Med., 350)3): 221-31, 15 January 2004.
|
74 |
27 |
J.C.
Venter, et al., "Environmental
genome shotgun sequencing of the Sargasso Sea," Science,
304(5667): 66-74, 2 April 2004.
|
47 |
| 5 |
A.
Bateman, et al., "The Pfam
protein familes database," Nucleic Acids Res., 32: D138-41, 1
January 2004.
|
73 |
28 |
M. Giavalisco, et al., "The Great
Observatories Origins Deep Survey: Initial results from optical and
near-infrared imaging," Astrophys. J., 600(2): L93-8, 10 January
2004.
|
46 |
| 6 |
J.G. Paez, et al., "EGFR mutations
in lung cancer: Correlation with clinical response to gefitinib therapy,"
Science, 304(5676): 1497-1500, 4 June 2004.
|
72 |
29 |
A. Airapetian, et al., "Evidence
for a narrow S =1 baryon state at a mass of 1528 MeV in quasi-real
photoproduction," Phys. Lett. B, 585(3-4): 213-22, 15 April
2004.
|
45 |
| 7 |
C.A. Regal, M. Greiner, D.S. Jin, "Observation
of resonance condensation of fermionic atom pairs," Phys. Rev. Lett.,
92(4): No. 040403, 30 January 2004.
|
71 |
30 |
R.S. Herbst, et al., "Gefitinib in
combination with paclitaxel and carboplatin in advanced non-small-cell lung
cancer: A phase III trial – INTACT 2," J. Clin. Oncol., 22(5):
785-94, 1 March 2004.
|
34 |
| 8 |
C.P. Cannon, et al., "Intensive
versus moderate lipid lowering with statins after acute coronary
syndromes," New Engl. J. Med., 350(15): 1495-1504, 8 April 2004.
|
66 |
31 |
K. Berns, et al., "A large-scale
RNAi screen in human cells identifies new components of the p53 pathway,"
Nature, 428(6981): 431-7, 25 March 2004. |
43 |
| 9 |
K.N.
Ferreira, et al., "Architecture of the
photosynthetic oxygen-evolving center," Science,
303(5665): 1831-8, 19 March 2004.
|
65 |
32 |
S.J. Hadziyannis, et al., "Peginterferon-alpha
2a and ribavirin combination therapy in chronic hepatitis C – A randomized
study of treatment duration and ribavirin dose," Ann. Int. Med.,
140(5): 346-55, 2 March 2004. |
42 |
| 10 |
M.
Tegmark, et al., "Cosmological parameters
from SDSS and WMAP," Phys. Rev. D, 69(10):
No. 103501, May 2004.
|
64 |
33 |
M.W. Zwierlin, et al., "Condensation
of pairs of fermionic atoms near a Feshbach resonance," Phys. Rev.
Lett., 91(12): No. 120403, 26 March 2004. |
41 |
| 11 |
F.
Heil, et al., "Species-specific recognition
of single-stranded RNA via toll-like receptor 7 and 8," Science, 303(5663): 1526-9, 5 March
2004.
|
64 |
34 |
W.S. Hwang, et al., "Evidence of a
pluripotent human embryonic stem cell line derived from a cloned blastocyst,"
Science, 303(5664): 1669-74, 12 March 2004.
|
41 |
| 12 |
S.S.
Diebold, et al., "Innate antiviral
responses by means of TLR7-mediated recognition of
single-stranded RNA," Science, 303(5663):
1529-31, 5 March 2004.
|
58 |
35 |
D.K. Zhang, et al., "A toll-like
receptor that prevents infection by uropathogenic bacteria," Science,
303(5663): 1522-6, 5 March 2004.
|
41 |
| 13 |
C.
Alt, et al., "Evidence for an exotic S = -2
baryon resonance in proton-proton collisions at the CERN
SPS," Phys. Rev. Lett., 92(4): No. 042003,
30 January 2004.
|
58 |
|
36 |
T.R. Mempel, et al., "T-cell
priming by dendritic cells in lymph nodes occurs in three distinct phases,"
Nature, 427(6970): 154-9, 8 January 2004.
|
41 |
| 14 |
S.E.
