Archive ScienceWatch

 ScienceWatch

As part of this bimonthly processing, ScienceWatch.com selects the Research Fronts with the largest absolute increase in size in each of the 22 major fields covered by Essential Science IndicatorsSM from Thomson Reuters. The size of a research front is determined by the number of core papers it contains. This Research Front on METASTATIC COLORECTAL CANCER from the field of Clinical Medicine was selected for mapping from the list of Top Topics for June 2008 (data from the first bimonthly period of 2008). The map is a diagrammatic representation of the 26 core papers comprising the front Clinical Medicine.

Each circle represents a highly cited paper whose bibliographic information is displayed when the user clicks on the circle. The lines between circles represent the strongest co-citation links for each paper (that is, indicating that the papers are frequently cited together). Papers close to each other on the map are generally more highly co-cited. The most recent paper(s) are indicated in pink. Prewett-2002 Kabbinavar-2003 Rothenberg-2003 Goldberg-2004 Tournigand-2004 Willett-2004 Saltz-2004 Grothey-2004 Hurwitz-2004 Cunningham-2004 Scartozzi-2004 Chung-2005 Moroni-2005 Hurwitz-2005 Kabbinavar-2005 Kabbinavar-2005 Colucci-2005 Kohne-2005 Folprecht-2006 Lievre-2006 Lenz-2006 Benvenuti-2007 Giantonio-2007 DiFiore-2007 VanCutsem-2007 Khambata-Ford-2007

METASTATIC COLORECTAL CANCER 

 


 Core Papers 

Label: Hurwitz-2004
Title: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
Journal: N ENGL J MED, 350 (23): 2335-2342 JUN 3 2004
Citations: 1442
Authors: Hurwitz, H;Fehrenbacher, L;Novotny, W;Cartwright, T;Hainsworth, J;Heim, W;Berlin, J;Baron, A;Griffing, S;Holmgren, E;Ferrara, N;Fyfe, G;Rogers, B;Ross, R;Kabbinavar, F
Addresses:
Duke Univ, Med Ctr, Dept Med Oncol & Transplantat, Rm 3802,Red Zone,Duke S Clin,Box 3052, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med Oncol & Transplantat, Durham, NC 27710 USA
Kaiser Permanente, Vallejo, CA USA
Genentech Inc, San Francisco, CA 94080 USA
Ocala Oncol, Ocala, FL USA
Sarah Cannon Canc Ctr, Nashville, TN USA
Hematol & Oncol Associates NE Penn, Scranton, PA USA
Vanderbilt Univ, Nashville, TN USA
Calif Pacific Med Ctr, San Francisco, CA USA
Univ Calif Los Angeles, Los Angeles, CA USA


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Label: Cunningham-2004
Title: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
Journal: N ENGL J MED, 351 (4): 337-345 JUL 22 2004
Citations: 792
Authors: Cunningham, D;Humblet, Y;Siena, S;Khayat, D;Bleiberg, H;Santoro, A;Bets, D;Mueser, M;Harstrick, A;Verslype, C;Chau, I;Van Cutsem, E
Addresses:
Royal Marsden Hosp, Dept Med, Downs Rd, Sutton SM2 5PT, Surrey, England
Royal Marsden Hosp, Dept Med, Sutton SM2 5PT, Surrey, England
Royal Marsden Hosp, London SW3 6JJ, England
Univ Catholique Louvain, St Luc Univ Hosp, B-1200 Brussels, Belgium
Osped Niguarda Ca Granda, Milan, Italy
Hop La Pitie Salpetriere, Paris, France
Inst Jules Bordet, B-1000 Brussels, Belgium
Ist Clin Humanitas, Rozzano Milano, Italy
Merck, Amsterdam, Netherlands
E Merck AG, D-6100 Darmstadt, Germany
Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium


