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The Hottest Research of 2006-07
by Christopher King

The Science Watch® Newsletter once again takes its annual look back at the hottest of recent research. The first table below lists the researchers who, during 2007, fielded the highest numbers of Hot Papers published over the last two years. The second table highlights the papers published during 2007 (aside from reviews) that were most cited by the end of the year.

Shizuo Akira
Shizuo Akira

For this latest annual roundup, Science Watch slightly changed the selection procedure for hot authors. Previously, selection was based on reports tallied in a single bimonthly Hot Papers file late in the year. This time, however, Science Watch made a special extraction to enumerate all occurrences of unique Hot Papers through the first ten months of 2007.

Of this year’s crop of scientists, the top-most are familiar names. A trio of high-energy physicists—Mikhail Kopytine, Basanta K. Nandi, and Thomas Peitzmann—return from last year’s roundup, again by virtue of their participation in not one but two large, multiauthor experimental collaborations: PHENIX and STAR at Brookhaven National Laboratory. For the three scientists, their contributions to research published over the last two years resulted in a dozen Hot Papers recorded during 2007. (The names on each tier of the table, incidentally, are listed alphabetically.)

Just below the physicists is another return appearance by an even more familiar name, who has become something of a fixture on this annual list of hot authors: Osaka University’s Shizuo Akira, who earns the distinction for a fourth year in a row, thanks to 11 Hot Papers on pathogen recognition and other aspects of the immune response.

Space scientist John A. Nousek of Penn State also contributed to 11 hot reports, on X-ray emissions and other phenomena related to gamma-ray bursts. High-impact astrophysics accounted for another place in the table, for Jon Brinkmann of the Apache Point Observatory, New Mexico, with his participation on 10 Hot Papers. Most of these are reports from the Sloan Digital Sky Survey mission; one such paper can currently be found at #6 in the latest Physics Top Ten.

The next author on the list, cancer geneticist Carlo M. Croce of Ohio State University, is interviewed in this issue and discusses his research on microRNA, the subject of his 10 Hot Papers over the last two years. In a similar vein, Howard Hughes Medical Institute investigator Todd R. Golub fielded 10 Hot Papers on gene expression in cancer.

The 10 hot reports featuring Columbia University’s Jeffrey A. Lieberman center on schizophrenia and its treatment; Lieberman discussed his highly cited research in a recent interview (Science Watch, 18[5]: 3-4, September/October 2007). And Harvard epidemiologist JoAnn Manson also contributed to 10 Hot Papers, on topics that include hormone-replacement therapy and women’s health, risk factors for diabetes, and diet supplementation in the prevention of cardiovascular disease and cancer.

Of 2007’s non-review papers, none approached the late-year citation total of a June Astrophysical Journal Supplement Series report from the Wilkinson Microwave Anisotropy Probe mission. This paper currently crowns the Physics Top Ten and is discussed in this issue by correspondent Simon Mitton.

Continuing its performance of recent years, the New England Journal of Medicine registered strongly in the year-end listing of papers, fielding 3 of the top 5 papers, and 15 overall. Science and Nature each scored with 6. Together, the three journals accounted for more than 60% of 2007’s hottest papers.End

Christopher King is the Editor of the Science Watch® Newsletter.

Table 1   |  Top

Scientists with Multiple Hot Papers

     Name      Institution      Field No. of Hot Papers
Mikhail Kopytine Kent State University Physics 12
Basanta K. Nandi Indian Inst. Technol., Bombay Physics 12
Thomas Peitzmann Utrecht University Physics 12
Shizuo Akira [see also | see also | see also] Osaka University Immunology 11
John A. Nousek Pennsylvania State University Space Science 11
Jonathan Brinkmann Apache Point Observatory Space Science 10
Carlo M. Croce Ohio State University Cancer Genetics 10
Todd R. Golub HHMI, Broad Institute Cancer Genetics 10
Jeffrey A. Lieberman Columbia University Psychiatry 10
JoAnn Manson Harvard University Epidemiology 10
Source: Thomson Scientific Hot Papers Database.
Table 2   |  Top

