Special Topic: Glioblastoma> 2-Year Papers
Published September 2011
10-Year Papers | 2-Year Papers
Clinical trials for therapies again abound here. Radiotherapy with concomitant and adjuvant temozolomide still appears to be achieving good results in patients. Other combinations being studied include cedirinab, bevacizumab alone or in combination with irinotecan, radiotherapy with concomitant and adjuvant erlotinab plus temozolomide, and erlotinab alone compared with temozolomide or carmustine.
There are multiple studies examining the potential role and implications of mutations in IDH1. Other research themes include the search for molecular predictors of survival or for therapeutic targets. The importance of examining the tumor's microenvironment is also discussed.
2-year Paper List:
***Article 1
Total Cites: 249
Article Title: Effects of radiotherapy with concomitant and adjuvant
temozolomide versus radiotherapy alone on survival in glioblastoma in a
randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Authors: Stupp, R, Hegi, ME, Mason, WP, van den Bent, MJ, Taphoorn, MJB,
Janzer, RC, Ludwin, SK, Allgeier, A, Fisher, B, Belanger, K, Hau, P,
Brandes, AA, Gijtenbeek, J, Marosi, C, Vecht, CJ, Mokhtari, K, Wesseling,
P, Villa, S, Eisenhauer, E, Gorlia, T, Weller, M, Lacombe, D, Cairncross,
JG, Mirimanoff, RO, European Org Res & Treatment, Canc Brain Tumour
Grp, Radiat Oncol Grp, Natl Canc Inst Canada Clin Trials
Journal: LANCET ONCOLOGY
Volume: 10
Page: 459-466
Year: 2009
Addresses:
· CHU Vaudois, Lausanne, Switzerland
· Univ Toronto, Princess Margaret Hosp, Toronto, Canada
· Erasmus Ctr, Daniel de Hoed Canc Ctr, Rotterdam, Netherlands
· Univ Med Ctr, Utrecht, Netherlands
· Queens Univ, Kingston, Canada
· EORTC DATA CTR, Brussels, Belgium
· Univ Western Ontario, London, Canada
· Ctr Hosp Univ, Hop Notre Dame, Montreal, Canada
· Univ Neurol Clin, Regensburg, Germany
· Azienda Osped Univ, Padua, Italy
· Radboud Univ Nijmegen, Nijmegen, Netherlands
· Med Univ Vienna, Vienna, Austria
· HOP LA PITIE SALPETRIERE, INSERM, UMR711, Paris, France
· Hop Paris, Paris, France
· Hosp Duran & Reynals, Inst Catala Oncol, Barcelona,
Spain
· Natl Canc Inst Canada, Clin Trials Grp, Kingston, Canada
· Univ Tubingen, Sch Med, Tubingen, Germany
· Univ Calgary, Calgary, Canada
· CHU Vaudois, Rue Bugnon 46, Lausanne, Switzerland
***Article 2
Special Topics
Interview with Henry S. Friedman
Total Cites: 195
Article Title: Bevacizumab Alone and in Combination With Irinotecan in
Recurrent Glioblastoma
Authors: Friedman,
HS, Prados, MD, Wen, PY, Mikkelsen, T, Schiff, D, Abrey, LE, Yung, WKA,
Paleologos, N, Nicholas, MK, Jensen, R, Vredenburgh, J, Huang, J, Zheng,
MX, Cloughesy, T
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 27
Page: 4733-4740
Year: 2009
Addresses:
· Duke Univ, Brain Tumor Ctr, Durham, NC, USA
· Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA,
USA
· Genentech Inc, San Francisco, CA, USA
· Univ Calif Los Angeles, Dept Neurol, Los Angeles Sch Med, Los
Angeles, CA, USA
· Brigham & Womens Hosp, Dept Neurol, Boston, MA, USA
· Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA, USA
· Henry Ford Hosp, Hermelin Brain Tumor Ctr, Detroit, MI, USA
· Univ Virginia, Dept Neurol, Charlottesville, VA, USA
· Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY, USA
· Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX,