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Label: Goldberg-2004
Title: A Randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
Journal: J CLIN ONCOL, 22 (1): 23-30 JAN 1 2004
Citations: 489
Authors: Goldberg, RM;Sargent, DJ;Morton, RF;Fuchs, CS;Ramanathan, RK;Williamson, SK;Findlay, BP;Pitot, HC;Alberts, SR
Addresses:
Univ N Carolina, Div Hematol Oncol, N Cent Canc Treatment Grp, CB 7305,3009 Old Clin Bldg, Chapel Hill, NC 27599 USA
Univ N Carolina, Div Hematol Oncol, N Cent Canc Treatment Grp, Chapel Hill, NC 27599 USA
Univ N Carolina, Div Med Oncol, Chapel Hill, NC USA
Mayo Clin, Div Biostat, N Cent Canc Treatment Grp, Rochester, MN USA
Iowa Oncol Res Assoc, Community Clin Oncol Program, N Cent Canc Treatment Grp, Des Moines, IA USA
Dana Farber Canc Inst, Dept Oncol, Canc & Acute Leukemia Grp B, Boston, MA 02115 USA
Univ Pittsburgh, Inst Canc, Div Med Oncol, Eastern Cooperat Oncol Grp, Pittsburgh, PA USA
Univ Kansas, Med Ctr, Div Hematol & Oncol, SW Oncol Grp, Kansas City, KS 66103 USA
Natl Canc Inst Canada, St Catharines, ON, Canada


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Label: Kabbinavar-2003
Title: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU) leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
Journal: J CLIN ONCOL, 21 (1): 60-65 JAN 1 2003
Citations: 478
Authors: Kabbinavar, F;Hurwitz, HI;Fehrenbacher, L;Meropol, NJ;Novotny, WF;Lieberman, G;Griffing, S;Bergsland, E
Addresses:
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, 10945 Le Conte Ave,Ste 2338J, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USA
Kaiser Permanente, Hematol Oncol Clin, Vallejo, CA USA
Genentech Inc, San Francisco, CA 94080 USA
Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USA
Duke Univ, Div Hematol & Oncol, Durham, NC USA
Fox Chase Canc Ctr, Div Med Sci, Philadelphia, PA 19111 USA
Fox Chase Canc Ctr, Dept Populat Sci, Philadelphia, PA 19111 USA


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Label: Saltz-2004
Title: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
Journal: J CLIN ONCOL, 22 (7): 1201-1208 APR 1 2004
Citations: 438
Authors: Saltz, LB;Meropol, NJ;Loehrer, PJ;Needle, MN;Kopit, J;Mayer, RJ
Addresses:
Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol Serv, Dept Med, 1275 York Ave, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol Serv, Dept Med, New York, NY 10021 USA
Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA 19111 USA
Indiana Univ, Ctr Canc, Indianapolis, IN USA
Walther Canc Inst, Indianapolis, IN USA
Imclone Syst Inc, Somerville, NJ USA
Bristol Myers Squibb Inc, Wallingford, CT USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA


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Label: Tournigand-2004
Title: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
Journal: J CLIN ONCOL, 22 (2): 229-237 JAN 15 2004
Citations: 438
Authors: Tournigand, C;Andre, T;Achille, E;Lledo, G;Flesh, M;Mery-Mignard, D;Quinaux, E;Couteau, C;Buyse, M;Ganem, G;Landi, B;Colin, P;Louvet, C;de Gramont, A
Addresses:
Hop St Antoine, 184 Rue Faubourg, F-75571 Paris 12, France
Hop St Antoine, F-75571 Paris 12, France
GERCOR, Paris, France
Hop Tenon, F-75970 Paris, France
Hop Georges Pompidou, Paris, France
Aventis, Paris, France
Int Inst Drug Dev, Paris, France
Clin Orangerie, Strasbourg, France
Clin St Jean, Lyon, France
Clin Drevon, Dijon, France
Ctr Jean Bernard, Le Mans, France
Clin Courlancy, Reims, France
Int Inst Drug Dev, Brussels, Belgium


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Label: Willett-2004
Title: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Journal: NATURE MED, 10 (2): 145-147 FEB 2004
Citations: 409
Authors: Willett, CG;Boucher, Y;di Tomaso, E;Duda, DG;Munn, LL;Tong, RT;Chung, DC;Sahani, DV;Kalva, SP;Kozin, SV;Mino, M;Cohen, KS;Scadden, DT;Hartford, AC;Fischman, AJ;Clark, JW;Ryan, DP;Zhu, AX;Blaszkowsky, LS;Chen, HX;Shellito, PC;Lauwers, GY;Jain, RK
Addresses:
Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
Massachusetts Gen Hosp, AIDS Res Ctr Expt Hematol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Nucl Med, Boston, MA 02114 USA
Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
Harvard Univ, Sch Med, Boston, MA 02114 USA
NCI, Canc Therapy Evaluat Program, Rockville, MD 20852 USA


