"Identification and analysis of functional elements in 1% of the
human genome by the ENCODE pilot project," by the ENCODE Project
Consortium (E. Birney, et al.), Nature, 447(7146):
799-815, 14 June 2007.
Abstract: "We report the generation and analysis of
functional data from multiple, diverse experiments performed on a targeted
1% of the human genome as part of the pilot phase of the ENCODE Project.
These data have been further integrated and augmented by a number of
evolutionary and computational analyses. Together, our results advance the
collective knowledge about human genome function in several major areas.
First, our studies provide convincing evidence that the genome is
pervasively transcribed, such that the majority of its bases can be found
in primary transcripts, including non-protein-coding transcripts, and those
that extensively overlap one another. Second, systematic examination of
transcriptional regulation has yielded new understanding about
transcription start sites, including their relationship to specific
regulatory sequences and features of chromatin accessibility and histone
modification. Third, a more sophisticated view of chromatin structure has
emerged, including its inter-relationship with DNA replication and
transcriptional regulation. Finally, integration of these new sources of
information, in particular with respect to mammalian evolution based on
inter- and intra-species sequence comparisons, has yielded new mechanistic
and evolutionary insights concerning the functional landscape of the human
genome. Together, these studies are defining a path for pursuit of a more
comprehensive characterization of human genome function."
This 2007 report from Nature was cited 55
times in current journal articles indexed by Clarivate
during March-April 2009. During that two-month period, only two other
biology papers published in the last two years, aside from reviews,
collected higher citation totals. Prior to the most recent bimonthly count,
citations to the paper have accrued as follows:
SOURCE:
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