USA
· Evanston NW Healthcare, Div Neurol, Evanston, IL, USA
· Univ Chicago, Dept Neurol, Chicago, IL, USA
· UNIV UTAH, Salt Lake City, UT, USA
· Duke Univ, Med Ctr, 047 Baker House,Trent Dr,DUMC Box 3624,
Durham, NC, USA
***Article 3
Total Cites: 157
Article Title: Phase II Trial of Single-Agent Bevacizumab Followed by
Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent
Glioblastoma
Authors: Kreisl, TN, Kim, L, Moore, K, Duic, P, Royce, C, Stroud, I,
Garren, N, Mackey, M, Butman, JA, Camphausen, K, Park, J, Albert, PS, Fine,
HA
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 27
Page: 740-745
Year: 2009
Addresses:
· NIH, Dept Radiol, Ctr Clin, Bethesda, MD, USA
· NCI, Neurooncol Branch, Radiat Oncol Branch, Bethesda, MD,
USA
· NCI, Biometr Branch, Bethesda, MD, USA
· NINDS, Surg Neurol Branch, Bethesda, MD, USA
· NIH, Dept Radiol, Ctr Clin, 9030 Old Georgetown Rd,Bloch Bldg
82,Room 235,MSC, Bethesda, MD, USA
***Article 4
Total Cites: 131
Article Title: Integrated Genomic Analysis Identifies Clinically Relevant
Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1,
EGFR, and NF1
Authors: Verhaak, RGW, Hoadley, KA, Purdom, E, Wang, V, Qi, Y, Wilkerson,
MD, Miller, CR, Ding, L, Golub, T, Mesirov, JP, Alexe, G, Lawrence, M,
Okelly, M, Tamayo, P, Weir, BA, Gabriel, S, Winckler, W, Gupta, S, Jakkula,
L, Feiler, HS, Hodgson, JG, James, CD, Sarkaria, JN, Brennan, C, Kahn, A,
Spellman, PT, Wilson, RK, Speed, TP, Gray, JW, Meyerson, M, Getz, G, Perou,
CM, Hayes, DN, Canc Genome Atlas Res Network
Journal: CANCER CELL
Volume: 17
Page: 98-110
Year: 2010
Addresses:
· Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC,
USA
· MIT, Eli & Edythe L Broad Inst, Cambridge, MA, USA
· Harvard Univ, Cambridge, MA, USA
· Dana Farber Canc Inst, Dept Med Oncol, Boston, MA, USA
· Univ N Carolina, Dept Genet, Chapel Hill, NC, USA
· Univ N Carolina, Div Med Oncol, Dept Internal Med, Chapel Hill,
NC, USA
· Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC,
USA
· Univ Calif Berkeley, Dept Stat, Berkeley, CA, USA
· Univ Calif Berkeley, Grp Biostat, Berkeley, CA, USA
· WASHINGTON UNIV, Sch Med, Dept Genet, Genome Ctr, St Louis, MO,
USA
· Dana Farber Canc Inst, Ctr Canc Genome Discovery, Dept Pediat
Oncol, Boston, MA, USA
· Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci,
Berkeley, CA, USA
· Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA,
USA
· MAYO CLIN & MAYO FDN, Dept Radiat Oncol, Rochester, MN,
USA
· Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY,
USA
· SRI Int, Fairfax, VA, USA
· Walter & Eliza Hall Inst Med Res, Parkville, Australia
***Article 5
Total Cites: 64
Article Title: Mutational analysis of IDH1 codon 132 in glioblastomas and
other common cancers
Authors: Kang, MR, Kim, MS, Oh, JE, Kim, YR, Song, SY, Seo, SI, Lee, JY,
Yon, NJ, Lee, SH
Journal: INTERNATIONAL JOURNAL OF CANCER
Volume: 125
Page: 353-355
Year: 2009
Addresses:
· Catholic Univ Korea, Dept Pathol, Coll Med, Seoul, South
Korea
· Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul,
South Korea
· Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul,
South Korea
· Catholic Univ Korea, Dept Urol, Coll Med, Seoul, South Korea
· Catholic Univ Korea, Dept Pathol, Coll Med, 505 Banpo Dong, Seoul,
South Korea
***Article 6
Total Cites: 63
Article Title: IDH1 mutations are present in the majority of common adult