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Label: Chung-2005
Title: Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
Journal: J CLIN ONCOL, 23 (9): 1803-1810 MAR 20 2005
Citations: 208
Authors: Chung, KY;Shia, J;Kemeny, NE;Shah, M;Schwartz, GK;Tse, A;Hamilton, A;Pan, D;Schrag, D;Schwartz, L;Klimstra, DS;Fridman, D;Kelsen, DP;Saltz, LB
Addresses:
Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol Serv, H-816, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol Serv, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Diagnost Imaging, New York, NY 10021 USA


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Label: Rothenberg-2003
Title: Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial
Journal: J CLIN ONCOL, 21 (11): 2059-2069 JUN 1 2003
Citations: 197
Authors: Rothenberg, ML;Oza, AM;Bigelow, RH;Berlin, JD;Marshall, JL;Ramanathan, RK;Hart, LL;Gupta, S;Garay, CA;Burger, BG;Le Bail, N;Haller, DG
Addresses:
Vanderbilt Ingram Canc Ctr, 777 Preston Res Bldg, Nashville, TN 37232 USA
Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA
Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada
Sanofi Synthelabo Res, Malvern, Worcs, England
Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15260 USA
Univ Penn, Ctr Canc, Philadelphia, PA 19104 USA
Lombardi Canc Ctr, Washington, DC USA
Florida Canc Specialists, Ft Myers, FL USA


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Label: Grothey-2004
Title: Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
Journal: J CLIN ONCOL, 22 (7): 1209-1214 APR 1 2004
Citations: 173
Authors: Grothey, A;Sargent, D;Goldberg, RM;Schmoll, HJ
Addresses:
Mayo Clin, Div Med Oncol, 200 1st St SW, Rochester, MN 55905 USA
Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA
Mayo Clin, Div Biostat, Rochester, MN 55905 USA
Univ N Carolina, Div Oncol, Chapel Hill, NC USA
Univ Halle, Dept Hematol & Oncol, Halle Saale, Germany


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Label: Moroni-2005
Title: Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
Journal: LANCET ONCOL, 6 (5): 279-286 MAY 2005
Citations: 147
Authors: Moroni, M;Veronese, S;Benvenuti, S;Marrapese, G;Sartore-Bianchi, A;Di Nicolantonio, F;Gambacorta, M;Siena, S;Bardelli, A
Addresses:
Osped Niguarda CaGranda, Falck Div Med Oncol, Piazza Opsed Maggiore 3, I-20162 Milan, Italy
Osped Niguarda CaGranda, Falck Div Med Oncol, I-20162 Milan, Italy
Osped Niguarda CaGranda, Serv Anat Patol, I-20162 Milan, Italy
Univ Turin, Oncogenomics Ctr, Inst Canc Res & Treatment, IRCC,Med Sch, Candiolo, Italy
Inst Mol Oncol, FIRC, IFOM, Milan, Italy


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Label: Prewett-2002
Title: Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
Journal: CLIN CANCER RES, 8 (5): 994-1003 MAY 2002
Citations: 145
Authors: Prewett, MC;Hooper, AT;Bassi, R;Ellis, LM;Waksal, HW;Hicklin, DJ
Addresses:
ImClone Syst Inc, Dept Immunol, 180 Varick St, New York, NY 10014 USA
ImClone Syst Inc, Dept Immunol, New York, NY 10014 USA
Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA


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Label: Kabbinavar-2005
Title: Addition of bevacizurnab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
Journal: J CLIN ONCOL, 23 (16): 3697-3705 JUN 1 2005
Citations: 135
Authors: Kabbinavar, FF;Schulz, J;McCleod, M;Patel, T;Hamm, JT;Hecht, JR;Mass, R;Perrou, B;Nelson, B;Novotny, WF
Addresses:
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, 10945 LeConte Ave,Suite 2338J, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USA
Genentech Inc, San Francisco, CA 94080 USA
Virginia Oncol Associates, Newport News, VA USA
Florida Canc Specialists, Ft Myers, FL USA
Mid Ohio Oncol Hematol Inc, Westerville, OH USA
Louisville Oncol, Louisville, KY USA


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Label: Hurwitz-2005
Title: Bevacizurnab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
Journal: J CLIN ONCOL, 23 (15): 3502-3508 MAY 20 2005
Citations: 108
Authors: Hurwitz, HI;Fehrenbacher, L;Hainsworth, JD;Heim, W;Berlin, J;Holmgren, E;Hambleton, J;Novotny, WF;Kabbinavar, F
Addresses:
Duke Univ, Med Ctr, Dept Med Oncol & Transplantat, Room 25132,Morris Bldg,Box 3052, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Med Oncol & Transplantat, Durham, NC 27710 USA
Genentech Inc, San Francisco, CA 94080 USA
Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
Sarah Cannon Canc Ctr, Nashville, TN USA
Hematol & Canc Ctr NE Penn, Dunmore, PA USA
Vanderbilt Univ, Med Ctr, Div Med Oncol, Nashville, TN USA


