The baseline time span for this database is (publication years)
1999-February 28, 2009 from the first bimonthly update (a 10-year + 2-month
period). The resulting database contained 3,228 (10 years) and 1,731 (2
years) papers. To construct the top 20 papers lists for the past decade and
the past two years, the papers were further narrowed down by the title
keywords "autophag*." This adjustment resulted in the top 20 papers being
selected from a pool of 1,266 (10 years) and 770 (2 years) papers.
***Article 1 Special
Topics Interview with Noboru Mizushima Special
Topics Interview with Yoshinori Ohsumi Special Topics
Interview with Eiki Kominami
Total Cites: 757
Article Title: LC3, a mammalian homologue of yeast Apg8p, is localized in
autophagosome membranes after processing
Authors: Kabeya, Y,
Mizushima,
N, Uero, T, Yamamoto, A, Kirisako, T, Noda, T,
Kominami,
E,
Ohsumi,
Y, Yoshimori, T
Journal: EMBO JOURNAL
Volume: 19
Page: 5720-5728
Year: 2000
Addresses:
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· JST, PRESTO, Kawaguchi, Japan
· JUNTENDO UNIV, Sch Med, Dept Biochem, Tokyo, Japan
· KANSAI MED UNIV, Dept Physiol, Moriguchi, Japan
· GRAD UNIV ADV STUDIES, Sch Life Sci, Dept Mol Biomech, Hayama,
Japan
· Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Japan
***Article 2 Science
Watch Newsletter Interview with Dan Klionsky
Total Cites: 608
Article Title: Cell biology - Autophagy as a regulated pathway of cellular
degradation
Authors:
Klionsky,
DJ, Emr, SD
Journal: SCIENCE
Volume: 290
Page: 1717-1721
Year: 2000
Addresses:
· UNIV MICHIGAN, Dept Biol, North Univ 830, Ann Arbor, MI, USA
· UNIV CALIF SAN DIEGO, Sch Med, Div Cellular & Mol Med, San
Diego, CA, USA
· HOWARD HUGHES MED INST, San Diego, CA, USA
· Univ Michigan, Dept Biol, North Univ 830, Nat Sci Bldg, Ann Arbor,
MI, USA
***Article 3
Total Cites: 482
Article Title: Induction of autophagy and inhibition of tumorigenesis by
beclin 1
Authors: Liang, XH, Jackson, S, Seaman, M, Brown, K, Kempkes, B, Hibshoosh,
H, Levine, B
Journal: NATURE
Volume: 402
Page: 672-676
Year: 1999
Addresses:
· COLUMBIA UNIV, Dept Med, New York, NY, USA
· COLUMBIA UNIV, Dept Pathol, New York, NY, USA
· ADDENBROOKES HOSP, Cambridge Inst Med Res, Dept Clin Biochem,
Cambridge, England
· GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT, Natl Res Ctr
Environm & Hlth, Inst Clin Mol Biol, Munich, Germany
· Columbia Univ Coll Phys & Surg, Dept Med, 630 W 168th St, New
York, NY, USA
***Article 4
Total Cites: 390
Article Title: Autophagy in health and disease: A double-edged sword
Authors: Shintani, T,
Klionsky,
DJ
Journal: SCIENCE
Volume: 306
Page: 990-995
Year: 2004
Addresses:
· UNIV MICHIGAN, Inst Life Sci, Ann Arbor, MI, USA
· UNIV MICHIGAN, Dept Mol Cellular & Dev Biol, Ann Arbor, MI,
USA
· UNIV MICHIGAN, Dept Biol Chem, Ann Arbor, MI, USA
· Univ Michigan, Inst Life Sci, Ann Arbor, MI, USA
***Article 5
Total Cites: 367
Article Title: Suppression of basal autophagy in neural cells causes
neurodegenerative disease in mice
Authors: Hara, T, Nakamura, K, Matsui, M, Yamamoto, A, Nakahara, Y,
Suzuki-migishima, R, Yokoyama, M, Mishima, K, Saito, I, Okano, H,
Mizushima,
N
Journal: NATURE
Volume: 441
Page: 885-889
Year: 2006
Addresses:
· TOKYO METROPOLITAN INST MED SCI, Dept Bioregulat & Metab,
Tokyo, Japan
· MITSUBISHI KAGAKU INST LIFE SCI, Mouse Genome Technol Lab, Tokyo,
Japan
· GRAD UNIV ADV STUDIES, Sch Life Sci, Dept Basic Biol, Okazaki,
Japan
