Superstars of
Biomedicine, 1990-97
Last fall Science Watch surveyed "high-impact"
biomedical research in the 1990s and presented rankings of top institutions and scientists
based on a select group of 1,381 high-impact papers (cited 300 times or more) published
between 1990 and 1996 (see Science Watch, 8[5]:1-2, September/October 1997).... 
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HHMI's
Graeme Bell on the Genetics of Diabetes
It is estimated that one to two percent
of the world population has diabetes mellitus, a condition defined as an elevated level of
glucose in the blood. Although high blood sugar alone infrequently produces symptoms, over
time the high levels of glucose cause damage to blood vessels and nerves, leading to heart
disease, kidney failure, and blindness.
Diabetes is not one disease, but several. In each type of diabetes a
different pathophysiology leads to the high glucose. In the most common form, non-insulin
dependent diabetes mellitus (NIDDM), individuals often produce an adequate amount of
insulin–the hormone that directs glucose metabolism–but their
tissues are less responsive to...
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