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Label: Kabbinavar-2005
Title: Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
Journal: J CLIN ONCOL, 23 (16): 3706-3712 JUN 1 2005
Citations: 87
Authors: Kabbinavar, FF;Hambleton, J;Mass, RD;Hurwitz, HL;Bergsland, E;Sarkar, S
Addresses:
Genentech Inc, Med Affairs, 1 DNA Way, San Francisco, CA 94080 USA
Genentech Inc, Med Affairs, San Francisco, CA 94080 USA
Univ Calif Los Angeles, Los Angeles, CA 90024 USA
Univ Calif San Francisco, San Francisco, CA 94143 USA
Duke Univ, Durham, NC 27706 USA


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Label: Lievre-2006
Title: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
Journal: CANCER RES, 66 (8): 3992-3995 APR 15 2006
Citations: 70
Authors: Lievre, A;Bachet, JB;Le Corre, D;Boige, V;Landi, B;Emile, JF;Cote, JF;Tomasic, G;Penna, C;Ducreux, M;Rougier, P;Penault-Llorca, F;Laurent-Puig, P
Addresses:
Univ Paris Descartes, INSERM, UMR 775, 45 Rue St Peres, F-75006 Paris, France
Univ Paris Descartes, INSERM, UMR 775, F-75006 Paris, France
Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Paris, France
Hop Ambroise Pare, Assistance Publ Hop Paris, Boulogne Billancourt, France
Univ Versailles, F-78000 Versailles, France
Inst Gustave Roussy, Villejuif, France
Ctr Jean Perrin, Clermont Ferrand, France
Univ Auvergne, Clermont Ferrand, France


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Label: Colucci-2005
Title: Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A Multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
Journal: J CLIN ONCOL, 23 (22): 4866-4875 AUG 1 2005
Citations: 63
Authors: Colucci, G;Gebbia, V;Paoletti, G;Giuliani, F;Caruso, M;Gebbia, N;Carteni, G;Agostara, B;Pezzella, G;Manzione, L;Borsellino, N;Misino, A;Romito, S;Durini, E;Cordio, S;Di Seri, M;Lopez, M;Maiello, E
Addresses:
Inst Oncol, Med & Expt Oncol Unit, Via Amendola 209, I-70126 Bari, Italy
Inst Oncol, Med & Expt Oncol Unit, I-70126 Bari, Italy
Univ Palermo, Palermo, Italy
Maddalena Hosp, Palermo, Italy
M Ascoli Hosp, Palermo, Italy
Ist Regina Elena, I-00161 Rome, Italy
Univ Roma La Sapienza, Rome, Italy
S Luigi Hosp, Ctr Oncol, Catania, Italy
Cardarelli Hosp, Naples, Italy
Osped Nord, Taranto, Italy
San Carlo Hosp, Potenza, Italy
Cardarelli Hosp, Campobasso, Italy
G Panico Hosp, Tricase, Italy


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Label: Kohne-2005
Title: Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group study 40986
Journal: J CLIN ONCOL, 23 (22): 4856-4865 AUG 1 2005
Citations: 59
Authors: Kohne, CH;van Cutsem, E;Wils, J;Bokemeyer, C;El-Serafi, M;Lutz, MP;Lorenz, M;Reichardt, P;Ruckle-Lanz, H;Frickhofen, N;Fuchs, R;Mergenthaler, HG;Langenbuch, T;Vanhoefer, U;Rougier, P;Voigtmann, R;Muller, L;Genicot, B;Anak, O;Nordlinger, B
Addresses:
Klinikum Oldenburg, Klin Oncol Hematol, Dr Edenstr 10, D-26133 Oldenburg, Germany
Univ Dresden, Dept Internal Med, Dresden, Germany
Univ Klin Tubingen, Tubingen, Germany
Med Klin, Saarbrucken, Germany
Charite Virchow Klinikum, Berlin, Germany
Univ Wurzburg, Med Poliklin, D-8700 Wurzburg, Germany
Dr Horst Schmidt Kliniken GmbH, Wiesbaden, Germany
St Antonius Hosp, Eschweiler, Germany
Katharinhosp, Stuttgart, Germany
Kreiskrankenhaus, Aurich, Germany
Univ Essen Gesamthsch, Essen, Germany
Marienenhosp Ruhr Univ, Herne, Germany
Onkol Schwerpunkpraxis, Leer, Germany
Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium
European Org Res Treatment Canc, Ctr Data, Brussels, Belgium
Laurentius Ziekenhuis, Roermond, Netherlands
Natl Canc Inst, Cairo, Egypt
Hop Ambroise Pare, Boulogne, France