The Red-Hot Research Papers of 2007




1 D.N. Spergel, et al., " Three-year Wilkinson Microwave Anistropy Probe (WMAP) observations: Implications for cosmology," Astrophys. J. Suppl. Ser., 170(2): 377-408, June 2007. 204
2 R.J. Motzer, et al., "Sunitinib versus interferon alfa in metastatic renal-cell carcinoma," New Engl. J. Med., 356(2): 115-24, 11 January 2007. 118
3 B. Escudier, et al., "Sorafenib in advanced clear-cell renal-cell carcinoma," New Engl. J. Med., 356(2): 125-34, 11 January 2007. 106
4 S.E. Nissen, K. Wolski, "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes," New Engl. J. Med., 356(24): 2457-71, 14 June 2007. 101
5 R. Sladek, et al., "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, 445(7130): 881-5, 22 February 2007. 92
6 G.W. Stone, et al., "Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents," New Engl. J. Med., 356(10): 998-1008, 8 March 2007. 68
7 E.L. Eisenstein, et al., "Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation," JAMA, 297(2): 159-68, 10 January 2007. 66
8 L.J. Scott, et al., "A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants," Science, 316(5829): 1341-5, 1 June 2007. 57
9 C. Kimchi-Sarfaty, et al., "A ‘silent’ polymorphism in the MDR1 gene changes substrate specificity," Science, 315(5811): 525-8, 26 January 2007. 57
10 B. Lagerqvist, et al., "Long-term outcomes with drug-eluting stents versus bare-metal stents in Sweden," New Engl. J. Med., 356(10): 1009-19, 8 March 2007. 54
11 P.M.A. Calverley, et al., "Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease," New Engl. J. Med., 356(8): 775-89, 22 February 2007. 53
12 A. Kastrati, et al., "Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents," New Engl. J. Med., 356(10): 1030-9, 8 March 2007. 52
13 W.E. Boden, et al., "Optimal medical therapy with or without PCI for stable coronary disease," New Engl. J. Med., 356(15): 1503-16, 12 April 2007. 50
14 J. Hampe, et al., "A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1," Nature Genetics, 39(2): 207-11, February 2007. 50
15 E. Zeggini, et al., "Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes," Science, 316(5829): 1336-41, 1 June 2007. 49
16 J. Daemen, et al., "Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: Data from a large two-institutional cohort study," Lancet, 369(9562): 667-78, 24 February 2007. 49
17 FUTURE II Study Group (L.L. Villa, et al.), "Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions," New Engl. J. Med., 356(19): 1915-27, 10 May 2007. 47
18 ENCODE Project Consortium (E. Birney, et al.), "Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project," Nature, 447(7146): 799-816, 14 June 2007. 47
19 L. Mauri, et al., "Stent thrombosis in randomized clinical trials of drug-eluting stents," New Engl. J. Med., 356(10): 1020-9, 8 March 2007. 46
20 M. Obeid, et al., "Calreticulin exposure dictates the immunogenicity of cancer cell death," Nature Medicine, 13(1): 54-61, January 2007. 46
21 S.N. Willis, et al., "Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak," Science, 315(5813): 856-9, 9 February 2007. 45
22 W.A. High, et al., "Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis," J. Am. Acad. Dermatol., 56(1): 21-6, January 2007. 44
23 R.C. Bailey, et al., "Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial," Lancet, 369(9562): 643-56, 24 February 2007. 43
24 T.M. Frayling, et al., "A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity," Science, 316(5826): 889-94, 11 May 2007. 42
25 S.E. Nissen, et al., "Effect of torcetrapib on the progression of coronary atherosclerosis," New Engl. J. Med., 356(13): 1304-16, 29 March 2007. 42
26 C. Greenman, et al., "Patterns of somatic mutation in human cancer genomes," Nature, 446(7132): 153-8, 8 March 2007. 42
27 C. Spaulding, et al., "A pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents," New Engl. J. Med., 356(10): 989-97, 8 March 2007. 42
28 R.H. Gray, et al., "Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial," Lancet, 369(9562): 657-66, 24 February 2007. 41
29 A. Phrommintikul, et al., "Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis," Lancet, 369(9559): 381-8, 3 February 2007. 41
30 C.W. Li, et al., "Identification of pancreatic cancer stem cells," Cancer Res., 67(3): 1030-7, 1 February 2007. 41
31 L.M. Scott, et al., "JAK2 exon 12 mutations in polysythemia vera and idiopathic erythrocytosis," New Engl. J. Med., 356(5): 459-68, 1 February 2007. 41
32 D.R. Broome, et al., "Gadodiamide-associated nephrogenic systemic fibrosis: Why radiologists should be concerned," Am. J. Roentgenol., 188(2): 586-92, February 2007. 41
33 A.S. Boyd, et al., "Gadolinium deposition in nephrogenic fibrosing dermopathy," J. Am. Acad. Dermatol., 56(1): 27-30, January 2007. 41
34 K.K. Wong, et al., "A comprehensive analysis of common copy-number variations in the human genome," Am. J. Human Genetics, 80(1): 91-104, January 2007. 40
35 W. Xue, et al., "Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas," Nature, 445(7128): 656-60, 8 February 2007. 39
36 D. Dudziak, et al., "Differential antigen processing by dendritic cell subsets in vivo," Science, 315(5808): 107-11, 5 January 2007. 39
37 L. Page, et al., "Three-year Wilkinson Microwave Anisotropy Probe (WMAP) observations: Polarization analysis," Astrophys. J. Suppl. Ser., 170(2): 335-76, June 2007. 37
38 J.D. Rioux, et al., "Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis," Nature Genetics, 39(5): 596-604, May 2007. 36
39 P.D. Home, et al., "Rosiglitazone evaluated for cardiovascular outcomes: an interim analysis," New Engl. J. Med., 357(1): 28-38, 5 July 2007. 35
40 Y. Zheng, et al., "Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis," Nature, 445(7128): 648-51, 8 February 2007. 35
41 J.E. Green, et al., "A 160-kilobit molecular electronic memory patterned at 10(11) bits per square centimetre," Nature, 445(7126): 414-7, 25 January 2007. 35
42 R. Liu, et al., "The prognostic role of a gene signature from tumorigenic breast-cancer cells," New Engl. J. Med., 356(3): 217-26, 18 January 2007. 35
SOURCE: Thomson Scientific Web of Science®
(Citations recorded as of late December 2007)


Analyses : Featured Analyses : The Hottest Research of 2006-07
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