The Hottest
Research of 1998
Time once again for Science Watch to take its customary
look back at the citation highlights of last years research. Above are the
researchers who... 
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UCSD's Michael Karin on
Signaling Pathways
The 20 microns between the cell membrane and the
genetic material in the cell nucleus is the playground of the molecules of signal
transduction, of the intricate and multifaceted redundancy of the pathways that take
signals from the membrane and convert them into the exquisitely selective control of our
genes. Within these pathways, the regulation of gene transcription is carried out by a
multitude of hormones and growth factors, which in turn are affected by environmental
stresses and a host of other phenomena. Over the past two decades, the study of signal
transduction has grown...  |