gliomas but rare in primary glioblastomas
Authors: Ichimura, K, Pearson, DM, Kocialkowski, S, Backlund, LM, Chan, R,
Jones, DTW, Collins, VP
Journal: NEURO-ONCOLOGY
Volume: 11
Page: 341-347
Year: 2009
Addresses:
· Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Div Mol
Histopathol, Cambridge, England
· Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol,
Stockholm, Sweden
***Article 7
Total Cites: 63
Article Title: Phase II Study of Erlotinib Plus Temozolomide During and
After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma
Multiforme or Gliosarcoma
Authors: Prados, MD, Chang, SM, Butowski, N, Deboer, R, Parvataneni, R,
Carliner, H, Kabuubi, P, Ayers-ringler, J, Rabbitt, J, Page, M, Fedoroff,
A, Sneed, PK, Berger, MS, Mcdermott, MW, Parsa, AT, Vandenberg, S, James,
CD, Lamborn, KR, Stokoe, D, Haas-kogan, DA
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 27
Page: 579-584
Year: 2009
Addresses:
· Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA,
USA
· Univ Calif San Francisco, Ctr Comprehens Canc, 400 Parnassus
Ave,Rm A808, San Francisco, CA, USA
***Article 8
Total Cites: 58
Article Title: Randomized Phase II Trial of Erlotinib Versus Temozolomide
or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study
26034
Authors: van den Bent, MJ, Brandes, AA, Rampling, R, Kouwenhoven, MCM,
Kros, JM, Carpentier, AF, Clement, PM, Frenay, M, Campone, M, Baurain, JF,
Armand, JP, Taphoorn, MJB, Tosoni, A, Kletzl, H, Klughammer, B, Lacombe, D,
Gorlia, T
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 27
Page: 1268-1274
Year: 2009
Addresses:
· Dr Daniel Den Hoed Canc Ctr, Neurooncol Unit, Rotterdam,
Netherlands
· Med Ctr Haaglanden, The Hague, Netherlands
· Bellaria Maggiore Hosp, Dept Med Oncol, Bologna, Italy
· WESTERN INFIRM & ASSOCIATED HOSP, Beatson Oncol Ctr, Glasgow,
Scotland
· Hop La Pitie Salpetriere, Paris, France
· Ctr Antoine Lacassagne, Nice, France
· Ctr Rene Gauducheau, Nantes, France
· Inst Gustave Roussy, Villejuif, France
· Univ Hosp Gasthuisberg, Louvain, Belgium
· Clin Univ St Luc, Brussels, Belgium
· EORTC DATA CTR, Ctr Data, Brussels, Belgium
· HOFFMANN LA ROCHE INC, Basel, Switzerland
· Dr Daniel Den Hoed Canc Ctr, Neurooncol Unit, POB 5201, Rotterdam,
Netherlands
***Article 9
Total Cites: 56
Article Title: SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in
Human Glioblastoma
Authors: Son, MJ, Woolard, K, Nam, DH, Lee, J, Fine, HA
Journal: Cell Stem Cell
Volume: 4
Page: 440-452
Year: 2009
Addresses:
· NCI, Neurooncol Branch, NINDS, NIH, Bethesda, MD, USA
· Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg,
Seoul, South Korea
***Article 10
Special Topics
Interview with Michael Weller
Total Cites: 49
Article Title: Molecular Predictors of Progression-Free and Overall
Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective
Translational Study of the German Glioma Network
Authors: Weller,
M, Felsberg, J, Hartmann, C, Berger, H, Steinbach, JP, Schramm, J,
Westphal, M, Schackert, G, Simon, M, Tonn, JC, Heese, O, Krex, D, Nikkhah,
G, Pietsch, T, Wiestler, O, Reifenberger, G, von Deimling, A, Loeffler,
M
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 27
Page: 5743-5750
Year: 2009
Addresses:
· UNIV ZURICH, Dept Neurol, Zurich, Switzerland
· Univ Bonn, Dept Neurosurg, Bonn, Germany
· Univ Bonn, Inst Neuropathol, Bonn, Germany
· Univ Tubingen, Dept Gen Neurol, Tubingen, Germany