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· Nagahama Inst Biosci & Technol, Dept Biosci, Nagahama,
Japan
· NIIGATA UNIV, Brain Res Inst, Niigata, Japan
· TSURUMI UNIV, Sch Dent Med, Dept Pathol, Yokohama, Japan
· KEIO UNIV, Sch Med, Dept Physiol, Tokyo, Japan
· JST, PRESTO, Kawaguchi, Japan
· JST, SORST, Kawaguchi, Japan
· Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab,
Tokyo, Japan
***Article 6 Special
Topics Interview with Isei Tanida Special Topics
Interview with Eiki Kominami
Total Cites: 362
Article Title: Loss of autophagy in the central nervous system causes
neurodegeneration in mice
Authors: Komatsu, M, Waguri, S, Chiba, T, Murata, S, Iwata, J,
Tanida,
I, Ueno, T, Koike, M, Uchiyama, Y,
Kominami,
E, Tanaka, K
Journal: NATURE
Volume: 441
Page: 880-884
Year: 2006
Addresses:
· TOKYO METROPOLITAN INST MED SCI, Lab Frontier Sci, Bunkyo Ku,
Tokyo, Japan
· JUNTENDO UNIV, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo,
Japan
· OSAKA UNIV, Grad Sch Med, Dept Cell Biol & Neurosci, Suita,
Japan
· Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku,
Tokyo, Japan
***Article 7
Total Cites: 351
Article Title: Regulation of an ATG7-beclin 1 program of autophagic cell
death by caspase-8
Authors: Yu, L, Alva, A, Su, H, Dutt, P, Freundt, E, Welsh, S, Baehrecke,
EH, Lenardo, MJ
Journal: SCIENCE
Volume: 304
Page: 1500-1502
Year: 2004
Addresses:
· NIAID, Immunol Lab, NIH, Bethesda, MD, USA
· UNIV MARYLAND, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD,
USA
· UNIV OXFORD, Weatherall Inst Mol Med, Oxford, England
***Article 8 Special
Topics Interview with David Rubinsztein
Total Cites: 348
Article Title: Inhibition of mTOR induces autophagy and reduces toxicity of
polyglutamine expansions in fly and mouse models of Huntington
disease
Authors: Ravikumar, B, Vacher, C, Berger, Z, Davies, JE, Luo, SQ, Oroz, LG,
Scaravilli, F, Easton, DF, Duden, R, Okane, CJ,
Rubinsztein,
DC
Journal: NATURE GENETICS
Volume: 36
Page: 585-595
Year: 2004
Addresses:
· ADDENBROOKES HOSP, Cambridge Inst Med Res, Dept Med Genet,
Cambridge, England
· UNIV CAMBRIDGE, Dept Genet, Cambridge, England
· UCL, Inst Neurol, Div Neuropathol, London, England
· UNIV CAMBRIDGE, Dept Publ Hlth, Genet Epidemiol Unit, Canc Res UK,
Cambridge, England
· ADDENBROOKES HOSP, Cambridge Inst Med Res, Dept Clin Biochem,
Cambridge, England
· Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet,
Wellcome MRC Bldg,Hills Rd, Cambridge, England
***Article 9
Total Cites: 341
Article Title: Dissection of autophagosome formation using Apg5-deficient
mouse embryonic stem cells
Authors:
Mizushima,
N, Yamamoto, A, Hatano, M, Kobayashi, Y, Kabeya, Y, Suzuki, K,
Tokuhisa, T,
Ohsumi,
Y, Yoshimori, T
Journal: JOURNAL OF CELL BIOLOGY
Volume: 152
Page: 657-667
Year: 2001
Addresses:
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· JST, PRESTO, Unit Proc & Combined Circuit, Kawaguchi,
Japan
· KANSAI MED UNIV, Dept Physiol, Moriguchi, Japan
· CHIBA UNIV, Grad Sch Med, Dept Dev Genet, Chiba, Japan
· GRAD UNIV ADV STUDIES, Sch Life Sci, Dept Mol Biomech, Okazaki,
Japan
· Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Japan
***Article 10
Total Cites: 327
Article Title: The role of autophagy during the early neonatal starvation
period
Authors: Kuma, A, Hatano, M, Matsui, M, Yamamoto, A, Nakaya, H, Yoshimori,
T, Ohsumi,
Y, Tokuhisa, T,
Mizushima,
N
Journal: NATURE
Volume: 432
Page: 1032-1036
Year: 2004
Addresses:
· JST, PRESTO, Times Arrow & Biosignaling, Kawaguchi,
Japan
· CHIBA UNIV, Dept Dev Genet H2, Chiba, Japan
· CHIBA UNIV, Grad Sch Med, Dept Pharmacol F2, Chiba, Japan
· CHIBA UNIV, Biomed Res Ctr, Chiba, Japan
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· GRAD UNIV ADV STUDIES, Sch Life Sci, Dept Mol Biomech, Okazaki,
Japan
· TOKYO METROPOLITAN INST MED SCI, Dept Bioregulat & Metab,
Tokyo, Japan
· Nagahama Inst Biosci & Technol, Dept Biosci, Nagahama,
Japan
· NATL INST GENET, Dept Cell Genet, Mishima, Japan
· Japan Sci & Technol Agcy, PRESTO, Times Arrow &
Biosignaling, Kawaguchi, Japan
***Article 11
Total Cites: 324
Article Title: Role of Bcl-2 family proteins in a non-apoptotic programmed
cell death dependent on autophagy genes
Authors: Shimizu, S, Kanaseki, T,
Mizushima,
N, Mizuta, T, Arakawa-kobayashi, S, Thompson, CB, Tsujimoto,
Y
Journal: NATURE CELL BIOLOGY
Volume: 6
Page: 1221-1228
Year: 2004
Addresses:
· OSAKA UNIV, Sch Med, Dept Post Genom & Dis, Suita, Japan
· JST, CREST, Suita, Japan
· JST, SORST, Suita, Japan
· JST, Natl Inst Bas Biol, Dept Cell Biol, Okazaki, Japan
· JST, PRESTO, Okazaki, Japan
· TOKYO METROPOLITAN INST MED SCI, Dept Bioregulat & Metab,
Tokyo, Japan
· UNIV PENN, Abramson Family Canc Res Inst, Dept Med, Philadelphia,
PA, USA
· UNIV PENN, Abramson Family Canc Res Inst, Dept Canc Biol,
Philadelphia, PA, USA
· Osaka Univ, Sch Med, Dept Post Genom & Dis, 2-2 Yamadaoka,
Suita, Japan
***Article 12
Total Cites: 321
Article Title: In vivo analysis of autophagy in response to nutrient
starvation using transgenic mice expressing a fluorescent autophagosome
marker
Authors:
Mizushima,
N, Yamamoto, A, Matsui, M, Yoshimori, T,
Ohsumi,
Y
Journal: MOLECULAR BIOLOGY OF THE CELL
Volume: 15
Page: 1101-1111
Year: 2004
Addresses:
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· JST, Times Arrow & Biosignaling, Kawaguchi, Japan
· JST, Unit Proc & Combined Circuit, Kawaguchi, Japan
· JST, CREST, Kawaguchi, Japan
· Nagaham Inst Biosci & Technol, Dept Biosci, Shiga, Japan
· GRAD UNIV ADV STUDIES, Sch Life Sci, Dept Mol Biomech, Okazaki,
Japan
· NATL INST GENET, Dept Cell Genet, Mishima, Japan
· Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Japan
***Article 13
Total Cites: 320
Article Title: Molecular dissection of autophagy: Two ubiquitin-like
systems
Authors:
Ohsumi,
Y
Journal: NAT REV MOL CELL BIO
Volume: 2
Page: 211-216
Year: 2001
Addresses:
· NATL INST BASIC BIOL, Dept Cell Biol, Okazaki, Japan
· Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Japan
***Article 14
Total Cites: 297
Article Title: Autophagy as a cell death and tumor suppressor
mechanism
Authors: Gozuacik, D, Kimchi, A
Journal: ONCOGENE
Volume: 23
Page: 2891-2906
Year: 2004
Addresses:
· WEIZMANN INST SCI, Dept Mol Genet, Rehovot, Israel
· Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel
***Article 15
Total Cites: 293
Article Title: Growth factor regulation of autophagy and cell survival in
the absence of apoptosis
Authors: Lum, JJ, Bauer, DE, Kong, M, Harris, MH, Li, C, Lindsten, T,
Thompson, CB
Journal: CELL
Volume: 120
Page: 237-248
Year: 2005
Addresses:
· UNIV PENN, Sch Med, Abramson Family Canc Res Inst, Dept Canc Biol,
Philadelphia, PA, USA
· UNIV PENN, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA,
USA
· Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Canc Biol,
Philadelphia, PA, USA
***Article 16
Total Cites: 291
Article Title: Autophagy in cell death: an innocent convict?