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Label: Scartozzi-2004
Title: Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: Implications for treatment with EGFR-targeted monoclonal antibodies
Journal: J CLIN ONCOL, 22 (23): 4772-4778 DEC 1 2004
Citations: 57
Authors: Scartozzi, M;Bearzi, I;Berardi, R;Mandolesi, A;Fabris, G;Cascinu, S
Addresses:
Riuniti Univ Politecn Marche, Clin Oncol Med, Azienda Osped Osped, Ist Anat Patol, Via Conca 60-020, Ancona, Italy
Riuniti Univ Politecn Marche, Clin Oncol Med, Azienda Osped Osped, Ist Anat Patol, Ancona, Italy


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Label: Folprecht-2006
Title: Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma
Journal: ANN ONCOL, 17 (3): 450-456 MAR 2006
Citations: 48
Authors: Folprecht, G;Lutz, MP;Schoffski, P;Seufferlein, T;Nolting, A;Pollert, P;Kohne, CH
Addresses:
Klinikum Oldenburg gGmbH, Dept Hematol & Oncol, Dr Eden Str 10, D-26133 Oldenburg, Germany
Klinikum Oldenburg gGmbH, Dept Hematol & Oncol, D-26133 Oldenburg, Germany
Univ Hosp, Dresden, Germany
Univ Hosp, Ulm, Germany
Hannover Med Sch, D-3000 Hannover, Germany
Merck KGaA, Darmstadt, Germany


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Label: Lenz-2006
Title: Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
Journal: J CLIN ONCOL, 24 (30): 4914-4921 OCT 20 2006
Citations: 34
Authors: Lenz, HJ;Van Cutsem, E;Khambata-Ford, S;Mayer, RJ;Gold, P;Stella, P;Mirtsching, B;Cohn, AL;Pippas, AW;Azarnia, N;Tsuchihashi, Z;Mauro, DJ;Rowinsky, EK
Addresses:
Imclone Syst, 33 Imclone Dr, Branchburg, NJ 08876 USA
Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA
Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium
Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA
Dana Farber Partners Canc Care, Boston, MA USA
Swedish Canc Inst, Seattle, WA USA
St Joseph Mercy Hosp, Ann Arbor, MI 48104 USA
Ctr Oncol Res & Treatment, Dallas, TX USA
Rocky Mt Canc Ctr, Denver, CO USA
Lakeland Reg Canc Ctr, Lakeland, FL USA
Imclone Syst Inc, New York, NY USA


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Label: Giantonio-2007
Title: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
Journal: J CLIN ONCOL, 25 (12): 1539-1544 APR 20 2007
Citations: 29
Authors: Giantonio, BJ;Catalano, PJ;Meropol, NJ;O'Dwyer, PJ;Mitchell, EP;Alberts, SR;Schwartz, MA;Benson, AB
Addresses:
12 Penn Tower,3400 Spruce St, Philadelphia, PA 19104 USA
Univ Penn, Philadelphia, PA 19104 USA
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Thomas Jefferson Univ, Philadelphia, PA 19107 USA
Dana Farber Canc Inst, Boston, MA 02115 USA
Mayo Clin, Rochester, MN USA
Mt Sinai Med Ctr, Miami, FL USA
Northwestern Univ, Chicago, IL 60611 USA


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Label: VanCutsem-2007
Title: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
Journal: J CLIN ONCOL, 25 (13): 1658-1664 MAY 1 2007
Citations: 28
Authors: Van Cutsem, E;Peeters, M;Siena, S;Humblet, Y;Hendlisz, A;Neyns, B;Canon, JL;Van Laethem, JL;Maurel, J;Richardson, G;Wolf, M;Amado, RG
Addresses:
Univ Hosp Gasthuisberg, Digest Oncol Unit, Herestr 49, B-3000 Louvain, Belgium
Univ Hosp Gasthuisberg, Digest Oncol Unit, B-3000 Louvain, Belgium
State Univ Ghent Hosp, B-9000 Ghent, Belgium
Univ Catholique Louvain, St Luc Univ Hosp, Louvain, Belgium
Inst Jules Bordet, B-1000 Brussels, Belgium
AZ Vrije Univ Brussel, Brussels, Belgium
Erasme Univ Hosp, B-1070 Brussels, Belgium
Ctr Hosp Nottre Dame & Reine Fabiola, Charleroi, Belgium
Osped Niguarda Ca Granda, Milan, Italy
Hosp Clin Barcelona, Barcelona, Spain
Cabrini Hosp, Melbourne, Vic, Australia
Amgen Inc, Thousand Oaks, CA 91320 USA