· Univ Dusseldorf, Inst Neuropathol, Dusseldorf, Germany
· Univ Heidelberg, Inst Pathol, Dept Neuropathol, Heidelberg,
Germany
· German Canc Res Ctr, Clin Cooperat Unit Neuropathol, Heidelberg,
Germany
· Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig,
Germany
· Goethe Univ Frankfurt, Dr Senckenberg Inst Neurooncol, Frankfurt,
Germany
· Univ Hamburg, Dept Neurosurg, Hamburg, Germany
· Tech Univ Dresden, Dept Neurosurg, Dresden, Germany
· Univ Munich, Dept Neurosurg, Munich, Germany
· Univ Freiburg, Dept Stereotact Neurosurg, Freiburg, Germany
· Univ Zurich Hosp, Dept Neurol, Frauenklin Str 26, Zurich,
Switzerland
***Article 11
Total Cites: 48
Article Title: A "Vascular Normalization Index" as Potential Mechanistic
Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent
Glioblastoma Patients
Authors: Sorensen, AG, Batchelor, TT, Zhang, WT, Chen, PJ, Yeo, P, Wang,
MY, Jennings, D, Wen, PY, Lahdenranta, J, Ancukiewicz, M, di Tomaso, E,
Duda, DG, Jain, RK
Journal: CANCER RESEARCH
Volume: 69
Page: 5296-5300
Year: 2009
Addresses:
· Massachusetts Gen Hosp, EL Steele Lab, AA Martinos Ctr Biomed
Imaging, Boston, MA, USA
· Massachusetts Gen Hosp, Pappas Ctr Neurooncol, Boston, MA,
USA
· Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA, USA
· Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA, USA
· Massachusetts Gen Hosp, EL Steele Lab, AA Martinos Ctr Biomed
Imaging, 100 Blossom St,Cox 734, Boston, MA, USA
***Article 12
Total Cites: 44
Article Title: Bead-based profiling of tyrosine kinase phosphorylation
identifies SRC as a potential target for glioblastoma therapy
Authors: Du, JY, Bernasconi, P, Clauser, KR, Mani, DR, Finn, SP, Beroukhim,
R, Burns, M, Julian, B, Peng, XP, Hieronymus, H, Maglathlin, RL, Lewis, TA,
Liau, LM, Nghiemphu, P, Mellinghoff, IK, Louis, DN, Loda, M, Carr, SA,
Kung, AL, Golub, TR
Journal: NATURE BIOTECHNOLOGY
Volume: 27
Page: 77-83
Year: 2009
Addresses:
· Harvard Univ, Broad Inst, Cambridge, MA, USA
· MIT, Cambridge, MA, USA
· Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA, USA
· Dana Farber Canc Inst, Dept Med Oncol, Boston, MA, USA
· Harvard Univ, Sch Med, Boston, MA, USA
· Howard Hughes Med Inst, Chevy Chase, MD, USA
· Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los
Angeles, CA, USA
· Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los
Angeles, CA, USA
· Mem Sloan Kettering Canc Ctr, Dept Neurol, Human Oncol &
Pathogenesis Program, New York, NY, USA
· Massachusetts Gen Hosp, Mol Pathol Unit, Boston, MA, USA
· Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA, USA
· Harvard Univ, Sch Med, Boston, MA, USA
· Harvard Univ, Broad Inst, 7 Cambridge Ctr, Cambridge, MA, USA
***Article 13
Total Cites: 44
Article Title: SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes
Stop of Proliferation and Loss of Tumorigenicity
Authors: Gangemi, RMR, Griffero, F, Marubbi, D, Perera, M, Capra, MC,
Malatesta, P, Ravetti, GL, Zona, GL, Daga, A, Corte, G
Journal: STEM CELLS
Volume: 27
Page: 40-48
Year: 2009
Addresses:
· Ist Nazl Ric Canc, Genoa, Italy
· Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa,
Italy
· Univ Genoa, Osped San Martino Genova, Anat Patol Osped, Genoa,
Italy
· Univ Genoa, Dipartimento Neurosci Oftalmol & Genet, Genoa,
Italy
· Ist Nazl Ric Canc, Largo R Benzi 10, Genoa, Italy
***Article 14
Total Cites: 43
Article Title: TGF-beta Increases Glioma-Initiating Cell Self-Renewal
