Science Watch® - Tracking Trends and Performance In Basic Research
March/April 1998



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The Red Hot Research Papers of 1997

Rank

Paper

Citations
1 J. Yang, et al., "Prevention of apoptosis by Bcl-2: Release ofcytochrome c from mitochondria blocked," Science, 275(5303):1129-32, 21 February 1997. 56
2 R.M. Kluck, et al., "The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis," Science, 275(5303):1132-6, 21 February 1997. 55
3 T.R. Franke, et al., "Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate," Science, 275(5300):665-8, 31 January 1997. 54
4 O. Zhuchenko, et al., "Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the a1A-voltage-dependent calcium channel," Nature Genetics, 15(1):62-9, January 1997. 47
5 R. Scully, et al., "Association of BRCA1 with Rad51 in mitotic and meiotic cells," Cell, 88(2):265-75, 24 January 1997. 46
6 H. Dudek, et al., "Regulation of neuronal survival by the serine-threonine protein kinase Akt," Science, 275(5300):661-5, 31 January 1997. 41
7 A.M. Chinnaiyan, et al., "Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death," Science, 275(5303):1122-6, 21 February 1997. 40
8 A. Kauffmann-Zeh, et al., "Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB," Nature, 385(6616):544-8, 6 February 1997. 40
9 M. Citron, et al., "Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid b-protein in both transfected cells and transgenic mice," Nature Medicine, 3(1):67-72, January 1997. 38
10 I. Wilmut, et al., "Viable offspring derived from fetal and adult mammalian cells," Nature, 385(6619):810-3, 27 February 1997. 37
11 A.J. Minn, et al., "Bcl-XL forms an ion channel in synthetic lipid membranes," Nature, 385(6614):353-7, 23 January 1997. 35
12 W. Fan, et al., "Role of melanocortinergic neurons in feeding and the agouti obesity syndrome," Nature, 385(6612):165-8, 9 January 1997. 34
13 J. Li, et al., "PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer," Science, 275(5308):1943-7, 28 March 1997. 33
14 C. Fleury, et al., "Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia," Nature Genetics, 15(3):269-72, March 1997. 33
15 D.G. Julian, et al., "Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT," The Lancet, 349(9053):667-74, 8 March 1997. 32
16 W. Xu, S.C. Harrison, M.J. Eck, "Three-dimensional structure of the tyrosine kinase c-Src," Nature, 385(6617):595-602,13 February 1997. 31
17 P.A. Steck, et al., "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers," Nature Genetics, 15(4):356-62, April 1997. 30
18 J.A. Cairns, et al., "Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT," The Lancet, 349(9053):675-82,8 March 1997. 30
19 P.J. Morin, et al., "Activation of b-catenin-Tcf signaling in colon cancer by mutations in b-catenin or APC," Science, 275(5307):1787-90, 21 March 1997. 29
20 H.J. Alter, et al., "The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease," New Engl. J. Med., 336(11):747-54, 13 March 1997. 29
21 D. Wu, H.D. Wallen, G. Nuñez, "Interaction and regulation of subcellular localization of CED-4 by CED-9," Science, 275(5303):1126-9, 21 February 1997. 29
22 C.C. Bradley, C.A. Sackett, R.G. Hulet, "Bose-Einstein condensation of lithium: Observation of limited condensate number," Phys. Rev. Lett., 78(6):985-9, 10 February 1997. 29
23 M.R. Andrews, et al., "Observation of interference between two Bose condensates," Science, 275(5300):637-41, 31 January 1997. 29
24 D. Huszar, et al., "Targeted disruption of the melanocortin-4 receptor results in obesity in mice," Cell, 88(1):131-41, 10 January 1997. 29
25 B. Rubinfeld, et al., "Stabilization of b-catenin by genetic defects in melanoma cell lines," Science, 275(5307):1790-2, 21 March 1997. 28
26 M.P. Lee, et al., "Human KVLQT1 gene shows tissue-specificimprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements," Nature Genetics, 15(2):181-5, February 1997. 28
27 V. Korinek, et al., "Constitutive transcriptional activation by a b-catenin-Tcf complex in APC-/- colon carcinoma," Science, 275(5307):1784-7, 21 March 1997. 27
28 G.G.J.M. Kuiper, et al., "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and b," Endocrinology, 138(3):863-70, March 1997. 27
29 F.S. Lee, et al., "Activation of the Ikba kinase complex by MEKK1, a kinase of the JNK pathway," Cell, 88(2):213-22, 24 January 1997. 27
30 R. Mahajan, et al., "A small ubiquitin-related polypeptide involved in the targeting RanGAP1 to nuclear pore complex protein RanBP2," Cell, 88(1):97-107, 10 January 1997. 27
31 H. Nielsen, et al., "Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites," Protein Eng., 10(1):1-6, January 1997. 27
32 M. Groll, et al., "Structure of 20S proteasome from yeast at 2.4 Å resolution," Nature, 386(6624):463-71, 3 April 1997. 26
33 N.L. Michael, et al., "The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression," Nature Medicine, 3(3):338-40, March 1997. 26
34 B. Pitt, et al., "Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)," The Lancet, 349(9054):747-52, 15 March 1997. 26
35 J.F. Bazan,et al., "A new class of membrane-bound chemokine with a CX3C motif," Nature, 385(6617):640-4, 13 February 1997. 26
36 M. Sano, et al., "A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease," New Engl. J. Med., 336(17):1216-22, 24 April 1997. 25
37 T. Banks, et al., "M theory as a matrix model: a conjecture," Phys. Rev. D, 55(8):5112-28, 15 April 1997. 25
38 J. He, "CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia," Nature, 385(6617):645-9, 13 February 1997. 25
39 F. Sicheri, I. Moarefi, J. Kuriyan, "Crystal structure of the Src family tyrosine kinase Hck," Nature, 385(6617):602-9, 13 February 1997. 25
40 H.L. Lai, et al., "Improved parton distributions from global analysis of recent deep inelastic scattering and inclusive jet data," Phys. Rev. D, 55(3):1280-96, 1 February 1997. 25

SOURCE: ISI'S Hot Papers Database

Science Watch®, March/April 1998, Vol. 9, No. 2
Citing URL: http://www.sciencewatch.com/march-april98/sw_march-april98_page2.htm

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