As part of this bimonthly processing,
ScienceWatch.com selects the Research Fronts with the largest absolute
increase in size in each of the 22 major
fields covered by
Essential Science IndicatorsSM
from Thomson
Reuters. The size of a research front is determined by the number of
core papers it contains. This Research Front on INTERLEUKIN PRODUCING HELPER T CELLS AND
INFLAMMATION from the field of
Clinical Medicine was
selected for mapping from the list of Top Topics for
April 2010 (data
from the sixth bimonthly period of
2009). The map is a diagrammatic
representation of the 47 core papers comprising the front
in
Clinical Medicine.
This front was also
selected as a Fast Moving Front (May
2010) in Clinical Medicine for the same
time period.
Each circle
represents a highly cited paper whose bibliographic information is displayed
when the user clicks on the circle. The lines between circles represent the
strongest co-citation links for each paper (that is, indicating that the papers
are frequently cited together). Papers close to each other on the map are
generally more highly co-cited. The most recent paper(s) are indicated in pink.
Annotations may have been added to this map which represent the main research
themes. These appear as labels attached to specific regions on the maps.
Core Papers
Label: Bettelli-2006 Title: Reciprocal developmental pathways for the generation of pathogenic effector T(H)17 and regulatory T cells Journal: NATURE, 441 (7090): 235-238 MAY 11 2006 Citations: 897 Authors: Bettelli, E;Carrier, YJ;Gao, WD;Korn, T;Strom, TB;Oukka, M;Weiner, HL;Kuchroo, VK Addresses:
Brigham & Womens Hosp, Ctr Neurol Dis, 77 Ave Louis Pasteur, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
Harvard Univ, Sch Med, Beth Israel Hosp, Transplant Res Ctr, Boston, MA 02115 USA
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Cambridge, MA 02139 USA
Label: Harrington-2005 Title: Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Journal: NAT IMMUNOL, 6 (11): 1123-1132 NOV 2005 Citations: 826 Authors: Harrington, LE;Hatton, RD;Mangan, PR;Turner, H;Murphy, TL;Murphy, KM;Weaver, CT Addresses:
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol & Immunol, St Louis, MO 63110 USA
Label: Veldhoen-2006 Title: TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Journal: IMMUNITY, 24 (2): 179-189 FEB 2006 Citations: 816 Authors: Veldhoen, M;Hocking, RJ;Atkins, CJ;Locksley, RM;Stockinger, B Addresses:
Natl Inst Med Res, MRC, Div Mol Immunol, Mill Hill, London NW7 1AA, England
Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England
Univ Calif San Francisco, Natl Inst Med Res, Div Immunoregulat, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Microbiol Immunol, San Francisco, CA 94143 USA
Label: Ivanov-2006 Title: The orphan nuclear receptor ROR gamma t directs the differentiation program of proinflammatory IL-17(+) T helper cells Journal: CELL, 126 (6): 1121-1133 SEP 22 2006 Citations: 577 Authors: Ivanov, II;McKenzie, BS;Zhou, L;Tadokoro, CE;Lepelley, A;Lafaille, JJ;Cua, DJ;Littman, DR Addresses:
NYU, Sch Med, Skirball Inst Biomol Med, Mol Pathogenesis Program, 550 1St Ave, New York, NY 10016 USA
NYU, Sch Med, Skirball Inst Biomol Med, Mol Pathogenesis Program, New York, NY 10016 USA
NYU, Sch Med, Howard Hughes Med Inst, Skirball Inst Biomol Med, New York, NY 10016 USA
Schering Plough BioPharm, DNAX Discovery Res, Palo Alto, CA 94304 USA
Label: Murphy-2003 Title: Divergent pro- and Antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation Journal: J EXP MED, 198 (12): 1951-1957 DEC 15 2003 Citations: 476 Authors: Murphy, CA;Langrish, CL;Chen, Y;Blumenschein, C;McClanahan, T;Kastelein, RA;Sedgwick, JD;Cua, DJ Addresses:
901 Calif Ave, Palo Alto, CA 94304 USA
DNA Res Inc, Discovery Res, Palo Alto, CA 94304 USA
