Science Watch® - Tracking Trends and Performance In Basic Research
March/April 1999



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The Red Hot Research Papers of 1998

Rank

Paper

Citations
1 M. Enari, et al., "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD," Nature, 391(6662):43-50, 1 January 1998. 112
2 A.G. Bodnar, et al., "Extension of life-span by introduction of telomerase into normal human cells," Science, 279(5349):349-52, 16 January 1998. 89
3 D.A. Doyle, et al., "The structure of the potassium channel: Molecular basis of K+ conduction and selectivity," Science, 280(5360):69-77, 3 April 1998. 76
4 H. Sakahira, M. Enari, S. Nagata, "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis," Nature, 391(6662):96-9, 1 January 1998. 54
5 T. Weber, et al., "SNAREpins: Minimal machinery for membrane fusion," Cell, 92(6):759-72, 20 March 1998. 45
6 R.O. Estacio, et al., "The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension," New Engl. J. Med., 338(10):645-52, 5 March 1998. 43
7 A. Brehm, et al., "Retinoblastoma protein recruits histone deacetylase to repress transcription," Nature, 391(6667):597-601, 5 February 1998. 41
8 F.J. Palella, et al., "Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection," New Engl. J. Med., 338(13):853-60, 26 March 1998. 39
9 V.M. Braud, et al., "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C," Nature, 391(6669):795-9, 19 February 1998. 39
10 L. Magnaghi-Jaulin, et al., "Retinoblastoma protein represses transcription by recruiting a histone deacetylase," Nature, 391(6667):601-5, 5 February 1998. 39
11 S.L. Rogers, et al., "A 24-week double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease," Neurology, 50(1):136-45, January 1998. 38
12 Y. Zhang, Y. Xiong, W.G. Yarbrough, "ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways," Cell, 92(6):725-34, 20 March 1998. 37
13 J. Pomerantz, et al., "The Ink4a tumor suppressor gene product, p19Arf , interacts with MDM2 and neutralizes MDM2’s inhibition of p53," Cell, 92(6):713-23, 20 March 1998. 36
14 S. Doublié, et al., "Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution," Nature, 391(6664):251-8, 15 January 1998. 35
15 R.J. Lin, et al., "Role of the histone deacetylase complex in acute promyelocytic leukaemia," Nature, 391(6669):811-4, 19 February 1998. 34
16 T. Rossé, et al., "Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c," Nature, 391(6666):496-9, 29 January 1998. 34
17 G. Pan, K. O’Rourke, V.M. Dixit, "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex," J. Biol. Chem., 273(10):5841-5, 6 March 1998. 32
18 R. Bonecchi, et al., "Differential expression of chemokine receptors and chemotactic responsiveness of Type 1 T helper cells (Th1s) and Th2s," J. Exp. Med., 187(1):129-34, 5 January 1998. 32  
19 M. Ricote, et al., "The peroxisome proliferator-activated receptor-g is a negative regulator of macrophage activation," Nature, 391(6662):79-82, 1 January 1998. 32  
20 E. Korzus, et al., "Transcription factor-specific requirements for coactivators and their acetyltransferase functions," Science, 279(5351):703-7, 30 January 1998. 31
21 F. Grignani, et al., "Fusion proteins of the retinoic acid receptor-a A recruit histone deacetylase in promyelocytic leukaemia," Nature, 391(6669):815-8, 19 February 1998. 30
22 L. Hansson, et al., "Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial," The Lancet, 351(9118):1755-62, 13 June 1998. 29
23 S.T. Cole, et al., "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence," Nature, 393(6685):537-44, 11 June 1998. 29
24 S. Nakamura, et al., "InGaN/GaN/AIGaN-based laser diodes with modulation-doped strained-layer superlattices grown on an epitaxially laterally overgrown GaN substrate," Appl. Phys. Lett., 72(2):211-3, 12 January 1998. 29
25 P. Tatti, et al., "Outcome results of the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET) in patients with hypertension and NIDDM," Diabetes Care, 21(4):597-603, April 1998. 28
26 K.C. Garcia, et al., "Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen," Science, 279(5354):1166-72, 20 February 1998. 28
27 K. Murali-Krishna, et al., "Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection," Immunity, 8(2):177-87, 2 February 1998. 28
28 G.S. Ogg, et al., "Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA," Science, 279(5359):2103-6, 27 March 1998. 27
29 C. Scaffidi, et al., "Two CD95 (APO-1/Fas) signaling pathways," EMBO J., 17(6):1675-87, 16 March 1998. 26
30 S. Igarishi, et al., "Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch," Nature Genetics, 18(2):111-7, February 1998. 26
31 C. Jiang, A.T. Ting, B. Seed, "PPAR-g agonists inhibit production of monocyte inflammatory cytokines," Nature, 391(6662):82-6, 1 January 1998.  26
32 H. Yasuda, et al., "Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL," Proc. Natl. Acad. Sci. USA, 95(7):3597-3602, March 1998. 25
33 M.L. Albert, B. Sautier, N. Bhardwaj, "Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs," Nature, 392(6671):86-9, 5 March 1998. 25
34 M. Tanaka, et al., "Downregulation of Fas ligand by shedding," Nature Medicine, 4(1):31-6, January 1998.   25

SOURCE: ISI'S Hot Papers Database

Science Watch®, March/April 1999, Vol. 10, No. 2
Citing URL: http://www.sciencewatch.com/march-april99/sw_march-april99_page2.htm

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