Authors: Levine, B, Yuan, JY
Journal: JOURNAL OF CLINICAL INVESTIGATION
Volume: 115
Page: 2679-2688
Year: 2005
Addresses:
· UT SOUTHWESTERN MED CTR, SW Med Ctr, Dept Internal Med, Dallas,
TX, USA
· UT SOUTHWESTERN MED CTR, SW Med Ctr, Dept Microbiol, Dallas, TX,
USA
· HARVARD UNIV, Sch Med, Dept Cell Biol, Boston, MA, USA
· Univ Texas, SW Med Ctr, Div Infect Dis, 5323 Harry Hines Blvd,
Dallas, TX, USA
***Article 17
Total Cites: 276
Article Title: Autophagy genes are essential for dauer development and
life-span extension in C-elegans
Authors: Melendez, A, Talloczy, Z, Seaman, M, Eskelinen, EL, Hall, DH,
Levine, B
Journal: SCIENCE
Volume: 301
Page: 1387-1391
Year: 2003
Addresses:
· COLUMBIA UNIV, Dept Med, New York, NY, USA
· ADDENBROOKES HOSP, Cambridge Inst Med Res, Dept Clin Biochem,
Cambridge, England
· UNIV KIEL, Inst Biochem, Kiel, Germany
· YESHIVA UNIV, Ctr C Elegans Anat, Bronx, NY, USA
· Columbia Univ Coll Phys & Surg, Dept Med, 630 W 168th St, New
York, NY, USA
***Article 18
Total Cites: 273
Article Title: Beclin 1, an autophagy gene essential for early embryonic
development, is a haploinsufficient tumor suppressor
Authors: Yue, ZY, Jin, SK, Yang, CW, Levine, AJ, Heintz, N
Journal: P NATL ACAD SCI USA
Volume: 100
Page: 15077-15082
Year: 2003
Addresses:
· ROCKEFELLER UNIV, Howard Hughes Med Inst, Mol Biol Lab, New York,
NY, USA
· ROCKEFELLER UNIV, Gene Targeting Facil, New York, NY, USA
· UNIV MED & DENT NEW JERSEY, Robert Wood Johnson Med Sch, Dept
Pharmacol, Piscataway, NJ, USA
· UNIV MED & DENT NEW JERSEY, Robert Wood Johnson Med Sch, Dept
Pediat, New Brunswick, NJ, USA
· Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, 1230 York
Ave, New York, NY, USA
***Article 19
Total Cites: 258
Article Title: Autophagy is a defense mechanism inhibiting BCG and
Mycobacterium tuberculosis survival in infected macrophages
Authors: Gutierrez, MG, Master, SS, Singh, SB, Taylor, GA, Colombo, MI,
Deretic, V
Journal: CELL
Volume: 119
Page: 753-766
Year: 2004
Addresses:
· UNIV NACL CUYO, CONICET, Fac Ciencias Med, Inst Histol &
Embriol, Mendoza, Argentina
· UNIV NEW MEXICO, Sch Med, Dept Mol Genet & Microbiol,
Albuquerque, NM, USA
· DUKE UNIV, Ctr Med, Dept Med, Durham, NC, USA
· DUKE UNIV, Ctr Med, Dept Immunol, Durham, NC, USA
· UNIV NEW MEXICO, Sch Med, Dept Cell Biol & Physiol,
Albuquerque, NM, USA
· Univ Nacl Cuyo, CONICET, Fac Ciencias Med, Inst Histol &
Embriol, Mendoza, Argentina
***Article 20
Total Cites: 251
Article Title: The autophagosomal-lysosomal compartment in programmed cell
death
Authors: Bursch, W
Journal: CELL DEATH DIFFER
Volume: 8
Page: 569-581
Year: 2001
Addresses:
· UNIV VIENNA, Inst Krebsforsch, Vienna, Austria
· Univ Vienna, Inst Krebsforsch, Borschkegasse 8A, Vienna, Austria