Sci-Bytes> Hot Paper in Biology
Week of August 14, 2011
"Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C," by Yasuhito Tanaka and 28 others, Nature Genetics, 41(10): 1105-9, October 2009.
[Authors' affiliations: 17 Japanese institutions]
Abstract: The recommended treatment for patients with
chronic hepatitis C, pegylated interferon-alpha (PEG-IFN-a) plus ribavirin
(RBV), does not provide sustained virologic response (SVR) in all patients.
We report a genome-wide association study (GWAS) to null virological
response (NVR) in the treatment of patients with hepatitis C virus (HCV)
genotype 1 within a Japanese population. We found two SNPs near the gene
IL28B on chromosome 19 to be strongly associated with NVR
(rs12980275, P = 1.93 x 10(-13), and rs8099917, 3.11 x 10(-15)). We
replicated these associations in an independent cohort (combined P values,
2.84 x 10(-27) (OR = 17.7; 95% CI = 10.0-31.3) and 2.68 x 10(-32) (OR =
27.1; 95% CI = 14.6-50.3), respectively). Compared to NVR, these SNPs were
also associated with SVR (rs12980275, P = 3.99 x 10(-24), and rs8099917, P
= 1.11 x 10(-27)). In further fine mapping of the region, seven SNPs
(rs8105790, rs11881222, rs8103142, rs28416813, rs4803219, rs8099917 and
rs7248668) located in the IL28B region showed the most significant
associations (P = 5.52 x 10(-28)-2.68 x 10(-32); OR = 22.3-27.1). Real-time
quantitative PCR assays in peripheral blood mononuclear cells showed lower
IL28B expression levels in individuals carrying the minor alleles
(P = 0.015).
This 2009 report from Nature Genetics was cited 57
times in current journal articles indexed by
Clarivate during
March-April 2011. During that two-month period, only one other biology
paper published in the last two years, aside from reviews, garnered a
higher number of citations. The paper has been ensconced roughly halfway
down the list of biology's Top Ten for several successive bimonthly periods
now, but this marks its highest placement to date. Prior to the most recent
tally, citations have accrued as follows:
January-February 2011: 24 citations
November-December 2010: 25
September-October 2010: 27
July-August 2010: 21
May-June 2010: 13
March-April 2010: 7
January-February 2010: 7
November-December 2009: 1
September-October 2009: 2
Total citations to date: 184
SOURCE: Hot Papers Database (Included with a subscription to the print newsletter Science Watch®, available from the Research Services Group of Thomson Reuters. Packaged on a CD that is mailed with each Science Watch issue, the Hot Papers Database contains data on hundreds of highly cited papers published during the last two years. User interface permits searching by author, organization, journal, field, and more. Total citations, as well as citations accrued during successive bimonthly periods, can be assessed and graphed.
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