The Science Watch® Newsletter once again takes its
annual look back at the hottest of recent research. The first
table below lists the researchers who, during 2007,
fielded the highest numbers of Hot Papers published over the last two
years. The second table highlights the papers published
during 2007 (aside from reviews) that were most cited by the end of the
year.
Shizuo Akira
For this latest annual roundup, Science Watch slightly changed the
selection procedure for hot authors. Previously, selection was based on
reports tallied in a single bimonthly Hot Papers file late in the year.
This time, however, Science Watch made a special extraction to
enumerate all occurrences of unique Hot Papers through the first ten months
of 2007.
Of this year’s crop of scientists, the top-most are familiar names. A
trio of high-energy physicists—Mikhail Kopytine, Basanta K. Nandi,
and Thomas Peitzmann—return from last year’s roundup, again by
virtue of their participation in not one but two large, multiauthor
experimental collaborations: PHENIX and STAR at Brookhaven National
Laboratory. For the three scientists, their contributions to research
published over the last two years resulted in a dozen Hot Papers recorded
during 2007. (The names on each tier of the table, incidentally, are listed
alphabetically.)
Just below the physicists is another return appearance by an even more
familiar name, who has become something of a fixture on this annual list of
hot authors: Osaka University’s
Shizuo Akira, who earns the distinction for a fourth
year in a row, thanks to 11 Hot Papers on pathogen recognition and other
aspects of the immune response.
Space scientist John A. Nousek of Penn State also contributed to 11 hot
reports, on X-ray emissions and other phenomena related to gamma-ray
bursts. High-impact astrophysics accounted for another place in the table,
for Jon Brinkmann of the Apache Point Observatory, New Mexico, with his
participation on 10 Hot Papers. Most of these are reports from the Sloan
Digital Sky Survey mission; one such paper can currently be found at #6 in
the latest
Physics Top Ten.
The next author on the list, cancer geneticist Carlo M. Croce of Ohio State
University, is interviewed in this issue and discusses his research on
microRNA, the subject of his 10 Hot Papers over the last two years. In a
similar vein, Howard Hughes Medical Institute investigator Todd R. Golub
fielded 10 Hot Papers on gene expression in cancer.
The 10 hot reports featuring Columbia University’s
Jeffrey
A. Lieberman center on
schizophrenia and
its treatment; Lieberman discussed his highly cited research in a recent
interview (Science Watch, 18[5]: 3-4,
September/October 2007). And Harvard epidemiologist
JoAnn Manson also contributed to 10 Hot Papers, on topics that include
hormone-replacement therapy
and women’s health, risk factors for
diabetes, and diet
supplementation in the prevention of cardiovascular disease and cancer.
Of 2007’s non-review papers, none approached the late-year citation
total of a June Astrophysical Journal Supplement Series report
from the Wilkinson Microwave Anisotropy Probe mission. This paper currently
crowns the Physics Top Ten and is discussed in this issue by correspondent
Simon Mitton.
Continuing its performance of recent years, the New England Journal of
Medicine registered strongly in the year-end listing of papers,
fielding 3 of the top 5 papers, and 15 overall. Science and
Nature each scored with 6. Together, the three journals accounted
for more than 60% of 2007’s hottest papers.
Christopher King is the Editor of the Science
Watch® Newsletter.
R.J. Motzer, et al., "Sunitinib versus interferon alfa
in metastatic renal-cell carcinoma," New Engl. J.
Med., 356(2): 115-24, 11 January 2007.
118
3
B. Escudier, et al., "Sorafenib in advanced clear-cell
renal-cell carcinoma," New Engl. J. Med., 356(2):
125-34, 11 January 2007.
106
4
S.E. Nissen, K. Wolski, "Effect of rosiglitazone on the risk of
myocardial infarction and death from cardiovascular causes,"
New Engl. J. Med., 356(24): 2457-71, 14 June 2007.
101
5
R. Sladek, et al., "A genome-wide association study
identifies novel risk loci for type 2
diabetes," Nature, 445(7130):
881-5, 22 February 2007.
92
6
G.W. Stone, et al., "Safety and efficacy of sirolimus-
and paclitaxel-eluting coronary stents," New Engl. J.
Med., 356(10): 998-1008, 8 March 2007.
68
7
E.L. Eisenstein, et al., "Clopidogrel use and
long-term clinical outcomes after drug-eluting stent
implantation," JAMA, 297(2): 159-68, 10 January 2007.
66
8
L.J. Scott, et al., "A genome-wide association study
of type 2 diabetes in Finns detects multiple susceptibility
variants," Science, 316(5829): 1341-5, 1 June 2007.
57
9
C. Kimchi-Sarfaty, et al., "A ‘silent’
polymorphism in the MDR1 gene changes substrate specificity,"
Science, 315(5811): 525-8, 26 January 2007.
57
10
B. Lagerqvist, et al., "Long-term outcomes with
drug-eluting stents versus bare-metal stents in Sweden,"
New Engl. J. Med., 356(10): 1009-19, 8 March 2007.
54
11
P.M.A. Calverley, et al., "Salmeterol and fluticasone
propionate and survival in chronic obstructive pulmonary
disease," New Engl. J. Med., 356(8): 775-89, 22
February 2007.
53
12
A. Kastrati, et al., "Analysis of 14 trials comparing
sirolimus-eluting stents with bare-metal stents," New Engl.
J. Med., 356(10): 1030-9, 8 March 2007.
52
13
W.E. Boden, et al., "Optimal medical therapy with or
without PCI for stable coronary disease," New Engl. J.
Med., 356(15): 1503-16, 12 April 2007.
50
14
J. Hampe, et al., "A genome-wide association scan of
nonsynonymous SNPs identifies a susceptibility variant for
Crohn disease in ATG16L1," Nature Genetics, 39(2):
207-11, February 2007.