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Label: DiFiore-2007
Title: Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
Journal: BRIT J CANCER, 96 (8): 1166-1169 APR 23 2007
Citations: 14
Authors: Di Fiore, F;Blanchard, F;Charbonnier, F;Le Pessot, F;Lamy, A;Galais, MP;Bastit, L;Killian, A;Sesboue, R;Tuech, JJ;Queuniet, AM;Paillot, B;Sabourin, JC;Michot, F;Michel, P;Frebourg, T
Addresses:
Rouen Uinv Hosp, Dept Hepatogastroenterol, Digest Oncol Unit, NW Canceropole, France
Rouen Uinv Hosp, Dept Hepatogastroenterol, Digest Oncol Unit, NW Canceropole, France
Fac Med, INSERM U614, Rouen, France
Rouen Uinv Hosp, Dept Pathol, NW Canceropole, France
Caen Univ Hosp, Dept Hepatogastroenterol, Digest Oncol Unit, NW Canceropole, France
Ctr Francois Baclesse, NW Canceropole, France
St Hilaire Med Ctr, Oncol Unit, Rouen, France
Rouen Uinv Hosp, Dept Surg, NW Canceropole, France


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Label: Khambata-Ford-2007
Title: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
Journal: J CLIN ONCOL, 25 (22): 3230-3237 AUG 1 2007
Citations: 12
Authors: Khambata-Ford, S;Garrett, CR;Meropol, NJ;Basik, M;Harbison, CT;Wu, S;Wong, TW;Huang, X;Takimoto, CH;Godwin, AK;Tan, BR;Krishnamurthi, SS;Burris, HA;Poplin, EA;Hidalgo, M;Baselga, J;Clark, EA;Mauro, DJ
Addresses:
Bristol Myers Squibb Co, Pharmaceut Res Inst, 311 Pennington Rocky Hill Rd 3B-2 06, Princeton, NJ 08543 USA
Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA
Canc Inst New Jersey, New Brunswick, NJ USA
H Lee Moffitt Canc Ctr & Res Inst, Div Gastrointestinal Oncol, Tampa, FL USA
Fox Chase Canc Ctr, Div Med Sci & Populat Sci, Philadelphia, PA 19111 USA
Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA
Washington Univ, Sch Med, St Louis, MO USA
Univ Hosp Cleveland, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
Case Western Reserve Univ, Cleveland, OH 44106 USA
Sarah Cannon Canc Ctr, Nashville, TN USA
Sidney Kimmel Comprehens Canc Ctr Johns Hop, Baltimore, MD USA
McGill Univ, Sir Mortimer B Davis Jewish Hosp, Quebec City, PQ, Canada
Univ Autonoma Barcelona, Vall Dhebron Univ Hosp, Oncol Program & Med Oncol Ser, E-08193 Barcelona, Spain


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Label: Benvenuti-2007
Title: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
Journal: CANCER RES, 67 (6): 2643-2648 MAR 15 2007
Citations: 9
Authors: Benvenuti, S;Sartore-Bianchi, A;Di Nicolantonio, F;Zanon, C;Moroni, M;Veronese, S;Siena, S;Bardelli, A
Addresses:
Univ Turin, Sch Med, Genet Mol Lab, Inst Canc Res & Treatment, Strada Prov 142,Km 3-95, I-10060 Candiolo, Torino, Italy
Univ Turin, Sch Med, Genet Mol Lab, Inst Canc Res & Treatment, I-10060 Candiolo, Torino, Italy
Osped Niguarda Ca Granda, Falck Div Med Oncol, Milan, Italy
FIRC Inst Mol Oncol, Milan, Italy


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Keywords: METASTATIC COLORECTAL CANCER PATIENTS TREATED; EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSING METASTATIC COLORECTAL CARCINOMA; PREVIOUSLY TREATED METASTATIC COLORECTAL CANCER; FIRST-LINE METASTATIC COLORECTAL CANCER; METASTATIC COLORECTAL CANCER TREATED.



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