 NIA’s Mark P. Mattson on Neuronal Degeneration
The death of the neuron is the ultimate act of pathology in a litany of devastating brain disorders from
Alzheimer’s and Huntington’s disease to Parkinson’s and stroke. Each of these conditions has its own trigger for neuronal degeneration—whether oxygen starvation,
amyloid-beta peptide aggregation, or genetic malfunction—but the biochemical cascades and signaling mechanisms that succumb on the route from cell dysfunction to cell death may be common to all. As a result, unraveling the genetic, cellular, and biochemical factors involved in the life and death of brain neurons has turned out to be one of the hottest research areas in
neuroscience.
To stay at the forefront of this research requires an ability to work across an array of experimental disease models and to effortlessly make the transition from cell cultures to animals and from animals to humans. This adaptability is one reason why the name of neuroscientist Mark P. Mattson, of the National Institute on Aging (NIA) in Baltimore, Maryland, is now perched comfortably atop the
ISI Essential Science Indicators
Web product rankings of hot researchers in neuroscience & behavior over the last decade. Mattson has published upwards of 250 neuroscience papers...
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 Twenty
Years of Citation Superstars
 cience Watch presents here the true citation elite of the last two decades. The table on the next page, ranks the 50 most-cited researchers of the last 20 years, based on papers published and cited in Thomson ISI-indexed journals between 1983 and 2002.
The table on this page lists the five most-cited papers published during the same period. The
rankings are based on data from the Thomson ISI Web of
Science.
Topping the list of scientists, with
more than 100,000 citations to his published research since
1983, is Bert Vogelstein of the Howard Hughes Medical
Institute, Johns Hopkins University Oncology Center,
Baltimore...
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