through the Induction of LIF in Human Glioblastoma
Authors: Penuelas, S, Anido, J, Prieto-sanchez, RM, Folch, G, Barba, I,
Cuartas, I, Garcia-dorado, D, Poca, MA, Sahuquillo, J, Baselga, J, Seoane,
J
Journal: CANCER CELL
Volume: 15
Page: 315-327
Year: 2009
Addresses:
· HOSP GEN VALLE HEBRON, Res Inst, Med Oncol Program, Barcelona,
Spain
· HOSP GEN VALLE HEBRON, Res Inst, Cardiovasc Program, Barcelona,
Spain
· HOSP GEN VALLE HEBRON, Res Inst, Neurosurg Program, Barcelona,
Spain
· Vall DHebron Inst Oncol, Barcelona, Spain
· UNIV AUTONOMA BARCELONA, Barcelona, Spain
· ICREA, Barcelona, Spain
· Vall DHebron Univ Hosp, Res Inst, Med Oncol Program, Barcelona,
Spain
***Article 15
Total Cites: 42
Article Title: Glioblastoma Subclasses Can Be Defined by Activity among
Signal Transduction Pathways and Associated Genomic Alterations
Authors: Brennan, C, Momota, H, Hambardzumyan, D, Ozawa, T, Tandon, A,
Pedraza, A, Holland, E
Journal: PLoS One
Volume: 4
Page:
Year: 2009
Addresses:
· Mem Sloan Kettering Canc Ctr, Dept Neurosurg, 1275 York Ave, New
York, NY, USA
***Article 16
Total Cites: 42
Article Title: IDH1 Mutations as Molecular Signature and Predictive Factor
of Secondary Glioblastomas
Authors: Nobusawa, S, Watanabe, T, Kleihues, P, Ohgaki, H
Journal: CLINICAL CANCER RESEARCH
Volume: 15
Page: 6002-6007
Year: 2009
Addresses:
· IARC, Mol Pathol Sect, Lyon, France
· UNIV ZURICH, Dept Pathol, Zurich, Switzerland
· IARC, Mol Pathol Sect, 150 Cours Albert Thomas, Lyon, France
***Article 17
Special Topic
Interview with: Roger E. McLendon
Total Cites: 41
Article Title: The hypoxic microenvironment maintains glioblastoma stem
cells and promotes reprogramming towards a cancer stem cell phenotype
Authors: Heddleston, JM, Li, ZZ,
Mclendon, RE,
Hjelmeland, AB, Rich, JN
Journal: CELL CYCLE
Volume: 8
Page: 3274-3284
Year: 2009
Addresses:
· CLEVELAND CLIN FDN, Dept Stem Cell Biol & Regenerat Med,
Cleveland, OH, USA
· Duke Univ, Med Ctr, Dept Pathol, Durham, NC, USA
· Cleveland Clin, Dept Stem Cell Biol & Regenerat Med,
Cleveland, OH, USA
***Article 18
Total Cites: 39
Article Title: MicroRNA-34a Inhibits Glioblastoma Growth by Targeting
Multiple Oncogenes
Authors: Li, YQ, Guessous, F, Zhang, Y, Dipierro, C, Kefas, B, Johnson, E,
Marcinkiewicz, L, Jiang, JM, Yang, YZ, Schmittgen, TD, Lopes, B, Schiff, D,
Purow, B, Abounader, R
Journal: CANCER RESEARCH
Volume: 69
Page: 7569-7576
Year: 2009
Addresses:
· Univ Virginia, Dept Microbiol, Charlottesville, VA, USA
· Univ Virginia, Dept Neurol, Charlottesville, VA, USA
· Univ Virginia, Dept Pathol, Charlottesville, VA, USA
· Ohio State Univ, Coll Pharm, Columbus, OH, USA
· Univ Virginia, Dept Microbiol, POB 800168, Charlottesville, VA,
USA
***Article 19
Total Cites: 38
Article Title: Phase II Study of Cediranib, an Oral Pan-Vascular
Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients
With Recurrent Glioblastoma
Authors: Batchelor, TT, Duda, DG, di Tomaso, E, Ancukiewicz, M, Plotkin,
SR, Gerstner, E, Eichler, AF, Drappatz, J, Hochberg, FH, Benner, T, Louis,
DN, Cohen, KS, Chea, H, Exarhopoulos, A, Loeffler, JS, Moses, MA, Ivy, P,
Sorensen, AG, Wen, PY, Jain, RK
Journal: JOURNAL OF CLINICAL ONCOLOGY
Volume: 28
Page: 2817-2823
Year: 2010
Addresses:
· Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas
Ctr Neurooncol, Boston, MA, USA
