"Induced pluripotent stem cell lines derived from human somatic
cells," by Junying Yu and 11 others, Science, 318(5858):
1917-20, 21 December 2007.
[Authors' affiliations: University of Wisconsin, Madison; WiCell Research
Institute, Madison, WI]
Abstract: "Somatic cell nuclear transfer allows
trans-acting factors present in the mammalian oocyte to reprogram somatic
cell nuclei to an undifferentiated state. We show that four factors
(OCT4, SOX2, NANOG, and LIN28) are
sufficient to reprogram human somatic cells to pluripotent stem cells that
exhibit the essential characteristics of embryonic stem (ES) cells. These
induced pluripotent human stem cells have normal karyotypes, express
telomerase activity, express cell surface markers and genes that
characterize human ES cells, and maintain the developmental potential to
differentiate into advanced derivatives of all three primary germ layers.
Such induced pluripotent human cell lines should be useful in the
production of new disease models and in drug development, as well as for
applications in transplantation medicine, once technical limitations (for
example, mutation through viral integration) are eliminated."
This 2007 report from Science was cited 53
times in current journal articles indexed by Clarivate
during May-June 2008. Of papers indexed in the last two years under the
heading of clinical medicine (excluding reviews), only one report received
a higher citation total during those two months. Prior to the most recently
bimonthly count, citations to Yu et al. have accrued as follows:
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