50
15
E. Zeggini, et al., "Replication of genome-wide
association signals in UK samples reveals risk loci for type 2
diabetes," Science, 316(5829): 1336-41, 1 June 2007.
49
16
J. Daemen, et al., "Early and late coronary stent
thrombosis of sirolimus-eluting and paclitaxel-eluting stents
in routine clinical practice: Data from a large
two-institutional cohort study," Lancet, 369(9562):
667-78, 24 February 2007.
49
17
FUTURE II Study Group (L.L. Villa, et al.),
"Quadrivalent vaccine against human papillomavirus to prevent
high-grade cervical lesions," New Engl. J. Med.,
356(19): 1915-27, 10 May 2007.
47
18
ENCODE Project Consortium (E. Birney, et al.),
"Identification and analysis of functional elements in 1% of
the human genome by the ENCODE pilot project," Nature,
447(7146): 799-816, 14 June 2007.
47
19
L. Mauri, et al., "Stent thrombosis in randomized
clinical trials of drug-eluting stents," New Engl. J.
Med., 356(10): 1020-9, 8 March 2007.
46
20
M. Obeid, et al., "Calreticulin exposure dictates the
immunogenicity of cancer cell death," Nature Medicine,
13(1): 54-61, January 2007.
46
21
S.N. Willis, et al.,
"Apoptosis initiated when BH3 ligands
engage multiple Bcl-2 homologs, not Bax or Bak,"
Science, 315(5813): 856-9, 9 February 2007.
45
22
W.A. High, et al., "Gadolinium is detectable within
the tissue of patients with nephrogenic systemic fibrosis,"
J. Am. Acad. Dermatol., 56(1): 21-6, January 2007.
44
23
R.C. Bailey, et al., "Male circumcision for HIV
prevention in young men in Kisumu, Kenya: a randomised
controlled trial," Lancet, 369(9562): 643-56, 24
February 2007.
43
24
T.M. Frayling, et al., "A common variant in the
FTO gene is associated with body mass index and
predisposes to childhood and adult
obesity," Science, 316(5826):
889-94, 11 May 2007.
42
25
S.E. Nissen, et al., "Effect of torcetrapib on the
progression of coronary atherosclerosis," New Engl. J.
Med., 356(13): 1304-16, 29 March 2007.
42
26
C. Greenman, et al., "Patterns of somatic mutation in
human cancer genomes," Nature, 446(7132): 153-8, 8
March 2007.
42
27
C. Spaulding, et al., "A pooled analysis of data
comparing sirolimus-eluting stents with bare-metal stents,"
New Engl. J. Med., 356(10): 989-97, 8 March 2007.
42
28
R.H. Gray, et al., "Male circumcision for HIV
prevention in men in Rakai, Uganda: a randomised trial,"
Lancet, 369(9562): 657-66, 24 February 2007.
41
29
A. Phrommintikul, et al., "Mortality and target
haemoglobin concentrations in anaemic patients with chronic
kidney disease treated with erythropoietin: a meta-analysis,"
Lancet, 369(9559): 381-8, 3 February 2007.
41
30
C.W. Li, et al., "Identification of pancreatic cancer
stem cells," Cancer Res.,
67(3): 1030-7, 1 February 2007.
41
31
L.M. Scott, et al., "JAK2 exon 12 mutations
in polysythemia vera and idiopathic erythrocytosis," New
Engl. J. Med., 356(5): 459-68, 1 February 2007.
41
32
D.R. Broome, et al., "Gadodiamide-associated
nephrogenic systemic fibrosis: Why radiologists should be
concerned," Am. J. Roentgenol., 188(2): 586-92,
February 2007.
41
33
A.S. Boyd, et al., "Gadolinium deposition in
nephrogenic fibrosing dermopathy," J. Am. Acad.
Dermatol., 56(1): 27-30, January 2007.
41
34
K.K. Wong, et al., "A comprehensive analysis of common
copy-number variations in the human genome," Am. J. Human
Genetics, 80(1): 91-104, January 2007.
40
35
W. Xue, et al., "Senescence and tumour clearance is
triggered by p53 restoration in murine liver carcinomas,"
Nature, 445(7128): 656-60, 8 February 2007.
39
36
D. Dudziak, et al., "Differential antigen processing
by dendritic cell subsets in vivo," Science,
315(5808): 107-11, 5 January 2007.
39
37
L. Page, et al., "Three-year Wilkinson Microwave
Anisotropy Probe (WMAP) observations:
Polarization analysis," Astrophys. J. Suppl. Ser.,
170(2): 335-76, June 2007.
37
38
J.D. Rioux, et al., "Genome-wide association study
identifies new susceptibility loci for Crohn disease and
implicates autophagy in disease pathogenesis," Nature
Genetics, 39(5): 596-604, May 2007.
36
39
P.D. Home, et al., "Rosiglitazone evaluated for
cardiovascular outcomes: an interim analysis," New Engl. J.
Med., 357(1): 28-38, 5 July 2007.
35
40
Y. Zheng, et al., "Interleukin-22, a T(H)17 cytokine,
mediates IL-23-induced dermal inflammation and acanthosis,"
Nature, 445(7128): 648-51, 8 February 2007.
35
41
J.E. Green, et al., "A 160-kilobit molecular
electronic memory patterned at 10(11) bits per square
centimetre," Nature, 445(7126): 414-7, 25 January
2007.
35
42
R. Liu, et al., "The prognostic role of a gene
signature from tumorigenic
breast-cancer cells," New Engl. J.
Med., 356(3): 217-26, 18 January 2007.
35
SOURCE: Thomson Scientific
Web of
Science®
(Citations recorded as of late December 2007)