Nissen, et al., "Effect of intensive
compared with moderate lipid-lowering therapy on
progression of coronary atherosclerosis – a randomized
controlled trial," JAMA-J. Amer. Med. Assn.,
291(9): 1071-80, 3 March 2004.
|
57 |
|
37 |
B. van den
Berg, et al., "X-ray
structure of a protein-conducting channel," Nature, 427(6969):
36-44, 1 January 2004.
|
41 |
| 15 |
S.M.
Li, et al., "A map of the interactome
network of the metazoan C. elegans," Science,
303(5657): 540-3, 23 January 2004.
|
57 |
|
38 |
C.Z. Chen, et al., "MicroRNAs
modulate hematopoietic lineage differentiation," Science,
303(5654): 83-6, 2 January 2004.
|
40 |
| 16 |
A.
Verdel, et al., "RNAi-mediated targeting of
heterochromatic by the RITS complex," Science,
303(5658): 672-6, 20 January 2004.
|
54 |
|
39 |
E. Lund, et al., "Nuclear export of
microRNA precursors," Science, 303(5654): 95-8, 2 January 2004.
|
39 |
| 17 |
A.H.Y.
Tong, et al., "Global mapping of the yeast
genetic interaction network," Science,
303(5659): 808-13, 6 February 2004.
|
53 |
|
40 |
A. Reynolds, et al., "Rational
siRNA design for RNA interference," Nature Biotech., 22(3):
326-30, March 2004.
|
38 |
| 18 |
L.T.
Vassilev, et al., "In vivo activation of
the p53 pathway by small-molecule antagonists of
MDM2," Science, 303(5659): 844-8, 6
February 2004.
|
50 |
|
41 |
R. Apweiler, et al., "UniProt: the
Universal Protein knowledgebase," Nucleic Acids Res., 32:
D115-9, 1 January 2004.
|
38 |
| 19 |
M.
Pal-Bhadra, et al., "Heterochromatic
silencing and HP1 localization in Drosophila are
dependent on the RNAi machinery," Science,
303(5658): 669-72, 30 January 2004.
|
50 |
|
42 |
N. Beisert, "The complete one-loop
dilatation operator of N=4 super Yang-Mills theory," Nucl. Phys. B,
676(1-2): 3-42, 5 January 2004.
|
37 |
| 20 |
C.A.
Llewelyn, et al., "Possible transmission of
variant Creutzfeldt-Jakob disease by blood
transfusion," Lancet, 363(9407): 417-21, 7
February 2004.
|
49 |
|
43 |
G. Giaccone, et al., "Gefitinib in
combination with gemcitabine and cisplatin in advanced non-small-cell lung
cancer: A phase III trial – INTACT 1," J. Clin. Oncol., 22(5):
777-84, 1 March 2004.
|
36 |
| 21 |
C.E.
Murry, et al., "Haematopoeitic stem cells
do not transdifferentiate into cardiac myocytes in
myocardial infarcts," Nature, 428(6983):
664-8, 8 April 2004.
|
48 |
|
44 |
S.W. Altmann, et al., "Niemann-Pick
C1 like 1 protein is critical for intestinal cholesterol absorption," Science,
303(5661): 1201-4, 20 February 2004.
|
36 |
| 22 |
L.B.
Balsam, et al., "Haematopoietic stem cells
adopt mature haematopoietic fates in ischaemic
myocardium," 428(6983): 668-73, 8 April 2004.
|
48 |
|
45 |
J.F. Colombel, et al., "The safety
profile of infliximab in patients with Crohn’s disease: The Mayo Clinic
experience in 500 patients," Gastroenterol., 126(1): 19-31,
January 2004.
|
36 |
| 23 |
A.H.
Mokdad, et al., "Actual causes of death in
the United States, 2000," Jama-J. Amer. Med.
Assn., 291(10): 1238-45, 10 March 2004.
|
48 |
|
46 |
N. Sato, et al., "Maintenance of
pluripotency in human and mouse embryonic stem cells through activation of Wnt
signaling by a pharmacological GSK-3-specific inhibitor," Nature
Medicine, 10(1): 55-63, January 2004.
|
36 |
|
|
Science
Watch®, March/April 2005, 2005, Vol. 16, No. 2
Citing URL: http://www.sciencewatch.com/march-april2005/sw_march-april2005_page1.htm |
|
.
