"The consensus coding sequences of human breast and colorectal
cancers," by Tobias Sjoblom and 28 others, Science, 314(6797): 268-74, 13 October 2006.
[Authors' affiliations: 11 U.S. institutions]
Abstract: "The elucidation of the human genome sequence
has made it possible to identify genetic alterations in cancers in
unprecedented detail. To begin a systematic analysis of such alterations,
we determined the sequence of well-annotated human protein-coding genes in
two common tumor types. Analysis of 13,023 genes in 11 breast and 11
colorectal cancers revealed that individual tumors accumulate an average of
~ 90 mutant genes but that only a subset of these contribute to the
neoplastic process. Using stringent criteria to delineate this subset, we
identified 189 genes (average of 11 per tumor) that were mutated at
significant frequency. The vast majority of these genes were not known to
be genetically altered in tumors
and are predicted to affect a wide range of cellular functions, including
transcription, adhesion, and invasion. These data define the genetic
landscape of two human cancer types, provide new targets for diagnostic and
therapeutic intervention,
and open fertile avenues for basic research in tumor biology."
This 2006 report in Science was cited 48
times in current journal articles indexed by Clarivate
during January-February 2008. Only two other medicine papers published in
the last two years, aside from reviews, collected higher citation totals
during that two-month period. Prior to the most recent bimonthly count,
citations to the paper have accrued as follows:
SOURCE:
Hot Papers
Database (Included with a subscription to the print newsletter
Science
Watch®, available from the
Research Services
Group of
Thomson
Reuters. Packaged on a CD that is mailed
with each Science Watch issue, the Hot Papers
Database contains data on hundreds of highly cited papers published during
the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as
citations accrued during successive bimonthly periods, can be assessed and
graphed. An updated CD containing the most recent bimonthly data is mailed
with every new issue of Science Watch, six times a
year. The CD also includes an electronic version of the Science
Watch issue in HTML format, for personal desktop
access.