· Massachusetts Gen Hosp, Dept Neurol, Boston, MA, USA
· Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA, USA
· Massachusetts Gen Hosp, Ctr Regenerat Med, Dept Pathol, Boston,
MA, USA
· Brigham & Womens Hosp, Dept Neurol, Boston, MA, USA
· Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA, USA
· Harvard Univ, Childrens Hosp, Sch Med, Vasc Biol Program, Boston,
MA, USA
· MIT, AA Martinos Ctr Biomed Imaging, Div Hlth Sci & Technol,
Charlestown, MA, USA
· Massachusetts Gen Hosp, Charlestown, MA, USA
· NCI, Canc Therapy Evaluat Program, Bethesda, MD, USA
· Massachusetts Gen Hosp, Ctr Canc, Stephen E & Catherine Pappas
Ctr Neurooncol, Yawkey 9E,55 Fruit St, Boston, MA, USA
***Article 20
Total Cites: 37
Article Title: A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in
Glioblastoma
Authors: Chen, RH, Nishimura, MC, Bumbaca, SM, Kharbanda, S, Forrest, WF,
Kasman, IM, Greve, JM, Soriano, RH, Gilmour, LL, Rivers, CS, Modrusan, Z,
Nacu, S, Guerrero, S, Edgar, KA, Wallin, JJ, Lamszus, K, Westphal, M, Heim,
S, James, CD, Vandenberg, SR, Costello, JF, Moorefield, S, Cowdrey, CJ,
Prados, M, Phillips, HS
Journal: CANCER CELL
Volume: 17
Page: 362-375
Year: 2010
Addresses:
· Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco,
CA, USA
· Genentech Inc, Dept Biostat, San Francisco, CA, USA
· Genentech Inc, Dept Mol Biol, San Francisco, CA, USA
· Genentech Inc, Dept Immunol, San Francisco, CA, USA
· Genentech Inc, Dept Bioinformat, San Francisco, CA, USA
· Genentech Inc, Dept Canc Signaling, San Francisco, CA, USA
· UNIV HAMBURG, Hamburg, Germany
· Definiens AG, Munich, Germany
· Univ Calif San Francisco, Brain Tumor Res Ctr, San Francisco, CA,
USA
About the 2-year Paper List:
The baseline time span for this database is January 1, 2001-July 17, 2011.
The resulting database contained 11,433 (10 years) and 4,272 (2 years)
papers. To construct the top 20 papers lists for the past decade and
the past two years, the papers were further narrowed down by the title
keywords "glioblastoma*." This adjustment
resulted in the top 20 papers being selected from a pool of 3,347 (10
years) and 1,347 (2 years) papers.
This information pertains to both the 2- and 10-year papers.
General Information
Reviewing highly cited papers can help to determine what research areas within a Special Topic have had a significant impact over a given period of time. Special Topics lists the 20 most-cited papers over the past decade and over the past two years, based on a set of criteria uniquely tailored to each individual Topic. Details of these criteria are given within each Topic.
By examining highly cited papers over both the past decade and over the most recent two-year period, we can make observations and comparisons regarding long-term trends and more recent activity that has the potential to be the next long-term trend.
What are Special Topics?
Special Topics, from ScienceWatch.com, is designed to complement Essential Science IndicatorsSM from Clarivate in providing citation analyses and commentary for selected scientific research areas that have experienced notable recent advances or are of special current interest.
Read about the overall methodology for Special Topics in the "What are Special Topics?" page.
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Image: Gliobastoma WHO grade IV - MRI coronal view, post contrast. 15 year old boy. Wiki Commons.