Francis J. McMahon talks
with ScienceWatch.com and answers a few
questions about this month's New Hot Paper in the field
of Neuroscience & Behavior.
Article Title: A genome-wide association study
implicates diacylglycerol kinase eta (DGKH) and several
other genes in the etiology of bipolar
disorder
Authors: Baum, AE, et al.
Eight genes implicated in our study
that play a role in lithium
(Li+)-sensitive signaling pathways.
Green lines denote enzymatic
transformations or cofactor
activations, red lines confirmed
inhibitory actions, blue lines protein
interactions of unknown nature from Lim
J, et al. (2006), or
hypothetical interactions. All colored
genes contain at least one replicated
SNP based on individual genotyping
(teal) or pooled (yellow) data.
Reference
Lim J, et al., "A
protein-protein interaction network for
human inherited ataxias and disorders
of Purkinje cell degeneration,"
Cell 125:801, 2006
Figure 2:
Figure 2:
Distribution of risk alleles among
cases and controls (a), and
relationship of prevalence ratio
(cases: controls) to total burden of
risk alleles (b). Data from ten
individually genotyped SNPs (rs4411993,
rs7683874, rs10937823, rs942518,
rs11021955, rs10120953, rs1170191,
rs9315885, rs9513877, rs2360111) are
plotted. The "tipping point" is
indicated by the red arrow. Cases are
indicated in red, controls in
green.