Label: Kolls-2004 Title: Interleukin-17 family members and inflammation Journal: IMMUNITY, 21 (4): 467-476 OCT 2004 Citations: 394 Authors: Kolls, JK;Linden, A Addresses:
Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm, Pittsburgh, PA 15213 USA
Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Pittsburgh, PA 15260 USA
Sahlgrenska Acad, Inst Internal Med, Dept Allergol & Resp Med, S-41345 Gothenburg, Sweden
Univ Gothenburg, S-41345 Gothenburg, Sweden
Label: Liang-2006 Title: Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides Journal: J EXP MED, 203 (10): 2271-2279 OCT 2 2006 Citations: 299 Authors: Liang, SC;Tan, XY;Luxenberg, DP;Karim, R;Dunussi-Joannopoulos, K;Collins, M;Fouser, LA Addresses:
Wyeth Res, Inflammat, Cambridge, MA 02140 USA
Wyeth Res, Inflammat, Cambridge, MA 02140 USA
Wyeth Res, Antibody Technol Grp, Cambridge, MA 02140 USA
Label: Zheng-2007 Title: Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Journal: NATURE, 445 (7128): 648-651 FEB 8 2007 Citations: 292 Authors: Zheng, Y;Danilenko, DM;Valdez, P;Kasman, I;Eastham-Anderson, J;Wu, JF;Ouyang, WJ Addresses:
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
Label: Zhou-2007 Title: IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Journal: NAT IMMUNOL, 8 (9): 967-974 SEP 2007 Citations: 287 Authors: Zhou, LA;Ivanov, II;Spolski, R;Min, R;Shenderov, K;Egawa, T;Levy, DE;Leonard, WJ;Littman, DR Addresses:
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NHLBI, Lab Mol Immunol, Bethesda, MD 20892 USA
NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
Label: Acosta-Rodriguez-2007 Title: Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells Journal: NAT IMMUNOL, 8 (9): 942-949 SEP 2007 Citations: 274 Authors: Acosta-Rodriguez, EV;Napolitani, G;Lanzavecchia, A;Sallusto, F Addresses:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Inst Res Biomed, CH-6500 Bellinzona, Switzerland
Label: Rogers-2005 Title: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins Journal: IMMUNITY, 22 (4): 507-517 APR 2005 Citations: 235 Authors: Rogers, NC;Slack, EC;Edwards, AD;Nolte, MA;Schulz, O;Schweighoffer, E;Williams, DL;Gordon, S;Tybulewicz, VL;Brown, GD;Sousa, CRE Addresses:
Canc Res UK, London Res Inst, Immunobiol Lab, 44 Lincolns Inn Fields, London WC2A 3PX, England
Canc Res UK, London Res Inst, Immunobiol Lab, London WC2A 3PX, England
Natl Inst Med Res, London NW7 1AA, England
E Tennessee State Univ, James H Quillen Coll Med, Dept Surg, Johnson City, TN 37614 USA
Univ Oxford, Sir William Dunn Sch Psychol, Oxford OX1 3RE, England
Label: Batten-2006 Title: Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells Journal: NAT IMMUNOL, 7 (9): 929-936 SEP 2006 Citations: 206 Authors: Batten, M;Li, J;Yi, S;Kljavin, NM;Danilenko, DM;Lucas, S;Lee, J;de Sauvage, FJ;Ghilardi, N Addresses:
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
Catholic Univ Louvain, Christian Duve Inst Cellular Pathol, B-3000 Louvain, Belgium
Label: Stumhofer-2006 Title: Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system Journal: NAT IMMUNOL, 7 (9): 937-945 SEP 2006 Citations: 202 Authors: Stumhofer, JS;Laurence, A;Wilson, EH;Huang, E;Tato, CM;Johnson, LM;Villarino, AV;Huang, QL;Yoshimura, A;Sehy, D;Saris, CJM;O'Shea, JJ;Hennighausen, L;Ernst, M;Hunter, CA Addresses:
Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA
eBiosci, New Technol Dept, San Diego, CA 92121 USA
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Fukuoka 8128582, Japan
Amgen Corp, Dept Inflammat Res, Newbury Pk, CA 91320 USA
NIDDKD, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA
Ludwig Inst Canc Res, Melbourne, Vic 3050, Australia
Label: LeibundGut-Landmann-2007 Title: Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 Journal: NAT IMMUNOL, 8 (6): 630-638 JUN 2007 Citations: 190 Authors: LeibundGut-Landmann, S;Gross, O;Robinson, MJ;Osorio, F;Slack, EC;Tsoni, SV;Schweighoffer, E;Tybulewicz, V;Brown, GD;Ruland, J;Sousa, CRE Addresses:
London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
London Res Inst, Canc Res UK, Lincolns Inn Fields Labs, Immunobiol Lab, London WC2A 3PX, England
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany
Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa
Natl Inst Med Res, London NW7 1AA, England
Label: Ouyang-2008 Title: The biological functions of T helper 17 cell effector cytokines in inflammation Journal: IMMUNITY, 28 (4): 454-467 APR 2008 Citations: 177 Authors: Ouyang, WJ;Kolls, JK;Zheng, Y Addresses:
Genentech Inc, Dept Immunol, 1 DNA Way, San Francisco, CA 94080 USA
Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm Med Allergy & Immunol, Pittsburgh, PA 15213 USA
Pfizer Global Res & Dev, St Louis Labs, Inflammat Pathways Grp, Chesterfield, MO 63017 USA
Label: Zhou-2008 Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing ROR gamma t function Journal: NATURE, 453 (7192): 236-U14 MAY 8 2008 Citations: 163 Authors: Zhou, L;Lopes, JE;Chong, MMW;Ivanov, II;Min, R;Victora, GD;Shen, YL;Du, JG;Rubtsov, YP;Rudensky, AY;Ziegler, SF;Littman, DR Addresses:
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, Howard Hughes Med Inst, New York, NY 10016 USA
Benaroya Res Inst, Program Immunol, Seattle, WA 98101 USA
Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA
Univ Washington, Dept Immunol, Howard Hughes Med Inst, Seattle, WA 98195 USA
Label: Manel-2008 Title: The differentiation of human T-H-17 cells requires transforming growth factor-beta and induction of the nuclear receptor ROR gamma t Journal: NAT IMMUNOL, 9 (6): 641-649 JUN 2008 Citations: 145 Authors: Manel, N;Unutmaz, D;Littman, DR Addresses:
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
Label: Saijo-2007 Title: Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans Journal: NAT IMMUNOL, 8 (1): 39-46 JAN 2007 Citations: 132 Authors: Saijo, S;Fujikado, N;Furuta, T;Chung, SH;Kotaki, H;Seki, K;Sudo, K;Akira, S;Adachi, Y;Ohno, N;Kinjo, T;Nakamura, K;Kawakami, K;Iwakura, Y Addresses:
Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, Tokyo 1088639, Japan
Univ Tokyo, Inst Med Sci, Dept Immunol & Microbiol, Minato Ku, Tokyo 1088639, Japan
Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan
Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Immunopharmacol Microbial Prod, Hachioji, Tokyo 1920392, Japan
Univ Ryukyus, Fac Med, Dept Med & Therapeut Control & Prevent Infect Dis, Okinawa 9030215, Japan
Tohoku Univ, Sch Hlth Sci, Dept Med Technol, Aoba Ku, Sendai, Miyagi 98088575, Japan
Label: Underhill-2005 Title: Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production Journal: BLOOD, 106 (7): 2543-2550 OCT 1 2005 Citations: 102 Authors: Underhill, DM;Rossnagle, E;Lowell, CA;Simmons, RM Addresses:
Inst Syst Biol, 1441 N 34th St, Seattle, WA 98103 USA
Inst Syst Biol, Seattle, WA 98103 USA
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
Label: Ichiyama-2008 Title: Foxp3 inhibits ROR gamma t-mediated IL-17A mRNA transcription through direct interaction with ROR gamma t Journal: J BIOL CHEM, 283 (25): 17003-17008 JUN 20 2008 Citations: 39 Authors: Ichiyama, K;Yoshida, H;Wakabayashi, Y;Chinen, T;Saeki, K;Nakaya, M;Takaesu, G;Hori, S;Yoshimura, A;Kobayashi, T Addresses:
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan
Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, Fukuoka 8128582, Japan
Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan
RIKEN Res Ctr Allergy & Immunol, Res Unit Immune Homeostasis, Tsurumi Ku, Kanagawa 2300045, Japan
KEYWORDS: HUMAN INTERLEUKIN 17-PRODUCING T HELPER MEMORY CELLS; HUMAN INTERLEUKIN 17-PRODUCING HELPER T CELLS; INTERLEUKIN 17-PRODUCING HUMAN T HELPER CELLS; INTERLEUKIN 17-PRODUCING T HELPER CELLS; INTERLEUKIN 17-PRODUCING CD4(+) EFFECTOR T CELLS DEVELOP.
[FRONT NUMBER: 6190 (2003-2009_6) (cli/imm: TT, APR 2010) (cli: fmf may
2010)]